The network for 'negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target

Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target.

NameDescriptionProbabilityFunc Analog Organism
Klrd1killer cell lectin-like receptor, subfamily D, member 10.958
Klra5killer cell lectin-like receptor, subfamily A, member 50.861
Gzmkgranzyme K0.677
Ccr2chemokine (C-C motif) receptor 20.670
Il7rinterleukin 7 receptor0.377
Igsf6immunoglobulin superfamily, member 60.374
Gzmbgranzyme B0.277
Mcpt8mast cell protease 80.241
Clec12aC-type lectin domain family 12, member A0.209
Vom1r93vomeronasal 1 receptor 930.208
Cd2Cd2 molecule0.203
Mmp12matrix metallopeptidase 120.198
Sellselectin L0.160
Xcl1chemokine (C motif) ligand 10.159
Nkg7natural killer cell group 7 sequence0.159
Cd8aCD8a molecule0.147
Gzmmgranzyme M (lymphocyte met-ase 1)0.147
Ccl4chemokine (C-C motif) ligand 40.147
Cd72Cd72 molecule0.113
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.113
Serpinb3aserine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A0.110
Prf1perforin 1 (pore forming protein)0.109
Sit1signaling threshold regulating transmembrane adaptor 10.107
Klrk1killer cell lectin-like receptor subfamily K, member 10.106
Klrc2killer cell lectin-like receptor subfamily C, member 20.106
Cyp2c13cytochrome P450, family 2, subfamily c, polypeptide 130.098
Acap1ArfGAP with coiled-coil, ankyrin repeat and PH domains 10.092
Ifnginterferon gamma0.090
Lilrb3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.087
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.076
Samsn1SAM domain, SH3 domain and nuclear localization signals, 10.074
Igfl3IGF-like family member 30.072
Slc17a1solute carrier family 17 (sodium phosphate), member 10.072
Zap70zeta-chain (TCR) associated protein kinase0.069
Klrb1akiller cell lectin-like receptor subfamily B, member 1A0.067
Klra17killer cell lectin-like receptor, subfamily A, member 170.067
Ugt2a1UDP glucuronosyltransferase 2 family, polypeptide A10.064
Slamf9SLAM family member 90.063
Rgs1regulator of G-protein signaling 10.062
Sh2d2aSH2 domain protein 2A0.056
Ccl5chemokine (C-C motif) ligand 50.055
Cyp2c12cytochrome P450, family 2, subfamily c, polypeptide 120.053
Cd3gCD3 molecule, gamma0.051
Trpv1transient receptor potential cation channel, subfamily V, member 10.051
Ccl9chemokine (C-C motif) ligand 90.048
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.044
MosMoloney sarcoma oncogene0.043
TcrbT-cell receptor beta chain0.043
Slc9a4solute carrier family 9 (sodium/hydrogen exchanger), member 40.041
Tlr7toll-like receptor 70.041
Reg3gregenerating islet-derived 3 gamma0.040
Ubdubiquitin D0.039
Ctsjcathepsin J0.038
Cst7cystatin F (leukocystatin)0.038
Pcsk1proprotein convertase subtilisin/kexin type 10.037
Pik3cdphosphoinositide-3-kinase, catalytic, delta polypeptide0.036
Il1rl1interleukin 1 receptor-like 10.036
Il18r1interleukin 18 receptor 10.035
Slc13a1solute carrier family 13 (sodium/sulfate symporters), member 10.033
Mcpt4mast cell protease 40.029
Ccl19chemokine (C-C motif) ligand 190.029
P2ry14purinergic receptor P2Y, G-protein coupled, 140.026
Tnni3kTNNI3 interacting kinase0.026
Gpr114G protein-coupled receptor 1140.025
Cxcl11chemokine (C-X-C motif) ligand 110.025
Itgalintegrin, alpha L0.025
Reg3bregenerating islet-derived 3 beta0.024
Cd247Cd247 molecule0.024
Gfra3GDNF family receptor alpha 30.023
Mcpt3mast cell peptidase 30.023
Clec4fC-type lectin domain family 4, member f0.023
Oas1b2-5 oligoadenylate synthetase 1B0.023
SpicSpi-C transcription factor (Spi-1/PU.1 related)0.023
Havcr1hepatitis A virus cellular receptor 10.023
Slfn3schlafen 30.022
Gimap4GTPase, IMAP family member 40.022
Nkx6-1NK6 homeobox 10.022
Klra22killer cell lectin-like receptor subfamily A, member 220.022
Parvgparvin, gamma0.022
Nox4NADPH oxidase 40.021
Epsti1epithelial stromal interaction 1 (breast)0.021
Oprm1opioid receptor, mu 10.020
Ccr5chemokine (C-C motif) receptor 50.019
Il10rainterleukin 10 receptor, alpha0.019
FcrlaFc receptor-like A0.019
Tmigd1transmembrane and immunoglobulin domain containing 10.019
LOC300024similar to Ly6-B antigen gene0.019
Unc5clunc-5 homolog C (C. elegans)-like0.019
Gucy2gguanylate cyclase 2G0.019
Gzmagranzyme A0.018
Klrc1killer cell lectin-like receptor subfamily C, member 10.018
Il2interleukin 20.018
Olr1226olfactory receptor 12260.018
RT1-HaRT1 class II, locus Ha0.018
Art2ADP-ribosyltransferase 20.017
Tnfrsf14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.017
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism