The network for 'interleukin 1 beta secretion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

interleukin 1 beta secretion

The regulated release of interleukin 1 beta from a cell.

Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.654
Tlr4toll-like receptor 40.494
Nat1N-acetyltransferase 10.383
Cybbcytochrome b-245, beta polypeptide0.344
Ptprcprotein tyrosine phosphatase, receptor type, C0.327
Casp1caspase 10.283
RT1-DaRT1 class II, locus Da0.220
Nrasneuroblastoma ras oncogene0.177
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.158
Akr1c14aldo-keto reductase family 1, member C140.147
Calcrlcalcitonin receptor-like0.129
RT1-Db1RT1 class II, locus Db10.122
Pdclphosducin-like0.122
Plauplasminogen activator, urokinase0.113
A3galt2alpha 1,3-galactosyltransferase 20.113
Ctsccathepsin C0.111
Csf1colony stimulating factor 1 (macrophage)0.106
Adam17ADAM metallopeptidase domain 170.106
Htr2b5-hydroxytryptamine (serotonin) receptor 2B0.099
Ets1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.090
Cdk2cyclin dependent kinase 20.089
S1pr2sphingosine-1-phosphate receptor 20.083
Cd38CD38 molecule0.078
Casp2caspase 20.077
Gabregamma-aminobutyric acid (GABA) A receptor, epsilon0.074
Oclnoccludin0.072
Cd53Cd53 molecule0.071
RT1-N3RT1 class Ib, locus N30.070
Fgfr2fibroblast growth factor receptor 20.063
Mmp3matrix metallopeptidase 30.058
Dock8dedicator of cytokinesis 80.056
Casp3caspase 30.055
Casp8caspase 80.054
Cd48Cd48 molecule0.050
Skap2src kinase associated phosphoprotein 20.048
Ms4a11membrane-spanning 4-domains, subfamily A, member 110.046
Cap1CAP, adenylate cyclase-associated protein 1 (yeast)0.044
Klra5killer cell lectin-like receptor, subfamily A, member 50.041
Cd47Cd47 molecule0.040
P2ry6pyrimidinergic receptor P2Y, G-protein coupled, 60.038
Accn3amiloride-sensitive cation channel 30.038
RT1-BbRT1 class II, locus Bb0.037
Cdc23CDC23 (cell division cycle 23, yeast, homolog)0.037
Itpr2inositol 1,4,5-triphosphate receptor, type 20.037
Cd44Cd44 molecule0.037
OgtO-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)0.035
Aif1allograft inflammatory factor 10.035
Casp4caspase 4, apoptosis-related cysteine peptidase0.035
Pdia4protein disulfide isomerase family A, member 40.032
siat7Dalpha-2,6-sialyltransferase ST6GalNAc IV0.031
Tmpothymopoietin0.031
Elf1E74-like factor 10.030
Ms4a6bmembrane-spanning 4-domains, subfamily A, member 6B0.030
Dhfrdihydrofolate reductase0.030
Apaf1apoptotic peptidase activating factor 10.029
Igsf6immunoglobulin superfamily, member 60.029
Calcrcalcitonin receptor0.028
Sec22aSEC22 vesicle trafficking protein homolog A (S. cerevisiae)0.028
Fcgr3aFc fragment of IgG, low affinity IIIa, receptor0.028
Ceacam10carcinoembryonic antigen-related cell adhesion molecule 100.027
Bdkrb2bradykinin receptor B20.025
Ptger2prostaglandin E receptor 2 (subtype EP2)0.025
Casp6caspase 60.025
RGD1564664similar to LOC387763 protein0.025
Crotcarnitine O-octanoyltransferase0.025
Casp7caspase 70.025
Fam198bfamily with sequence similarity 198, member B0.024
Slc30a2solute carrier family 30 (zinc transporter), member 20.024
Il1ainterleukin 1 alpha0.024
Lsm6LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)0.024
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.023
RT1-BaRT1 class II, locus Ba0.023
Abcg3l1ATP-binding cassette, subfamily G (WHITE), member 3-like 10.021
P2rx7purinergic receptor P2X, ligand-gated ion channel, 70.021
Ptprhprotein tyrosine phosphatase, receptor type, H0.021
Slc22a25solute carrier family 22, member 250.020
Apobec1apolipoprotein B mRNA editing enzyme, catalytic polypeptide 10.019
Bmpr1abone morphogenetic protein receptor, type IA0.019
Psen1presenilin 10.018
Cxcl10chemokine (C-X-C motif) ligand 100.018
RGD1307254similar to RIKEN cDNA 1200011I180.018
Rpa2replication protein A20.018
Mmp12matrix metallopeptidase 120.018
Parp14poly (ADP-ribose) polymerase family, member 140.018
Leprotleptin receptor overlapping transcript0.017
Cnot6CCR4-NOT transcription complex, subunit 60.017
Adaradenosine deaminase, RNA-specific0.017
Actc1actin, alpha, cardiac muscle 10.017
Tgfbr2transforming growth factor, beta receptor II0.017
Lig3ligase III, DNA, ATP-dependent0.017
Ptpn18protein tyrosine phosphatase, non-receptor type 180.016
Exoc7exocyst complex component 70.016
Pctpphosphatidylcholine transfer protein0.016
Vcam1vascular cell adhesion molecule 10.016
Socs3suppressor of cytokine signaling 30.016
Gnb4guanine nucleotide binding protein (G protein), beta polypeptide 40.015
Pde11aphosphodiesterase 11A0.015
P2rx1purinergic receptor P2X, ligand-gated ion channel, 10.015
Tfpitissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)0.015
Lmo2LIM domain only 20.015
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.998
NLRC4NLR family, CARD domain containing 40.994
PYCARDPYD and CARD domain containing0.959
RIPK2receptor-interacting serine-threonine kinase 20.814
SNTB2syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)0.697
HPhaptoglobin0.404
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.335
IDEinsulin-degrading enzyme0.243
APOC1apolipoprotein C-I0.215
ALBalbumin0.196
A2Malpha-2-macroglobulin0.190
MEFVMediterranean fever0.106
BIRC3baculoviral IAP repeat containing 30.083
CASP4caspase 4, apoptosis-related cysteine peptidase0.074
CARD16caspase recruitment domain family, member 160.056
APOC3apolipoprotein C-III0.050
PYDC2pyrin domain containing 20.048
FZD1frizzled homolog 1 (Drosophila)0.045
LCATlecithin-cholesterol acyltransferase0.032
APOA2apolipoprotein A-II0.031
CCL4chemokine (C-C motif) ligand 40.030
APOC2apolipoprotein C-II0.026
CAV1caveolin 1, caveolae protein, 22kDa0.025
ELF4E74-like factor 4 (ets domain transcription factor)0.024
NOD2nucleotide-binding oligomerization domain containing 20.024
BTN3A2butyrophilin, subfamily 3, member A20.022
CARD6caspase recruitment domain family, member 60.020
APOA1apolipoprotein A-I0.017
FGAfibrinogen alpha chain0.016
NCF2neutrophil cytosolic factor 20.016
LRP6low density lipoprotein receptor-related protein 60.016
IL18interleukin 18 (interferon-gamma-inducing factor)0.016
NLRP1NLR family, pyrin domain containing 10.015
MLKLmixed lineage kinase domain-like0.015
CCR7chemokine (C-C motif) receptor 70.014
BTN3A3butyrophilin, subfamily 3, member A30.013
EVI2Aecotropic viral integration site 2A0.013
TNFRSF10Ctumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain0.013
IFI16interferon, gamma-inducible protein 160.013
FASFas (TNF receptor superfamily, member 6)0.013
STX12syntaxin 120.013
HCP5HLA complex P50.013
TXNDC2thioredoxin domain containing 2 (spermatozoa)0.013
CLEC2BC-type lectin domain family 2, member B0.012
IL21Rinterleukin 21 receptor0.012
MS4A1membrane-spanning 4-domains, subfamily A, member 10.012
TP53BP1tumor protein p53 binding protein 10.012
GBP5guanylate binding protein 50.011
CAV2caveolin 20.011
BTN3A1butyrophilin, subfamily 3, member A10.010
SERPINB1serpin peptidase inhibitor, clade B (ovalbumin), member 10.010
BCL2A1BCL2-related protein A10.010
INADLInaD-like (Drosophila)0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Casp4caspase 4, apoptosis-related cysteine peptidase0.973
Gbp5guanylate binding protein 50.950
Lyz2lysozyme 20.939
PycardPYD and CARD domain containing0.929
Casp1caspase 10.910
Ccr2chemokine (C-C motif) receptor 20.703
Ccr1chemokine (C-C motif) receptor 10.658
Il1binterleukin 1 beta0.545
Socs1suppressor of cytokine signaling 10.441
Ccl2chemokine (C-C motif) ligand 20.433
Cd44CD44 antigen0.352
Tlr4toll-like receptor 40.350
Ifngr1interferon gamma receptor 10.267
Cd7CD7 antigen0.259
FaslFas ligand (TNF superfamily, member 6)0.216
Klrk1killer cell lectin-like receptor subfamily K, member 10.215
Aim2absent in melanoma 20.206
Gzmbgranzyme B0.198
Klrd1killer cell lectin-like receptor, subfamily D, member 10.165
Cxcl13chemokine (C-X-C motif) ligand 130.164
Ccl8chemokine (C-C motif) ligand 80.159
Dkk1dickkopf homolog 1 (Xenopus laevis)0.157
Ctswcathepsin W0.155
Pax2paired box gene 20.152
Klrg1killer cell lectin-like receptor subfamily G, member 10.151
Il27rainterleukin 27 receptor, alpha0.150
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.146
C3ar1complement component 3a receptor 10.144
Cd40CD40 antigen0.137
Mndalmyeloid nuclear differentiation antigen like0.136
Pdcd1programmed cell death 10.133
Gzmagranzyme A0.123
Xcl1chemokine (C motif) ligand 10.122
Muc13mucin 13, epithelial transmembrane0.120
Ccl4chemokine (C-C motif) ligand 40.115
Ctla4cytotoxic T-lymphocyte-associated protein 40.109
Ccl22chemokine (C-C motif) ligand 220.103
Selpselectin, platelet0.103
Batfbasic leucine zipper transcription factor, ATF-like0.103
Ccl3chemokine (C-C motif) ligand 30.102
Ifnginterferon gamma0.102
Pax1paired box gene 10.100
Slamf8SLAM family member 80.097
Irf1interferon regulatory factor 10.087
Itgaxintegrin alpha X0.084
Ncr1natural cytotoxicity triggering receptor 10.082
Ubdubiquitin D0.079
Pax8paired box gene 80.076
Ccl12chemokine (C-C motif) ligand 120.076
Wnt4wingless-related MMTV integration site 40.075
Ciitaclass II transactivator0.070
Tnfsf10tumor necrosis factor (ligand) superfamily, member 100.068
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.067
Cd96CD96 antigen0.067
Il18interleukin 180.065
Cd160CD160 antigen0.064
Prdm1PR domain containing 1, with ZNF domain0.064
Aireautoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)0.063
Il18r1interleukin 18 receptor 10.061
3110079O15RikRIKEN cDNA 3110079O15 gene0.061
Gzmkgranzyme K0.058
Mmp3matrix metallopeptidase 30.056
Itgb2integrin beta 20.055
Folr2folate receptor 2 (fetal)0.055
Ccr3chemokine (C-C motif) receptor 30.053
Il2rbinterleukin 2 receptor, beta chain0.053
Elk4ELK4, member of ETS oncogene family0.053
Xcr1chemokine (C motif) receptor 10.052
Ccr5chemokine (C-C motif) receptor 50.052
AW112010expressed sequence AW1120100.051
Nkx2-3NK2 transcription factor related, locus 3 (Drosophila)0.051
Fut7fucosyltransferase 70.048
Gpr132G protein-coupled receptor 1320.047
Il1rl1interleukin 1 receptor-like 10.047
Il2rainterleukin 2 receptor, alpha chain0.045
Tbx21T-box 210.043
Fzd10frizzled homolog 10 (Drosophila)0.042
H2-Ab1histocompatibility 2, class II antigen A, beta 10.042
Mmp7matrix metallopeptidase 70.042
Abca1ATP-binding cassette, sub-family A (ABC1), member 10.041
Mybphmyosin binding protein H0.041
Nkg7natural killer cell group 7 sequence0.040
Anxa4annexin A40.040
Krt86keratin 860.040
Fxyd2FXYD domain-containing ion transport regulator 20.040
Sh2d2aSH2 domain protein 2A0.039
Cd3eCD3 antigen, epsilon polypeptide0.038
Il15interleukin 150.037
Batf3basic leucine zipper transcription factor, ATF-like 30.037
Mmp12matrix metallopeptidase 120.037
Icosinducible T-cell co-stimulator0.037
Cxcl2chemokine (C-X-C motif) ligand 20.037
Klrb1bkiller cell lectin-like receptor subfamily B member 1B0.035
Cd86CD86 antigen0.035
Sftpbsurfactant associated protein B0.034
FaddFas (TNFRSF6)-associated via death domain0.034
Fcgr1Fc receptor, IgG, high affinity I0.034
Ifnar1interferon (alpha and beta) receptor 10.033
Cxcl9chemokine (C-X-C motif) ligand 90.033
Ptgirprostaglandin I receptor (IP)0.032
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism