The network for 'heart morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

heart morphogenesis

The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.

NameDescriptionProbabilityFunc Analog Organism
Actc1actin, alpha, cardiac muscle 10.583
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.538
Myh7myosin, heavy chain 7, cardiac muscle, beta0.517
Casq2calsequestrin 2 (cardiac muscle)0.516
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.460
Robo1roundabout homolog 1 (Drosophila)0.392
Chrna4cholinergic receptor, nicotinic, alpha 40.262
Gata6GATA binding protein 60.244
Cxxc4CXXC finger 40.218
Myoz2myozenin 20.208
Klk1lkallikrein 1-like peptidase0.206
RT1-DOaRT1 class II, locus DOa0.199
Atp1b1ATPase, Na+/K+ transporting, beta 1 polypeptide0.199
Prpg1proline-rich proteoglycan 10.197
Myh6myosin, heavy chain 6, cardiac muscle, alpha0.194
Actn2actinin alpha 20.194
Bmp7bone morphogenetic protein 70.193
Gnrhrgonadotropin releasing hormone receptor0.190
Btg2BTG family, member 20.187
Akt1v-akt murine thymoma viral oncogene homolog 10.186
Cald1caldesmon 10.185
Vegfavascular endothelial growth factor A0.181
Pls3plastin 3 (T-isoform)0.180
Phox2apaired-like homeobox 2a0.179
Mpripmyosin phosphatase Rho interacting protein0.178
Ctgfconnective tissue growth factor0.162
Pou2f2POU class 2 homeobox 20.160
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.156
Andproandrogen regulated protein0.150
Inpp4binositol polyphosphate-4-phosphatase, type II0.149
Ctnnd2catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)0.148
Fgfr1Fibroblast growth factor receptor 10.145
Nfibnuclear factor I/B0.141
Fgf7fibroblast growth factor 70.138
Pgm3phosphoglucomutase 30.135
Cap1CAP, adenylate cyclase-associated protein 1 (yeast)0.133
Arnt2aryl hydrocarbon receptor nuclear translocator 20.131
Smad7SMAD family member 70.130
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.129
Hes3hairy and enhancer of split 3 (Drosophila)0.129
Cox6a2cytochrome c oxidase, subunit VIa, polypeptide 20.129
Nrg1neuregulin 10.128
Appamyloid beta (A4) precursor protein0.127
Fat2FAT tumor suppressor homolog 2 (Drosophila)0.125
Cox4i2cytochrome c oxidase subunit IV isoform 20.122
Npr1natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)0.121
Dbhdopamine beta-hydroxylase (dopamine beta-monooxygenase)0.120
Fzd2frizzled homolog 2 (Drosophila)0.119
Ctf1cardiotrophin 10.117
Sox17SRY (sex determining region Y)-box 170.116
P22k15cystatin related protein 20.114
Arhgap1Rho GTPase activating protein 10.113
Slit3slit homolog 3 (Drosophila)0.112
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.111
Il11interleukin 110.111
Wt1Wilms tumor 10.111
Gabrr1gamma-aminobutyric acid (GABA) receptor, rho 10.110
Tubb5tubulin, beta 50.110
Scn3asodium channel, voltage-gated, type III, alpha0.110
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.109
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.105
Rararetinoic acid receptor, alpha0.105
Bmp6bone morphogenetic protein 60.104
Lnpepleucyl/cystinyl aminopeptidase0.104
Dchs1dachsous 1 (Drosophila)0.103
Col9a1collagen, type IX, alpha 10.102
Tnp1transition protein 10.102
Mylk2myosin light chain kinase 20.102
Slco2a1solute carrier organic anion transporter family, member 2a10.101
Igfbp5insulin-like growth factor binding protein 50.101
Myom1myomesin 10.100
Eif4heukaryotic translation initiation factor 4H0.100
Actbactin, beta0.099
Cryaacrystallin, alpha A0.098
Pipprolactin induced protein0.096
Foxi2forkhead box I20.095
UncxUNC homeobox0.094
Agtr2angiotensin II receptor, type 20.094
Sdc3syndecan 30.093
Gpr176G protein-coupled receptor 1760.093
Chrnb1cholinergic receptor, nicotinic, beta 1 (muscle)0.093
Fabp6fatty acid binding protein 6, ileal0.092
Atp7bATPase, Cu++ transporting, beta polypeptide0.092
Nfianuclear factor I/A0.092
Scn5asodium channel, voltage-gated, type V, alpha subunit0.091
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.090
Csrp3cysteine and glycine-rich protein 30.089
Cfl1cofilin 1, non-muscle0.088
Pank2pantothenate kinase 2 (Hallervorden-Spatz syndrome)0.088
Hand2heart and neural crest derivatives expressed 20.087
Igf2insulin-like growth factor 20.087
Nek9NIMA (never in mitosis gene a)- related kinase 90.086
RestRE1-silencing transcription factor0.086
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tbx1T-box 11.000
cdh2cadherin 2, neuronal0.999
fgf8afibroblast growth factor 8 a0.999
myod1myogenic differentiation 10.997
fn1fibronectin 10.996
hnf1baHNF1 homeobox Ba0.995
sox9aSRY-box containing gene 9a0.991
ttnatitin a0.989
wnt11rwingless-type MMTV integration site family, member 11, related0.989
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.985
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.982
gata5GATA-binding protein 50.981
slc8a1asolute carrier family 8 (sodium/calcium exchanger), member 1a0.980
tbx2aT-box gene 2a0.979
tbx18T-box 180.977
nkx2.5NK2 transcription factor related 50.974
kdrlkinase insert domain receptor like0.973
aldh1a2aldehyde dehydrogenase 1 family, member A20.972
ndr2nodal-related 20.971
bmp4bone morphogenetic protein 40.966
tal1T-cell acute lymphocytic leukemia 10.966
tpm4tropomyosin 40.965
vmhcventricular myosin heavy chain0.963
tbx5aT-box 5a0.957
foxa2forkhead box A20.957
myl7myosin, light polypeptide 7, regulatory0.943
hey2hairy/enhancer-of-split related with YRPW motif 20.942
atoh1aatonal homolog 1a0.940
foxh1forkhead box H10.939
hspb1heat shock protein, alpha-crystallin-related, 10.935
gata4GATA-binding protein 40.929
tbx2bT-box 2b0.929
pcdh8protocadherin 80.927
tbx16T-box gene 160.923
spry4sprouty (Drosophila) homolog 40.920
fgfrl1bfibroblast growth factor receptor-like 1b0.915
tmem2transmembrane protein 20.911
gata3GATA-binding protein 30.907
sox32SRY-box containing gene 320.905
pkd2polycystic kidney disease 20.903
unc45bunc-45 homolog B (C. elegans)0.896
smad9MAD homolog 9 (Drosophila)0.887
crabp2acellular retinoic acid binding protein 2, a0.884
fhlafour and a half LIM domains a0.871
desmadesmin a0.842
shhbsonic hedgehog b0.841
alcamaactivated leukocyte cell adhesion molecule a0.840
lamb1alaminin, beta 1a0.835
ntlano tail a0.833
bmp2abone morphogenetic protein 2a0.832
tnnt2atroponin T2a, cardiac0.827
lmo4aLIM domain only 4a0.826
smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.825
spns2spinster homolog 2 (Drosophila)0.818
cacnb4acalcium channel, voltage-dependent, beta 4a subunit0.806
chsy1chondroitin sulfate synthase 10.804
cdx4caudal type homeo box transcription factor 40.797
smyd1bSET and MYND domain containing 1b0.791
fzd8bfrizzled homolog 8b0.787
tnni1btroponin I, skeletal, slow b0.785
cacnb4bcalcium channel, voltage-dependent, beta 4b subunit0.777
myl1myosin, light chain 1, alkali; skeletal, fast0.771
notch1bnotch homolog 1b0.768
six4bsine oculis homeobox homolog 4b0.766
tnnc1atroponin C type 1a (slow)0.762
eya4eyes absent homolog 4 (Drosophila)0.759
amotl2aangiomotin like 2a0.753
prdm1aPR domain containing 1a, with ZNF domain0.746
ephb4beph receptor B4b0.731
traf4atnf receptor-associated factor 4a0.730
oepone-eyed pinhead0.725
notch2notch homolog 20.725
tp73tumor protein p730.723
smyhc1slow myosin heavy chain 10.722
eya1eyes absent homolog 10.719
tnni2a.4troponin I, skeletal, fast 2a.40.707
pou5f1POU domain, class 5, transcription factor 10.700
acvr1lactivin A receptor, type I like0.694
cdh1cadherin 1, epithelial0.680
lamc1laminin, gamma 10.678
neurodneurogenic differentiation0.677
mef2camyocyte enhancer factor 2ca0.673
gapdhglyceraldehyde-3-phosphate dehydrogenase0.671
slit3slit (Drosophila) homolog 30.671
zic1zic family member 1 (odd-paired homolog, Drosophila)0.667
evx1even-skipped homeobox 10.666
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.665
rbfox1lRNA binding protein, fox-1 homolog (C. elegans) 1-like0.661
foxn4forkhead box N40.656
ift88intraflagellar transport 88 homolog0.653
hand2heart and neural crest derivatives expressed transcript 20.652
lrrc6leucine rich repeat containing 60.648
foxi1forkhead box I10.646
ccm2cerebral cavernous malformation 20.641
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
MadMothers against dpp0.997
EgfrEpidermal growth factor receptor0.995
cicubitus interruptus0.990
slp1sloppy paired 10.976
nkdnaked cuticle0.928
wupAwings up A0.845
gcmglial cells missing0.678
gbbglass bottom boat0.656
stumpsCG31317 gene product from transcript CG31317-RC0.656
rheaCG6831 gene product from transcript CG6831-RA0.643
eveeven skipped0.631
Rac1CG2248 gene product from transcript CG2248-RA0.602
MhcMyosin heavy chain0.541
CG14869CG14869 gene product from transcript CG14869-RB0.481
AtpalphaNa pump alpha subunit0.479
fkhfork head0.427
jebjelly belly0.419
bowlbrother of odd with entrails limited0.406
VangVan Gogh0.356
LanB2Laminin B20.325
dallydivision abnormally delayed0.315
eyaeyes absent0.304
Ggamma1G protein gamma 10.283
Mlp84BMuscle LIM protein at 84B0.230
osaCG7467 gene product from transcript CG7467-RD0.209
Akt1CG4006 gene product from transcript CG4006-RA0.185
emcextra macrochaetae0.171
DadDaughters against dpp0.170
Mpk2CG5475 gene product from transcript CG5475-RB0.168
slmbsupernumerary limbs0.149
jingCG9397 gene product from transcript CG9397-RI0.146
Cyp316a1CG8540 gene product from transcript CG8540-RA0.140
vvlventral veins lacking0.138
LanB1CG7123 gene product from transcript CG7123-RA0.133
PvrPDGF- and VEGF-receptor related0.132
Tm2Tropomyosin 20.130
abd-Aabdominal A0.118
snssticks and stones0.116
nrv2nervana 20.115
Pka-C1cAMP-dependent protein kinase 10.112
mewmultiple edematous wings0.109
fasfaint sausage0.106
betaggt-Ibeta subunit of type I geranylgeranyl transferase0.106
LanALaminin A0.105
argosCG4531 gene product from transcript CG4531-RA0.104
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
EGFRepidermal growth factor receptor0.997
ESR1estrogen receptor 10.997
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.984
TPM1tropomyosin 1 (alpha)0.981
SMAD3SMAD family member 30.979
JAG1jagged 10.959
NOTCH1notch 10.958
SMAD4SMAD family member 40.953
EP300E1A binding protein p3000.942
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.914
CSNK1Ecasein kinase 1, epsilon0.891
CAV1caveolin 1, caveolae protein, 22kDa0.883
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.878
TAL1T-cell acute lymphocytic leukemia 10.865
MYOD1myogenic differentiation 10.858
SMAD7SMAD family member 70.834
FSTL1follistatin-like 10.823
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.814
AXIN1axin 10.788
SMAD1SMAD family member 10.777
EPAS1endothelial PAS domain protein 10.768
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.765
YAP1Yes-associated protein 10.725
CTGFconnective tissue growth factor0.716
TNNC1troponin C type 1 (slow)0.714
CALD1caldesmon 10.709
TNNI1troponin I type 1 (skeletal, slow)0.708
WWP2WW domain containing E3 ubiquitin protein ligase 20.708
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.686
TRIM63tripartite motif containing 630.669
BMPR1Abone morphogenetic protein receptor, type IA0.665
NCOR1nuclear receptor corepressor 10.662
TGFB1transforming growth factor, beta 10.660
CASKcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.658
GATA4GATA binding protein 40.653
SP1Sp1 transcription factor0.650
ACTA1actin, alpha 1, skeletal muscle0.572
NRP1neuropilin 10.570
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.560
PKP4plakophilin 40.560
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.555
MYOZ1myozenin 10.548
TNNT3troponin T type 3 (skeletal, fast)0.520
GSK3Bglycogen synthase kinase 3 beta0.519
RUNX1runt-related transcription factor 10.515
TBX5T-box 50.510
MSX1msh homeobox 10.494
ANGPT2angiopoietin 20.455
WDR5WD repeat domain 50.451
TCF4transcription factor 40.446
FOXD3forkhead box D30.437
SMAD6SMAD family member 60.437
NOTCH3notch 30.430
INADLInaD-like (Drosophila)0.417
CYR61cysteine-rich, angiogenic inducer, 610.397
PBX1pre-B-cell leukemia homeobox 10.387
TNNI2troponin I type 2 (skeletal, fast)0.381
ESR2estrogen receptor 2 (ER beta)0.377
FZD1frizzled homolog 1 (Drosophila)0.375
TGFB2transforming growth factor, beta 20.365
DVL3dishevelled, dsh homolog 3 (Drosophila)0.363
SOX2SRY (sex determining region Y)-box 20.363
BMP2bone morphogenetic protein 20.353
RTN4reticulon 40.352
SMYD1SET and MYND domain containing 10.351
TP73tumor protein p730.344
SOX11SRY (sex determining region Y)-box 110.341
FLNAfilamin A, alpha0.311
NR4A1nuclear receptor subfamily 4, group A, member 10.304
PPARAperoxisome proliferator-activated receptor alpha0.296
ILKintegrin-linked kinase0.294
PRKACAprotein kinase, cAMP-dependent, catalytic, alpha0.284
CSRP3cysteine and glycine-rich protein 3 (cardiac LIM protein)0.272
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.271
HES1hairy and enhancer of split 1, (Drosophila)0.269
COL2A1collagen, type II, alpha 10.260
HAP1huntingtin-associated protein 10.258
DVL1dishevelled, dsh homolog 1 (Drosophila)0.256
ATF2activating transcription factor 20.251
MYL2myosin, light chain 2, regulatory, cardiac, slow0.250
SRFserum response factor (c-fos serum response element-binding transcription factor)0.245
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.244
MYOGmyogenin (myogenic factor 4)0.243
HDAC1histone deacetylase 10.241
SIN3ASIN3 homolog A, transcription regulator (yeast)0.239
PAX8paired box 80.235
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.233
ARNTaryl hydrocarbon receptor nuclear translocator0.227
MYH7myosin, heavy chain 7, cardiac muscle, beta0.227
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.218
CKMcreatine kinase, muscle0.217
RARAretinoic acid receptor, alpha0.215
MDFIMyoD family inhibitor0.213
NCOR2nuclear receptor corepressor 20.211
LRP6low density lipoprotein receptor-related protein 60.209
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Pitx2paired-like homeodomain transcription factor 21.000
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)1.000
Tgfb2transforming growth factor, beta 21.000
Gli3GLI-Kruppel family member GLI31.000
Foxc1forkhead box C11.000
Shhsonic hedgehog1.000
Fgfr2fibroblast growth factor receptor 21.000
Gata4GATA binding protein 41.000
Fgf8fibroblast growth factor 81.000
Foxc2forkhead box C20.999
Mesp1mesoderm posterior 10.999
Otx2orthodenticle homolog 2 (Drosophila)0.999
Bmp4bone morphogenetic protein 40.999
Pax3paired box gene 30.998
Meox2mesenchyme homeobox 20.998
Smad6MAD homolog 6 (Drosophila)0.998
Tbx3T-box 30.997
Vegfavascular endothelial growth factor A0.997
Pax2paired box gene 20.997
Ctnnb1catenin (cadherin associated protein), beta 10.997
Vangl2vang-like 2 (van gogh, Drosophila)0.996
Zic3zinc finger protein of the cerebellum 30.995
Jag1jagged 10.994
Smad3MAD homolog 3 (Drosophila)0.994
Efnb2ephrin B20.994
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.992
Rargretinoic acid receptor, gamma0.992
Gata6GATA binding protein 60.991
Foxh1forkhead box H10.991
Hoxd13homeobox D130.991
Hoxa13homeobox A130.990
Tbx1T-box 10.989
Hand1heart and neural crest derivatives expressed transcript 10.985
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.983
Rxraretinoid X receptor alpha0.977
Gli2GLI-Kruppel family member GLI20.972
Chd7chromodomain helicase DNA binding protein 70.970
Foxg1forkhead box G10.970
Acvr1activin A receptor, type 10.969
Grb10growth factor receptor bound protein 100.965
Wnt7awingless-related MMTV integration site 7A0.964
Ptpn11protein tyrosine phosphatase, non-receptor type 110.960
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.960
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.959
Sall4sal-like 4 (Drosophila)0.952
Tlx3T-cell leukemia, homeobox 30.951
Hoxa1homeobox A10.950
Fgf10fibroblast growth factor 100.948
Pax6paired box gene 60.945
Pax1paired box gene 10.945
Lhx3LIM homeobox protein 30.944
Smad7MAD homolog 7 (Drosophila)0.940
Sox11SRY-box containing gene 110.939
Rarbretinoic acid receptor, beta0.936
En1engrailed 10.936
Tcfap2atranscription factor AP-2, alpha0.929
Robo1roundabout homolog 1 (Drosophila)0.926
Eya1eyes absent 1 homolog (Drosophila)0.924
Pitx1paired-like homeodomain transcription factor 10.918
Slit3slit homolog 3 (Drosophila)0.913
Arid1aAT rich interactive domain 1A (SWI-like)0.912
Hes1hairy and enhancer of split 1 (Drosophila)0.908
Ednraendothelin receptor type A0.907
Ptch1patched homolog 10.904
Hand2heart and neural crest derivatives expressed transcript 20.902
Fgfr1fibroblast growth factor receptor 10.901
Etv4ets variant gene 4 (E1A enhancer binding protein, E1AF)0.900
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.891
Hoxa10homeobox A100.885
Alx4aristaless-like homeobox 40.884
Gscgoosecoid homeobox0.880
Notch1Notch gene homolog 1 (Drosophila)0.878
Col2a1collagen, type II, alpha 10.874
Wnt3awingless-related MMTV integration site 3A0.874
Mks1Meckel syndrome, type 10.870
Tcf15transcription factor 150.868
Sox7SRY-box containing gene 70.865
Myod1myogenic differentiation 10.864
Sox2SRY-box containing gene 20.857
Ece1endothelin converting enzyme 10.855
Hspg2perlecan (heparan sulfate proteoglycan 2)0.854
Dll4delta-like 4 (Drosophila)0.851
Prrx1paired related homeobox 10.851
Ptenphosphatase and tensin homolog0.851
Scn5asodium channel, voltage-gated, type V, alpha0.848
Ift88intraflagellar transport 88 homolog (Chlamydomonas)0.847
Axin1axin 10.846
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.840
Pax8paired box gene 80.839
Fgf15fibroblast growth factor 150.836
Snai1snail homolog 1 (Drosophila)0.835
Foxa2forkhead box A20.833
Gata5GATA binding protein 50.827
Hoxd11homeobox D110.823
Pthlhparathyroid hormone-like peptide0.820
Ntrk3neurotrophic tyrosine kinase, receptor, type 30.810
Lhx1LIM homeobox protein 10.810
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism