The network for 'tetrapyrrole metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

tetrapyrrole metabolic process

The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.

NameDescriptionProbabilityFunc Analog Organism
Hmbshydroxymethylbilane synthase0.806
Aladaminolevulinate, delta-, dehydratase0.707
Atp5f1ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B10.705
Mdh1malate dehydrogenase 1, NAD (soluble)0.395
Slc25a3solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 30.328
Trap1TNF receptor-associated protein 10.289
Akr7a2aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)0.279
Mpstmercaptopyruvate sulfurtransferase0.225
ApehN-acylaminoacyl-peptide hydrolase0.224
Mosc2MOCO sulphurase C-terminal domain containing 20.208
Fechferrochelatase0.202
Oaz1ornithine decarboxylase antizyme 10.156
Uroduroporphyrinogen decarboxylase0.150
Litaflipopolysaccharide-induced TNF factor0.143
Icam1intercellular adhesion molecule 10.137
Apobapolipoprotein B0.136
LOC293989cytochrome P450-like0.134
Nr5a2nuclear receptor subfamily 5, group A, member 20.106
Fh1fumarate hydratase 10.096
Ppoxprotoporphyrinogen oxidase0.093
Hspd1heat shock protein 1 (chaperonin)0.090
Tmem14ctransmembrane protein 14C0.087
Sult1b1sulfotransferase family, cytosolic, 1B, member 10.084
Gpx4glutathione peroxidase 40.084
Srxn1sulfiredoxin 1 homolog (S. cerevisiae)0.083
Ppifpeptidylprolyl isomerase F0.076
Mipepmitochondrial intermediate peptidase0.073
Stat3signal transducer and activator of transcription 30.071
Ccscopper chaperone for superoxide dismutase0.068
RGD1308134similar to RIKEN cDNA 1110020A230.066
Fabp1fatty acid binding protein 1, liver0.065
Cyp4a10cytochrome P450, family 4, subfamily a, polypeptide 100.064
Esr2estrogen receptor 2 (ER beta)0.060
Timp1TIMP metallopeptidase inhibitor 10.057
Grhprglyoxylate reductase/hydroxypyruvate reductase0.054
Prm2protamine 20.053
Uqcrfs1ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 10.052
Atp5a1ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle0.052
Mri1methylthioribose-1-phosphate isomerase homolog (S. cerevisiae)0.049
Hmox1heme oxygenase (decycling) 10.048
Kng1kininogen 10.047
Ube2aubiquitin-conjugating enzyme E2A (RAD6 homolog)0.043
Cyp4a8cytochrome P450, family 4, subfamily a, polypeptide 80.043
Cyp2b1cytochrome P450, family 2, subfamily b, polypeptide 10.039
Dmgdhdimethylglycine dehydrogenase0.039
Ftlferritin, light polypeptide0.039
Dnpepaspartyl aminopeptidase0.036
Slc25a4solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 40.036
Acracrosin0.035
Hphaptoglobin0.035
Hbxiphepatitis B virus x interacting protein0.035
A1i3alpha-1-inhibitor III0.034
Cryabcrystallin, alpha B0.032
Mt2Ametallothionein 2A0.031
Prdx1peroxiredoxin 10.030
Mettl7bmethyltransferase like 7B0.030
RGD1311910similar to hypothetical p38 protein0.030
Sordsorbitol dehydrogenase0.029
Iah1isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae)0.029
Ciao1cytosolic iron-sulfur protein assembly 1 homolog (S. cerevisiae)0.028
Idh2isocitrate dehydrogenase 2 (NADP+), mitochondrial0.028
Fbp1fructose-1,6-bisphosphatase 10.028
Gnsglucosamine (N-acetyl)-6-sulfatase0.027
Ier3immediate early response 30.027
Tmem205transmembrane protein 2050.027
Pttg1ippituitary tumor-transforming 1 interacting protein0.024
Fgafibrinogen alpha chain0.024
Ltbrlymphotoxin beta receptor (TNFR superfamily, member 3)0.023
Cyp3a23/3a1cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 10.023
Alkbh7alkB, alkylation repair homolog 7 (E. coli)0.023
Cd151CD151 molecule (Raph blood group)0.023
Hspa8heat shock protein 80.022
mrpl11mitochondrial ribosomal protein L110.022
Slc25a5solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 50.022
Tstthiosulfate sulfurtransferase0.021
Grngranulin0.020
Cyp2b3cytochrome P450, family 2, subfamily b, polypeptide 30.019
Ctsacathepsin A0.019
Serpina10serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 100.019
Asgr1asialoglycoprotein receptor 10.019
Fggfibrinogen gamma chain0.019
Pcyt2phosphate cytidylyltransferase 2, ethanolamine0.019
Slc3a2solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 20.018
Akr1a1aldo-keto reductase family 1, member A1 (aldehyde reductase)0.018
Cyp1a2cytochrome P450, family 1, subfamily a, polypeptide 20.018
Ppiapeptidylprolyl isomerase A (cyclophilin A)0.018
Apoa1apolipoprotein A-I0.018
Apohapolipoprotein H (beta-2-glycoprotein I)0.018
Lgals3lectin, galactoside-binding, soluble, 30.017
Acp2acid phosphatase 2, lysosomal0.017
CnbpCCHC-type zinc finger, nucleic acid binding protein0.017
Mtr5-methyltetrahydrofolate-homocysteine methyltransferase0.017
Galtgalactose-1-phosphate uridylyltransferase0.016
Park7Parkinson disease (autosomal recessive, early onset) 70.016
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.016
Galmgalactose mutarotase (aldose 1-epimerase)0.016
Abcb11ATP-binding cassette, subfamily B (MDR/TAP), member 110.015
Crisp2cysteine-rich secretory protein 20.015
Setd6SET domain containing 60.015
Gsta4glutathione S-transferase alpha 40.015
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tfr1atransferrin receptor 1a0.810
alas2aminolevulinate, delta-, synthetase 20.643
hbbe3hemoglobin beta embryonic-30.578
urosuroporphyrinogen III synthase0.331
hbae3hemoglobin alpha embryonic-30.237
fechferrochelatase0.205
gata1aGATA binding protein 1a0.157
ppoxprotoporphyrinogen oxidase0.151
epb41erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)0.139
uroduroporphyrinogen decarboxylase0.106
iba57IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)0.098
slc25a37solute carrier family 25, member 370.061
aco1aconitase 1, soluble0.058
hbbe2hemoglobin beta embryonic-20.045
slc4a1asolute carrier family 4, anion exchanger, member 1a0.038
ddtD-dopachrome tautomerase0.037
nfe2nuclear factor, erythroid-derived 20.036
zgc:194876zgc:1948760.036
kbpkif1-binding protein0.034
glrxglutaredoxin (thioltransferase)0.034
cmybtranscription factor cmyb0.027
hbaa1hemoglobin alpha adult-10.025
tspotranslocator protein0.024
klf4Kruppel-like factor 40.022
slc25a39solute carrier family 25, member 390.022
zgc:153921zgc:1539210.021
slc11a2solute carrier family 11 (proton-coupled divalent metal ion transporters), member 20.020
slc12a3solute carrier family 12 (sodium/chloride transporters), member 30.020
LOC100151531zinc finger protein Gfi-1b-like0.020
tmem14ctransmembrane protein 14C0.019
ikzf1IKAROS family zinc finger 1 (Ikaros)0.019
hmbsbhydroxymethylbilane synthase, b0.018
npsnlnephrosin-like0.018
igfbp1binsulin-like growth factor binding protein 1b0.018
tie2endothelium-specific receptor tyrosine kinase 20.018
serpinf2serine (or cysteine) peptidase inhibitor, clade F, member 20.017
pdap1pdgfa associated protein 10.017
prdx2peroxiredoxin 20.017
hoxc12bhomeo box C12b0.017
pou2f1aPOU class 2 homeobox 1a0.017
procprotein C (inactivator of coagulation factors Va and VIIIa)0.017
masp2mannan-binding lectin serine peptidase 20.016
si:dkeyp-66d7.2si:dkeyp-66d7.20.016
upp2uridine phosphorylase 20.016
nfatc4nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 40.016
zgc:63602zgc:636020.015
zgc:114172zgc:1141720.015
blvrbbiliverdin reductase B (flavin reductase (NADPH))0.015
cpceruloplasmin0.015
zgc:136866zgc:1368660.014
cyp2v2cytochrome P450, family 2, subfamily V, polypeptide 20.014
adipor2adiponectin receptor 20.014
znhit1zinc finger, HIT-type containing 10.014
echdc2enoyl CoA hydratase domain containing 20.013
hbbe1.1hemoglobin beta embryonic-1.10.013
zgc:110231zgc:1102310.013
hint2histidine triad nucleotide binding protein 20.012
atp5ibATP synthase, H+ transporting, mitochondrial F0 complex, subunit e, duplicate b0.012
glipr2GLI pathogenesis-related 20.012
zgc:92745zgc:927450.012
eomesaeomesodermin homolog a0.012
zgc:73345zgc:733450.012
snrk1SNF related kinase 10.012
harbi1harbinger transposase derived 10.012
atxn7l3ataxin 7-like 30.012
clasp2cytoplasmic linker associated protein 20.012
mdm2transformed 3T3 cell double minute 2 homolog (mouse)0.012
rnf17ring finger protein 170.012
keap1akelch-like ECH-associated protein 1a0.011
cyp2aa4cytochrome P450, family 2, subfamily AA, polypeptide 40.011
ssr2signal sequence receptor, beta0.011
dab2disabled homolog 2 (Drosophila)0.011
sult3st1sulfotransferase family 3, cytosolic sulfotransferase 10.011
selpselectin P0.011
cishcytokine inducible SH2-containing protein0.010
st3gal4ST3 beta-galactoside alpha-2,3-sialyltransferase 40.010
brp44brain protein 440.010
cyp3c1cytochrome P450, family 3, subfamily c, polypeptide 10.010
zgc:112430zgc:1124300.010
hibadha3-hydroxyisobutyrate dehydrogenase a0.010
cdc73cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SPTBspectrin, beta, erythrocytic0.978
OBSCNobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF0.622
SPTA1spectrin, alpha, erythrocytic 1 (elliptocytosis 2)0.587
ANK1ankyrin 1, erythrocytic0.565
SLC25A3solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 30.277
RHAGRh-associated glycoprotein0.232
TRADDTNFRSF1A-associated via death domain0.091
FADDFas (TNFRSF6)-associated via death domain0.084
ATP5A1ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle0.068
SLC4A1solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)0.055
RPL3ribosomal protein L30.031
CYP2A6cytochrome P450, family 2, subfamily A, polypeptide 60.028
ATP5OATP synthase, H+ transporting, mitochondrial F1 complex, O subunit0.021
OXA1Loxidase (cytochrome c) assembly 1-like0.019
COX4I1cytochrome c oxidase subunit IV isoform 10.018
AKR7A2aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)0.018
ETFBelectron-transfer-flavoprotein, beta polypeptide0.017
TTNtitin0.017
GRHPRglyoxylate reductase/hydroxypyruvate reductase0.017
PCBD1pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha0.016
ATP5F1ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B10.015
ADD2adducin 2 (beta)0.013
EEF2eukaryotic translation elongation factor 20.012
GYPBglycophorin B (MNS blood group)0.012
ATP5BATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide0.012
TKTtransketolase0.011
HADHAhydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit0.010
EPB42erythrocyte membrane protein band 4.20.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Spna1spectrin alpha 11.000
Ank1ankyrin 1, erythroid1.000
Hbb-b1hemoglobin, beta adult major chain0.996
Hbb-b2hemoglobin, beta adult minor chain0.956
Spnb1spectrin beta 10.923
Slc4a1solute carrier family 4 (anion exchanger), member 10.875
Klf1Kruppel-like factor 1 (erythroid)0.759
Exoc6exocyst complex component 60.616
Cps1carbamoyl-phosphate synthetase 10.594
Epb4.1erythrocyte protein band 4.10.593
Pklrpyruvate kinase liver and red blood cell0.501
Add2adducin 2 (beta)0.494
Cyp2c38cytochrome P450, family 2, subfamily c, polypeptide 380.476
Slc40a1solute carrier family 40 (iron-regulated transporter), member 10.473
Cyp2c29cytochrome P450, family 2, subfamily c, polypeptide 290.412
Ahspalpha hemoglobin stabilizing protein0.387
Hsd3b2hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 20.364
Cyp2a12cytochrome P450, family 2, subfamily a, polypeptide 120.348
Cyp3a11cytochrome P450, family 3, subfamily a, polypeptide 110.335
CrpC-reactive protein, pentraxin-related0.274
Fechferrochelatase0.263
Slc11a2solute carrier family 11 (proton-coupled divalent metal ion transporters), member 20.254
Cyp2b9cytochrome P450, family 2, subfamily b, polypeptide 90.246
Prkag1protein kinase, AMP-activated, gamma 1 non-catalytic subunit0.242
Keg1kidney expressed gene 10.208
Mup5major urinary protein 50.200
Ugt2b1UDP glucuronosyltransferase 2 family, polypeptide B10.186
Ttc7tetratricopeptide repeat domain 70.178
Cyp4a14cytochrome P450, family 4, subfamily a, polypeptide 140.169
F9coagulation factor IX0.167
G6pcglucose-6-phosphatase, catalytic0.163
Cyp2e1cytochrome P450, family 2, subfamily e, polypeptide 10.154
Cyp2c50cytochrome P450, family 2, subfamily c, polypeptide 500.149
Cyp2c39cytochrome P450, family 2, subfamily c, polypeptide 390.144
Cyp2d9cytochrome P450, family 2, subfamily d, polypeptide 90.140
Azgp1alpha-2-glycoprotein 1, zinc0.137
Hba-a2hemoglobin alpha, adult chain 20.135
Cyp2c54cytochrome P450, family 2, subfamily c, polypeptide 540.125
Urosuroporphyrinogen III synthase0.123
Akr1c6aldo-keto reductase family 1, member C60.121
Tmprss6transmembrane serine protease 60.105
Baatbile acid-Coenzyme A: amino acid N-acyltransferase0.103
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.097
Cyp2b10cytochrome P450, family 2, subfamily b, polypeptide 100.094
Eporerythropoietin receptor0.093
Aadacarylacetamide deacetylase (esterase)0.089
Hrghistidine-rich glycoprotein0.089
Hpd4-hydroxyphenylpyruvic acid dioxygenase0.087
Gsta2glutathione S-transferase, alpha 2 (Yc2)0.086
Cyp7a1cytochrome P450, family 7, subfamily a, polypeptide 10.085
Lect2leukocyte cell-derived chemotaxin 20.083
Serpina1cserine (or cysteine) peptidase inhibitor, clade A, member 1C0.078
Slc27a5solute carrier family 27 (fatty acid transporter), member 50.078
Otcornithine transcarbamylase0.074
Cyp1a2cytochrome P450, family 1, subfamily a, polypeptide 20.071
Timd2T-cell immunoglobulin and mucin domain containing 20.069
Slc22a1solute carrier family 22 (organic cation transporter), member 10.069
Cfhr1complement factor H-related 10.064
Upp2uridine phosphorylase 20.062
Albalbumin0.061
Catcatalase0.060
Cyp4b1cytochrome P450, family 4, subfamily b, polypeptide 10.059
Hgdhomogentisate 1, 2-dioxygenase0.057
Cyp3a13cytochrome P450, family 3, subfamily a, polypeptide 130.056
Pigrpolymeric immunoglobulin receptor0.056
Tattyrosine aminotransferase0.054
Krtap6-1keratin associated protein 6-10.053
Cd59bCD59b antigen0.052
Cyp3a25cytochrome P450, family 3, subfamily a, polypeptide 250.052
Cml2camello-like 20.052
Spna2spectrin alpha 20.050
Cyp8b1cytochrome P450, family 8, subfamily b, polypeptide 10.049
Pon1paraoxonase 10.049
Hfe2hemochromatosis type 2 (juvenile) (human homolog)0.048
Mbl2mannose-binding lectin (protein C) 20.047
C9complement component 90.047
Ugt2a3UDP glucuronosyltransferase 2 family, polypeptide A30.047
Cyp2b13cytochrome P450, family 2, subfamily b, polypeptide 130.047
Beta-shemoglobin subunit beta-1-like0.046
Vnn3vanin 30.046
Bhmtbetaine-homocysteine methyltransferase0.046
Slc22a18solute carrier family 22 (organic cation transporter), member 180.045
Serpina6serine (or cysteine) peptidase inhibitor, clade A, member 60.045
Sult2a2sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 20.044
Dmgdhdimethylglycine dehydrogenase precursor0.043
Mat1amethionine adenosyltransferase I, alpha0.043
Hsd3b5hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 50.043
Sult1d1sulfotransferase family 1D, member 10.043
Afmafamin0.042
Hsd3b4hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 40.042
Serpind1serine (or cysteine) peptidase inhibitor, clade D, member 10.042
Slco1b2solute carrier organic anion transporter family, member 1b20.041
Inmtindolethylamine N-methyltransferase0.039
Hsd3b3hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 30.039
Fmo3flavin containing monooxygenase 30.038
Tdo2tryptophan 2,3-dioxygenase0.037
Abcb4ATP-binding cassette, sub-family B (MDR/TAP), member 40.036
Apohapolipoprotein H0.036
Rdh7retinol dehydrogenase 70.036
Cpceruloplasmin0.035
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
HEM2Hem2p0.218
HEM12Hem12p0.105
HEM3Hem3p0.048
PAN1Pan1p0.046
COX18Cox18p0.045
TOM20Tom20p0.041
COX4Cox4p0.040
GLT1Glt1p0.038
MNP1Mnp1p0.037
LEU5Leu5p0.031
SRD1Srd1p0.030
TOM40Tom40p0.029
PUS6Pus6p0.028
BAP3Bap3p0.028
LEU2Leu2p0.028
YLR264C-Ahypothetical protein0.028
PMI40Pmi40p0.028
LSC1Lsc1p0.026
ADH2Adh2p0.026
NDE1Nde1p0.025
COX2Cox2p0.025
MF(ALPHA)2Mf(alpha)2p0.025
ARP10Arp10p0.025
YHR009Chypothetical protein0.025
RMD6Rmd6p0.025
PUF3Puf3p0.024
YLR162Whypothetical protein0.024
CPD1Cpd1p0.024
YOL038C-Ahypothetical protein0.024
COX5BCox5bp0.024
TOS6Tos6p0.024
YLR042Chypothetical protein0.023
SCO1Sco1p0.023
MER1Mer1p0.023
BIO2Bio2p0.022
OPT2Opt2p0.021
PDC6Pdc6p0.021
ARG8Arg8p0.021
PET9Pet9p0.021
SCM4Scm4p0.021
HXT3Hxt3p0.021
MF(ALPHA)1Mf(alpha)1p0.021
SWC7Swc7p0.021
YJR120Whypothetical protein0.020
HOR2Hor2p0.020
CWP1Cwp1p0.020
SPL2Spl2p0.020
YOL013W-Ahypothetical protein0.020
CUP1-1Cup1-1p0.020
AVT7Avt7p0.020
UPS3Ups3p0.020
DIC1Dic1p0.019
YAR068Whypothetical protein0.019
HPF1Hpf1p0.019
YBR013Chypothetical protein0.019
YCH1Ych1p0.019
NAM9Nam9p0.018
FMT1Fmt1p0.018
PUT4Put4p0.018
YJL218Whypothetical protein0.018
ZPS1Zps1p0.018
BIO4Bio4p0.018
BSC1Bsc1p0.018
YLR177Whypothetical protein0.018
ALD6Ald6p0.017
AUA1Aua1p0.017
YIR035Chypothetical protein0.017
YDL012Chypothetical protein0.017
ALT2Alt2p0.017
CTR2Ctr2p0.017
MDH1Mdh1p0.017
MRPL19Mrpl19p0.017
YPR157Whypothetical protein0.017
PTR2Ptr2p0.016
REE1Ree1p0.016
ICS2Ics2p0.016
YAL064Whypothetical protein0.016
MFA2Mfa2p0.016
YAR066Whypothetical protein0.016
BNA4Bna4p0.016
ATP6Atp6p0.016
COS12Cos12p0.016
NRG2Nrg2p0.016
SUC2Suc2p0.016
CAB2Cab2p0.016
YPR096Chypothetical protein0.016
YBL029Whypothetical protein0.016
LYS20Lys20p0.016
YNR014Whypothetical protein0.016
YDL241Whypothetical protein0.016
YIH1Yih1p0.016
YLR040Chypothetical protein0.016
ANB1Anb1p0.016
WSC4Wsc4p0.015
BIO5Bio5p0.015
SRX1Srx1p0.015
TIR3Tir3p0.015
SCT1Sct1p0.015
RRN5Rrn5p0.015
YOL014Whypothetical protein0.015