The network for 'positive regulation of immunoglobulin production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of immunoglobulin production

Any process that activates or increases the frequency, rate, or extent of immunoglobulin production.

NameDescriptionProbabilityFunc Analog Organism
Cd37CD37 molecule0.578
RT1-Db1RT1 class II, locus Db10.305
Fggfibrinogen gamma chain0.296
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.286
Laptm5lysosomal protein transmembrane 50.229
Bin2bridging integrator 20.219
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.184
Hckhemopoietic cell kinase0.179
Dnase1l3deoxyribonuclease 1-like 30.168
Cxcr4chemokine (C-X-C motif) receptor 40.163
Myh9myosin, heavy chain 9, non-muscle0.146
Ptpn6protein tyrosine phosphatase, non-receptor type 60.144
Anpepalanyl (membrane) aminopeptidase0.141
Arl5cADP-ribosylation factor-like 5C0.139
Sellselectin L0.133
Casp1caspase 10.117
Ptafrplatelet-activating factor receptor0.116
RT1-BbRT1 class II, locus Bb0.114
Tnfrsf14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.110
Sykspleen tyrosine kinase0.101
Dnase1deoxyribonuclease I0.100
Fgfr1Fibroblast growth factor receptor 10.098
Icam1intercellular adhesion molecule 10.097
Csn1s1casein alpha s10.096
Il10interleukin 100.095
Cd247Cd247 molecule0.089
Ctsecathepsin E0.088
RT1-BaRT1 class II, locus Ba0.088
Arhgap9Rho GTPase activating protein 90.084
Ptprcprotein tyrosine phosphatase, receptor type, C0.083
Arhgap25Rho GTPase activating protein 250.083
Tmed10transmembrane emp24-like trafficking protein 10 (yeast)0.080
Arhgap4Rho GTPase activating protein 40.080
Cybbcytochrome b-245, beta polypeptide0.079
Uts2rurotensin 2 receptor0.079
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.078
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.077
Il2rginterleukin 2 receptor, gamma0.074
Myo1emyosin IE0.072
Hbg1hemoglobin, gamma A0.072
Olr1278olfactory receptor 12780.071
Il2rainterleukin 2 receptor, alpha0.070
Pim1pim-1 oncogene0.069
Cd79bCd79b molecule, immunoglobulin-associated beta0.068
Il1r1interleukin 1 receptor, type I0.067
Pglyrp1peptidoglycan recognition protein 10.066
Calcrcalcitonin receptor0.065
Mca32mast cell antigen 320.057
Gja4gap junction protein, alpha 40.057
Cmklr1chemokine-like receptor 10.053
Fgafibrinogen alpha chain0.053
Cd2Cd2 molecule0.053
Plac8placenta-specific 80.053
C3ar1complement component 3a receptor 10.050
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.050
Igh-6immunoglobulin heavy chain 60.049
Vav1vav 1 guanine nucleotide exchange factor0.048
Il1binterleukin 1 beta0.048
Rps6ka1ribosomal protein S6 kinase polypeptide 10.047
Clec9aC-type lectin domain family 9, member a0.047
Acta2smooth muscle alpha-actin0.046
Gdnfglial cell derived neurotrophic factor0.045
Nos3nitric oxide synthase 3, endothelial cell0.045
Mobkl2aMOB1, Mps One Binder kinase activator-like 2A (yeast)0.044
Mpeg1macrophage expressed 10.044
Srd5a2steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)0.044
Vegfcvascular endothelial growth factor C0.043
Pzppregnancy-zone protein0.042
Lcp2lymphocyte cytosolic protein 20.042
Il17rainterleukin 17 receptor A0.042
Aebp1AE binding protein 10.040
Itgb4integrin, beta 40.040
Cyp2d1cytochrome P450, family 2, subfamily d, polypeptide 10.040
Kmokynurenine 3-monooxygenase (kynurenine 3-hydroxylase)0.040
Il4rainterleukin 4 receptor, alpha0.039
Abcc2ATP-binding cassette, subfamily C (CFTR/MRP), member 20.039
Smad7SMAD family member 70.039
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.038
Aldh1a2aldehyde dehydrogenase 1 family, member A20.038
Ly86lymphocyte antigen 860.038
Smad1SMAD family member 10.038
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.038
Il2rbinterleukin 2 receptor, beta0.038
Sh2b2SH2B adaptor protein 20.037
Ptpn18protein tyrosine phosphatase, non-receptor type 180.037
Ppapdc1bphosphatidic acid phosphatase type 2 domain containing 1B0.037
Surf4surfeit 40.037
Fmnl1formin-like 10.036
Tln1talin 10.036
Apobapolipoprotein B0.035
Lrg1leucine-rich alpha-2-glycoprotein 10.035
Apbb1ipamyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein0.034
Fabp2fatty acid binding protein 2, intestinal0.033
Ccl5chemokine (C-C motif) ligand 50.033
Socs3suppressor of cytokine signaling 30.033
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.033
Inpp5dinositol polyphosphate-5-phosphatase D0.032
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
IL4Rinterleukin 4 receptor0.998
IL2RGinterleukin 2 receptor, gamma0.868
INPP5Dinositol polyphosphate-5-phosphatase, 145kDa0.258
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.241
PTPN6protein tyrosine phosphatase, non-receptor type 60.207
GRAP2GRB2-related adaptor protein 20.199
TNFRSF13Btumor necrosis factor receptor superfamily, member 13B0.176
TRAF3TNF receptor-associated factor 30.170
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.114
ITGALintegrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)0.090
IL6Rinterleukin 6 receptor0.067
ASH2Lash2 (absent, small, or homeotic)-like (Drosophila)0.065
SMC1Astructural maintenance of chromosomes 1A0.058
C16orf53chromosome 16 open reading frame 530.052
CD22CD22 molecule0.050
IL4interleukin 40.044
CD80CD80 molecule0.039
TNFRSF17tumor necrosis factor receptor superfamily, member 170.036
SEMA4Dsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D0.030
TMEM173transmembrane protein 1730.030
TRAF5TNF receptor-associated factor 50.028
TP53BP1tumor protein p53 binding protein 10.028
TGFBR1transforming growth factor, beta receptor 10.026
TRAF2TNF receptor-associated factor 20.026
TRAF1TNF receptor-associated factor 10.025
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.025
IL8interleukin 80.025
TNFRSF14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.024
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.023
CD40CD40 molecule, TNF receptor superfamily member 50.023
THBS1thrombospondin 10.022
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.022
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)0.021
TNFRSF9tumor necrosis factor receptor superfamily, member 90.021
GATAD2BGATA zinc finger domain containing 2B0.020
LRMPlymphoid-restricted membrane protein0.017
SYKspleen tyrosine kinase0.016
CTLA4cytotoxic T-lymphocyte-associated protein 40.015
IL13RA1interleukin 13 receptor, alpha 10.015
LCKlymphocyte-specific protein tyrosine kinase0.014
SFPQsplicing factor proline/glutamine-rich0.014
TDP1tyrosyl-DNA phosphodiesterase 10.013
JAK1Janus kinase 10.013
MAP3K14mitogen-activated protein kinase kinase kinase 140.013
IKZF1IKAROS family zinc finger 1 (Ikaros)0.012
MS4A1membrane-spanning 4-domains, subfamily A, member 10.012
LATlinker for activation of T cells0.012
IL10RAinterleukin 10 receptor, alpha0.012
RCN3reticulocalbin 3, EF-hand calcium binding domain0.012
BIRC3baculoviral IAP repeat containing 30.012
ICAM1intercellular adhesion molecule 10.012
PIK3CDphosphoinositide-3-kinase, catalytic, delta polypeptide0.011
PIK3CGphosphoinositide-3-kinase, catalytic, gamma polypeptide0.011
RAC2ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)0.011
SELPLGselectin P ligand0.011
ARHGDIBRho GDP dissociation inhibitor (GDI) beta0.011
ZFP36L2zinc finger protein 36, C3H type-like 20.010
ACVR2Bactivin A receptor, type IIB0.010
TRAF3IP2TRAF3 interacting protein 20.010
NOM1nucleolar protein with MIF4G domain 10.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ifnginterferon gamma0.826
Ccl2chemokine (C-C motif) ligand 20.740
FynFyn proto-oncogene0.734
Csf2rb2colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)0.695
Foxp3forkhead box P30.695
Stat5bsignal transducer and activator of transcription 5B0.669
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.623
Tbx3T-box 30.522
Socs1suppressor of cytokine signaling 10.511
Lyz2lysozyme 20.452
Cd28CD28 antigen0.436
Il10interleukin 100.422
Tlr4toll-like receptor 40.415
Pitx1paired-like homeodomain transcription factor 10.400
Csf1colony stimulating factor 1 (macrophage)0.385
Pitx2paired-like homeodomain transcription factor 20.345
Ccl7chemokine (C-C motif) ligand 70.330
Ccr2chemokine (C-C motif) receptor 20.317
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.262
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.203
Irf9interferon regulatory factor 90.201
Tnftumor necrosis factor0.197
Ccr1chemokine (C-C motif) receptor 10.196
Stat5asignal transducer and activator of transcription 5A0.181
Stat3signal transducer and activator of transcription 30.178
Pdcd1programmed cell death 10.172
Il6stinterleukin 6 signal transducer0.168
Il6interleukin 60.162
FaslFas ligand (TNF superfamily, member 6)0.147
Wt1Wilms tumor 1 homolog0.143
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.139
Tbx5T-box 50.139
Ccr7chemokine (C-C motif) receptor 70.130
Il2interleukin 20.126
Itga3integrin alpha 30.126
Prf1perforin 1 (pore forming protein)0.117
FasFas (TNF receptor superfamily member 6)0.103
Il4interleukin 40.098
Ccl8chemokine (C-C motif) ligand 80.096
Hoxa1homeobox A10.094
Notonotochord homolog (Xenopus laevis)0.083
Ptgs2prostaglandin-endoperoxide synthase 20.082
TcraT-cell receptor alpha chain0.076
Hcn4hyperpolarization-activated, cyclic nucleotide-gated K+ 40.072
Selpselectin, platelet0.072
Il1r1interleukin 1 receptor, type I0.072
Nos2nitric oxide synthase 2, inducible0.071
Mmp9matrix metallopeptidase 90.071
Nckap1lNCK associated protein 1 like0.070
Icosinducible T-cell co-stimulator0.069
Ccr5chemokine (C-C motif) receptor 50.067
C3ar1complement component 3a receptor 10.067
Batfbasic leucine zipper transcription factor, ATF-like0.067
Fgfr2fibroblast growth factor receptor 20.059
Sall1sal-like 1 (Drosophila)0.057
Fgf10fibroblast growth factor 100.056
Cd5CD5 antigen0.056
Scn5asodium channel, voltage-gated, type V, alpha0.056
Ly9lymphocyte antigen 90.054
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.052
Cxcl2chemokine (C-X-C motif) ligand 20.051
Rag2recombination activating gene 20.051
Il13interleukin 130.049
Mmp3matrix metallopeptidase 30.047
Lcp1lymphocyte cytosolic protein 10.047
Cd7CD7 antigen0.046
Rag1recombination activating gene 10.044
Il4rainterleukin 4 receptor, alpha0.044
Map3k14mitogen-activated protein kinase kinase kinase 140.044
Il10rainterleukin 10 receptor, alpha0.044
Ccl3chemokine (C-C motif) ligand 30.044
Itgb1integrin beta 1 (fibronectin receptor beta)0.042
Il1rl1interleukin 1 receptor-like 10.042
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.041
Ch25hcholesterol 25-hydroxylase0.040
Pou5f1POU domain, class 5, transcription factor 10.040
Pax2paired box gene 20.040
Lag3lymphocyte-activation gene 30.040
Ltalymphotoxin A0.038
NanogNanog homeobox0.037
Gja5gap junction protein, alpha 50.036
Sh2d2aSH2 domain protein 2A0.036
Sall4sal-like 4 (Drosophila)0.036
Gzmagranzyme A0.035
Pdcd1lg2programmed cell death 1 ligand 20.035
Rxraretinoid X receptor alpha0.035
Jak2Janus kinase 20.034
Gzmkgranzyme K0.034
Ccl12chemokine (C-C motif) ligand 120.034
BtkBruton agammaglobulinemia tyrosine kinase0.033
Ubdubiquitin D0.033
Ifnar2interferon (alpha and beta) receptor 20.032
Il2rbinterleukin 2 receptor, beta chain0.032
Mmp12matrix metallopeptidase 120.031
WasWiskott-Aldrich syndrome homolog (human)0.030
Cd247CD247 antigen0.030
Lcp2lymphocyte cytosolic protein 20.030
Ctla4cytotoxic T-lymphocyte-associated protein 40.029
Cxcl1chemokine (C-X-C motif) ligand 10.029
Tbx4T-box 40.028
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism