The network for 'negative regulation of collagen biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of collagen biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.

NameDescriptionProbabilityFunc Analog Organism
Mef2dmyocyte enhancer factor 2D0.213
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.109
G6pcglucose-6-phosphatase, catalytic subunit0.101
Cyp4b1cytochrome P450, family 4, subfamily b, polypeptide 10.089
Pla2g2cphospholipase A2, group IIC0.088
Crybb1crystallin, beta B10.088
Pou3f2POU class 3 homeobox 20.077
Hrhairless0.070
Acot12acyl-CoA thioesterase 120.062
Gna11guanine nucleotide binding protein, alpha 110.060
Prdm2PR domain containing 2, with ZNF domain0.059
Foxe1forkhead box E1 (thyroid transcription factor 2)0.057
Fgf1fibroblast growth factor 10.054
Gzmbgranzyme B0.053
DaoD-amino-acid oxidase0.048
LOC293989cytochrome P450-like0.046
Slc18a3solute carrier family 18 (vesicular acetylcholine), member 30.046
Ptger2prostaglandin E receptor 2 (subtype EP2)0.043
Pklrpyruvate kinase, liver and RBC0.042
Il1r2interleukin 1 receptor, type II0.040
Cyp4f1cytochrome P450, family 4, subfamily f, polypeptide 10.040
Pparaperoxisome proliferator activated receptor alpha0.040
Defb1defensin beta 10.038
Ptprhprotein tyrosine phosphatase, receptor type, H0.037
Nr1i3nuclear receptor subfamily 1, group I, member 30.037
Accn2amiloride-sensitive cation channel 2, neuronal0.037
P2ry4pyrimidinergic receptor P2Y, G-protein coupled, 40.035
Aldobaldolase B, fructose-bisphosphate0.034
Dnase1deoxyribonuclease I0.033
Ptafrplatelet-activating factor receptor0.033
Hnf4ahepatocyte nuclear factor 4, alpha0.033
Hand1heart and neural crest derivatives expressed 10.032
Cyp2b1cytochrome P450, family 2, subfamily b, polypeptide 10.030
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.030
Cyp2d4cytochrome P450, family 2, subfamily d, polypeptide 40.028
Hipk3homeodomain interacting protein kinase 30.028
Uoxurate oxidase0.027
Ly6g6elymphocyte antigen 6 complex, locus G6E0.026
Il1ainterleukin 1 alpha0.026
Cyp1a1cytochrome P450, family 1, subfamily a, polypeptide 10.025
Tnftumor necrosis factor (TNF superfamily, member 2)0.025
Acox3acyl-Coenzyme A oxidase 3, pristanoyl0.025
Lrrc10leucine-rich repeat-containing 100.024
Sh2b3SH2B adaptor protein 30.024
Ugt2a1UDP glucuronosyltransferase 2 family, polypeptide A10.024
Trib1tribbles homolog 1 (Drosophila)0.024
Kcna5potassium voltage-gated channel, shaker-related subfamily, member 50.023
Il1r1interleukin 1 receptor, type I0.023
Serpina3mserine (or cysteine) proteinase inhibitor, clade A, member 3M0.023
MlxiplMLX interacting protein-like0.023
Pfkfb26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 20.022
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.022
Slco2a1solute carrier organic anion transporter family, member 2a10.022
Dckdeoxycytidine kinase0.022
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.021
Slc5a1solute carrier family 5 (sodium/glucose cotransporter), member 10.021
Cps1carbamoyl-phosphate synthetase 10.021
Pfkfb46-phosphofructo-2-kinase/fructose-2,6-biphosphatase 40.021
Gsk3aglycogen synthase kinase 3 alpha0.021
Cyp3a9cytochrome P450, family 3, subfamily a, polypeptide 90.021
Pcsk4proprotein convertase subtilisin/kexin type 40.020
Galr3galanin receptor 30.020
Fcer2Fc fragment of IgE, low affinity II, receptor for (CD23)0.020
RGD1564163similar to RIKEN cDNA 1700025K230.020
Oas1b2-5 oligoadenylate synthetase 1B0.020
LOC363331similar to plasma membrane associated protein, S3-120.020
Ros1c-ros oncogene 1 , receptor tyrosine kinase0.019
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.019
Dhdpsldihydrodipicolinate synthase-like, mitochondrial0.019
Kcnab2potassium voltage-gated channel, shaker-related subfamily, beta member 20.019
Pdp2pyruvate dehyrogenase phosphatase catalytic subunit 20.019
Ralgdsral guanine nucleotide dissociation stimulator0.018
Endogendonuclease G0.018
Adora2aadenosine A2a receptor0.018
Slc26a1solute carrier family 26 (sulfate transporter), member 10.018
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.018
Ceacam10carcinoembryonic antigen-related cell adhesion molecule 100.018
Mapk8ip2mitogen-activated protein kinase 8 interacting protein 20.018
P2ry1purinergic receptor P2Y, G-protein coupled, 10.018
Adra2badrenergic, alpha-2B-, receptor0.018
Slc22a6solute carrier family 22 (organic anion transporter), member 60.018
Dlgap2discs, large (Drosophila) homolog-associated protein 20.018
LOC680711hypothetical protein LOC6807110.018
siat7Dalpha-2,6-sialyltransferase ST6GalNAc IV0.018
Zfp36zinc finger protein 360.018
Ifrd1interferon-related developmental regulator 10.018
Lect1leukocyte cell derived chemotaxin 10.018
Xpnpep2X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound0.018
Olr837olfactory receptor 8370.018
Ddr1discoidin domain receptor tyrosine kinase 10.017
Slc22a3solute carrier family 22 (extraneuronal monoamine transporter), member 30.017
Slc2a2solute carrier family 2 (facilitated glucose transporter), member 20.017
Gcgrglucagon receptor0.017
Tfebtranscription factor EB0.017
Kif12kinesin family member 120.017
Kcnj8potassium inwardly-rectifying channel, subfamily J, member 80.017
Olr59olfactory receptor 590.017
Mthfrmethylenetetrahydrofolate reductase (NAD(P)H)0.017
Fgfr4fibroblast growth factor receptor 40.017
Acsm2acyl-CoA synthetase medium-chain family member 20.016
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.857
IL8interleukin 80.660
IL6Rinterleukin 6 receptor0.476
S100BS100 calcium binding protein B0.341
IL6interleukin 6 (interferon, beta 2)0.319
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.166
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.115
CXCL2chemokine (C-X-C motif) ligand 20.113
CXCL3chemokine (C-X-C motif) ligand 30.094
ESRRGestrogen-related receptor gamma0.048
ICAM1intercellular adhesion molecule 10.047
IL1Binterleukin 1, beta0.031
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.025
JAK1Janus kinase 10.019
TNFAIP6tumor necrosis factor, alpha-induced protein 60.019
CCL2chemokine (C-C motif) ligand 20.017
TTRtransthyretin0.015
CCL20chemokine (C-C motif) ligand 200.014
S100A1S100 calcium binding protein A10.013
IER3immediate early response 30.012
SMAD9SMAD family member 90.011
ZC3H12Azinc finger CCCH-type containing 12A0.010
TNFAIP3tumor necrosis factor, alpha-induced protein 30.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism