The network for 'progesterone metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

progesterone metabolic process

The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants.

NameDescriptionProbabilityFunc Analog Organism
Nr5a2nuclear receptor subfamily 5, group A, member 20.361
Sult1b1sulfotransferase family, cytosolic, 1B, member 10.255
Cyp4a10cytochrome P450, family 4, subfamily a, polypeptide 100.193
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.136
Clca4chloride channel accessory 40.090
Lhcgrluteinizing hormone/choriogonadotropin receptor0.085
LOC293989cytochrome P450-like0.085
Ugt2bUDP glycosyltransferase 2 family, polypeptide B0.078
Sult1c3sulfotransferase family, cytosolic, 1C, member 30.076
Dnase1l3deoxyribonuclease 1-like 30.057
Ptger3prostaglandin E receptor 3 (subtype EP3)0.046
LOC494499LOC494499 protein0.044
Akp3alkaline phosphatase 3, intestine, not Mn requiring0.043
Cyp2c22cytochrome P450, family 2, subfamily c, polypeptide 220.033
A1i3alpha-1-inhibitor III0.033
Sisucrase-isomaltase (alpha-glucosidase)0.033
Nr0b2nuclear receptor subfamily 0, group B, member 20.033
Kcnj15potassium inwardly-rectifying channel, subfamily J, member 150.032
Tacr2tachykinin receptor 20.030
Pank2pantothenate kinase 2 (Hallervorden-Spatz syndrome)0.029
Cyp3a23/3a1cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 10.027
Cyp4f1cytochrome P450, family 4, subfamily f, polypeptide 10.027
Sult2a1sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 10.026
Phexphosphate regulating endopeptidase homolog, X-linked0.025
Cyp2c12cytochrome P450, family 2, subfamily c, polypeptide 120.024
Hsd17b2hydroxysteroid (17-beta) dehydrogenase 20.024
Starsteroidogenic acute regulatory protein0.022
Spink1serine peptidase inhibitor, Kazal type 10.022
Prlrprolactin receptor0.022
LOC100361547Cytochrome P450, family 2, subfamily c, polypeptide 7-like0.021
Hrh2histamine receptor H 20.021
Cyp2b1cytochrome P450, family 2, subfamily b, polypeptide 10.021
Idh1isocitrate dehydrogenase 1 (NADP+), soluble0.020
Cyp2d2cytochrome P450, family 2, subfamily d, polypeptide 20.020
Cdcp1CUB domain containing protein 10.018
Cyp2a1cytochrome P450, family 2, subfamily a, polypeptide 10.018
Ces2ccarboxylesterase 2C0.018
Cuzd1CUB and zona pellucida-like domains 10.018
Asgr2asialoglycoprotein receptor 20.018
Cyp2d4cytochrome P450, family 2, subfamily d, polypeptide 40.017
Hsd17b4hydroxysteroid (17-beta) dehydrogenase 40.017
As3mtarsenic (+3 oxidation state) methyltransferase0.016
Phyhphytanoyl-CoA 2-hydroxylase0.016
Adh1alcohol dehydrogenase 1 (class I)0.016
Akr1c18aldo-keto reductase family 1, member C180.016
Akr1c14aldo-keto reductase family 1, member C140.015
Acadmacyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain0.015
Clec2dC-type lectin domain family 2, member d0.015
Prss3protease, serine, 30.015
Aqp9aquaporin 90.015
Apohapolipoprotein H (beta-2-glycoprotein I)0.015
Cyp3a2cytochrome P450, family 3, subfamily a, polypeptide 20.015
Cyb5acytochrome b5 type A (microsomal)0.014
Dnase1deoxyribonuclease I0.014
Kcnh4potassium voltage-gated channel, subfamily H (eag-related), member 40.014
Pxmp2peroxisomal membrane protein 20.013
Olr1701olfactory receptor 17010.013
Agxtalanine-glyoxylate aminotransferase0.013
Ugt2b5UDP glucuronosyltransferase 2 family, polypeptide B50.013
Sult1e1sulfotransferase family 1E, estrogen-preferring, member 10.013
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.013
Rxrgretinoid X receptor gamma0.013
Ucp1uncoupling protein 1 (mitochondrial, proton carrier)0.013
Cyp1a2cytochrome P450, family 1, subfamily a, polypeptide 20.013
Sv2csynaptic vesicle glycoprotein 2c0.013
Gjb3gap junction protein, beta 30.012
Mettl7bmethyltransferase like 7B0.012
Fam108b1family with sequence similarity 108, member B10.012
Ehhadhenoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase0.012
Gsta4glutathione S-transferase alpha 40.012
Fabp1fatty acid binding protein 1, liver0.011
Dpp4dipeptidylpeptidase 40.011
Vtcn1V-set domain containing T cell activation inhibitor 10.011
Rln1relaxin 10.011
Ppp3r2protein phosphatase 3, regulatory subunit B, beta isoform0.011
Cyp4b1cytochrome P450, family 4, subfamily b, polypeptide 10.010
Etfdhelectron-transferring-flavoprotein dehydrogenase0.010
Cgm4carcinoembryonic antigen gene family 40.010
Ces1fcarboxylesterase 1F0.010
Hsd3b1hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 10.010
Cyp2j4cytochrome P450, family 2, subfamily j, polypeptide 40.010
Eci2enoyl-Coenzyme A delta isomerase 20.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
AKR1C3aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)0.991
AKR1C2aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)0.651
AKR1C1aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)0.460
INSRinsulin receptor0.078
PRMT2protein arginine methyltransferase 20.029
PTPN1protein tyrosine phosphatase, non-receptor type 10.027
ZHX1zinc fingers and homeoboxes 10.025
EID1EP300 interacting inhibitor of differentiation 10.020
DECR12,4-dienoyl CoA reductase 1, mitochondrial0.018
SEP1515 kDa selenoprotein0.011
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Stat5bsignal transducer and activator of transcription 5B0.999
Leprleptin receptor0.993
Stat5asignal transducer and activator of transcription 5A0.989
Foxp3forkhead box P30.945
Slc12a1solute carrier family 12, member 10.923
Irf9interferon regulatory factor 90.896
Arandrogen receptor0.857
Prlrprolactin receptor0.841
Il10interleukin 100.833
Esr1estrogen receptor 1 (alpha)0.822
Ghrgrowth hormone receptor0.816
Stat3signal transducer and activator of transcription 30.765
Il4rainterleukin 4 receptor, alpha0.741
Akr1c21aldo-keto reductase family 1, member C210.568
Il6stinterleukin 6 signal transducer0.540
Myd88myeloid differentiation primary response gene 880.526
Mep1ameprin 1 alpha0.516
Smad3MAD homolog 3 (Drosophila)0.486
Hao2hydroxyacid oxidase 20.420
Mc2rmelanocortin 2 receptor0.410
Aadacarylacetamide deacetylase (esterase)0.403
Hsd3b2hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 20.388
Esr2estrogen receptor 2 (beta)0.386
Umoduromodulin0.373
Otcornithine transcarbamylase0.358
Hgdhomogentisate 1, 2-dioxygenase0.358
Afmafamin0.313
Il1r1interleukin 1 receptor, type I0.303
Fbp1fructose bisphosphatase 10.293
Keg1kidney expressed gene 10.289
Hsd3b5hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 50.279
Lhcgrluteinizing hormone/choriogonadotropin receptor0.272
Nckap1lNCK associated protein 1 like0.265
Akr1c6aldo-keto reductase family 1, member C60.260
Cyp2c50cytochrome P450, family 2, subfamily c, polypeptide 500.255
Slc2a2solute carrier family 2 (facilitated glucose transporter), member 20.253
Ppargperoxisome proliferator activated receptor gamma0.250
Coro1bcoronin, actin binding protein 1B0.217
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.216
Kitkit oncogene0.214
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.214
Cyp2j5cytochrome P450, family 2, subfamily j, polypeptide 50.212
Tgfb1transforming growth factor, beta 10.207
Nr3c1nuclear receptor subfamily 3, group C, member 10.197
Hsd3b6hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 60.186
Lepleptin0.169
Ncoa3nuclear receptor coactivator 30.161
Hsd3b3hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 30.161
Serpina6serine (or cysteine) peptidase inhibitor, clade A, member 60.159
Timd2T-cell immunoglobulin and mucin domain containing 20.159
Ttrtransthyretin0.158
Slc2a9solute carrier family 2 (facilitated glucose transporter), member 90.156
Nfil3nuclear factor, interleukin 3, regulated0.152
Lyz2lysozyme 20.151
Cyp2a12cytochrome P450, family 2, subfamily a, polypeptide 120.151
Serpina1aserine (or cysteine) peptidase inhibitor, clade A, member 1A0.149
Trim21tripartite motif-containing 210.147
Mbl2mannose-binding lectin (protein C) 20.143
Cyp2c29cytochrome P450, family 2, subfamily c, polypeptide 290.140
C9complement component 90.135
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.132
Pomcpro-opiomelanocortin-alpha0.124
Abcc2ATP-binding cassette, sub-family C (CFTR/MRP), member 20.124
Cps1carbamoyl-phosphate synthetase 10.119
Prf1perforin 1 (pore forming protein)0.117
Uoxurate oxidase0.113
Krt20keratin 200.111
Aldobaldolase B, fructose-bisphosphate0.107
Agtr1aangiotensin II receptor, type 1a0.106
Adh4alcohol dehydrogenase 4 (class II), pi polypeptide0.106
Hsd3b1hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 10.105
Upp2uridine phosphorylase 20.105
F13bcoagulation factor XIII, beta subunit0.105
Albalbumin0.104
Vdrvitamin D receptor0.103
Cyp4a14cytochrome P450, family 4, subfamily a, polypeptide 140.096
Cyp2c38cytochrome P450, family 2, subfamily c, polypeptide 380.093
Ugt3a2UDP glycosyltransferases 3 family, polypeptide A20.089
Acsm2acyl-CoA synthetase medium-chain family member 20.089
Cyp7a1cytochrome P450, family 7, subfamily a, polypeptide 10.089
Lgals9lectin, galactose binding, soluble 90.088
Spna1spectrin alpha 10.088
Ifnar2interferon (alpha and beta) receptor 20.087
Trap1atumor rejection antigen P1A0.082
H2-K1histocompatibility 2, K1, K region0.082
Cyp2d26cytochrome P450, family 2, subfamily d, polypeptide 260.078
Nphp1nephronophthisis 1 (juvenile) homolog (human)0.077
Mug2murinoglobulin 20.076
Cyp2c68cytochrome P450, family 2, subfamily c, polypeptide 680.076
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.074
Aqp8aquaporin 80.074
Cyp3a11cytochrome P450, family 3, subfamily a, polypeptide 110.072
Serpinc1serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 10.072
Ptpn11protein tyrosine phosphatase, non-receptor type 110.072
Gcgroup specific component0.072
Ugt2b1UDP glucuronosyltransferase 2 family, polypeptide B10.071
Slc17a1solute carrier family 17 (sodium phosphate), member 10.070
CrpC-reactive protein, pentraxin-related0.070
Il2interleukin 20.069
Klrc1killer cell lectin-like receptor subfamily C, member 10.069
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism