IMP: Integrative Multi-species Prediction

The network for 'necroptotic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

necroptotic process

A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former.

Rattus norvegicus

Name	Description	Probability
Mcpt8	mast cell protease 8	0.844
Cma1	chymase 1, mast cell	0.319
Cpa3	carboxypeptidase A3, mast cell	0.213
Prf1	perforin 1 (pore forming protein)	0.205
Il1b	interleukin 1 beta	0.191
Klrd1	killer cell lectin-like receptor, subfamily D, member 1	0.180
Ccl5	chemokine (C-C motif) ligand 5	0.158
Ppp3r1	protein phosphatase 3, regulatory subunit B, alpha isoform	0.118
Nkg7	natural killer cell group 7 sequence	0.105
Mcpt10	mast cell protease 10	0.092
Klrg1	killer cell lectin-like receptor subfamily G, member 1	0.088
Xcl1	chemokine (C motif) ligand 1	0.083
Clca4	chloride channel accessory 4	0.073
LOC100361261	rCG23560-like	0.071
Tmigd1	transmembrane and immunoglobulin domain containing 1	0.066
Mdh1	malate dehydrogenase 1, NAD (soluble)	0.066
Tcrb	T-cell receptor beta chain	0.063
Rabac1	Rab acceptor 1 (prenylated)	0.059
Slc25a3	solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3	0.053
Gapdh	glyceraldehyde-3-phosphate dehydrogenase	0.051
Mcpt2	mast cell protease 2	0.051
Slfn2	schlafen 2	0.050
Ms4a2	membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)	0.050
Prm2	protamine 2	0.047
LOC100361706	lambda-chain C1-region-like	0.046
Art2	ADP-ribosyltransferase 2	0.045
Rps6kb1	ribosomal protein S6 kinase, polypeptide 1	0.044
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.042
Aldoa	aldolase A, fructose-bisphosphate	0.041
Klrb1a	killer cell lectin-like receptor subfamily B, member 1A	0.041
Dnase1l3	deoxyribonuclease 1-like 3	0.041
Spam1	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)	0.040
Ifit3	interferon-induced protein with tetratricopeptide repeats 3	0.040
Cd2	Cd2 molecule	0.038
Cd3g	CD3 molecule, gamma	0.035
Neurl3	neuralized homolog 3 (Drosophila)	0.035
Oas1b	2-5 oligoadenylate synthetase 1B	0.034
Mcpt9	mast cell protease 9	0.033
Zcchc6	zinc finger, CCHC domain containing 6	0.033
Cd247	Cd247 molecule	0.031
Myd88	myeloid differentiation primary response gene 88	0.029
LOC24906	RoBo-1	0.028
Il6	interleukin 6	0.028
Ubd	ubiquitin D	0.028
RGD1564878	similar to natural killer cell protease 7	0.028
RGD1309621	similar to hypothetical protein FLJ10652	0.026
Il2rb	interleukin 2 receptor, beta	0.026
Cd52	CD52 antigen	0.026
Cd8a	CD8a molecule	0.026
Tmf1	TATA element modulatory factor 1	0.025
Gzma	granzyme A	0.025
Lilrb3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.025
Cxcl10	chemokine (C-X-C motif) ligand 10	0.024
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.024
Hck	hemopoietic cell kinase	0.024
Bcl10	B-cell CLL/lymphoma 10	0.024
Cela1	chymotrypsin-like elastase family, member 1	0.023
Klrc2	killer cell lectin-like receptor subfamily C, member 2	0.023
Igh-6	immunoglobulin heavy chain 6	0.023
Atp5b	ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide	0.022
Hist1h2ba	histone cluster 1, H2ba	0.022
Spink1	serine peptidase inhibitor, Kazal type 1	0.022
Tsx	testis specific X-linked gene	0.022
Cdh17	cadherin 17	0.022
Lgals4	lectin, galactoside-binding, soluble, 4	0.022
Got1	glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)	0.022
Lmna	lamin A	0.022
Grina	glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)	0.021
RatNP-3b	defensin RatNP-3 precursor	0.021
Nr1h3	nuclear receptor subfamily 1, group H, member 3	0.021
Cox4i1	cytochrome c oxidase subunit IV isoform 1	0.021
Stip1	stress-induced phosphoprotein 1	0.021
Hnf1a	HNF1 homeobox A	0.021
Clec9a	C-type lectin domain family 9, member a	0.020
Trpv1	transient receptor potential cation channel, subfamily V, member 1	0.020
Stat4	signal transducer and activator of transcription 4	0.020
Gzmb	granzyme B	0.020
Olr1	oxidized low density lipoprotein (lectin-like) receptor 1	0.020
Pla2g2a	phospholipase A2, group IIA (platelets, synovial fluid)	0.020
Ton	tonin	0.020
Pttg1ip	pituitary tumor-transforming 1 interacting protein	0.020
Fcnb	ficolin B	0.020
Tgm1	transglutaminase 1, K polypeptide	0.019
Tpsab1	tryptase alpha/beta 1	0.019
Klre1	killer cell lectin-like receptor, family E, member 1	0.019
Ear11	eosinophil-associated, ribonuclease A family, member 11	0.019
PVR	poliovirus receptor	0.019
Irgm	immunity-related GTPase family, M	0.018
Zap70	zeta-chain (TCR) associated protein kinase	0.018
Semg1	semenogelin I	0.018
Gzmm	granzyme M (lymphocyte met-ase 1)	0.018
Fabp4	fatty acid binding protein 4, adipocyte	0.018
Trim23	tripartite motif-containing 23	0.018
Gzmc	granzyme C	0.018
Arhgef5	Rho guanine nucleotide exchange factor (GEF) 5	0.018
Rnf10	ring finger protein 10	0.018
Gfi1	growth factor independent 1 transcription repressor	0.018
Sh2d2a	SH2 domain protein 2A	0.018
Adora2a	adenosine A2a receptor	0.018
Tbc1d15	TBC1 domain family, member 15	0.017

Loading network...

Caenorhabditis elegans

Name	Description	Probability	Func Analog Organism

Loading network...

Danio rerio

Name	Description	Probability	Func Analog Organism

Loading network...

Drosophila melanogaster

Name	Description	Probability	Func Analog Organism

Loading network...

Homo sapiens

Name	Description	Probability
CASP8	caspase 8, apoptosis-related cysteine peptidase	1.000
BIRC3	baculoviral IAP repeat containing 3	0.998
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.977
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.887
FAS	Fas (TNF receptor superfamily, member 6)	0.871
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.869
CFLAR	CASP8 and FADD-like apoptosis regulator	0.860
TRAF1	TNF receptor-associated factor 1	0.852
FADD	Fas (TNFRSF6)-associated via death domain	0.842
BIRC2	baculoviral IAP repeat containing 2	0.841
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.766
RIPK3	receptor-interacting serine-threonine kinase 3	0.342
TNFRSF6B	tumor necrosis factor receptor superfamily, member 6b, decoy	0.315
TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	0.272
TRADD	TNFRSF1A-associated via death domain	0.187
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.171
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.170
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.121
RNF31	ring finger protein 31	0.115
XIAP	X-linked inhibitor of apoptosis	0.114
FZR1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.098
SMCR7	Smith-Magenis syndrome chromosome region, candidate 7	0.088
HDAC6	histone deacetylase 6	0.067
FASLG	Fas ligand (TNF superfamily, member 6)	0.064
BBS10	Bardet-Biedl syndrome 10	0.063
TRAF3	TNF receptor-associated factor 3	0.056
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.049
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.040
TNIP1	TNFAIP3 interacting protein 1	0.036
SQSTM1	sequestosome 1	0.035
TANK	TRAF family member-associated NFKB activator	0.033
CDC14B	CDC14 cell division cycle 14 homolog B (S. cerevisiae)	0.029
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.028
SLC25A3	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3	0.025
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.025
RIPK2	receptor-interacting serine-threonine kinase 2	0.025
BID	BH3 interacting domain death agonist	0.024
C1orf93	chromosome 1 open reading frame 93	0.021
TRIM39	tripartite motif containing 39	0.018
NOD2	nucleotide-binding oligomerization domain containing 2	0.018
NOD1	nucleotide-binding oligomerization domain containing 1	0.018
FBXO33	F-box protein 33	0.017
TNF	tumor necrosis factor	0.016
EIF4A1	eukaryotic translation initiation factor 4A1	0.016
RIPK4	receptor-interacting serine-threonine kinase 4	0.015
DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	0.014
MYL6	myosin, light chain 6, alkali, smooth muscle and non-muscle	0.014
USP15	ubiquitin specific peptidase 15	0.014
ZBTB16	zinc finger and BTB domain containing 16	0.013
TRIM25	tripartite motif containing 25	0.012
RPL8	ribosomal protein L8	0.012
THOC3	THO complex 3	0.012
SHARPIN	SHANK-associated RH domain interactor	0.012
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.011
BCL10	B-cell CLL/lymphoma 10	0.011
TRIM21	tripartite motif containing 21	0.011
MYH14	myosin, heavy chain 14, non-muscle	0.010

Loading network...

Mus musculus

Name	Description	Probability
Tnf	tumor necrosis factor	1.000
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.999
Casp8	caspase 8	0.999
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.991
Ikbkg	inhibitor of kappaB kinase gamma	0.969
Tlr4	toll-like receptor 4	0.952
Traf2	TNF receptor-associated factor 2	0.928
Il10	interleukin 10	0.913
Itch	itchy, E3 ubiquitin protein ligase	0.901
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.886
Myd88	myeloid differentiation primary response gene 88	0.835
Ikbkb	inhibitor of kappaB kinase beta	0.811
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.771
Fadd	Fas (TNFRSF6)-associated via death domain	0.765
Cd40	CD40 antigen	0.754
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.694
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.631
Lta	lymphotoxin A	0.609
Traf6	TNF receptor-associated factor 6	0.604
Bcl3	B-cell leukemia/lymphoma 3	0.577
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.554
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.544
Casp1	caspase 1	0.448
Gbp5	guanylate binding protein 5	0.438
Nlrp3	NLR family, pyrin domain containing 3	0.435
Ripk3	receptor-interacting serine-threonine kinase 3	0.418
Sharpin	SHANK-associated RH domain interacting protein	0.392
Rnf31	ring finger protein 31	0.353
Hccs	holocytochrome c synthetase	0.351
Fas	Fas (TNF receptor superfamily member 6)	0.347
Cd19	CD19 antigen	0.326
Pten	phosphatase and tensin homolog	0.317
Pycard	PYD and CARD domain containing	0.314
Il7	interleukin 7	0.295
Trp53	transformation related protein 53	0.260
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.259
Tox	thymocyte selection-associated high mobility group box	0.247
Ifng	interferon gamma	0.247
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.237
Il6st	interleukin 6 signal transducer	0.230
Il1r1	interleukin 1 receptor, type I	0.227
Aim2	absent in melanoma 2	0.225
Hif1a	hypoxia inducible factor 1, alpha subunit	0.218
C1qbp	complement component 1, q subcomponent binding protein	0.203
Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a	0.179
Stim2	stromal interaction molecule 2	0.159
Casp7	caspase 7	0.154
Igh	immunoglobulin heavy chain complex	0.147
Tnfsf11	tumor necrosis factor (ligand) superfamily, member 11	0.146
Cyld	cylindromatosis (turban tumor syndrome)	0.145
Lrrk2	leucine-rich repeat kinase 2	0.137
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.119
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.106
Tlr2	toll-like receptor 2	0.098
Casp3	caspase 3	0.096
Ahr	aryl-hydrocarbon receptor	0.093
Cxcl13	chemokine (C-X-C motif) ligand 13	0.091
Ptgs2	prostaglandin-endoperoxide synthase 2	0.087
Eif2ak2	eukaryotic translation initiation factor 2-alpha kinase 2	0.083
Il6	interleukin 6	0.079
Card11	caspase recruitment domain family, member 11	0.078
Stat3	signal transducer and activator of transcription 3	0.076
2310061I04Rik	RIKEN cDNA 2310061I04 gene	0.071
Tnfsf14	tumor necrosis factor (ligand) superfamily, member 14	0.070
Sfn	stratifin	0.070
Prkcd	protein kinase C, delta	0.065
Mlkl	mixed lineage kinase domain-like	0.060
Il18	interleukin 18	0.059
Cd44	CD44 antigen	0.059
Emx1	empty spiracles homolog 1 (Drosophila)	0.057
Bcl6	B-cell leukemia/lymphoma 6	0.051
Ly96	lymphocyte antigen 96	0.049
Il15	interleukin 15	0.049
Ticam1	toll-like receptor adaptor molecule 1	0.048
Ctnnb1	catenin (cadherin associated protein), beta 1	0.047
Socs1	suppressor of cytokine signaling 1	0.045
Il1b	interleukin 1 beta	0.044
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.044
Rel	reticuloendotheliosis oncogene	0.043
Naip2	NLR family, apoptosis inhibitory protein 2	0.042
Icos	inducible T-cell co-stimulator	0.041
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.039
Rb1	retinoblastoma 1	0.038
Aldh2	aldehyde dehydrogenase 2, mitochondrial	0.036
Il2ra	interleukin 2 receptor, alpha chain	0.036
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.035
Csf1	colony stimulating factor 1 (macrophage)	0.034
Apoe	apolipoprotein E	0.034
Ccl2	chemokine (C-C motif) ligand 2	0.033
Ltb	lymphotoxin B	0.031
Batf2	basic leucine zipper transcription factor, ATF-like 2	0.030
Irf6	interferon regulatory factor 6	0.030
Pdcd1lg2	programmed cell death 1 ligand 2	0.029
Psen1	presenilin 1	0.028
Sirt1	sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)	0.028
Eya2	eyes absent 2 homolog (Drosophila)	0.027
Slc4a7	solute carrier family 4, sodium bicarbonate cotransporter, member 7	0.026
Naip6	NLR family, apoptosis inhibitory protein 6	0.025
Gja1	gap junction protein, alpha 1	0.023
Smad5	MAD homolog 5 (Drosophila)	0.022

Loading network...

Saccharomyces cerevisiae

Name	Description	Probability	Func Analog Organism