The network for 'necroptotic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

necroptotic process

A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former.

NameDescriptionProbabilityFunc Analog Organism
Mcpt8mast cell protease 80.844
Cma1chymase 1, mast cell0.319
Cpa3carboxypeptidase A3, mast cell0.213
Prf1perforin 1 (pore forming protein)0.205
Il1binterleukin 1 beta0.191
Klrd1killer cell lectin-like receptor, subfamily D, member 10.180
Ccl5chemokine (C-C motif) ligand 50.158
Ppp3r1protein phosphatase 3, regulatory subunit B, alpha isoform0.118
Nkg7natural killer cell group 7 sequence0.105
Mcpt10mast cell protease 100.092
Klrg1killer cell lectin-like receptor subfamily G, member 10.088
Xcl1chemokine (C motif) ligand 10.083
Clca4chloride channel accessory 40.073
Tmigd1transmembrane and immunoglobulin domain containing 10.066
Mdh1malate dehydrogenase 1, NAD (soluble)0.066
TcrbT-cell receptor beta chain0.063
Rabac1Rab acceptor 1 (prenylated)0.059
Slc25a3solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 30.053
Gapdhglyceraldehyde-3-phosphate dehydrogenase0.051
Mcpt2mast cell protease 20.051
Slfn2schlafen 20.050
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.050
Prm2protamine 20.047
LOC100361706lambda-chain C1-region-like0.046
Art2ADP-ribosyltransferase 20.045
Rps6kb1ribosomal protein S6 kinase, polypeptide 10.044
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.042
Aldoaaldolase A, fructose-bisphosphate0.041
Klrb1akiller cell lectin-like receptor subfamily B, member 1A0.041
Dnase1l3deoxyribonuclease 1-like 30.041
Spam1sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)0.040
Ifit3interferon-induced protein with tetratricopeptide repeats 30.040
Cd2Cd2 molecule0.038
Cd3gCD3 molecule, gamma0.035
Neurl3neuralized homolog 3 (Drosophila)0.035
Oas1b2-5 oligoadenylate synthetase 1B0.034
Mcpt9mast cell protease 90.033
Zcchc6zinc finger, CCHC domain containing 60.033
Cd247Cd247 molecule0.031
Myd88myeloid differentiation primary response gene 880.029
Il6interleukin 60.028
Ubdubiquitin D0.028
RGD1564878similar to natural killer cell protease 70.028
RGD1309621similar to hypothetical protein FLJ106520.026
Il2rbinterleukin 2 receptor, beta0.026
Cd52CD52 antigen0.026
Cd8aCD8a molecule0.026
Tmf1TATA element modulatory factor 10.025
Gzmagranzyme A0.025
Lilrb3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.025
Cxcl10chemokine (C-X-C motif) ligand 100.024
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.024
Hckhemopoietic cell kinase0.024
Bcl10B-cell CLL/lymphoma 100.024
Cela1chymotrypsin-like elastase family, member 10.023
Klrc2killer cell lectin-like receptor subfamily C, member 20.023
Igh-6immunoglobulin heavy chain 60.023
Atp5bATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide0.022
Hist1h2bahistone cluster 1, H2ba0.022
Spink1serine peptidase inhibitor, Kazal type 10.022
Tsxtestis specific X-linked gene0.022
Cdh17cadherin 170.022
Lgals4lectin, galactoside-binding, soluble, 40.022
Got1glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)0.022
Lmnalamin A0.022
Grinaglutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)0.021
RatNP-3bdefensin RatNP-3 precursor0.021
Nr1h3nuclear receptor subfamily 1, group H, member 30.021
Cox4i1cytochrome c oxidase subunit IV isoform 10.021
Stip1stress-induced phosphoprotein 10.021
Hnf1aHNF1 homeobox A0.021
Clec9aC-type lectin domain family 9, member a0.020
Trpv1transient receptor potential cation channel, subfamily V, member 10.020
Stat4signal transducer and activator of transcription 40.020
Gzmbgranzyme B0.020
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.020
Pla2g2aphospholipase A2, group IIA (platelets, synovial fluid)0.020
Pttg1ippituitary tumor-transforming 1 interacting protein0.020
Fcnbficolin B0.020
Tgm1transglutaminase 1, K polypeptide0.019
Tpsab1tryptase alpha/beta 10.019
Klre1killer cell lectin-like receptor, family E, member 10.019
Ear11eosinophil-associated, ribonuclease A family, member 110.019
PVRpoliovirus receptor0.019
Irgmimmunity-related GTPase family, M0.018
Zap70zeta-chain (TCR) associated protein kinase0.018
Semg1semenogelin I0.018
Gzmmgranzyme M (lymphocyte met-ase 1)0.018
Fabp4fatty acid binding protein 4, adipocyte0.018
Trim23tripartite motif-containing 230.018
Gzmcgranzyme C0.018
Arhgef5Rho guanine nucleotide exchange factor (GEF) 50.018
Rnf10ring finger protein 100.018
Gfi1growth factor independent 1 transcription repressor0.018
Sh2d2aSH2 domain protein 2A0.018
Adora2aadenosine A2a receptor0.018
Tbc1d15TBC1 domain family, member 150.017
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CASP8caspase 8, apoptosis-related cysteine peptidase1.000
BIRC3baculoviral IAP repeat containing 30.998
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.977
CASP10caspase 10, apoptosis-related cysteine peptidase0.887
FASFas (TNF receptor superfamily, member 6)0.871
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.869
CFLARCASP8 and FADD-like apoptosis regulator0.860
TRAF1TNF receptor-associated factor 10.852
FADDFas (TNFRSF6)-associated via death domain0.842
BIRC2baculoviral IAP repeat containing 20.841
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.766
RIPK3receptor-interacting serine-threonine kinase 30.342
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.315
TNFSF10tumor necrosis factor (ligand) superfamily, member 100.272
TRADDTNFRSF1A-associated via death domain0.187
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.171
TNFAIP3tumor necrosis factor, alpha-induced protein 30.170
CASP7caspase 7, apoptosis-related cysteine peptidase0.121
RNF31ring finger protein 310.115
XIAPX-linked inhibitor of apoptosis0.114
FZR1fizzy/cell division cycle 20 related 1 (Drosophila)0.098
SMCR7Smith-Magenis syndrome chromosome region, candidate 70.088
HDAC6histone deacetylase 60.067
FASLGFas ligand (TNF superfamily, member 6)0.064
BBS10Bardet-Biedl syndrome 100.063
TRAF3TNF receptor-associated factor 30.056
CASP9caspase 9, apoptosis-related cysteine peptidase0.049
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.040
TNIP1TNFAIP3 interacting protein 10.036
SQSTM1sequestosome 10.035
TANKTRAF family member-associated NFKB activator0.033
CDC14BCDC14 cell division cycle 14 homolog B (S. cerevisiae)0.029
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.028
SLC25A3solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 30.025
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.025
RIPK2receptor-interacting serine-threonine kinase 20.025
BIDBH3 interacting domain death agonist0.024
C1orf93chromosome 1 open reading frame 930.021
TRIM39tripartite motif containing 390.018
NOD2nucleotide-binding oligomerization domain containing 20.018
NOD1nucleotide-binding oligomerization domain containing 10.018
FBXO33F-box protein 330.017
TNFtumor necrosis factor0.016
EIF4A1eukaryotic translation initiation factor 4A10.016
RIPK4receptor-interacting serine-threonine kinase 40.015
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.014
MYL6myosin, light chain 6, alkali, smooth muscle and non-muscle0.014
USP15ubiquitin specific peptidase 150.014
ZBTB16zinc finger and BTB domain containing 160.013
TRIM25tripartite motif containing 250.012
RPL8ribosomal protein L80.012
THOC3THO complex 30.012
SHARPINSHANK-associated RH domain interactor0.012
MDM2Mdm2 p53 binding protein homolog (mouse)0.011
BCL10B-cell CLL/lymphoma 100.011
TRIM21tripartite motif containing 210.011
MYH14myosin, heavy chain 14, non-muscle0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tnftumor necrosis factor1.000
Casp4caspase 4, apoptosis-related cysteine peptidase0.999
Casp8caspase 80.999
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.991
Ikbkginhibitor of kappaB kinase gamma0.969
Tlr4toll-like receptor 40.952
Traf2TNF receptor-associated factor 20.928
Il10interleukin 100.913
Itchitchy, E3 ubiquitin protein ligase0.901
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.886
Myd88myeloid differentiation primary response gene 880.835
Ikbkbinhibitor of kappaB kinase beta0.811
Map3k14mitogen-activated protein kinase kinase kinase 140.771
FaddFas (TNFRSF6)-associated via death domain0.765
Cd40CD40 antigen0.754
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.694
Tnfaip3tumor necrosis factor, alpha-induced protein 30.631
Ltalymphotoxin A0.609
Traf6TNF receptor-associated factor 60.604
Bcl3B-cell leukemia/lymphoma 30.577
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.554
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.544
Casp1caspase 10.448
Gbp5guanylate binding protein 50.438
Nlrp3NLR family, pyrin domain containing 30.435
Ripk3receptor-interacting serine-threonine kinase 30.418
SharpinSHANK-associated RH domain interacting protein0.392
Rnf31ring finger protein 310.353
Hccsholocytochrome c synthetase0.351
FasFas (TNF receptor superfamily member 6)0.347
Cd19CD19 antigen0.326
Ptenphosphatase and tensin homolog0.317
PycardPYD and CARD domain containing0.314
Il7interleukin 70.295
Trp53transformation related protein 530.260
Map3k8mitogen-activated protein kinase kinase kinase 80.259
Toxthymocyte selection-associated high mobility group box0.247
Ifnginterferon gamma0.247
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.237
Il6stinterleukin 6 signal transducer0.230
Il1r1interleukin 1 receptor, type I0.227
Aim2absent in melanoma 20.225
Hif1ahypoxia inducible factor 1, alpha subunit0.218
C1qbpcomplement component 1, q subcomponent binding protein0.203
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.179
Stim2stromal interaction molecule 20.159
Casp7caspase 70.154
Ighimmunoglobulin heavy chain complex0.147
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.146
Cyldcylindromatosis (turban tumor syndrome)0.145
Lrrk2leucine-rich repeat kinase 20.137
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.119
Map3k7mitogen-activated protein kinase kinase kinase 70.106
Tlr2toll-like receptor 20.098
Casp3caspase 30.096
Ahraryl-hydrocarbon receptor0.093
Cxcl13chemokine (C-X-C motif) ligand 130.091
Ptgs2prostaglandin-endoperoxide synthase 20.087
Eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.083
Il6interleukin 60.079
Card11caspase recruitment domain family, member 110.078
Stat3signal transducer and activator of transcription 30.076
2310061I04RikRIKEN cDNA 2310061I04 gene0.071
Tnfsf14tumor necrosis factor (ligand) superfamily, member 140.070
Prkcdprotein kinase C, delta0.065
Mlklmixed lineage kinase domain-like0.060
Il18interleukin 180.059
Cd44CD44 antigen0.059
Emx1empty spiracles homolog 1 (Drosophila)0.057
Bcl6B-cell leukemia/lymphoma 60.051
Ly96lymphocyte antigen 960.049
Il15interleukin 150.049
Ticam1toll-like receptor adaptor molecule 10.048
Ctnnb1catenin (cadherin associated protein), beta 10.047
Socs1suppressor of cytokine signaling 10.045
Il1binterleukin 1 beta0.044
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.044
Relreticuloendotheliosis oncogene0.043
Naip2NLR family, apoptosis inhibitory protein 20.042
Icosinducible T-cell co-stimulator0.041
Itgb1integrin beta 1 (fibronectin receptor beta)0.039
Rb1retinoblastoma 10.038
Aldh2aldehyde dehydrogenase 2, mitochondrial0.036
Il2rainterleukin 2 receptor, alpha chain0.036
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.035
Csf1colony stimulating factor 1 (macrophage)0.034
Apoeapolipoprotein E0.034
Ccl2chemokine (C-C motif) ligand 20.033
Ltblymphotoxin B0.031
Batf2basic leucine zipper transcription factor, ATF-like 20.030
Irf6interferon regulatory factor 60.030
Pdcd1lg2programmed cell death 1 ligand 20.029
Psen1presenilin 10.028
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.028
Eya2eyes absent 2 homolog (Drosophila)0.027
Slc4a7solute carrier family 4, sodium bicarbonate cotransporter, member 70.026
Naip6NLR family, apoptosis inhibitory protein 60.025
Gja1gap junction protein, alpha 10.023
Smad5MAD homolog 5 (Drosophila)0.022
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism