The network for 'cellular response to cholesterol' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular response to cholesterol

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus.

NameDescriptionProbabilityFunc Analog Organism
Idi1isopentenyl-diphosphate delta isomerase 10.107
Hmgcr3-hydroxy-3-methylglutaryl-Coenzyme A reductase0.090
Sqlesqualene epoxidase0.063
Cyp51cytochrome P450, family 510.051
Acat3acetyl-Coenzyme A acetyltransferase 30.027
Cst3cystatin C0.027
Insig1insulin induced gene 10.018
Sult1a1sulfotransferase family, cytosolic, 1A, phenol-preferring, member 10.018
Ech1enoyl coenzyme A hydratase 1, peroxisomal0.013
Fdpsfarnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)0.011
Dhcr2424-dehydrocholesterol reductase0.011
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HMGCR3-hydroxy-3-methylglutaryl-CoA reductase0.639
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.186
SMOsmoothened homolog (Drosophila)0.043
LRRK2leucine-rich repeat kinase 20.034
LDLRlow density lipoprotein receptor0.031
CAPRIN2caprin family member 20.023
FCN2ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)0.023
DHCR2424-dehydrocholesterol reductase0.022
DKK1dickkopf homolog 1 (Xenopus laevis)0.018
FAM82A2family with sequence similarity 82, member A20.017
AMMECR1Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 10.016
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.014
MBL2mannose-binding lectin (protein C) 2, soluble0.013
NOS1APnitric oxide synthase 1 (neuronal) adaptor protein0.013
MMP14matrix metallopeptidase 14 (membrane-inserted)0.011
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Gli2GLI-Kruppel family member GLI20.858
Fgfr2fibroblast growth factor receptor 20.835
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.802
Ptch1patched homolog 10.763
Fgfr3fibroblast growth factor receptor 30.697
Sox9SRY-box containing gene 90.670
Gli3GLI-Kruppel family member GLI30.602
Smosmoothened homolog (Drosophila)0.589
Fstfollistatin0.568
Bmp4bone morphogenetic protein 40.554
Prrx1paired related homeobox 10.523
Bmp7bone morphogenetic protein 70.485
Fgfr1fibroblast growth factor receptor 10.450
Foxc1forkhead box C10.432
Ctnnb1catenin (cadherin associated protein), beta 10.429
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.389
Fshrfollicle stimulating hormone receptor0.371
Msx1homeobox, msh-like 10.316
Foxc2forkhead box C20.276
Shhsonic hedgehog0.270
Psen1presenilin 10.264
Meox2mesenchyme homeobox 20.209
Ror2receptor tyrosine kinase-like orphan receptor 20.196
Nf1neurofibromatosis 10.158
Amhr2anti-Mullerian hormone type 2 receptor0.157
Mn1meningioma 10.120
Alx1ALX homeobox 10.098
Bmp2bone morphogenetic protein 20.094
Zeb1zinc finger E-box binding homeobox 10.094
Otx2orthodenticle homolog 2 (Drosophila)0.086
Apcadenomatosis polyposis coli0.084
Msx2homeobox, msh-like 20.080
Runx2runt related transcription factor 20.075
Mks1Meckel syndrome, type 10.072
Tgfb2transforming growth factor, beta 20.060
BmperBMP-binding endothelial regulator0.056
Npr2natriuretic peptide receptor 20.048
Disp1dispatched homolog 1 (Drosophila)0.046
Vangl2vang-like 2 (van gogh, Drosophila)0.045
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.043
Chrdchordin0.039
Rararetinoic acid receptor, alpha0.033
HhipHedgehog-interacting protein0.031
Tcfap2atranscription factor AP-2, alpha0.031
Otx1orthodenticle homolog 1 (Drosophila)0.029
Nognoggin0.028
Rspo2R-spondin 2 homolog (Xenopus laevis)0.026
Col1a1collagen, type I, alpha 10.026
Lrp6low density lipoprotein receptor-related protein 60.025
Gja1gap junction protein, alpha 10.025
Kitlkit ligand0.024
Esr1estrogen receptor 1 (alpha)0.024
Prrx2paired related homeobox 20.022
Gsk3bglycogen synthase kinase 3 beta0.019
Pax3paired box gene 30.018
Col2a1collagen, type II, alpha 10.018
Ednraendothelin receptor type A0.018
Ece1endothelin converting enzyme 10.017
Rarbretinoic acid receptor, beta0.017
Apaf1apoptotic peptidase activating factor 10.016
Acvr1activin A receptor, type 10.015
Inhainhibin alpha0.015
Hand1heart and neural crest derivatives expressed transcript 10.013
Pofut1protein O-fucosyltransferase 10.012
Inhbbinhibin beta-B0.012
Fgfrl1fibroblast growth factor receptor-like 10.012
Tbx1T-box 10.011
Kif3akinesin family member 3A0.011
Inhbainhibin beta-A0.011
Hspg2perlecan (heparan sulfate proteoglycan 2)0.011
Mesdc2mesoderm development candidate 20.010
Cdkn1bcyclin-dependent kinase inhibitor 1B0.010
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism