The network for 'negative regulation of response to biotic stimulus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of response to biotic stimulus

Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus.

NameDescriptionProbabilityFunc Analog Organism
Gzmbgranzyme B0.029
Cishcytokine inducible SH2-containing protein0.021
Il1rninterleukin 1 receptor antagonist0.021
Art2ADP-ribosyltransferase 20.020
Klra5killer cell lectin-like receptor, subfamily A, member 50.020
Prdx4peroxiredoxin 40.019
Klrd1killer cell lectin-like receptor, subfamily D, member 10.019
Slc9a4solute carrier family 9 (sodium/hydrogen exchanger), member 40.018
Atf3activating transcription factor 30.018
Mmp12matrix metallopeptidase 120.017
Btg2BTG family, member 20.017
Klrk1killer cell lectin-like receptor subfamily K, member 10.016
Agaaspartylglucosaminidase0.016
Socs3suppressor of cytokine signaling 30.016
Slc13a1solute carrier family 13 (sodium/sulfate symporters), member 10.015
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.015
Rxraretinoid X receptor alpha0.015
Tnni3kTNNI3 interacting kinase0.014
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.014
Ccr2chemokine (C-C motif) receptor 20.014
RGD1304644similar to RIKEN cDNA 2310046K010.013
Irf2interferon regulatory factor 20.013
Galnt10UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)0.013
Slc48a1solute carrier family 48 (heme transporter), member 10.013
Rhobras homolog gene family, member B0.013
Pon2paraoxonase 20.013
Akr1b7aldo-keto reductase family 1, member B70.013
Sellselectin L0.013
Mapk6mitogen-activated protein kinase 60.012
Hipk3homeodomain interacting protein kinase 30.012
Reg3bregenerating islet-derived 3 beta0.012
Serpinb3aserine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A0.012
Unc5clunc-5 homolog C (C. elegans)-like0.012
Oas1i2 ' -5 ' oligoadenylate synthetase 1I0.012
Pink1PTEN induced putative kinase 10.012
Nrd1nardilysin 10.012
Il7rinterleukin 7 receptor0.012
Ccl4chemokine (C-C motif) ligand 40.012
S100vpS100 calcium-binding protein, ventral prostate0.012
Ccr5chemokine (C-C motif) receptor 50.012
Sit1signaling threshold regulating transmembrane adaptor 10.012
Gpx2glutathione peroxidase 20.012
Scinscinderin0.012
RGD1564664similar to LOC387763 protein0.012
Skap1src kinase associated phosphoprotein 10.012
Trpm1transient receptor potential cation channel, subfamily M, member 10.012
LOC300024similar to Ly6-B antigen gene0.012
Cd8aCD8a molecule0.012
FasFas (TNF receptor superfamily, member 6)0.011
Reg3gregenerating islet-derived 3 gamma0.011
Igsf6immunoglobulin superfamily, member 60.011
FosFBJ osteosarcoma oncogene0.011
Lrp1low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)0.011
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.011
Clns1achloride channel, nucleotide-sensitive, 1A0.011
Maged2melanoma antigen, family D, 20.011
Gzmkgranzyme K0.011
Pdk2pyruvate dehydrogenase kinase, isozyme 20.011
Bchebutyrylcholinesterase0.011
Tnftumor necrosis factor (TNF superfamily, member 2)0.011
Eef2eukaryotic translation elongation factor 20.011
Cldn7claudin 70.011
Nfe2l1nuclear factor, erythroid derived 2,-like 10.011
Cd2Cd2 molecule0.011
Clec12aC-type lectin domain family 12, member A0.011
Ccl3chemokine (C-C motif) ligand 30.011
Sh2d2aSH2 domain protein 2A0.011
Tm2d1TM2 domain containing 10.011
Klf9Kruppel-like factor 90.011
LOC100361053mCG1039741-like0.011
Gucy2gguanylate cyclase 2G0.011
Klrb1akiller cell lectin-like receptor subfamily B, member 1A0.011
Dymdymeclin0.011
Cd247Cd247 molecule0.011
Slfn3schlafen 30.010
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.010
Sbk1SH3-binding domain kinase 10.010
Ccl9chemokine (C-C motif) ligand 90.010
Dusp1dual specificity phosphatase 10.010
GemGTP binding protein (gene overexpressed in skeletal muscle)0.010
Tusc3tumor suppressor candidate 30.010
Serpinb3serine protease inhibitor B30.010
Il1rl1interleukin 1 receptor-like 10.010
Nkg7natural killer cell group 7 sequence0.010
Dclre1cDNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)0.010
Bcl6bB-cell CLL/lymphoma 6, member B (zinc finger protein)0.010
Serpinf1serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 10.010
Mafav-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.010
Rnf14ring finger protein 140.010
Lrrc14bleucine rich repeat containing 14B0.010
Mmp3matrix metallopeptidase 30.010
Rnf146ring finger protein 1460.010
Cd69Cd69 molecule0.010
Lamtor1RhoA activator C11orf59 homolog0.010
Errfi1ERBB receptor feedback inhibitor 10.010
Tfectranscription factor EC0.010
Pgcpplasma glutamate carboxypeptidase0.010
Ptafrplatelet-activating factor receptor0.010
Xcl1chemokine (C motif) ligand 10.010
Klrc1killer cell lectin-like receptor subfamily C, member 10.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
AttAAttacin-A0.065
RelRelish0.053
PGRP-LCPeptidoglycan recognition protein LC0.036
PGRP-SAPeptidoglycan recognition protein SA0.035
PGRP-LFPeptidoglycan recognition protein LF0.032
PGRP-LBPeptidoglycan recognition protein LB0.027
Mpk2CG5475 gene product from transcript CG5475-RB0.017
CG14614CG14614 gene product from transcript CG14614-RA0.017
DrsDrosomycin0.015
p38bCG7393 gene product from transcript CG7393-RA0.015
pirkpoor Imd response upon knock-in0.014
CG16718CG16718 gene product from transcript CG16718-RA0.013
CG9184CG9184 gene product from transcript CG9184-RB0.012
rlrolled0.011
CG18594CG18594 gene product from transcript CG18594-RA0.011
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
IFIT1interferon-induced protein with tetratricopeptide repeats 10.537
JUNjun proto-oncogene0.370
CYLDcylindromatosis (turban tumor syndrome)0.340
IFIT5interferon-induced protein with tetratricopeptide repeats 50.220
IFIT2interferon-induced protein with tetratricopeptide repeats 20.205
ATF4activating transcription factor 4 (tax-responsive enhancer element B67)0.186
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 20.158
FOSFBJ murine osteosarcoma viral oncogene homolog0.137
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.127
SMAD4SMAD family member 40.122
IFIT3interferon-induced protein with tetratricopeptide repeats 30.103
PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activator0.093
SMURF2SMAD specific E3 ubiquitin protein ligase 20.091
DICER1dicer 1, ribonuclease type III0.084
JUNBjun B proto-oncogene0.073
DUSP1dual specificity phosphatase 10.057
IL4Rinterleukin 4 receptor0.050
SNTA1syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)0.043
PCBP1poly(rC) binding protein 10.038
MOV10Mov10, Moloney leukemia virus 10, homolog (mouse)0.035
DDX60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.034
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.032
IFI44interferon-induced protein 440.031
RANBP3RAN binding protein 30.031
SMURF1SMAD specific E3 ubiquitin protein ligase 10.029
HDAC6histone deacetylase 60.027
HERC5hect domain and RLD 50.025
EPSTI1epithelial stromal interaction 1 (breast)0.024
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.024
WWP1WW domain containing E3 ubiquitin protein ligase 10.023
FZR1fizzy/cell division cycle 20 related 1 (Drosophila)0.022
SAMD9sterile alpha motif domain containing 90.022
ZFP36zinc finger protein 36, C3H type, homolog (mouse)0.022
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.021
EGR1early growth response 10.021
ANKRD13Aankyrin repeat domain 13A0.020
MDM4Mdm4 p53 binding protein homolog (mouse)0.018
TAX1BP1Tax1 (human T-cell leukemia virus type I) binding protein 10.018
ZFYVE9zinc finger, FYVE domain containing 90.018
ATF3activating transcription factor 30.017
IER2immediate early response 20.017
WWP2WW domain containing E3 ubiquitin protein ligase 20.017
ISG15ISG15 ubiquitin-like modifier0.016
CDC14BCDC14 cell division cycle 14 homolog B (S. cerevisiae)0.015
CD320CD320 molecule0.014
PARP14poly (ADP-ribose) polymerase family, member 140.014
INSRinsulin receptor0.014
TARBP2TAR (HIV-1) RNA binding protein 20.014
MAVSmitochondrial antiviral signaling protein0.013
PTPN1protein tyrosine phosphatase, non-receptor type 10.013
ZFAND5zinc finger, AN1-type domain 50.013
KLF5Kruppel-like factor 5 (intestinal)0.013
OASL2'-5'-oligoadenylate synthetase-like0.012
SP100SP100 nuclear antigen0.012
ZRANB1zinc finger, RAN-binding domain containing 10.012
HNRNPLheterogeneous nuclear ribonucleoprotein L0.012
SAMD9Lsterile alpha motif domain containing 9-like0.012
MAPKAPK3mitogen-activated protein kinase-activated protein kinase 30.012
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.012
RAPGEF2Rap guanine nucleotide exchange factor (GEF) 20.012
LGALS3lectin, galactoside-binding, soluble, 30.012
ATF5activating transcription factor 50.011
STAT1signal transducer and activator of transcription 1, 91kDa0.011
FBXL15F-box and leucine-rich repeat protein 150.011
PKN1protein kinase N10.011
TMEM173transmembrane protein 1730.011
EIF2C2eukaryotic translation initiation factor 2C, 20.010
EIF2C1eukaryotic translation initiation factor 2C, 10.010
CEBPBCCAAT/enhancer binding protein (C/EBP), beta0.010
NEDD4neural precursor cell expressed, developmentally down-regulated 40.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ddx60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.506
Stat3signal transducer and activator of transcription 30.179
Trim30dtripartite motif-containing 30D0.176
Stat2signal transducer and activator of transcription 20.168
Trp53transformation related protein 530.089
FosFBJ osteosarcoma oncogene0.089
Ifit1interferon-induced protein with tetratricopeptide repeats 10.082
Usp18ubiquitin specific peptidase 180.071
Trim30atripartite motif-containing 30A0.067
Ifi44interferon-induced protein 440.064
Rsad2radical S-adenosyl methionine domain containing 20.055
Spna1spectrin alpha 10.042
Oasl22'-5' oligoadenylate synthetase-like 20.037
Irf7interferon regulatory factor 70.037
Samd9lsterile alpha motif domain containing 9-like0.036
Rtp4receptor transporter protein 40.035
Foxp3forkhead box P30.035
Btg2B-cell translocation gene 2, anti-proliferative0.033
Oas32'-5' oligoadenylate synthetase 30.032
Aicdaactivation-induced cytidine deaminase0.030
Atf3activating transcription factor 30.029
Zfp36zinc finger protein 360.027
Prlrprolactin receptor0.027
Bcl3B-cell leukemia/lymphoma 30.027
Cxcr4chemokine (C-X-C motif) receptor 40.027
Oas22'-5' oligoadenylate synthetase 20.027
Sp100nuclear antigen Sp1000.026
Traf6TNF receptor-associated factor 60.026
Oas1b2'-5' oligoadenylate synthetase 1B0.026
Cyldcylindromatosis (turban tumor syndrome)0.025
Oasl12'-5' oligoadenylate synthetase-like 10.024
Parp14poly (ADP-ribose) polymerase family, member 140.024
Per1period homolog 1 (Drosophila)0.023
Trim25tripartite motif-containing 250.022
Sfpi1SFFV proviral integration 10.022
Per2period homolog 2 (Drosophila)0.021
Il4rainterleukin 4 receptor, alpha0.021
Stat1signal transducer and activator of transcription 10.020
BlnkB-cell linker0.020
Rac1RAS-related C3 botulinum substrate 10.020
Egr1early growth response 10.019
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.018
Ubcubiquitin C0.018
1810019J16RikRIKEN cDNA 1810019J16 gene0.018
Uba7ubiquitin-like modifier activating enzyme 70.018
Isg15ISG15 ubiquitin-like modifier0.017
Sfnstratifin0.017
Nr4a1nuclear receptor subfamily 4, group A, member 10.017
Ifit3interferon-induced protein with tetratricopeptide repeats 30.016
Mrpl3mitochondrial ribosomal protein L30.016
Mapk8mitogen-activated protein kinase 80.016
Traf2TNF receptor-associated factor 20.016
Mx2myxovirus (influenza virus) resistance 20.015
Znfx1zinc finger, NFX1-type containing 10.015
Trim21tripartite motif-containing 210.015
Il6stinterleukin 6 signal transducer0.013
Dusp1dual specificity phosphatase 10.013
Trim12atripartite motif-containing 12A0.013
Ccl4chemokine (C-C motif) ligand 40.012
Tnip1TNFAIP3 interacting protein 10.012
Rnf135ring finger protein 1350.012
Ifi35interferon-induced protein 350.012
Unc93b1unc-93 homolog B1 (C. elegans)0.012
Mknk2MAP kinase-interacting serine/threonine kinase 20.011
Zbp1Z-DNA binding protein 10.011
Tax1bp1Tax1 (human T-cell leukemia virus type I) binding protein 10.011
Gbp7guanylate binding protein 70.011
Stat6signal transducer and activator of transcription 60.011
Pim1proviral integration site 10.011
Epsti1epithelial stromal interaction 1 (breast)0.010
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.010
Nfil3nuclear factor, interleukin 3, regulated0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism