The network for 'negative regulation of macromolecule metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of macromolecule metabolic process

Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

NameDescriptionProbabilityFunc Analog Organism
Junbjun B proto-oncogene0.669
Dusp1dual specificity phosphatase 10.643
Errfi1ERBB receptor feedback inhibitor 10.587
DbpD site of albumin promoter (albumin D-box) binding protein0.580
Ifitm3interferon induced transmembrane protein 30.553
Nfyanuclear transcription factor-Y alpha0.550
Eif4heukaryotic translation initiation factor 4H0.547
Btg2BTG family, member 20.532
Metmet proto-oncogene0.495
JunJun oncogene0.459
Klf9Kruppel-like factor 90.405
Nek9NIMA (never in mitosis gene a)- related kinase 90.399
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.399
FosFBJ osteosarcoma oncogene0.397
Nedd4neural precursor cell expressed, developmentally down-regulated 40.384
Casp2caspase 20.368
Foxi2forkhead box I20.346
Ppp2cbprotein phosphatase 2, catalytic subunit, beta isoform0.336
Anxa5annexin A50.329
Sfrs1splicing factor, arginine/serine-rich 10.321
Dynll1dynein light chain LC8-type 10.320
S100a10S100 calcium binding protein A100.300
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.297
Tgfbr2transforming growth factor, beta receptor II0.284
Adra2badrenergic, alpha-2B-, receptor0.277
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.277
Nrg2neuregulin 20.274
Irs1insulin receptor substrate 10.274
Stip1stress-induced phosphoprotein 10.269
Tcfe2atranscription factor E2a0.269
Cd9CD9 molecule0.266
Rhobras homolog gene family, member B0.266
Iappislet amyloid polypeptide0.262
RestRE1-silencing transcription factor0.254
Klf4Kruppel-like factor 4 (gut)0.248
Arpc1bactin related protein 2/3 complex, subunit 1B0.248
Ppm1gprotein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform0.245
Asgr1asialoglycoprotein receptor 10.243
Ier2immediate early response 20.243
Mgpmatrix Gla protein0.239
Cdk2cyclin dependent kinase 20.237
Stat6signal transducer and activator of transcription 60.236
Jak1Janus kinase 10.235
Ptpn1protein tyrosine phosphatase, non-receptor type 10.235
Nfianuclear factor I/A0.233
Thbdthrombomodulin0.231
Hnrnpkheterogeneous nuclear ribonucleoprotein K0.230
Anxa4annexin A40.228
Kdm6blysine (K)-specific demethylase 6B0.228
Sgk1serum/glucocorticoid regulated kinase 10.227
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.227
Arf6ADP-ribosylation factor 60.219
Adora2aadenosine A2a receptor0.218
Slc30a1solute carrier family 30 (zinc transporter), member 10.216
Hes1hairy and enhancer of split 1 (Drosophila)0.215
Lbrlamin B receptor0.213
Galr3galanin receptor 30.210
Mapk8ip2mitogen-activated protein kinase 8 interacting protein 20.210
Smad2SMAD family member 20.207
Rararetinoic acid receptor, alpha0.207
Egr1early growth response 10.206
Nr4a3nuclear receptor subfamily 4, group A, member 30.206
Creb1cAMP responsive element binding protein 10.205
Onecut1one cut homeobox 10.202
Jak2Janus kinase 20.201
Gja1gap junction protein, alpha 10.199
Trim47tripartite motif-containing 470.197
Dchs1dachsous 1 (Drosophila)0.196
Ywhaqtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.191
Ambpalpha-1-microglobulin/bikunin precursor0.191
Tcp11t-complex protein 110.190
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.190
Cdk4cyclin-dependent kinase 40.187
Smad7SMAD family member 70.186
Myo1bmyosin Ib0.185
Lifleukemia inhibitory factor0.184
Smad6SMAD family member 60.184
Hoxb7homeo box B70.184
Dccdeleted in colorectal carcinoma0.182
Top2atopoisomerase (DNA) II alpha0.182
Ptprkprotein tyrosine phosphatase, receptor type, K, extracellular region0.181
Nr2f6nuclear receptor subfamily 2, group F, member 60.181
Metap2methionyl aminopeptidase 20.179
Flt1FMS-related tyrosine kinase 10.179
Nr4a1nuclear receptor subfamily 4, group A, member 10.179
Scn4asodium channel, voltage-gated, type IV, alpha subunit0.178
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.177
Mbl1mannose-binding lectin (protein A) 10.177
Il12binterleukin 12B0.177
Slc15a1solute carrier family 15 (oligopeptide transporter), member 10.177
Nrgnneurogranin0.176
Tcf4transcription factor 40.176
Bat1HLA-B associated transcript 10.175
Slc18a3solute carrier family 18 (vesicular acetylcholine), member 30.174
Alx1ALX homeobox 10.174
Pfkfb36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 30.173
Phlda1pleckstrin homology-like domain, family A, member 10.173
F2coagulation factor II (thrombin)0.172
Pik3r1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.172
Abcb4ATP-binding cassette, subfamily B (MDR/TAP), member 40.172
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
egl-18Protein EGL-180.894
vab-3Protein VAB-30.689
snr-2Protein SNR-20.640
glp-1Protein GLP-10.615
nhr-67Protein NHR-670.591
hlh-2Protein HLH-20.581
let-502Protein LET-5020.578
lin-53Protein LIN-530.575
egl-46Protein EGL-460.565
egl-27Protein EGL-270.553
atn-1Protein ATN-10.546
mdf-2Protein MDF-20.539
csn-4Protein CSN-40.517
ten-1Protein TEN-10.491
cacn-1Protein CACN-10.478
pal-1Protein PAL-10.467
hcp-3Protein HCP-30.459
pha-4Protein PHA-40.459
inx-3Protein INX-30.455
zyg-9Protein ZYG-90.442
his-16Protein HIS-160.440
abi-1Protein ABI-10.433
his-45Protein HIS-450.428
elt-6Protein ELT-60.428
CELE_C25A1.4Protein C25A1.40.427
lmn-1Protein LMN-10.409
nhr-2Protein NHR-20.396
pqbp-1.1Protein PQBP-1.10.387
atg-2Protein ATG-20.385
egl-13Protein EGL-130.372
his-5Protein HIS-50.343
lin-35Protein LIN-350.341
imb-2Protein IMB-20.334
tbb-2Protein TBB-20.332
zyg-1Protein ZYG-10.325
his-48Protein HIS-480.324
capg-1Protein CAPG-10.322
npp-4Protein NPP-40.316
CELE_C17E4.6Protein C17E4.60.312
klp-19Protein KLP-190.312
daf-14Protein DAF-140.311
lin-66Protein LIN-660.310
plk-3Protein PLK-30.306
par-5Protein PAR-50.306
his-1Protein HIS-10.306
his-46Protein HIS-460.303
npp-7Protein NPP-70.301
rec-8Protein REC-80.298
CELE_C23G10.8Protein C23G10.80.297
CELE_C24H12.5Protein C24H12.50.290
R11A8.7Protein R11A8.70.287
cnd-1Protein CND-10.284
inx-13Protein INX-130.282
hum-5Protein HUM-50.282
pry-1Protein PRY-10.281
dve-1Protein DVE-10.276
cam-1Protein CAM-10.275
daf-3Protein DAF-30.275
his-52Protein HIS-520.269
cids-2Protein CIDS-20.265
B0336.3Protein B0336.30.262
nhr-25Protein NHR-250.261
mes-3Protein MES-30.261
hlh-11Protein HLH-110.261
F49C12.9Protein F49C12.90.260
CELE_T23B5.3Protein T23B5.30.257
sdz-28Protein SDZ-280.257
daf-4Protein DAF-40.256
htz-1Protein HTZ-10.255
mcm-7Protein MCM-70.250
age-1Protein AGE-10.238
CELE_F19F10.9Protein F19F10.90.235
lin-15AProtein LIN-15A0.234
his-3Protein HIS-30.234
ptr-14Protein PTR-140.232
his-42Protein HIS-420.230
cfim-2Protein CFIM-20.230
nap-1Protein NAP-10.230
unc-62Protein UNC-620.230
F59E12.9Protein F59E12.90.229
daf-1Protein DAF-10.228
lin-12Protein LIN-120.227
his-47Protein HIS-470.226
egl-8Protein EGL-80.225
his-50Protein HIS-500.224
air-2Protein AIR-20.223
tbx-8Protein TBX-80.222
sgo-1Protein SGO-10.222
mat-3Protein MAT-30.221
bet-1Protein BET-10.221
gld-1Protein GLD-10.220
csr-1Protein CSR-10.216
F55F8.9Protein F55F8.90.216
hlh-1Protein HLH-10.216
F25H5.5Protein F25H5.50.215
nol-5Protein NOL-50.213
mcm-4Protein MCM-40.211
ect-2Protein ECT-20.210
unc-6Protein UNC-60.210
ceh-27Protein CEH-270.209
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
bmp2bbone morphogenetic protein 2b0.991
fgf3fibroblast growth factor 30.869
gata6GATA-binding protein 60.752
gli1GLI-Kruppel family member 10.669
robo3roundabout homolog 30.657
etv5bets variant 5b0.641
spry4sprouty (Drosophila) homolog 40.641
six3bsine oculis homeobox homolog 3b0.639
cdc25cell division cycle 25 homolog0.569
aldh1a2aldehyde dehydrogenase 1 family, member A20.549
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.545
igf1rbinsulin-like growth factor 1b receptor0.542
ikzf1IKAROS family zinc finger 1 (Ikaros)0.526
ndr2nodal-related 20.521
runx2brunt-related transcription factor 2b0.495
dlx5adistal-less homeobox gene 5a0.481
dlx3bdistal-less homeobox gene 3b0.467
egr1early growth response 10.455
dlx2adistal-less homeobox gene 2a0.435
gro1groucho 10.433
zff9zinc finger protein 90.426
smosmoothened homolog (Drosophila)0.418
whsc1Wolf-Hirschhorn syndrome candidate 10.416
foxi1forkhead box I10.390
nap1l1nucleosome assembly protein 1, like 10.390
dusp6dual specificity phosphatase 60.387
fzd7afrizzled homolog 7a0.384
chdchordin0.381
tgfb3transforming growth factor, beta 30.367
her6hairy-related 60.364
tfap2atranscription factor AP-2 alpha0.362
gpiaglucose phosphate isomerase a0.361
nclnucleolin0.358
bocbrother of CDO0.350
pax8paired box gene 80.345
ascl1aachaete-scute complex-like 1a (Drosophila)0.340
mab21l2mab-21-like 20.339
sox11bSRY-box containing gene 11b0.338
vsx1visual system homeobox 1 homolog, chx10-like0.331
notch1anotch homolog 1a0.331
six3asine oculis homeobox homolog 3a0.321
clockclock0.314
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.313
wnt1wingless-type MMTV integration site family, member 10.310
tal1T-cell acute lymphocytic leukemia 10.306
wnt2bbwingless-type MMTV integration site family, member 2Bb0.306
robo1roundabout homolog 10.304
otpborthopedia homolog b0.302
lyzlysozyme0.301
lhx1aLIM homeobox 1a0.300
pou1f1POU domain, class 1, transcription factor 10.291
ywhaqbtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b0.283
rasl11bRAS-like, family 11, member B0.281
nadl1.1neural adhesion molecule L1.10.279
robo2roundabout homolog 20.278
rx3retinal homeobox gene 30.265
rab11fip4aRAB11 family interacting protein 4 (class II) a0.263
klf4Kruppel-like factor 40.262
lmx1b.1LIM homeobox transcription factor 1, beta 10.262
frem3Fras1 related extracellular matrix 30.262
kctd15apotassium channel tetramerisation domain containing 15a0.262
tardbpTAR DNA binding protein0.259
flot2aflotillin 2a0.253
pea3ETS-domain transcription factor pea30.249
mecomMDS1 and EVI1 complex locus0.248
gata5GATA-binding protein 50.247
zgc:101606zgc:1016060.244
flhfloating head0.233
ccnd1cyclin D10.231
hoxb1bhomeo box B1b0.230
jag2jagged 20.229
tbx6T-box gene 60.226
slit3slit (Drosophila) homolog 30.225
cdh1cadherin 1, epithelial0.224
ywhabbtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b0.219
irx4biroquois homeobox protein 4b0.216
pbx1apre-B-cell leukemia transcription factor 1a0.214
sema3aasemaphorin 3aa0.214
otx1borthodenticle homolog 1b0.213
elk4ELK4, ETS-domain protein0.213
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.211
cry1acryptochrome 1a0.209
her11hairy-related 110.208
rad21RAD21 homolog (S. pombe)0.207
sox19aSRY-box containing gene 19a0.205
zic1zic family member 1 (odd-paired homolog, Drosophila)0.205
gata4GATA-binding protein 40.203
smc4structural maintenance of chromosomes 40.203
sox21aSRY-box containing gene 21a0.203
tyrtyrosinase0.202
sox4aSRY-box containing gene 4a0.200
hmgb1ahigh-mobility group box 1a0.198
diexfdigestive organ expansion factor homolog0.196
cdh23cadherin-like 230.196
fzd5frizzled homolog 50.193
wt1awilms tumor 1a0.193
sox11aSRY-box containing gene 11a0.191
her1hairy-related 10.188
zgc:77714zgc:777140.186
bmp4bone morphogenetic protein 40.186
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
RPD3Rpd3p0.999
SIN3Sin3p0.996
GLC7Glc7p0.991
SIR2Sir2p0.989
SIR4Sir4p0.984
HHF1Hhf1p0.983
RAP1Rap1p0.955
CTK1Ctk1p0.951
SNF1Snf1p0.949
RTF1Rtf1p0.934
SET1Set1p0.930
SSE1Sse1p0.930
RIF1Rif1p0.928
SIN4Sin4p0.924
HMO1Hmo1p0.914
CCR4Ccr4p0.908
HDA1Hda1p0.902
RXT2Rxt2p0.902
GAL11Gal11p0.897
SIR3Sir3p0.885
PIL1Pil1p0.884
FKH2Fkh2p0.866
HOG1Hog1p0.863
AFT1Aft1p0.854
SIC1Sic1p0.847
SAS2Sas2p0.835
ORC1Orc1p0.832
CTI6Cti6p0.830
RNR4Rnr4p0.821
RPN4Rpn4p0.819
ADR1Adr1p0.818
ESF1Esf1p0.815
CYC8Cyc8p0.814
SDS3Sds3p0.809
SUM1Sum1p0.792
HTB1Htb1p0.782
IRE1Ire1p0.774
RLF2Rlf2p0.772
ARX1Arx1p0.766
ZDS2Zds2p0.753
CDC6Cdc6p0.745
DPB2Dpb2p0.743
ASF1Asf1p0.742
HTZ1Htz1p0.737
CTF18Ctf18p0.730
HTB2Htb2p0.730
CKA2Cka2p0.726
STE4Ste4p0.724
FKH1Fkh1p0.720
PPH21Pph21p0.719
MRC1Mrc1p0.717
GSY2Gsy2p0.712
NET1Net1p0.706
BDF1Bdf1p0.702
HDA2Hda2p0.699
HHT1Hht1p0.697
BOI2Boi2p0.690
UBP10Ubp10p0.684
HCM1Hcm1p0.684
RRM3Rrm3p0.668
STB3Stb3p0.664
RAD9Rad9p0.663
DEP1Dep1p0.660
PUB1Pub1p0.658
CDC20Cdc20p0.654
RSC2Rsc2p0.643
HAT2Hat2p0.643
PHO23Pho23p0.642
ORC2Orc2p0.640
HAS1Has1p0.631
PAF1Paf1p0.630
RAD51Rad51p0.630
HFI1Hfi1p0.629
DHH1Dhh1p0.628
POL2Pol2p0.623
NRG1Nrg1p0.619
HAT1Hat1p0.616
SPT16Spt16p0.613
ORC5Orc5p0.607
YTA7Yta7p0.606
SCH9Sch9p0.604
ROX3Rox3p0.594
UBP8Ubp8p0.589
RGR1Rgr1p0.589
SLX5Slx5p0.588
HHO1Hho1p0.587
RNR2Rnr2p0.582
SGV1Sgv1p0.578
PHO85Pho85p0.575
SSN3Ssn3p0.570
SPT8Spt8p0.567
MUM2Mum2p0.567
UME1Ume1p0.566
HSE1Hse1p0.563
IFH1Ifh1p0.562
NTO1Nto1p0.557
PGD1Pgd1p0.541
STN1Stn1p0.537
UME6Ume6p0.536
CHL1Chl1p0.535