The network for 'skeletal system development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

skeletal system development

The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).

NameDescriptionProbabilityFunc Analog Organism
Col1a1collagen, type I, alpha 10.937
Col3a1collagen, type III, alpha 10.683
Col12a1collagen, type XII, alpha 10.682
Egr2early growth response 20.557
Sparcsecreted protein, acidic, cysteine-rich (osteonectin)0.544
Col5a1collagen, type V, alpha 10.460
Hoxb7homeo box B70.434
Ets1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.388
Col5a2collagen, type V, alpha 20.365
DbpD site of albumin promoter (albumin D-box) binding protein0.345
Ptpn14protein tyrosine phosphatase, non-receptor type 140.260
Bmp6bone morphogenetic protein 60.235
Hoxa1homeo box A10.213
Atp1b2ATPase, Na+/K+ transporting, beta 2 polypeptide0.199
Pcolceprocollagen C-endopeptidase enhancer0.196
Lef1lymphoid enhancer binding factor 10.192
Dab2disabled homolog 2 (Drosophila)0.190
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.149
Col9a1collagen, type IX, alpha 10.147
UncxUNC homeobox0.147
Igfbp5insulin-like growth factor binding protein 50.146
Flt1FMS-related tyrosine kinase 10.144
Tgfbr2transforming growth factor, beta receptor II0.140
Ompolfactory marker protein0.139
Sdc3syndecan 30.137
Gpr176G protein-coupled receptor 1760.135
Esr1estrogen receptor 10.124
Sod3superoxide dismutase 3, extracellular0.120
Gria4glutamate receptor, ionotrophic, AMPA 40.119
Col1a2collagen, type I, alpha 20.118
Slc26a1solute carrier family 26 (sulfate transporter), member 10.117
Twist2twist homolog 2 (Drosophila)0.110
Shox2short stature homeobox 20.110
Cpzcarboxypeptidase Z0.108
Gja5gap junction protein, alpha 50.107
Rararetinoic acid receptor, alpha0.106
Plxnd1plexin D10.105
Nfyanuclear transcription factor-Y alpha0.104
Otx1orthodenticle homeobox 10.101
Hoxc4homeo box C40.100
Hoxb8homeo box B80.097
Fgfr2fibroblast growth factor receptor 20.096
Sox17SRY (sex determining region Y)-box 170.092
Scarf2scavenger receptor class F, member 20.088
Sfrp4secreted frizzled-related protein 40.088
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.088
Col8a1collagen, type VIII, alpha 10.086
RhdRh blood group, D antigen0.085
Fat2FAT tumor suppressor homolog 2 (Drosophila)0.085
Pld1phospholipase D10.084
Trpm8transient receptor potential cation channel, subfamily M, member 80.084
Ltbp4latent transforming growth factor beta binding protein 40.083
Aebp1AE binding protein 10.083
Igfbp4insulin-like growth factor binding protein 40.082
Irs1insulin receptor substrate 10.082
Cyp4a3cytochrome P450, family 4, subfamily a, polypeptide 30.081
Neurod2neurogenic differentiation 20.080
Srpxsushi-repeat-containing protein, X-linked0.080
Hapln1hyaluronan and proteoglycan link protein 10.079
Fbn1fibrillin 10.079
Prrx1paired related homeobox 10.078
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.077
Degs2degenerative spermatocyte homolog 2, lipid desaturase (Drosophila)0.077
Pklrpyruvate kinase, liver and RBC0.075
Loxlysyl oxidase0.074
Nppcnatriuretic peptide precursor C0.074
Adarb2adenosine deaminase, RNA-specific, B20.074
Mpzmyelin protein zero0.071
Crygecrystallin, gamma E0.071
Ascl2achaete-scute complex homolog 2 (Drosophila)0.070
Pecam1platelet/endothelial cell adhesion molecule 10.070
Ece1endothelin converting enzyme 10.070
Tnctenascin C0.069
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.069
Prrx2paired related homeobox 20.068
Anxa1annexin A10.068
Capn6calpain 60.067
Zfp469zinc finger protein 4690.066
Gdf11growth differentiation factor 110.061
Anxa2annexin A20.061
Slc6a5solute carrier family 6 (neurotransmitter transporter, glycine), member 50.059
Megf10multiple EGF-like domains 100.059
Lamc1laminin, gamma 10.058
Ng23Ng23 protein0.058
P4hbprolyl 4-hydroxylase, beta polypeptide0.058
Foxd4forkhead box D40.058
Megf6multiple EGF-like-domains 60.057
Cd44Cd44 molecule0.057
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.056
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
sox9aSRY-box containing gene 9a1.000
prdm1aPR domain containing 1a, with ZNF domain0.999
bmp2bbone morphogenetic protein 2b0.999
barx1BarH-like homeobox 10.997
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.996
gli2aGLI-Kruppel family member GLI2a0.996
bmp2abone morphogenetic protein 2a0.996
ptch1patched 10.995
foxi1forkhead box I10.995
sox9bSRY-box containing gene 9b0.992
gata3GATA-binding protein 30.990
jag1bjagged 1b0.987
col1a1acollagen, type I, alpha 1a0.984
tp63tumor protein p630.983
fli1afriend leukemia integration 1a0.981
uxs1UDP-glucuronic acid decarboxylase 10.976
dlx2adistal-less homeobox gene 2a0.973
tbx1T-box 10.971
bmp1abone morphogenetic protein 1a0.971
pitx3paired-like homeodomain transcription factor 30.968
dlx3bdistal-less homeobox gene 3b0.967
fgf3fibroblast growth factor 30.967
hoxc8ahomeo box C8a0.965
hoxa4ahomeo box A4a0.963
atoh1aatonal homolog 1a0.962
crabp2acellular retinoic acid binding protein 2, a0.962
edn1endothelin 10.960
raraaretinoic acid receptor, alpha a0.954
hoxb4ahomeo box B4a0.951
shhasonic hedgehog a0.950
bglapbone gamma-carboxyglutamate (gla) protein0.933
fgf8afibroblast growth factor 8 a0.931
eya1eyes absent homolog 10.931
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.929
disp1dispatched homolog 1 (Drosophila)0.927
notch2notch homolog 20.927
foxa2forkhead box A20.923
dlx5adistal-less homeobox gene 5a0.923
sec24dSEC24 family, member D (S. cerevisiae)0.918
fgf10afibroblast growth factor 10a0.916
prdm16PR domain containing 160.915
col5a2lcollagen, type V, alpha 2-like0.913
pitx2paired-like homeodomain transcription factor 20.909
egr1early growth response 10.902
efnb2aephrin B2a0.885
six4bsine oculis homeobox homolog 4b0.884
hoxb6ahomeo box B6a0.882
tfap2atranscription factor AP-2 alpha0.869
hoxb5bhomeo box B5b0.868
tp53tumor protein p530.868
brpf1bromodomain and PHD finger containing, 10.867
osr1odd-skipped related 1 (Drosophila)0.866
hoxd4ahomeo box D4a0.860
fzd8afrizzled homolog 8a0.860
hhiphedgehog interacting protein0.858
ctgfconnective tissue growth factor0.857
sulf1sulfatase 10.843
hoxa5ahomeo box A5a0.840
gata2aGATA-binding protein 2a0.838
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.838
col5a1procollagen, type V, alpha 10.833
gdf6agrowth differentiation factor 6a0.832
bmp4bone morphogenetic protein 40.831
hoxc4ahomeo box C4a0.820
emx3empty spiracles homeobox 30.811
col2a1acollagen type II, alpha-1a0.811
loxl3blysyl oxidase-like 3b0.810
hoxa3ahomeo box A3a0.797
dlx4bdistal-less homeobox gene 4b0.784
cdx4caudal type homeo box transcription factor 40.782
foxd3forkhead box D30.769
pax2apaired box gene 2a0.766
dmrt2adoublesex and mab-3 related transcription factor 2a0.765
mecomMDS1 and EVI1 complex locus0.764
ltkleukocyte tyrosine kinase0.761
gpr126G protein-coupled receptor 1260.756
wnt11wingless-type MMTV integration site family, member 110.754
snai1asnail homolog 1a (Drosophila)0.749
meis1myeloid ecotropic viral integration 10.743
ndr2nodal-related 20.737
nkx3.2NK3 homeobox 20.737
enpp1ectonucleotide pyrophosphatase/phosphodiesterase 10.731
dlx4adistal-less homeobox gene 4a0.720
tbx18T-box 180.720
runx2brunt-related transcription factor 2b0.719
hoxb2ahomeo box B2a0.713
chpfchondroitin polymerizing factor0.712
hoxb3ahomeo box B3a0.702
ihhaIndian hedgehog homolog a0.696
pcsk5bproprotein convertase subtilisin/kexin type 5b0.693
furinafurin (paired basic amino acid cleaving enzyme) a0.692
fam20bfamily with sequence similarity 20, member B (H. sapiens)0.691
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
FGFR2fibroblast growth factor receptor 21.000
SMAD3SMAD family member 30.998
TP53tumor protein p530.998
COL1A1collagen, type I, alpha 10.994
CTGFconnective tissue growth factor0.990
RUNX1runt-related transcription factor 10.988
SMAD7SMAD family member 70.982
LOXlysyl oxidase0.954
MMP14matrix metallopeptidase 14 (membrane-inserted)0.944
FBN1fibrillin 10.943
HOXB5homeobox B50.930
BMP2bone morphogenetic protein 20.930
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.920
MYOD1myogenic differentiation 10.915
HSPG2heparan sulfate proteoglycan 20.910
NCOR2nuclear receptor corepressor 20.905
COL3A1collagen, type III, alpha 10.902
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.883
EP300E1A binding protein p3000.883
HOXD9homeobox D90.876
ATN1atrophin 10.876
FN1fibronectin 10.871
SMAD4SMAD family member 40.867
DDR2discoidin domain receptor tyrosine kinase 20.855
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.841
TAL1T-cell acute lymphocytic leukemia 10.836
COL2A1collagen, type II, alpha 10.835
PDX1pancreatic and duodenal homeobox 10.832
TGFB1transforming growth factor, beta 10.772
PBX1pre-B-cell leukemia homeobox 10.758
TRIP6thyroid hormone receptor interactor 60.752
HOXC8homeobox C80.749
BMP4bone morphogenetic protein 40.739
SHC1SHC (Src homology 2 domain containing) transforming protein 10.721
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.711
NOTCH3notch 30.710
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.709
ESR1estrogen receptor 10.704
PAX3paired box 30.702
MEIS1Meis homeobox 10.697
HOXA10homeobox A100.695
LTBP2latent transforming growth factor beta binding protein 20.690
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.686
NOTCH1notch 10.681
POSTNperiostin, osteoblast specific factor0.677
MEOX2mesenchyme homeobox 20.667
COL5A2collagen, type V, alpha 20.667
RUNX1T1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.662
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.661
EGFRepidermal growth factor receptor0.659
FSTL1follistatin-like 10.658
MSX1msh homeobox 10.644
HOXA11homeobox A110.639
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.634
PPARAperoxisome proliferator-activated receptor alpha0.630
FGF1fibroblast growth factor 1 (acidic)0.612
MAPK1mitogen-activated protein kinase 10.599
GH1growth hormone 10.594
INHBAinhibin, beta A0.591
ADAM15ADAM metallopeptidase domain 150.588
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.586
POU3F2POU class 3 homeobox 20.584
COL6A1collagen, type VI, alpha 10.583
TNCtenascin C0.582
HMGA2high mobility group AT-hook 20.575
IGFBP5insulin-like growth factor binding protein 50.571
FGF3fibroblast growth factor 30.568
HOXB6homeobox B60.565
SULF1sulfatase 10.551
LBX1ladybird homeobox 10.550
WNT1wingless-type MMTV integration site family, member 10.549
MAGOHmago-nashi homolog, proliferation-associated (Drosophila)0.544
CEBPBCCAAT/enhancer binding protein (C/EBP), beta0.541
HOXC6homeobox C60.536
WNT2wingless-type MMTV integration site family member 20.532
EGR1early growth response 10.514
SMAD6SMAD family member 60.508
CACNA1Acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.507
LAMB1laminin, beta 10.503
HOXC11homeobox C110.503
COL1A2collagen, type I, alpha 20.498
THBS1thrombospondin 10.492
MRC2mannose receptor, C type 20.488
COL4A1collagen, type IV, alpha 10.485
ACVR1activin A receptor, type I0.481
HOXA4homeobox A40.472
RING1ring finger protein 10.471
FBLN1fibulin 10.468
TBX5T-box 50.452
HOXB9homeobox B90.450
PRRX2paired related homeobox 20.446
FBLN2fibulin 20.444
FGF18fibroblast growth factor 180.442
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.441
SOX1SRY (sex determining region Y)-box 10.441
NR4A1nuclear receptor subfamily 4, group A, member 10.438
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Gli3GLI-Kruppel family member GLI31.000
Fgfr2fibroblast growth factor receptor 21.000
Shhsonic hedgehog1.000
Dlx5distal-less homeobox 51.000
Prrx1paired related homeobox 11.000
Gli2GLI-Kruppel family member GLI21.000
Fgfr3fibroblast growth factor receptor 31.000
Fgfr1fibroblast growth factor receptor 11.000
Ctnnb1catenin (cadherin associated protein), beta 11.000
Pax3paired box gene 31.000
Hand1heart and neural crest derivatives expressed transcript 11.000
Bmp4bone morphogenetic protein 41.000
Mmp14matrix metallopeptidase 14 (membrane-inserted)1.000
Foxc1forkhead box C10.999
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.999
Trp53transformation related protein 530.999
Bmp7bone morphogenetic protein 70.999
Tcfap2atranscription factor AP-2, alpha0.999
Rargretinoic acid receptor, gamma0.999
Pitx2paired-like homeodomain transcription factor 20.999
Pbx1pre B-cell leukemia transcription factor 10.999
Eya1eyes absent 1 homolog (Drosophila)0.999
Pax9paired box gene 90.999
Pax2paired box gene 20.999
Otx2orthodenticle homolog 2 (Drosophila)0.999
Vegfavascular endothelial growth factor A0.999
Prrx2paired related homeobox 20.999
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.999
Sox9SRY-box containing gene 90.999
Hand2heart and neural crest derivatives expressed transcript 20.999
Msx1homeobox, msh-like 10.998
Twist2twist homolog 2 (Drosophila)0.998
Hoxa1homeobox A10.998
Fgf8fibroblast growth factor 80.998
Meox2mesenchyme homeobox 20.998
Ptenphosphatase and tensin homolog0.998
Hoxd11homeobox D110.998
Tgfb2transforming growth factor, beta 20.997
Fgf10fibroblast growth factor 100.997
Tbx1T-box 10.996
Col2a1collagen, type II, alpha 10.996
Col1a1collagen, type I, alpha 10.996
Foxc2forkhead box C20.996
Hoxa10homeobox A100.995
Smosmoothened homolog (Drosophila)0.995
Alx4aristaless-like homeobox 40.995
Zeb1zinc finger E-box binding homeobox 10.994
Lmx1aLIM homeobox transcription factor 1 alpha0.993
Runx2runt related transcription factor 20.993
Psen1presenilin 10.992
Tgfbr2transforming growth factor, beta receptor II0.992
Hoxa13homeobox A130.991
Gscgoosecoid homeobox0.990
Wnt3awingless-related MMTV integration site 3A0.989
Fbn1fibrillin 10.989
Hoxd13homeobox D130.988
Ascl1achaete-scute complex homolog 1 (Drosophila)0.985
Pitx1paired-like homeodomain transcription factor 10.984
Twist1twist homolog 1 (Drosophila)0.983
Vangl2vang-like 2 (van gogh, Drosophila)0.981
Pkd1polycystic kidney disease 1 homolog0.981
Alx3aristaless-like homeobox 30.980
Rarbretinoic acid receptor, beta0.979
Gas1growth arrest specific 10.979
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.978
Hoxa11homeobox A110.977
Msx2homeobox, msh-like 20.975
Hoxa2homeobox A20.975
Pthlhparathyroid hormone-like peptide0.975
Rspo2R-spondin 2 homolog (Xenopus laevis)0.974
Wnt5awingless-related MMTV integration site 5A0.970
AxlAXL receptor tyrosine kinase0.969
Gbx2gastrulation brain homeobox 20.969
Col6a2collagen, type VI, alpha 20.968
Zic3zinc finger protein of the cerebellum 30.966
Rnf2ring finger protein 20.962
Pax1paired box gene 10.961
Col11a1collagen, type XI, alpha 10.961
Pcsk5proprotein convertase subtilisin/kexin type 50.960
Tbx3T-box 30.957
Sox2SRY-box containing gene 20.957
Sfrp2secreted frizzled-related protein 20.956
Tbx15T-box 150.954
Ptch1patched homolog 10.953
Wt1Wilms tumor 1 homolog0.951
Hoxb3homeobox B30.949
Cdkn2acyclin-dependent kinase inhibitor 2A0.949
Thbs1thrombospondin 10.948
Pou3f3POU domain, class 3, transcription factor 30.947
Neurog3neurogenin 30.946
Tcf21transcription factor 210.942
Npr3natriuretic peptide receptor 30.941
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.939
Ror2receptor tyrosine kinase-like orphan receptor 20.939
Alx1ALX homeobox 10.939
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.938
Pax6paired box gene 60.938
Mmp2matrix metallopeptidase 20.933
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism