Process View
The network for 'negative regulation of interleukin 2 production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production.
Name | Description | Probability | Func Analog Organism |
---|---|---|---|
CCR5 | chemokine (C-C motif) receptor 5 | 0.815 | |
YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | 0.444 | |
RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.322 | |
CXCL2 | chemokine (C-X-C motif) ligand 2 | 0.266 | |
WDR5 | WD repeat domain 5 | 0.230 | |
CXCL9 | chemokine (C-X-C motif) ligand 9 | 0.192 | |
AR | androgen receptor | 0.100 | |
UBE2D4 | ubiquitin-conjugating enzyme E2D 4 (putative) | 0.090 | |
KAT5 | K(lysine) acetyltransferase 5 | 0.076 | |
TRIM21 | tripartite motif containing 21 | 0.074 | |
CCL2 | chemokine (C-C motif) ligand 2 | 0.070 | |
CCL8 | chemokine (C-C motif) ligand 8 | 0.063 | |
PML | promyelocytic leukemia | 0.061 | |
MED15 | mediator complex subunit 15 | 0.058 | |
CCL18 | chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) | 0.055 | |
CCR7 | chemokine (C-C motif) receptor 7 | 0.053 | |
CXCL10 | chemokine (C-X-C motif) ligand 10 | 0.052 | |
RGS1 | regulator of G-protein signaling 1 | 0.049 | |
SLMAP | sarcolemma associated protein | 0.048 | |
RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.047 | |
TRIM5 | tripartite motif containing 5 | 0.045 | |
CCL13 | chemokine (C-C motif) ligand 13 | 0.041 | |
DPP4 | dipeptidyl-peptidase 4 | 0.039 | |
CCL5 | chemokine (C-C motif) ligand 5 | 0.035 | |
EIF3F | eukaryotic translation initiation factor 3, subunit F | 0.033 | |
ZNF263 | zinc finger protein 263 | 0.033 | |
TNF | tumor necrosis factor | 0.031 | |
PRKD2 | protein kinase D2 | 0.029 | |
CDK11B | cyclin-dependent kinase 11B | 0.028 | |
HDAC4 | histone deacetylase 4 | 0.026 | |
MDM4 | Mdm4 p53 binding protein homolog (mouse) | 0.026 | |
CXCL11 | chemokine (C-X-C motif) ligand 11 | 0.026 | |
TRIM39 | tripartite motif containing 39 | 0.025 | |
IL8 | interleukin 8 | 0.023 | |
PLK3 | polo-like kinase 3 | 0.022 | |
PPARA | peroxisome proliferator-activated receptor alpha | 0.022 | |
IFI16 | interferon, gamma-inducible protein 16 | 0.022 | |
IFNG | interferon, gamma | 0.021 | |
IL6 | interleukin 6 (interferon, beta 2) | 0.018 | |
MAGEA2 | melanoma antigen family A, 2 | 0.018 | |
CCR4 | chemokine (C-C motif) receptor 4 | 0.018 | |
RNF11 | ring finger protein 11 | 0.017 | |
EEF1G | eukaryotic translation elongation factor 1 gamma | 0.017 | |
IL1B | interleukin 1, beta | 0.017 | |
ARIH2 | ariadne homolog 2 (Drosophila) | 0.016 | |
FPR3 | formyl peptide receptor 3 | 0.016 | |
MMP12 | matrix metallopeptidase 12 (macrophage elastase) | 0.016 | |
IKZF3 | IKAROS family zinc finger 3 (Aiolos) | 0.016 | |
CCL19 | chemokine (C-C motif) ligand 19 | 0.014 | |
IDE | insulin-degrading enzyme | 0.014 | |
ZNF473 | zinc finger protein 473 | 0.013 | |
CXCL13 | chemokine (C-X-C motif) ligand 13 | 0.013 | |
HDAC7 | histone deacetylase 7 | 0.013 | |
CCL4 | chemokine (C-C motif) ligand 4 | 0.013 | |
ATM | ataxia telangiectasia mutated | 0.013 | |
TRIM17 | tripartite motif containing 17 | 0.012 | |
UBD | ubiquitin D | 0.012 | |
KIAA1377 | KIAA1377 | 0.012 | |
CCL22 | chemokine (C-C motif) ligand 22 | 0.011 | |
IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 0.011 | |
IL7R | interleukin 7 receptor | 0.011 | |
NCOR1 | nuclear receptor corepressor 1 | 0.011 | |
IL2RB | interleukin 2 receptor, beta | 0.011 | |
TRIM26 | tripartite motif containing 26 | 0.010 | |
FHL1 | four and a half LIM domains 1 | 0.010 |
Name | Description | Probability | Func Analog Organism |
---|---|---|---|
Gata6 | GATA binding protein 6 | 0.975 | |
Cd80 | CD80 antigen | 0.905 | |
Irf1 | interferon regulatory factor 1 | 0.841 | |
Gata4 | GATA binding protein 4 | 0.427 | |
Nkx2-5 | NK2 transcription factor related, locus 5 (Drosophila) | 0.404 | |
Sox4 | SRY-box containing gene 4 | 0.367 | |
Pycard | PYD and CARD domain containing | 0.340 | |
Pdcd1 | programmed cell death 1 | 0.311 | |
Ikzf1 | IKAROS family zinc finger 1 | 0.238 | |
Socs1 | suppressor of cytokine signaling 1 | 0.225 | |
App | amyloid beta (A4) precursor protein | 0.199 | |
Il27ra | interleukin 27 receptor, alpha | 0.172 | |
Dmap1 | DNA methyltransferase 1-associated protein 1 | 0.170 | |
Tnfrsf4 | tumor necrosis factor receptor superfamily, member 4 | 0.167 | |
Il2 | interleukin 2 | 0.161 | |
Foxp2 | forkhead box P2 | 0.150 | |
Ripk1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.125 | |
Tbx5 | T-box 5 | 0.116 | |
Foxp1 | forkhead box P1 | 0.111 | |
Zfpm2 | zinc finger protein, multitype 2 | 0.104 | |
Foxp3 | forkhead box P3 | 0.085 | |
Dll1 | delta-like 1 (Drosophila) | 0.085 | |
Tcra | T-cell receptor alpha chain | 0.081 | |
Card11 | caspase recruitment domain family, member 11 | 0.081 | |
Cd28 | CD28 antigen | 0.080 | |
Ctla4 | cytotoxic T-lymphocyte-associated protein 4 | 0.073 | |
Map3k8 | mitogen-activated protein kinase kinase kinase 8 | 0.073 | |
Gata5 | GATA binding protein 5 | 0.068 | |
Foxn1 | forkhead box N1 | 0.065 | |
Bcl2l11 | BCL2-like 11 (apoptosis facilitator) | 0.064 | |
Ifngr1 | interferon gamma receptor 1 | 0.052 | |
Prf1 | perforin 1 (pore forming protein) | 0.049 | |
Ep400 | E1A binding protein p400 | 0.048 | |
Il4 | interleukin 4 | 0.047 | |
Stat6 | signal transducer and activator of transcription 6 | 0.046 | |
Il2rb | interleukin 2 receptor, beta chain | 0.045 | |
Lyn | Yamaguchi sarcoma viral (v-yes-1) oncogene homolog | 0.044 | |
Cd44 | CD44 antigen | 0.044 | |
Map3k14 | mitogen-activated protein kinase kinase kinase 14 | 0.043 | |
Myb | myeloblastosis oncogene | 0.041 | |
Aplp2 | amyloid beta (A4) precursor-like protein 2 | 0.039 | |
Ptpn14 | protein tyrosine phosphatase, non-receptor type 14 | 0.038 | |
Casp4 | caspase 4, apoptosis-related cysteine peptidase | 0.038 | |
Mefv | Mediterranean fever | 0.036 | |
Batf2 | basic leucine zipper transcription factor, ATF-like 2 | 0.035 | |
Ttc7 | tetratricopeptide repeat domain 7 | 0.033 | |
Tbx21 | T-box 21 | 0.033 | |
Tnip1 | TNFAIP3 interacting protein 1 | 0.033 | |
Atxn1 | ataxin 1 | 0.032 | |
Cd5 | CD5 antigen | 0.031 | |
Abl1 | c-abl oncogene 1, non-receptor tyrosine kinase | 0.031 | |
Ifng | interferon gamma | 0.031 | |
Max | Max protein | 0.029 | |
Hr | hairless | 0.029 | |
Cyp26c1 | cytochrome P450, family 26, subfamily c, polypeptide 1 | 0.027 | |
Gli2 | GLI-Kruppel family member GLI2 | 0.026 | |
Arid1b | AT rich interactive domain 1B (SWI-like) | 0.025 | |
Lat | linker for activation of T cells | 0.024 | |
Plp1 | proteolipid protein (myelin) 1 | 0.022 | |
Notch3 | Notch gene homolog 3 (Drosophila) | 0.022 | |
P4hb | prolyl 4-hydroxylase, beta polypeptide | 0.022 | |
Nfkb1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 | 0.021 | |
Jak1 | Janus kinase 1 | 0.020 | |
Cd4 | CD4 antigen | 0.020 | |
Zfp362 | zinc finger protein 362 | 0.020 | |
Epha1 | Eph receptor A1 | 0.020 | |
Rgs1 | regulator of G-protein signaling 1 | 0.020 | |
Rel | reticuloendotheliosis oncogene | 0.019 | |
Dsg4 | desmoglein 4 | 0.019 | |
Il22 | interleukin 22 | 0.019 | |
Sp110 | Sp110 nuclear body protein | 0.017 | |
Casp1 | caspase 1 | 0.017 | |
Ctsl | cathepsin L | 0.017 | |
Cxcl9 | chemokine (C-X-C motif) ligand 9 | 0.017 | |
Ooep | oocyte expressed protein homolog (dog) | 0.017 | |
Cic | capicua homolog (Drosophila) | 0.017 | |
Hoxa1 | homeobox A1 | 0.017 | |
Traf6 | TNF receptor-associated factor 6 | 0.016 | |
Opcml | opioid binding protein/cell adhesion molecule-like | 0.016 | |
Tcrd | T-cell receptor delta chain | 0.016 | |
Batf | basic leucine zipper transcription factor, ATF-like | 0.016 | |
Icos | inducible T-cell co-stimulator | 0.015 | |
Tbx3 | T-box 3 | 0.015 | |
Clu | clusterin | 0.015 | |
Mst1r | macrophage stimulating 1 receptor (c-met-related tyrosine kinase) | 0.015 | |
Tle6 | transducin-like enhancer of split 6, homolog of Drosophila E(spl) | 0.015 | |
Naip6 | NLR family, apoptosis inhibitory protein 6 | 0.015 | |
Cd274 | CD274 antigen | 0.014 | |
Cd160 | CD160 antigen | 0.014 | |
Rc3h1 | RING CCCH (C3H) domains 1 | 0.014 | |
Rxra | retinoid X receptor alpha | 0.014 | |
Inhba | inhibin beta-A | 0.014 | |
Ubd | ubiquitin D | 0.014 | |
Dusp2 | dual specificity phosphatase 2 | 0.013 | |
Runx1 | runt related transcription factor 1 | 0.013 | |
Wiz | widely-interspaced zinc finger motifs | 0.013 | |
Ccl24 | chemokine (C-C motif) ligand 24 | 0.013 | |
Tbx20 | T-box 20 | 0.013 | |
Cxcr2 | chemokine (C-X-C motif) receptor 2 | 0.013 | |
Ticam1 | toll-like receptor adaptor molecule 1 | 0.013 |