The network for 'skeletal muscle contraction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

skeletal muscle contraction

A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control.

NameDescriptionProbabilityFunc Analog Organism
Hspa8heat shock protein 80.873
Chrna1cholinergic receptor, nicotinic, alpha 1 (muscle)0.295
Svs3aseminal vesicle secretory protein 3A0.127
Ckmcreatine kinase, muscle0.125
Hsph1heat shock 105/110 protein 10.092
Myoz2myozenin 20.091
Actc1actin, alpha, cardiac muscle 10.090
Chrnecholinergic receptor, nicotinic, epsilon0.086
Stip1stress-induced phosphoprotein 10.068
Cmtm2aCKLF-like MARVEL transmembrane domain containing 2A0.064
Csrp3cysteine and glycine-rich protein 30.057
Atp2a1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.051
Tnni2troponin I type 2 (skeletal, fast)0.050
Muskmuscle, skeletal, receptor tyrosine kinase0.050
Myh3myosin, heavy chain 3, skeletal muscle, embryonic0.049
Chordc1cysteine and histidine-rich domain (CHORD)-containing 10.048
Gja3gap junction protein, alpha 30.046
Tnni1troponin I type 1 (skeletal, slow)0.041
Hspd1heat shock protein 1 (chaperonin)0.040
Myl1myosin, light chain 10.040
Mybpc1myosin binding protein C, slow type0.034
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.031
Mylk2myosin light chain kinase 20.031
Grik3glutamate receptor, ionotropic, kainate 30.028
Actn2actinin alpha 20.028
Casq2calsequestrin 2 (cardiac muscle)0.028
Pitx3paired-like homeodomain 30.027
Mylpfmyosin light chain, phosphorylatable, fast skeletal muscle0.026
Ampd1adenosine monophosphate deaminase 1 (isoform M)0.025
Clcn1chloride channel 10.025
Hrchistidine rich calcium binding protein0.024
Fgf14fibroblast growth factor 140.024
Ckmt2creatine kinase, mitochondrial 2, sarcomeric0.023
Chrna6cholinergic receptor, nicotinic, alpha 60.023
Cryba1crystallin, beta A10.023
Olr1082olfactory receptor 10820.023
Acta1actin, alpha 1, skeletal muscle0.022
Vom2r27vomeronasal 2 receptor, 270.022
Mybphmyosin binding protein H0.021
Chrnb2cholinergic receptor, nicotinic, beta 2 (neuronal)0.021
Gna15guanine nucleotide binding protein, alpha 150.021
Htr75-hydroxytryptamine (serotonin) receptor 70.021
Hmga2high mobility group AT-hook 20.020
Hand1heart and neural crest derivatives expressed 10.019
Mmp9matrix metallopeptidase 90.019
Prm2protamine 20.019
Mmp13matrix metallopeptidase 130.019
Cox8bcytochrome c oxidase, subunit VIIIb0.019
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.018
Cntn2contactin 2 (axonal)0.018
Myf6myogenic factor 60.018
Pthparathyroid hormone0.018
Cox6a2cytochrome c oxidase, subunit VIa, polypeptide 20.018
Atp7bATPase, Cu++ transporting, beta polypeptide0.018
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.017
Mybpc2myosin binding protein C, fast-type0.016
Myh2myosin, heavy chain 2, skeletal muscle, adult0.016
Sstr5somatostatin receptor 50.016
Cd79bCd79b molecule, immunoglobulin-associated beta0.016
Myh7myosin, heavy chain 7, cardiac muscle, beta0.016
Gabrg3gamma-aminobutyric acid (GABA) A receptor, gamma 30.015
Myh6myosin, heavy chain 6, cardiac muscle, alpha0.015
Gzmkgranzyme K0.015
Myl3myosin, light chain 3, alkali; ventricular, skeletal, slow0.015
Otporthopedia homeobox0.015
Accn2amiloride-sensitive cation channel 2, neuronal0.015
Cd28Cd28 molecule0.015
Rin1Ras and Rab interactor 10.015
Oprl1opiate receptor-like 10.015
LOC60591calcium-activated potassium channel beta subunit0.015
Chrnb3cholinergic receptor, nicotinic, beta 30.015
RGD1559748similar to Palate lung and nasal carcinoma-like protein precursor (Tongue plunc-like protein)0.015
Kbtbd10kelch repeat and BTB (POZ) domain containing 100.014
Npy5rneuropeptide Y receptor Y50.014
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.014
Chrnb1cholinergic receptor, nicotinic, beta 1 (muscle)0.014
Gfi1growth factor independent 1 transcription repressor0.014
Pitx2paired-like homeodomain 20.014
Syt2synaptotagmin II0.014
Ncoa4nuclear receptor coactivator 40.014
Edn2endothelin 20.013
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.013
Slc17a7solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 70.013
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.013
Casp12caspase 120.013
Oprm1opioid receptor, mu 10.013
Phkg1phosphorylase kinase, gamma 10.013
Smad3SMAD family member 30.013
Il2rainterleukin 2 receptor, alpha0.013
Toretrispanning orphan0.012
Lrrc15leucine rich repeat containing 150.012
Svs1seminal vesicle secretory protein 10.012
Hspa5heat shock protein 50.012
Colqcollagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase0.012
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.967
ryr1bryanodine receptor 1b (skeletal)0.949
hsp90a.1heat shock protein 90-alpha 10.852
myhz2myosin, heavy polypeptide 2, fast muscle specific0.810
tnnt3btroponin T3b, skeletal, fast0.774
myhz1.1myosin, heavy polypeptide 1.1, skeletal muscle0.771
smyhc2slow myosin heavy chain 20.763
tnni1altroponin I, skeletal, slow like0.760
smyhc1slow myosin heavy chain 10.736
tnnc1btroponin C type 1b (slow)0.688
lama2laminin, alpha 20.652
myhc4myosin heavy chain 40.583
mylz2myosin, light polypeptide 2, skeletal muscle0.582
lamb2laminin, beta 2 (laminin S)0.567
smyd1bSET and MYND domain containing 1b0.384
tnnt3atroponin T3a, skeletal, fast0.351
tnni2a.4troponin I, skeletal, fast 2a.40.346
actn3aactinin alpha 3a0.316
tnnt1troponin T1, skeletal, slow0.276
unc45bunc-45 homolog B (C. elegans)0.241
actn3bactinin alpha 3b0.240
myhz1.2myosin, heavy polypeptide 1.2, skeletal muscle0.214
muskmuscle, skeletal, receptor tyrosine kinase0.170
ryr3ryanodine receptor 30.164
smyhc1lslow myosin heavy chain 1, like0.073
stac3SH3 and cysteine rich domain 30.069
tnni1btroponin I, skeletal, slow b0.064
ryr1aryanodine receptor 1a (skeletal)0.042
LOC100149148novel protein similar to myosin heavy chain 4 (myhc4)0.039
acta1aactin, alpha 1a, skeletal muscle0.030
vgll2bvestigial like 2b0.024
dnajb1bDnaJ (Hsp40) homolog, subfamily B, member 1b0.023
kbtbd10bkelch repeat and BTB (POZ) domain containing 10b0.023
chrndcholinergic receptor, nicotinic, delta polypeptide0.019
tnnc2troponin C type 2 (fast)0.015
LOC566040protein notum homolog0.014
flncbfilamin C, gamma b (actin binding protein 280)0.013
lbx2ladybird homeobox homolog 2 (Drosophila)0.011
myf6myogenic factor 60.011
ampd1adenosine monophosphate deaminase 1 (isoform M)0.011
smyhc3slow myosin heavy chain 30.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
TNNC1troponin C type 1 (slow)1.000
TNNI1troponin I type 1 (skeletal, slow)0.999
TNNT3troponin T type 3 (skeletal, fast)0.998
ATP2A1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.997
LIN7Blin-7 homolog B (C. elegans)0.991
SMYD1SET and MYND domain containing 10.960
MYOZ1myozenin 10.952
DTNAdystrobrevin, alpha0.940
TRIM63tripartite motif containing 630.929
LDB3LIM domain binding 30.897
COX6A2cytochrome c oxidase subunit VIa polypeptide 20.895
MYH7myosin, heavy chain 7, cardiac muscle, beta0.888
CKMcreatine kinase, muscle0.873
TNNI2troponin I type 2 (skeletal, fast)0.818
TNNT2troponin T type 2 (cardiac)0.814
MYL1myosin, light chain 1, alkali; skeletal, fast0.807
MYH1myosin, heavy chain 1, skeletal muscle, adult0.805
MYBPC2myosin binding protein C, fast type0.766
MYLPFmyosin light chain, phosphorylatable, fast skeletal muscle0.745
MYL4myosin, light chain 4, alkali; atrial, embryonic0.744
MYH2myosin, heavy chain 2, skeletal muscle, adult0.725
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.660
ACTN3actinin, alpha 30.647
MYL2myosin, light chain 2, regulatory, cardiac, slow0.553
ACTA1actin, alpha 1, skeletal muscle0.528
MYBPHmyosin binding protein H0.492
CSRP3cysteine and glycine-rich protein 3 (cardiac LIM protein)0.453
TNNC2troponin C type 2 (fast)0.437
MYH6myosin, heavy chain 6, cardiac muscle, alpha0.342
CAV3caveolin 30.337
CHUKconserved helix-loop-helix ubiquitous kinase0.306
CHRNA1cholinergic receptor, nicotinic, alpha 1 (muscle)0.279
MYD88myeloid differentiation primary response gene (88)0.275
SYNMsynemin, intermediate filament protein0.265
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.255
MYBPC1myosin binding protein C, slow type0.254
TICAM2toll-like receptor adaptor molecule 20.248
ACTA2actin, alpha 2, smooth muscle, aorta0.244
MYL3myosin, light chain 3, alkali; ventricular, skeletal, slow0.242
MYH8myosin, heavy chain 8, skeletal muscle, perinatal0.235
SGCAsarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)0.224
ASCC2activating signal cointegrator 1 complex subunit 20.207
ANKRD2ankyrin repeat domain 2 (stretch responsive muscle)0.190
MYH4myosin, heavy chain 4, skeletal muscle0.188
TNNI3troponin I type 3 (cardiac)0.169
MYOZ2myozenin 20.136
CACNA1Scalcium channel, voltage-dependent, L type, alpha 1S subunit0.128
DAG1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.126
FLNAfilamin A, alpha0.122
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.119
PGAM2phosphoglycerate mutase 2 (muscle)0.099
ACTC1actin, alpha, cardiac muscle 10.094
SRPK3SRSF protein kinase 30.093
SYNPO2Lsynaptopodin 2-like0.092
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.086
HAP1huntingtin-associated protein 10.071
HSPB3heat shock 27kDa protein 30.063
PYGMphosphorylase, glycogen, muscle0.062
CHRNDcholinergic receptor, nicotinic, delta0.058
ARRDC3arrestin domain containing 30.057
RAPSNreceptor-associated protein of the synapse0.055
SNTB1syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)0.053
MTORmechanistic target of rapamycin (serine/threonine kinase)0.053
TRPM7transient receptor potential cation channel, subfamily M, member 70.051
MAP3K14mitogen-activated protein kinase kinase kinase 140.051
CHRNGcholinergic receptor, nicotinic, gamma0.051
HSPG2heparan sulfate proteoglycan 20.050
MYOGmyogenin (myogenic factor 4)0.049
HSPB2heat shock 27kDa protein 20.048
TRPM6transient receptor potential cation channel, subfamily M, member 60.047
HRChistidine rich calcium binding protein0.045
CASQ2calsequestrin 2 (cardiac muscle)0.044
ABCC8ATP-binding cassette, sub-family C (CFTR/MRP), member 80.043
SNTA1syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)0.041
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.041
PLD3phospholipase D family, member 30.040
MYF6myogenic factor 6 (herculin)0.038
SGCGsarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)0.038
TNNI3KTNNI3 interacting kinase0.037
ACTN2actinin, alpha 20.037
MAP3K3mitogen-activated protein kinase kinase kinase 30.037
UCP3uncoupling protein 3 (mitochondrial, proton carrier)0.034
CASQ1calsequestrin 1 (fast-twitch, skeletal muscle)0.033
MYOM1myomesin 1, 185kDa0.033
PDPK13-phosphoinositide dependent protein kinase-10.033
TNNT1troponin T type 1 (skeletal, slow)0.033
CACNB1calcium channel, voltage-dependent, beta 1 subunit0.032
CACNG1calcium channel, voltage-dependent, gamma subunit 10.032
CLCN1chloride channel 1, skeletal muscle0.030
MYBPC3myosin binding protein C, cardiac0.030
RPL3Lribosomal protein L3-like0.029
GFI1Bgrowth factor independent 1B transcription repressor0.029
MYH3myosin, heavy chain 3, skeletal muscle, embryonic0.028
APOBEC2apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 20.026
NFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta0.026
TCAPtitin-cap (telethonin)0.025
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism