The network for 'cell fate commitment involved in pattern specification' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cell fate commitment involved in pattern specification

The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells within a field of cells that will exhibit a certain pattern of differentiation. Positional information is established through protein signals that emanate from a localized source within a developmental field resulting in specification of a cell type. Those signals are then interpreted in a cell-autonomous manner resulting in the determination of the cell type.

NameDescriptionProbabilityFunc Analog Organism
Grin2aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.124
Dlg4discs, large homolog 4 (Drosophila)0.105
Hk1hexokinase 10.048
Syngap1synaptic Ras GTPase activating protein 1 homolog (rat)0.038
Rararetinoic acid receptor, alpha0.038
Dgkidiacylglycerol kinase, iota0.036
Il13interleukin 130.034
Grin1glutamate receptor, ionotropic, N-methyl D-aspartate 10.032
Dlgap1discs, large (Drosophila) homolog-associated protein 10.031
Pdk2pyruvate dehydrogenase kinase, isozyme 20.028
Baiap2BAI1-associated protein 20.028
NrarpNotch-regulated ankyrin repeat protein0.027
Sdk2sidekick homolog 2 (chicken)0.026
Magi2membrane associated guanylate kinase, WW and PDZ domain containing 20.024
Syn1synapsin I0.024
Exoc5exocyst complex component 50.023
Dlg3discs, large homolog 3 (Drosophila)0.022
Nlgn2neuroligin 20.022
Shank1SH3 and multiple ankyrin repeat domains 10.021
Vps29vacuolar protein sorting 29 homolog (S. cerevisiae)0.021
Nfe2l2nuclear factor, erythroid derived 2, like 20.020
Gucy1a2guanylate cyclase 1, soluble, alpha 20.020
Lrfn2leucine rich repeat and fibronectin type III domain containing 20.020
LOC100361571keratin associated protein 1-3-like0.019
Trhr2thyrotropin releasing hormone receptor 20.019
Il12binterleukin 12B0.019
Syt11synaptotagmin XI0.019
Dcaf7DDB1 and CUL4 associated factor 70.018
Gna15guanine nucleotide binding protein, alpha 150.017
Dlg1discs, large homolog 1 (Drosophila)0.016
Hp1bp3heterochromatin protein 1, binding protein 30.016
Sdc3syndecan 30.016
Magi1membrane associated guanylate kinase, WW and PDZ domain containing 10.016
Rab5aRAB5A, member RAS oncogene family0.015
Best2bestrophin 20.015
Mllt4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.014
Rc3h2ring finger and CCCH-type zinc finger domains 20.014
Pik3r2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.014
Tpcr12putative olfactory receptor0.014
Syt7synaptotagmin VII0.014
Slc6a4solute carrier family 6 (neurotransmitter transporter, serotonin), member 40.014
Atp2a3ATPase, Ca++ transporting, ubiquitous0.013
Bdkrb2bradykinin receptor B20.013
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.013
Pitx3paired-like homeodomain 30.013
Narg1NMDA receptor regulated 10.013
Slc18a3solute carrier family 18 (vesicular acetylcholine), member 30.013
Megf10multiple EGF-like domains 100.013
Elk3ELK3, ETS-domain protein0.013
Cnksr2connector enhancer of kinase suppressor of Ras 20.013
Npy5rneuropeptide Y receptor Y50.013
Dock6dedicator of cytokinesis 60.013
Prss22protease, serine, 220.012
Hpcal4hippocalcin-like 40.012
Unc5aunc-5 homolog A (C. elegans)0.012
Ascl1achaete-scute complex homolog 1 (Drosophila)0.012
Pkn2protein kinase N20.012
Slc8a2solute carrier family 8 (sodium/calcium exchanger), member 20.012
Lrrc7leucine rich repeat containing 70.012
Caskcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.012
Gja4gap junction protein, alpha 40.011
Mgat3mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase0.011
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform0.011
Tanc1tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 10.011
Ikzf5IKAROS family zinc finger 50.011
Pcdhgc3protocadherin gamma subfamily C, 30.011
Sox7SRY (sex determining region Y)-box 70.011
Fam100afamily with sequence similarity 100, member A0.011
Tceb3transcription elongation factor B (SIII), polypeptide 30.011
St18suppression of tumorigenicity 180.011
Pspparotid secretory protein0.011
Eif4eeukaryotic translation initiation factor 4E0.011
Garnl1GTPase activating Rap/RanGAP domain-like 10.010
Scamp1secretory carrier membrane protein 10.010
Sox17SRY (sex determining region Y)-box 170.010
Txnl1thioredoxin-like 10.010
Il5interleukin 50.010
Doc2adouble C2-like domains, alpha0.010
Dctn4dynactin 40.010
Grin2dglutamate receptor, ionotropic, N-methyl D-aspartate 2D0.010
Cnga3cyclic nucleotide gated channel alpha 30.010
Batf3basic leucine zipper transcription factor, ATF-like 30.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
hlh-1Protein HLH-10.115
elt-6Protein ELT-60.102
cnd-1Protein CND-10.071
egl-18Protein EGL-180.052
nhr-67Protein NHR-670.033
ten-1Protein TEN-10.029
fkh-2Protein FKH-20.027
pha-4Protein PHA-40.026
egl-46Protein EGL-460.025
hnd-1Protein HND-10.020
hlh-14Protein HLH-140.010
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
hnf1baHNF1 homeobox Ba0.551
wnt1wingless-type MMTV integration site family, member 10.459
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.410
gli1GLI-Kruppel family member 10.378
wnt5bwingless-type MMTV integration site family, member 5b0.319
tbx1T-box 10.314
dbx1adeveloping brain homeobox 1a0.277
wnt3wingless-type MMTV integration site family, member 30.274
wnt4awingless-type MMTV integration site family, member 4a0.272
fezf2FEZ family zinc finger 20.257
wnt2wingless-type MMTV integration site family member 20.252
gro2groucho 20.233
nkx2.2aNK2 transcription factor related 2a0.216
fzd8afrizzled homolog 8a0.204
neurod4neurogenic differentiation 40.187
foxa2forkhead box A20.187
fgf17fibroblast growth factor 170.177
flhfloating head0.165
wif1wnt inhibitory factor 10.139
otx2orthodenticle homolog 20.125
atoh1aatonal homolog 1a0.119
wnt8bwingless-type MMTV integration site family, member 8b0.112
her3hairy-related 30.106
wnt2bbwingless-type MMTV integration site family, member 2Bb0.106
ephb4beph receptor B4b0.095
wlswntless homolog (Drosophila)0.088
tbx16T-box gene 160.088
ascl1bachaete-scute complex-like 1b (Drosophila)0.087
fzd10frizzled homolog 100.086
nr2e1nuclear receptor subfamily 2, group E, member 10.085
sox19aSRY-box containing gene 19a0.082
dlg2discs, large (Drosophila) homolog 20.080
wnt3awingless-type MMTV integration site family, member 3A0.074
fzd7afrizzled homolog 7a0.071
her8ahairy-related 8a0.063
hoxd4ahomeo box D4a0.062
wnt11rwingless-type MMTV integration site family, member 11, related0.060
ascl1aachaete-scute complex-like 1a (Drosophila)0.056
foxn4forkhead box N40.056
vsx2visual system homeobox 20.053
ndr2nodal-related 20.053
lhx1bLIM homeobox 1b0.052
rx2retinal homeobox gene 20.052
ptf1apancreas specific transcription factor, 1a0.051
notch1anotch homolog 1a0.051
tpbgltrophoblast glycoprotein-like0.051
dkk1bdickkopf 1b0.048
traf4atnf receptor-associated factor 4a0.046
her12hairy-related 120.045
hmgcrb3-hydroxy-3-methylglutaryl-Coenzyme A reductase b0.039
atoh1batonal homolog 1b0.037
wnt11wingless-type MMTV integration site family, member 110.036
vsx1visual system homeobox 1 homolog, chx10-like0.034
eng2aengrailed 2a0.034
gro1groucho 10.032
jag2jagged 20.031
oprd1bopioid receptor, delta 1b0.031
prdm14PR domain containing 140.031
her1hairy-related 10.031
bmp2abone morphogenetic protein 2a0.029
fgf3fibroblast growth factor 30.027
sfrp1asecreted frizzled-related protein 1a0.027
notch3notch homolog 30.026
slc17a7solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 70.026
lhx2bLIM homeobox 2b0.025
fgfr1bfibroblast growth factor receptor 1b0.025
sox1aSRY-box containing gene 1a0.024
frzbfrizzled-related protein0.024
restRE1-silencing transcription factor0.023
nog1noggin 10.022
tcf7l1atranscription factor 7-like 1a (T-cell specific, HMG-box)0.022
lhx5LIM homeobox 50.022
nkx6.2NK6 transcription factor related, locus 20.022
olig3oligodendrocyte transcription factor 30.022
foxa1forkhead box A10.021
evx1even-skipped homeobox 10.021
otx1aorthodenticle homolog 1a0.021
admpanti-dorsalizing morphogenic protein0.020
tmpoathymopoietin a0.020
has2hyaluronan synthase 20.020
nkx2.2bNK2 transcription factor related 2b0.019
cdkn1ccyclin-dependent kinase inhibitor 1C (p57, Kip2)0.019
pdlim3aPDZ and LIM domain 3a0.019
atoh1catonal homolog 1c0.019
tbx5aT-box 5a0.019
jag1bjagged 1b0.019
six3bsine oculis homeobox homolog 3b0.018
wnt9bwingless-type MMTV integration site family, member 9B0.018
alcambactivated leukocyte cell adhesion molecule b0.016
celsr2cadherin, EGF LAG seven-pass G-type receptor 2 and cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)0.016
ntlano tail a0.016
dccdeleted in colorectal carcinoma0.016
dag1dystroglycan 10.015
col4a5collagen, type IV, alpha 5 (Alport syndrome)0.015
glceaglucuronyl C5-epimerase a0.015
sox17SRY-box containing gene 170.015
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
E(spl)Enhancer of split1.000
HLHm7E(spl) region transcript m70.994
HLHmgammaE(spl) region transcript mgamma0.975
HLHmdeltaE(spl) region transcript mdelta0.969
HLHm5E(spl) region transcript m50.947
malphaE(spl) region transcript malpha0.862
HLHmbetaE(spl) region transcript mbeta0.861
m4E(spl) region transcript m40.784
amosabsent MD neurons and olfactory sensilla0.564
TomTwin of m40.434
Su(H)Suppressor of Hairless0.398
m2E(spl) region transcript m20.295
argosCG4531 gene product from transcript CG4531-RA0.280
CtBPC-terminal Binding Protein0.220
Traf4TNF-receptor-associated factor 40.207
dallydivision abnormally delayed0.197
MadMothers against dpp0.185
TolloCG6890 gene product from transcript CG6890-RA0.169
NotumCG13076 gene product from transcript CG13076-RB0.127
emcextra macrochaetae0.123
MsiMale-specific insect derived growth factor0.105
Stat92ESignal-transducer and activator of transcription protein at 92E0.069
Abd-BAbdominal B0.069
HLHm3E(spl) region transcript m30.067
gcmglial cells missing0.057
eyaeyes absent0.056
m6E(spl) region transcript m60.048
Wnt2Wnt oncogene analog 20.047
dcodiscs overgrown0.038
Lim1CG11354 gene product from transcript CG11354-RA0.038
PoxnPox neuro0.037
Fas2Fasciclin 20.035
bibbig brain0.034
dlg1discs large 10.034
gbbglass bottom boat0.032
sogshort gastrulation0.030
Cdc42CG12530 gene product from transcript CG12530-RA0.030
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
JAG1jagged 11.000
NOTCH1notch 11.000
NOTCH3notch 31.000
SUFUsuppressor of fused homolog (Drosophila)0.984
GDAguanine deaminase0.975
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.949
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.938
STK36serine/threonine kinase 360.910
DVL1dishevelled, dsh homolog 1 (Drosophila)0.890
NOTCH2notch 20.883
JAG2jagged 20.882
TGIF1TGFB-induced factor homeobox 10.877
DLL1delta-like 1 (Drosophila)0.850
ADAM17ADAM metallopeptidase domain 170.799
MAML1mastermind-like 1 (Drosophila)0.750
PEX26peroxisomal biogenesis factor 260.678
SNIP1Smad nuclear interacting protein 10.611
RCN3reticulocalbin 3, EF-hand calcium binding domain0.606
RAB11FIP2RAB11 family interacting protein 2 (class I)0.563
GLI1GLI family zinc finger 10.539
HIC1hypermethylated in cancer 10.463
VHLvon Hippel-Lindau tumor suppressor0.436
RAB11FIP1RAB11 family interacting protein 1 (class I)0.420
RHOXF2Rhox homeobox family, member 20.385
GFI1Bgrowth factor independent 1B transcription repressor0.354
CUL2cullin 20.329
KCNA4potassium voltage-gated channel, shaker-related subfamily, member 40.319
CDK11Bcyclin-dependent kinase 11B0.290
XIAPX-linked inhibitor of apoptosis0.287
MID1IP1MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))0.256
GRIN2Cglutamate receptor, ionotropic, N-methyl D-aspartate 2C0.236
DCUN1D1DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)0.223
BAZ2Bbromodomain adjacent to zinc finger domain, 2B0.216
ATP2B2ATPase, Ca++ transporting, plasma membrane 20.195
ZNF263zinc finger protein 2630.186
GRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.185
QPRTquinolinate phosphoribosyltransferase0.183
ZNF512Bzinc finger protein 512B0.170
ZNF764zinc finger protein 7640.158
FZD1frizzled homolog 1 (Drosophila)0.153
SOX13SRY (sex determining region Y)-box 130.152
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.152
EGFL7EGF-like-domain, multiple 70.148
ATN1atrophin 10.147
TCF4transcription factor 40.143
CEP164centrosomal protein 164kDa0.130
ZIC1Zic family member 1 (odd-paired homolog, Drosophila)0.129
LMX1ALIM homeobox transcription factor 1, alpha0.127
GLIS3GLIS family zinc finger 30.124
WT1Wilms tumor 10.120
ATXN1Lataxin 1-like0.117
KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)0.112
DLGAP1discs, large (Drosophila) homolog-associated protein 10.109
ASB7ankyrin repeat and SOCS box containing 70.105
LGALS8lectin, galactoside-binding, soluble, 80.105
RBX1ring-box 1, E3 ubiquitin protein ligase0.096
BAHD1bromo adjacent homology domain containing 10.082
NLGN1neuroligin 10.082
ARandrogen receptor0.079
RAB11FIP3RAB11 family interacting protein 3 (class II)0.078
SMAD1SMAD family member 10.076
KRTAP4-12keratin associated protein 4-120.075
CAMK2Acalcium/calmodulin-dependent protein kinase II alpha0.074
NOTCH2NLnotch 2 N-terminal like0.070
LCORLligand dependent nuclear receptor corepressor-like0.070
CAPZA2capping protein (actin filament) muscle Z-line, alpha 20.069
THAP11THAP domain containing 110.068
OLIG2oligodendrocyte lineage transcription factor 20.066
MNX1motor neuron and pancreas homeobox 10.060
BHLHE23basic helix-loop-helix family, member e230.060
PDX1pancreatic and duodenal homeobox 10.058
PITX1paired-like homeodomain 10.058
KLF4Kruppel-like factor 4 (gut)0.056
CTBP2C-terminal binding protein 20.056
WNT10Awingless-type MMTV integration site family, member 10A0.056
CASKcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.055
LHX2LIM homeobox 20.053
CRIPTcysteine-rich PDZ-binding protein0.052
ANKS1Bankyrin repeat and sterile alpha motif domain containing 1B0.051
IKZF1IKAROS family zinc finger 1 (Ikaros)0.051
DCUN1D5DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae)0.050
SPENspen homolog, transcriptional regulator (Drosophila)0.050
DLG3discs, large homolog 3 (Drosophila)0.049
ZNF219zinc finger protein 2190.049
WNT4wingless-type MMTV integration site family, member 40.049
LRRK2leucine-rich repeat kinase 20.047
ZEB1zinc finger E-box binding homeobox 10.046
PROX1prospero homeobox 10.046
AXIN1axin 10.046
ARIH2ariadne homolog 2 (Drosophila)0.046
LBX1ladybird homeobox 10.045
SOX1SRY (sex determining region Y)-box 10.043
DLL4delta-like 4 (Drosophila)0.042
ERGv-ets erythroblastosis virus E26 oncogene homolog (avian)0.041
PIK3CBphosphoinositide-3-kinase, catalytic, beta polypeptide0.041
ASB2ankyrin repeat and SOCS box containing 20.040
CSNK1Ecasein kinase 1, epsilon0.040
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Pax6paired box gene 60.999
Otx2orthodenticle homolog 2 (Drosophila)0.996
Emx1empty spiracles homolog 1 (Drosophila)0.994
Pitx2paired-like homeodomain transcription factor 20.953
Gli3GLI-Kruppel family member GLI30.937
Vangl2vang-like 2 (van gogh, Drosophila)0.920
Psen1presenilin 10.916
Foxc1forkhead box C10.911
Sox2SRY-box containing gene 20.908
Notch1Notch gene homolog 1 (Drosophila)0.876
Ascl1achaete-scute complex homolog 1 (Drosophila)0.857
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.789
Fgf8fibroblast growth factor 80.751
Insm1insulinoma-associated 10.709
Gscgoosecoid homeobox0.706
Pdx1pancreatic and duodenal homeobox 10.660
Fgfr2fibroblast growth factor receptor 20.657
Emx2empty spiracles homolog 2 (Drosophila)0.645
Isl1ISL1 transcription factor, LIM/homeodomain0.642
Tcfap2atranscription factor AP-2, alpha0.634
Hoxd3homeobox D30.575
Pax2paired box gene 20.545
Ctnnb1catenin (cadherin associated protein), beta 10.525
Ptk7PTK7 protein tyrosine kinase 70.517
Foxa2forkhead box A20.514
Hes1hairy and enhancer of split 1 (Drosophila)0.498
Lhx5LIM homeobox protein 50.484
Ptf1apancreas specific transcription factor, 1a0.464
Msx1homeobox, msh-like 10.456
Hoxd13homeobox D130.441
Lhx4LIM homeobox protein 40.399
Dll1delta-like 1 (Drosophila)0.356
Lhx3LIM homeobox protein 30.347
Vangl1vang-like 1 (van gogh, Drosophila)0.345
Hoxb3homeobox B30.337
Sall3sal-like 3 (Drosophila)0.324
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.300
Neurog3neurogenin 30.275
Gbx2gastrulation brain homeobox 20.273
Sox11SRY-box containing gene 110.269
Foxg1forkhead box G10.264
Sox3SRY-box containing gene 30.254
Ror2receptor tyrosine kinase-like orphan receptor 20.251
Dvl2dishevelled 2, dsh homolog (Drosophila)0.249
Rargretinoic acid receptor, gamma0.248
Sox9SRY-box containing gene 90.225
Neurog2neurogenin 20.220
Otx1orthodenticle homolog 1 (Drosophila)0.219
Nkx6-1NK6 homeobox 10.209
Six3sine oculis-related homeobox 3 homolog (Drosophila)0.202
Neurod1neurogenic differentiation 10.199
Gli2GLI-Kruppel family member GLI20.198
Phox2bpaired-like homeobox 2b0.193
Hes5hairy and enhancer of split 5 (Drosophila)0.187
Hmx1H6 homeobox 10.179
Atoh7atonal homolog 7 (Drosophila)0.178
Nkx3-2NK3 homeobox 20.177
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.174
Foxc2forkhead box C20.167
Wnt3awingless-related MMTV integration site 3A0.167
Notch2Notch gene homolog 2 (Drosophila)0.166
Arxaristaless related homeobox0.160
Foxb1forkhead box B10.143
Hoxa5homeobox A50.140
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.139
Hoxb4homeobox B40.138
Pax3paired box gene 30.136
Fgf3fibroblast growth factor 30.135
Pax1paired box gene 10.134
Six2sine oculis-related homeobox 2 homolog (Drosophila)0.130
Fgf15fibroblast growth factor 150.123
Retret proto-oncogene0.121
Phox2apaired-like homeobox 2a0.120
Barx1BarH-like homeobox 10.118
Nhlh1nescient helix loop helix 10.115
Gdnfglial cell line derived neurotrophic factor0.115
Lhx1LIM homeobox protein 10.113
Pax8paired box gene 80.113
Hoxa4homeobox A40.111
Nkx1-2NK1 transcription factor related, locus 2 (Drosophila)0.111
Hoxa2homeobox A20.111
Nkx2-2NK2 transcription factor related, locus 2 (Drosophila)0.110
Tbx3T-box 30.107
Hoxd11homeobox D110.106
Sall4sal-like 4 (Drosophila)0.100
Tcf15transcription factor 150.100
Tlx3T-cell leukemia, homeobox 30.100
Smosmoothened homolog (Drosophila)0.099
Onecut1one cut domain, family member 10.098
Nkx2-3NK2 transcription factor related, locus 3 (Drosophila)0.097
Hand2heart and neural crest derivatives expressed transcript 20.092
Chd7chromodomain helicase DNA binding protein 70.092
Tlx2T-cell leukemia, homeobox 20.089
Tbx1T-box 10.087
Zic2zinc finger protein of the cerebellum 20.087
Hoxb6homeobox B60.085
Pitx3paired-like homeodomain transcription factor 30.084
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism