The network for 'regulated secretory pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulated secretory pathway

A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand.

NameDescriptionProbabilityFunc Analog Organism
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform0.250
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.146
Litaflipopolysaccharide-induced TNF factor0.126
Tgfbr3transforming growth factor, beta receptor III0.084
Ciitaclass II, major histocompatibility complex, transactivator0.081
Atp2a3ATPase, Ca++ transporting, ubiquitous0.078
Cybbcytochrome b-245, beta polypeptide0.064
Inpp5dinositol polyphosphate-5-phosphatase D0.062
Hckhemopoietic cell kinase0.061
Tnfrsf8tumor necrosis factor receptor superfamily, member 80.056
Calm1calmodulin 10.055
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.055
Ppp2caprotein phosphatase 2, catalytic subunit, alpha isoform0.051
Cx3cr1chemokine (C-X3-C motif) receptor 10.050
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.049
Itpr2inositol 1,4,5-triphosphate receptor, type 20.046
Adap1ArfGAP with dual PH domains 10.045
Syt3synaptotagmin III0.044
Nptnneuroplastin0.044
Csf1colony stimulating factor 1 (macrophage)0.042
Arl11ADP-ribosylation factor-like 110.041
Ptger2prostaglandin E receptor 2 (subtype EP2)0.039
Dock8dedicator of cytokinesis 80.037
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 10.036
Fut2fucosyltransferase 2 (secretor status included)0.035
Atp6ap1ATPase, H+ transporting, lysosomal accessory protein 10.035
Ccr5chemokine (C-C motif) receptor 50.034
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.033
Arhgap25Rho GTPase activating protein 250.033
Ptafrplatelet-activating factor receptor0.032
Atp6v1aATPase, H+ transporting, lysosomal V1 subunit A0.032
Hpgdshematopoietic prostaglandin D synthase0.031
Stxbp1syntaxin binding protein 10.030
Impa1Inositol (myo)-1(or 4)-monophosphatase 10.030
Cyp2s1cytochrome P450, family 2, subfamily s, polypeptide 10.030
Cxcr3chemokine (C-X-C motif) receptor 30.029
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.029
Ppp2r2cprotein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform0.029
Il2rbinterleukin 2 receptor, beta0.029
Syt7synaptotagmin VII0.028
Ptprcprotein tyrosine phosphatase, receptor type, C0.028
Cfpcomplement factor properdin0.027
Sirpasignal-regulatory protein alpha0.026
Slc9a1solute carrier family 9 (sodium/hydrogen exchanger), member 10.026
Cd86CD86 molecule0.026
Ms4a11membrane-spanning 4-domains, subfamily A, member 110.026
Arhgap4Rho GTPase activating protein 40.025
Cd38CD38 molecule0.025
Morf4l2mortality factor 4 like 20.024
RGD1559748similar to Palate lung and nasal carcinoma-like protein precursor (Tongue plunc-like protein)0.024
Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.024
Kcnk1potassium channel, subfamily K, member 10.024
Folr2folate receptor 2 (fetal)0.024
Slc16a8solute carrier family 16, member 8 (monocarboxylic acid transporter 3)0.024
Tuba1ctubulin, alpha 1C0.023
Pgam1phosphoglycerate mutase 1 (brain)0.022
Ppp2cbprotein phosphatase 2, catalytic subunit, beta isoform0.022
Adaradenosine deaminase, RNA-specific0.022
Actg1actin, gamma 10.022
Tm9sf2transmembrane 9 superfamily member 20.021
C5ar1complement component 5a receptor 10.021
Cd68Cd68 molecule0.021
NsfN-ethylmaleimide-sensitive factor0.020
Crhbpcorticotropin releasing hormone binding protein0.020
Apbb1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.019
Phox2apaired-like homeobox 2a0.019
Gp2glycoprotein 2 (zymogen granule membrane)0.019
Mapk10mitogen activated protein kinase 100.018
Gnazguanine nucleotide binding protein (G protein), alpha z polypeptide0.018
RGD1307722similar to hypothetical protein MGC207000.018
Ctsecathepsin E0.018
Cltcclathrin, heavy chain (Hc)0.018
Itgamintegrin, alpha M0.018
Pitpnaphosphatidylinositol transfer protein, alpha0.018
Il2rginterleukin 2 receptor, gamma0.018
Slc14a1solute carrier family 14 (urea transporter), member 10.017
Rabac1Rab acceptor 1 (prenylated)0.017
Grm8glutamate receptor, metabotropic 80.017
Igsf6immunoglobulin superfamily, member 60.017
Zic1Zic family member 1 (odd-paired homolog, Drosophila)0.017
Acap1ArfGAP with coiled-coil, ankyrin repeat and PH domains 10.017
Tpsab1tryptase alpha/beta 10.016
Adora2aadenosine A2a receptor0.016
Hk1hexokinase 10.016
Notch4Notch homolog 4 (Drosophila)0.016
Dnase1l3deoxyribonuclease 1-like 30.016
Gja6gap junction protein, alpha 60.016
Eif4heukaryotic translation initiation factor 4H0.016
C1ql1complement component 1, q subcomponent-like 10.016
Itgadintegrin, alpha D0.016
Kynukynureninase (L-kynurenine hydrolase)0.016
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.016
RT1-BaRT1 class II, locus Ba0.016
Kcnj16potassium inwardly-rectifying channel, subfamily J, member 160.016
Snap25synaptosomal-associated protein 250.016
Ywhaqtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.015
Clstn3calsyntenin 30.015
Kcnip3Kv channel interacting protein 3, calsenilin0.015
Nrasneuroblastoma ras oncogene0.015
Rap1bRAP1B, member of RAS oncogene family0.015
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
unc-9Protein UNC-90.013
ZK686.3Protein ZK686.30.012
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
stnAstoned A0.043
KhcKinesin heavy chain0.016
endoAendophilin A0.016
laplike-AP1800.015
mbcmyoblast city0.014
n-sybn-synaptobrevin0.012
Gad1Glutamic acid decarboxylase 10.011
miminus0.011
Rab5Rab-protein 50.011
Mekk1CG7717 gene product from transcript CG7717-RB0.010
cdicenter divider0.010
Pk61CProtein kinase 61C0.010
Pabp2CG2163 gene product from transcript CG2163-RA0.010
par-1CG8201 gene product from transcript CG8201-RA0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.572
CCR5chemokine (C-C motif) receptor 50.488
EGFRepidermal growth factor receptor0.294
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.282
PLCG1phospholipase C, gamma 10.221
BLNKB-cell linker0.211
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.206
LATlinker for activation of T cells0.203
GRB2growth factor receptor-bound protein 20.186
GBAglucosidase, beta, acid0.185
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.164
SYKspleen tyrosine kinase0.155
CCL4chemokine (C-C motif) ligand 40.150
SNAP23synaptosomal-associated protein, 23kDa0.146
UBASH3Bubiquitin associated and SH3 domain containing B0.123
FCGR2AFc fragment of IgG, low affinity IIa, receptor (CD32)0.120
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.116
C19orf50chromosome 19 open reading frame 500.111
VEGFAvascular endothelial growth factor A0.089
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.085
EEA1early endosome antigen 10.084
PPLperiplakin0.081
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.071
SNTB2syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)0.062
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.057
GAB1GRB2-associated binding protein 10.056
CCL5chemokine (C-C motif) ligand 50.056
IL2RGinterleukin 2 receptor, gamma0.056
RAB14RAB14, member RAS oncogene family0.053
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.048
CCL2chemokine (C-C motif) ligand 20.045
SHC1SHC (Src homology 2 domain containing) transforming protein 10.044
SHC2SHC (Src homology 2 domain containing) transforming protein 20.044
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.042
CCR7chemokine (C-C motif) receptor 70.042
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.042
CXCL9chemokine (C-X-C motif) ligand 90.041
VAV1vav 1 guanine nucleotide exchange factor0.041
TFF1trefoil factor 10.038
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.038
CCR1chemokine (C-C motif) receptor 10.036
ZNF746zinc finger protein 7460.036
SLASrc-like-adaptor0.035
BTKBruton agammaglobulinemia tyrosine kinase0.035
DPP4dipeptidyl-peptidase 40.034
CXCL10chemokine (C-X-C motif) ligand 100.034
COPB2coatomer protein complex, subunit beta 2 (beta prime)0.032
CARD11caspase recruitment domain family, member 110.032
ANXA4annexin A40.031
PTPRJprotein tyrosine phosphatase, receptor type, J0.030
COPB1coatomer protein complex, subunit beta 10.030
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.029
CLASP1cytoplasmic linker associated protein 10.029
CDH5cadherin 5, type 2 (vascular endothelium)0.029
IL4interleukin 40.028
CXCL2chemokine (C-X-C motif) ligand 20.027
IL7Rinterleukin 7 receptor0.026
KRT8keratin 80.026
CCL13chemokine (C-C motif) ligand 130.026
CCL3chemokine (C-C motif) ligand 30.025
RAB10RAB10, member RAS oncogene family0.025
APPL2adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 20.024
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.024
ITM2Bintegral membrane protein 2B0.024
TNFtumor necrosis factor0.024
SNAP25synaptosomal-associated protein, 25kDa0.024
RAB5ARAB5A, member RAS oncogene family0.024
CCL22chemokine (C-C motif) ligand 220.023
STX12syntaxin 120.021
IFNGinterferon, gamma0.021
COPAcoatomer protein complex, subunit alpha0.021
CAV1caveolin 1, caveolae protein, 22kDa0.021
SOS1son of sevenless homolog 1 (Drosophila)0.021
PDGFAplatelet-derived growth factor alpha polypeptide0.021
KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.021
CMIPc-Maf-inducing protein0.020
AKT2v-akt murine thymoma viral oncogene homolog 20.020
IL10interleukin 100.020
CRHcorticotropin releasing hormone0.019
MLPHmelanophilin0.019
IL4Rinterleukin 4 receptor0.019
CCL7chemokine (C-C motif) ligand 70.019
IL2RBinterleukin 2 receptor, beta0.019
VCAM1vascular cell adhesion molecule 10.018
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.018
RABIFRAB interacting factor0.018
FGFR1fibroblast growth factor receptor 10.017
CCL8chemokine (C-C motif) ligand 80.017
PDE6Dphosphodiesterase 6D, cGMP-specific, rod, delta0.017
IL1Binterleukin 1, beta0.017
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.016
ARCN1archain 10.016
ROD1ROD1 regulator of differentiation 1 (S. pombe)0.016
INSRinsulin receptor0.016
KITLGKIT ligand0.015
SDCBPsyndecan binding protein (syntenin)0.015
HEXBhexosaminidase B (beta polypeptide)0.015
GSK3Bglycogen synthase kinase 3 beta0.015
SOS2son of sevenless homolog 2 (Drosophila)0.015
PLEKpleckstrin0.015
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ikzf1IKAROS family zinc finger 10.943
Inpp5dinositol polyphosphate-5-phosphatase D0.931
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.930
Ptprcprotein tyrosine phosphatase, receptor type, C0.824
Csf2rb2colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)0.728
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.726
Dok2docking protein 20.676
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.666
MefvMediterranean fever0.542
Il10rainterleukin 10 receptor, alpha0.540
Clec4nC-type lectin domain family 4, member n0.537
Csf1rcolony stimulating factor 1 receptor0.522
Ccr1chemokine (C-C motif) receptor 10.515
Cd19CD19 antigen0.511
Ifnginterferon gamma0.500
Ccr6chemokine (C-C motif) receptor 60.448
Msr1macrophage scavenger receptor 10.443
C3ar1complement component 3a receptor 10.437
Ptk2PTK2 protein tyrosine kinase 20.430
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.373
Emr1EGF-like module containing, mucin-like, hormone receptor-like sequence 10.372
Prf1perforin 1 (pore forming protein)0.355
C5ar1complement component 5a receptor 10.355
Cd4CD4 antigen0.341
Grb2growth factor receptor bound protein 20.331
Hcsthematopoietic cell signal transducer0.311
Fcgr1Fc receptor, IgG, high affinity I0.291
Cd22CD22 antigen0.276
Cxcr3chemokine (C-X-C motif) receptor 30.266
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.264
TyrobpTYRO protein tyrosine kinase binding protein0.260
Nfam1Nfat activating molecule with ITAM motif 10.252
Foxp3forkhead box P30.249
Il4interleukin 40.243
Ccl2chemokine (C-C motif) ligand 20.216
Pik3cgphosphoinositide-3-kinase, catalytic, gamma polypeptide0.216
Fcgr2bFc receptor, IgG, low affinity IIb0.215
Tbxas1thromboxane A synthase 1, platelet0.215
Grap2GRB2-related adaptor protein 20.210
CblCasitas B-lineage lymphoma0.198
Trpv1transient receptor potential cation channel, subfamily V, member 10.190
Prdm1PR domain containing 1, with ZNF domain0.177
AF251705cDNA sequence AF2517050.176
Cd180CD180 antigen0.173
P2rx7purinergic receptor P2X, ligand-gated ion channel, 70.173
Gab2growth factor receptor bound protein 2-associated protein 20.168
Xcr1chemokine (C motif) receptor 10.161
Ccr5chemokine (C-C motif) receptor 50.158
FcrlaFc receptor-like A0.158
Csf3rcolony stimulating factor 3 receptor (granulocyte)0.156
ItkIL2-inducible T-cell kinase0.155
Ms4a6dmembrane-spanning 4-domains, subfamily A, member 6D0.154
Fcgr3Fc receptor, IgG, low affinity III0.153
Anxa1annexin A10.153
Mlphmelanophilin0.152
Map3k14mitogen-activated protein kinase kinase kinase 140.144
4632428N05RikRIKEN cDNA 4632428N05 gene0.144
Stx11syntaxin 110.144
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.143
Mmp9matrix metallopeptidase 90.140
S1pr4sphingosine-1-phosphate receptor 40.138
Metmet proto-oncogene0.130
Itgaxintegrin alpha X0.123
Clec4dC-type lectin domain family 4, member d0.123
Clec7aC-type lectin domain family 7, member a0.121
Ccl6chemokine (C-C motif) ligand 60.120
Ccl9chemokine (C-C motif) ligand 90.119
WasWiskott-Aldrich syndrome homolog (human)0.118
Cd247CD247 antigen0.116
Myo1fmyosin IF0.113
Il1rninterleukin 1 receptor antagonist0.113
Lyz2lysozyme 20.112
Fut4fucosyltransferase 40.105
BC013712cDNA sequence BC0137120.103
Dok1docking protein 10.102
Cd68CD68 antigen0.102
Itgalintegrin alpha L0.099
Tlr2toll-like receptor 20.096
Ncf1neutrophil cytosolic factor 10.096
Klrb1bkiller cell lectin-like receptor subfamily B member 1B0.096
Ncf4neutrophil cytosolic factor 40.095
Lamp2lysosomal-associated membrane protein 20.095
Cx3cr1chemokine (C-X3-C) receptor 10.095
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.089
Batfbasic leucine zipper transcription factor, ATF-like0.084
Cybbcytochrome b-245, beta polypeptide0.084
Fgd3FYVE, RhoGEF and PH domain containing 30.084
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.083
Ptafrplatelet-activating factor receptor0.081
Mpeg1macrophage expressed gene 10.081
Il2interleukin 20.080
Snai1snail homolog 1 (Drosophila)0.080
Sypsynaptophysin0.080
Galnt6UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 60.079
Aif1allograft inflammatory factor 10.079
Igsf6immunoglobulin superfamily, member 60.079
Hrh1histamine receptor H10.078
Mrc1mannose receptor, C type 10.078
Mitfmicrophthalmia-associated transcription factor0.078
Cnr2cannabinoid receptor 2 (macrophage)0.077
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism