The network for 'plasminogen activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

plasminogen activation

The process in which inactive plasminogen is processed to active plasmin. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide.

NameDescriptionProbabilityFunc Analog Organism
F2coagulation factor II (thrombin)0.412
Pzppregnancy-zone protein0.324
Serpina1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.209
Procprotein C0.208
Serpind1serpin peptidase inhibitor, clade D (heparin cofactor), member 10.122
Apoa2apolipoprotein A-II0.111
Serpinf2serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 20.081
Serpina6serine (or cysteine) peptidase inhibitor, clade A, member 60.080
Fabp1fatty acid binding protein 1, liver0.075
Gja1gap junction protein, alpha 10.075
LOC312273Trypsin V-A0.070
Exosc7exosome component 70.065
Itih1inter-alpha trypsin inhibitor, heavy chain 10.063
Etnk2ethanolamine kinase 20.061
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.059
Gcgroup specific component0.059
Spp2secreted phosphoprotein 20.057
Serpina10serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 100.053
Cct7chaperonin containing Tcp1, subunit 7 (eta)0.045
Mbl2mannose-binding lectin (protein C) 20.045
Aimp1aminoacyl tRNA synthetase complex-interacting multifunctional protein 10.045
Slc27a5solute carrier family 27 (fatty acid transporter), member 50.043
Fetubfetuin B0.040
Nfe2nuclear factor, erythroid derived 20.039
Ambpalpha-1-microglobulin/bikunin precursor0.039
Serpina11serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 110.036
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.034
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.034
Tpsab1tryptase alpha/beta 10.033
Itih4inter alpha-trypsin inhibitor, heavy chain 40.033
Marcksl1MARCKS-like 10.033
Agxt2alanine-glyoxylate aminotransferase 20.031
Serpinc1serpin peptidase inhibitor, clade C (antithrombin), member 10.030
Plauplasminogen activator, urokinase0.029
Cct2chaperonin containing TCP1, subunit 2 (beta)0.029
Cpb2carboxypeptidase B2 (plasma)0.028
Hpd4-hydroxyphenylpyruvate dioxygenase0.027
Clec4fC-type lectin domain family 4, member f0.026
C8bcomplement component 8, beta polypeptide0.026
Gulogulonolactone (L-) oxidase0.025
Cma1chymase 1, mast cell0.025
Cd9CD9 molecule0.025
Haao3-hydroxyanthranilate 3,4-dioxygenase0.025
Otcornithine carbamoyltransferase0.025
Amy2amylase 2, pancreatic0.024
Itih3inter-alpha trypsin inhibitor, heavy chain 30.024
Timp3TIMP metallopeptidase inhibitor 30.023
Apohapolipoprotein H (beta-2-glycoprotein I)0.023
Hdchistidine decarboxylase0.022
Cficomplement factor I0.021
Azgp1alpha-2-glycoprotein 1, zinc-binding0.020
Gprc5cG protein-coupled receptor, family C, group 5, member C0.020
Rhobras homolog gene family, member B0.020
Lgals2lectin, galactoside-binding, soluble, 20.020
Lipclipase, hepatic0.019
Mbl1mannose-binding lectin (protein A) 10.019
Creb3l3cAMP responsive element binding protein 3-like 30.019
Plaurplasminogen activator, urokinase receptor0.018
IhhIndian hedgehog0.018
Foxa2forkhead box A20.018
Aqp8aquaporin 80.018
Pcsk9proprotein convertase subtilisin/kexin type 90.018
Slc17a1solute carrier family 17 (sodium phosphate), member 10.017
Puf60poly-U binding splicing factor 600.017
Pla1aphospholipase A1 member A0.017
Cidebcell death-inducing DFFA-like effector b0.017
Ptger3prostaglandin E receptor 3 (subtype EP3)0.017
Masp2mannan-binding lectin serine peptidase 20.016
Tnfrsf12atumor necrosis factor receptor superfamily, member 12a0.016
Agmatagmatine ureohydrolase (agmatinase)0.016
Lamc1laminin, gamma 10.015
Adamts1ADAM metallopeptidase with thrombospondin type 1 motif, 10.015
Lao1L-amino acid oxidase 10.015
Slc25a41solute carrier family 25, member 410.015
Epxeosinophil peroxidase0.015
Slc26a1solute carrier family 26 (sulfate transporter), member 10.015
Cela1chymotrypsin-like elastase family, member 10.015
Tcp1t-complex 10.015
Tnni1troponin I type 1 (skeletal, slow)0.015
Cytl1cytokine like 10.015
NagsN-acetylglutamate synthase0.015
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.014
LOC681996similar to AHA1, activator of heat shock 90kDa protein ATPase homolog 10.014
Slc6a12solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 120.014
Cdkn1acyclin-dependent kinase inhibitor 1A0.014
Olr1307olfactory receptor 13070.014
Kng1kininogen 10.014
Gatmglycine amidinotransferase (L-arginine:glycine amidinotransferase)0.014
Gkn2gastrokine 20.013
Cyp8b1cytochrome P450, family 8, subfamily b, polypeptide 10.013
RGD1564614similar to complement factor H-related protein0.013
Errfi1ERBB receptor feedback inhibitor 10.013
Upb1ureidopropionase, beta0.012
Asgr2asialoglycoprotein receptor 20.012
Fgafibrinogen alpha chain0.012
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
pcsk5bproprotein convertase subtilisin/kexin type 5b0.327
itln1intelectin 10.164
cd209CD209 molecule0.139
figlafactor in the germline alpha0.052
eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.045
pcsk7proprotein convertase subtilisin/kexin type 70.033
cntfrciliary neurotrophic factor receptor0.023
pcsk1proprotein convertase subtilisin/kexin type 10.020
slco1d1solute carrier organic anion transporter family, member 1D10.019
LOC100538108tissue-type plasminogen activator-like0.017
pcsk2proprotein convertase subtilisin/kexin type 20.017
col12a1collagen, type XII, alpha 10.016
plauaplasminogen activator, urokinase a0.013
itln3intelectin 30.012
pkzprotein kinase containing Z-DNA binding domains0.012
pcsk9proprotein convertase subtilisin/kexin type 90.011
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 11.000
PLAUplasminogen activator, urokinase1.000
PLATplasminogen activator, tissue1.000
PLAURplasminogen activator, urokinase receptor0.990
KNG1kininogen 10.720
TNFRSF12Atumor necrosis factor receptor superfamily, member 12A0.678
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.538
C1Scomplement component 1, s subcomponent0.497
ORM1orosomucoid 10.492
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.436
APOHapolipoprotein H (beta-2-glycoprotein I)0.435
C1Rcomplement component 1, r subcomponent0.401
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.391
FN1fibronectin 10.375
METmet proto-oncogene (hepatocyte growth factor receptor)0.346
LPAlipoprotein, Lp(a)0.214
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.183
PCOLCEprocollagen C-endopeptidase enhancer0.132
SERPINC1serpin peptidase inhibitor, clade C (antithrombin), member 10.116
TGFB1transforming growth factor, beta 10.101
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)0.101
NNMTnicotinamide N-methyltransferase0.071
SPHK1sphingosine kinase 10.067
INHBAinhibin, beta A0.061
C3complement component 30.060
SAA4serum amyloid A4, constitutive0.057
CYR61cysteine-rich, angiogenic inducer, 610.054
CPN1carboxypeptidase N, polypeptide 10.050
SERPINF2serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 20.045
COL1A1collagen, type I, alpha 10.044
AEBP1AE binding protein 10.043
EMP1epithelial membrane protein 10.037
TNCtenascin C0.036
GJB1gap junction protein, beta 1, 32kDa0.031
C8Acomplement component 8, alpha polypeptide0.031
F2coagulation factor II (thrombin)0.028
SERPIND1serpin peptidase inhibitor, clade D (heparin cofactor), member 10.028
LRP1low density lipoprotein receptor-related protein 10.028
TFR2transferrin receptor 20.027
FGBfibrinogen beta chain0.025
F10coagulation factor X0.024
SERPINA5serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 50.023
MASP2mannan-binding lectin serine peptidase 20.023
SERPINA6serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 60.022
EBPemopamil binding protein (sterol isomerase)0.022
LAMC3laminin, gamma 30.021
SRPXsushi-repeat containing protein, X-linked0.021
OSMRoncostatin M receptor0.021
PIGRpolymeric immunoglobulin receptor0.020
FDFT1farnesyl-diphosphate farnesyltransferase 10.020
ITIH1inter-alpha (globulin) inhibitor H10.019
APOEapolipoprotein E0.019
RCN3reticulocalbin 3, EF-hand calcium binding domain0.018
HSPG2heparan sulfate proteoglycan 20.018
SPP2secreted phosphoprotein 2, 24kDa0.018
GAS6growth arrest-specific 60.018
HAAO3-hydroxyanthranilate 3,4-dioxygenase0.017
TIMP3TIMP metallopeptidase inhibitor 30.017
C4BPBcomplement component 4 binding protein, beta0.017
NSDHLNAD(P) dependent steroid dehydrogenase-like0.017
IGFBP3insulin-like growth factor binding protein 30.017
TNFAIP6tumor necrosis factor, alpha-induced protein 60.017
IGF1insulin-like growth factor 1 (somatomedin C)0.017
FAPfibroblast activation protein, alpha0.017
AMBPalpha-1-microglobulin/bikunin precursor0.016
COL6A3collagen, type VI, alpha 30.016
XDHxanthine dehydrogenase0.016
ECM1extracellular matrix protein 10.016
APOBapolipoprotein B (including Ag(x) antigen)0.016
RDH16retinol dehydrogenase 16 (all-trans)0.016
PROZprotein Z, vitamin K-dependent plasma glycoprotein0.016
CPceruloplasmin (ferroxidase)0.016
WFDC2WAP four-disulfide core domain 20.015
RARRES2retinoic acid receptor responder (tazarotene induced) 20.015
AZGP1alpha-2-glycoprotein 1, zinc-binding0.015
FUT6fucosyltransferase 6 (alpha (1,3) fucosyltransferase)0.014
IL8interleukin 80.014
IGFALSinsulin-like growth factor binding protein, acid labile subunit0.014
ARG1arginase, liver0.014
ITIH4inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)0.013
APOA1apolipoprotein A-I0.013
SERPINE2serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 20.013
C2complement component 20.013
VEGFCvascular endothelial growth factor C0.013
CLEC4GC-type lectin domain family 4, member G0.013
FGGfibrinogen gamma chain0.012
TFF1trefoil factor 10.012
NR1H4nuclear receptor subfamily 1, group H, member 40.012
FOSL1FOS-like antigen 10.012
THY1Thy-1 cell surface antigen0.012
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.012
RAB17RAB17, member RAS oncogene family0.012
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Procprotein C0.099
Itih1inter-alpha trypsin inhibitor, heavy chain 10.096
Hist1h1chistone cluster 1, H1c0.085
F2coagulation factor II0.055
Hist1h2brhistone cluster 1 H2br0.032
Hist2h3c1histone cluster 2, H3c10.030
Apoa1apolipoprotein A-I0.029
Hbb-b1hemoglobin, beta adult major chain0.025
Ambpalpha 1 microglobulin/bikunin0.025
Hist1h2bphistone cluster 1, H2bp0.024
Ptgs2prostaglandin-endoperoxide synthase 20.019
Serpinc1serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 10.019
Ces1ccarboxylesterase 1C0.017
Cyr61cysteine rich protein 610.016
Cyp2c70cytochrome P450, family 2, subfamily c, polypeptide 700.015
Slc27a5solute carrier family 27 (fatty acid transporter), member 50.014
Loxlysyl oxidase0.012
Hist1h2bkhistone cluster 1, H2bk0.012
Cpn1carboxypeptidase N, polypeptide 10.012
Thbs2thrombospondin 20.012
Pzppregnancy zone protein0.011
Uhrf1ubiquitin-like, containing PHD and RING finger domains, 10.011
Slc26a9solute carrier family 26, member 90.011
Serpina10serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 100.011
Tnctenascin C0.011
Akr1c6aldo-keto reductase family 1, member C60.011
Mdm2transformed mouse 3T3 cell double minute 20.010
Hist1h2bbhistone cluster 1, H2bb0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism