The network for 'regulation of cardiac muscle tissue development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of cardiac muscle tissue development

Any process that modulates the frequency, rate or extent of cardiac muscle tissue development.

NameDescriptionProbabilityFunc Analog Organism
LOC100362824caveolin 2-like0.467
Cav1caveolin 1, caveolae protein0.400
Cdkn3cyclin-dependent kinase inhibitor 30.292
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.236
Cav2caveolin 20.172
Top2atopoisomerase (DNA) II alpha0.163
Ube2cubiquitin-conjugating enzyme E2C0.163
Phkg1phosphorylase kinase, gamma 10.121
Traf4af1TRAF4 associated factor 10.106
Syt8synaptotagmin VIII0.105
Strnstriatin, calmodulin binding protein0.096
Fdft1farnesyl diphosphate farnesyl transferase 10.096
Nos3nitric oxide synthase 3, endothelial cell0.094
Ccnb2cyclin B20.079
Gja3gap junction protein, alpha 30.078
Prrx1paired related homeobox 10.063
Sqlesqualene epoxidase0.060
Fgf16fibroblast growth factor 160.056
Pttg1pituitary tumor-transforming 10.053
KitlgKIT ligand0.053
Akt2v-akt murine thymoma viral oncogene homolog 20.052
Fgfr2fibroblast growth factor receptor 20.052
Prp15proline-rich protein 150.050
Cdk1cyclin-dependent kinase 10.050
Prl8a2prolactin family 8, subfamily a, member 20.047
Ccnb1cyclin B10.046
Ppypancreatic polypeptide0.043
Timp3TIMP metallopeptidase inhibitor 30.040
Tacr2tachykinin receptor 20.039
Fgf14fibroblast growth factor 140.039
Tnni1troponin I type 1 (skeletal, slow)0.038
Rrm2ribonucleotide reductase M20.037
Racgap1Rac GTPase-activating protein 10.036
Mpp2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)0.036
Oprd1opioid receptor, delta 10.036
Prkcaprotein kinase C, alpha0.036
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.035
Adarb2adenosine deaminase, RNA-specific, B20.035
Slc10a2solute carrier family 10 (sodium/bile acid cotransporter family), member 20.032
Muskmuscle, skeletal, receptor tyrosine kinase0.030
Smad7SMAD family member 70.030
Syngap1synaptic Ras GTPase activating protein 1 homolog (rat)0.030
Nek9NIMA (never in mitosis gene a)- related kinase 90.029
Pcdhgc3protocadherin gamma subfamily C, 30.029
Hpcal4hippocalcin-like 40.029
Svs1seminal vesicle secretory protein 10.029
Gfi1growth factor independent 1 transcription repressor0.029
Ehd2EH-domain containing 20.028
Svs4seminal vesicle secretory protein 40.027
Cks2CDC28 protein kinase regulatory subunit 20.027
Npr3natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)0.027
Metmet proto-oncogene0.026
Smad3SMAD family member 30.026
Crybb2crystallin, beta B20.025
Htr65-hydroxytryptamine (serotonin) receptor 60.025
Mcammelanoma cell adhesion molecule0.024
Serpine2serine (or cysteine) peptidase inhibitor, clade E, member 20.024
Akp3alkaline phosphatase 3, intestine, not Mn requiring0.024
Kcnj10potassium inwardly-rectifying channel, subfamily J, member 100.024
Enpp6ectonucleotide pyrophosphatase/phosphodiesterase 60.024
Ldhclactate dehydrogenase C0.023
Lamc1laminin, gamma 10.023
Foxi2forkhead box I20.023
Chrm1cholinergic receptor, muscarinic 10.023
Tpc1808tropic 18080.022
Kifc1kinesin family member C10.022
Vdrvitamin D (1,25- dihydroxyvitamin D3) receptor0.022
Ednraendothelin receptor type A0.022
Cdkn2bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.021
Gabrg3gamma-aminobutyric acid (GABA) A receptor, gamma 30.021
Ngfnerve growth factor (beta polypeptide)0.021
Fam70bfamily with sequence similarity 70, member B0.021
Notch2Notch homolog 2 (Drosophila)0.021
Galr2galanin receptor 20.021
Dusp4dual specificity phosphatase 40.020
Creb1cAMP responsive element binding protein 10.020
Adamts13ADAM metallopeptidase with thrombospondin type 1 motif, 130.020
Olr837olfactory receptor 8370.020
Cdca3cell division cycle associated 30.020
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.019
Igfbp5insulin-like growth factor binding protein 50.019
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.019
Camkk2calcium/calmodulin-dependent protein kinase kinase 2, beta0.019
Olfml2bolfactomedin-like 2B0.018
Pnliprp1pancreatic lipase-related protein 10.018
Kcnh7potassium voltage-gated channel, subfamily H (eag-related), member 70.018
LOC689399hypothetical protein LOC6893990.018
Stx2syntaxin 20.018
Stmn1stathmin 10.017
Hspb2heat shock protein beta 20.017
Cpxm2carboxypeptidase X (M14 family), member 20.017
Dnah2dynein, axonemal, heavy chain 20.017
Ghrgrowth hormone receptor0.017
Il11interleukin 110.017
Nrg1neuregulin 10.016
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tbx1T-box 10.941
kdrlkinase insert domain receptor like0.882
mef2cbmyocyte enhancer factor 2cb0.801
fgf8afibroblast growth factor 8 a0.799
bmp4bone morphogenetic protein 40.754
has2hyaluronan synthase 20.691
gli1GLI-Kruppel family member 10.620
hey2hairy/enhancer-of-split related with YRPW motif 20.530
tbx5aT-box 5a0.515
nkx2.5NK2 transcription factor related 50.501
meis2.2myeloid ecotropic viral integration site 2.20.416
spry4sprouty (Drosophila) homolog 40.403
rbfox1lRNA binding protein, fox-1 homolog (C. elegans) 1-like0.370
wnt1wingless-type MMTV integration site family, member 10.341
wlswntless homolog (Drosophila)0.332
pcdh8protocadherin 80.322
hspb1heat shock protein, alpha-crystallin-related, 10.321
wnt4awingless-type MMTV integration site family, member 4a0.317
wnt5bwingless-type MMTV integration site family, member 5b0.299
fli1afriend leukemia integration 1a0.279
fgfr1afibroblast growth factor receptor 1a0.268
gata5GATA-binding protein 50.264
tbx2bT-box 2b0.261
gata6GATA-binding protein 60.259
fgf3fibroblast growth factor 30.248
metmet proto-oncogene (hepatocyte growth factor receptor)0.247
fn1fibronectin 10.241
gro1groucho 10.238
mtpmicrosomal triglyceride transfer protein0.235
aldh1a2aldehyde dehydrogenase 1 family, member A20.230
tbx20T-box 200.229
gpiaglucose phosphate isomerase a0.220
klf4Kruppel-like factor 40.210
alcambactivated leukocyte cell adhesion molecule b0.202
wnt2bbwingless-type MMTV integration site family, member 2Bb0.201
wnt11rwingless-type MMTV integration site family, member 11, related0.199
klf4aKruppel-like transcription factor 4a0.191
bocbrother of CDO0.183
esr2aestrogen receptor 2a0.178
etv2ets variant gene 20.178
gro2groucho 20.171
vasavasa homolog0.171
vcanaversican a0.160
hand2heart and neural crest derivatives expressed transcript 20.158
crip2cysteine-rich protein 20.157
oepone-eyed pinhead0.153
tbx2aT-box gene 2a0.153
wnt8awingless-type MMTV integration site family, member 8a0.152
pdlim7PDZ and LIM domain 70.150
sema3aasemaphorin 3aa0.142
smad9MAD homolog 9 (Drosophila)0.138
rasgef1baRasGEF domain family, member 1Ba0.135
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.131
myf5myogenic factor 50.129
gbx2gastrulation brain homeo box 20.129
fzd7bfrizzled homolog 7b0.125
igf1rbinsulin-like growth factor 1b receptor0.125
myl7myosin, light polypeptide 7, regulatory0.119
mef2camyocyte enhancer factor 2ca0.119
wnt3wingless-type MMTV integration site family, member 30.116
LOC100000687signal peptide, CUB and EGF-like domain-containing protein 3-like0.114
pld1aphospholipase D1a0.111
trpv4transient receptor potential cation channel, subfamily V, member 40.109
scube2signal peptide, CUB domain, EGF-like 20.109
pax2apaired box gene 2a0.105
rbpms2RNA binding protein with multiple splicing 20.101
dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.099
esrraestrogen-related receptor alpha0.097
sox21aSRY-box containing gene 21a0.097
aplnrbapelin receptor b0.097
wnt8bwingless-type MMTV integration site family, member 8b0.097
sfrp1asecreted frizzled-related protein 1a0.096
efnb3bephrin B3b0.095
fynaFYN oncogene related to SRC, FGR, YES a0.094
fgf17fibroblast growth factor 170.094
tbx18T-box 180.092
foxj1aforkhead box J1a0.092
ttnatitin a0.092
kif23kinesin family member 230.088
hspb12heat shock protein, alpha-crystallin-related, b120.087
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.086
her7hairy and enhancer of split related-70.084
lats1LATS, large tumor suppressor, homolog 1 (Drosophila)0.084
hnf1baHNF1 homeobox Ba0.084
zbtb4zinc finger and BTB domain containing 40.083
prickle1aprickle-like 1 (Drosophila) a0.083
ptenbphosphatase and tensin homolog B (mutated in multiple advanced cancers 1)0.083
smyd1bSET and MYND domain containing 1b0.083
sulf1sulfatase 10.082
fstl1bfollistatin-like 1b0.081
rxrabretinoid x receptor, alpha b0.081
tead3aTEA domain family member 3 a0.081
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
FGFR2fibroblast growth factor receptor 21.000
SRFserum response factor (c-fos serum response element-binding transcription factor)1.000
FGF1fibroblast growth factor 1 (acidic)1.000
TBX5T-box 50.999
FGF10fibroblast growth factor 100.991
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.991
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.988
FGFR1fibroblast growth factor receptor 10.937
JAG1jagged 10.895
UCHL1ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)0.888
BMPR1Abone morphogenetic protein receptor, type IA0.864
LRP6low density lipoprotein receptor-related protein 60.839
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.797
FGF2fibroblast growth factor 2 (basic)0.741
EP300E1A binding protein p3000.709
NOTCH1notch 10.553
HDAC4histone deacetylase 40.416
FSTL1follistatin-like 10.402
MAML1mastermind-like 1 (Drosophila)0.301
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.266
TGFB1transforming growth factor, beta 10.250
FGF7fibroblast growth factor 70.242
FZD1frizzled homolog 1 (Drosophila)0.235
MEF2Amyocyte enhancer factor 2A0.221
KAT2BK(lysine) acetyltransferase 2B0.215
BMP2bone morphogenetic protein 20.197
HDAC1histone deacetylase 10.176
GATA4GATA binding protein 40.169
FRS2fibroblast growth factor receptor substrate 20.161
WWOXWW domain containing oxidoreductase0.152
NCK2NCK adaptor protein 20.141
DKK1dickkopf homolog 1 (Xenopus laevis)0.140
LRRK2leucine-rich repeat kinase 20.133
PLCG1phospholipase C, gamma 10.128
RUNX1runt-related transcription factor 10.124
TGFB3transforming growth factor, beta 30.120
KRT5keratin 50.114
ANKS1Bankyrin repeat and sterile alpha motif domain containing 1B0.112
NOTCH3notch 30.109
CABLES1Cdk5 and Abl enzyme substrate 10.096
FGF8fibroblast growth factor 8 (androgen-induced)0.095
HDAC9histone deacetylase 90.091
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.086
ESR1estrogen receptor 10.085
TP73tumor protein p730.082
SATB2SATB homeobox 20.082
DEAF1deformed epidermal autoregulatory factor 1 (Drosophila)0.079
SMAD7SMAD family member 70.072
DLG2discs, large homolog 2 (Drosophila)0.072
BMP7bone morphogenetic protein 70.068
FGF4fibroblast growth factor 40.063
FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1)0.063
AXIN1axin 10.060
KLF13Kruppel-like factor 130.059
MYOD1myogenic differentiation 10.058
NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.058
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.057
NRP1neuropilin 10.053
FZD8frizzled homolog 8 (Drosophila)0.049
ATXN1Lataxin 1-like0.045
KRT6Ckeratin 6C0.044
TGFB2transforming growth factor, beta 20.044
WNT3Awingless-type MMTV integration site family, member 3A0.040
SIRT1sirtuin 10.039
NCOA1nuclear receptor coactivator 10.038
NCOA3nuclear receptor coactivator 30.037
MKL1megakaryoblastic leukemia (translocation) 10.034
HIPK2homeodomain interacting protein kinase 20.032
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.029
LBX1ladybird homeobox 10.028
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.025
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.025
FGFR3fibroblast growth factor receptor 30.024
PTGISprostaglandin I2 (prostacyclin) synthase0.024
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.023
WNT3wingless-type MMTV integration site family, member 30.022
ARandrogen receptor0.022
NCOR2nuclear receptor corepressor 20.021
SNAI1snail homolog 1 (Drosophila)0.021
AMMECR1Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 10.020
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.019
FOXF1forkhead box F10.018
AHRaryl hydrocarbon receptor0.018
MDM2Mdm2 p53 binding protein homolog (mouse)0.018
RPS6KA5ribosomal protein S6 kinase, 90kDa, polypeptide 50.017
SPENspen homolog, transcriptional regulator (Drosophila)0.017
FOXA2forkhead box A20.017
GAB2GRB2-associated binding protein 20.017
GATAD2BGATA zinc finger domain containing 2B0.016
NOSTRINnitric oxide synthase trafficker0.016
PPP1R13Bprotein phosphatase 1, regulatory (inhibitor) subunit 13B0.016
VEGFAvascular endothelial growth factor A0.016
RAXretina and anterior neural fold homeobox0.016
TBX1T-box 10.014
NEDD4neural precursor cell expressed, developmentally down-regulated 40.014
CIR1corepressor interacting with RBPJ, 10.014
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)1.000
Shhsonic hedgehog1.000
Gli3GLI-Kruppel family member GLI31.000
Tbx3T-box 31.000
Fgfr2fibroblast growth factor receptor 21.000
Fgf8fibroblast growth factor 81.000
Efnb2ephrin B21.000
Gata4GATA binding protein 41.000
Hand2heart and neural crest derivatives expressed transcript 21.000
Pax2paired box gene 20.999
Hey2hairy/enhancer-of-split related with YRPW motif 20.999
Foxc2forkhead box C20.999
Foxc1forkhead box C10.999
Pitx2paired-like homeodomain transcription factor 20.999
Tbx1T-box 10.999
Bmp4bone morphogenetic protein 40.998
Ntf3neurotrophin 30.998
Gli2GLI-Kruppel family member GLI20.997
Jag1jagged 10.996
Tgfb2transforming growth factor, beta 20.994
Hand1heart and neural crest derivatives expressed transcript 10.992
Ror2receptor tyrosine kinase-like orphan receptor 20.991
Gata6GATA binding protein 60.989
Notch1Notch gene homolog 1 (Drosophila)0.988
Pax3paired box gene 30.987
Hoxa1homeobox A10.986
Wnt3awingless-related MMTV integration site 3A0.985
Meox2mesenchyme homeobox 20.983
Sox9SRY-box containing gene 90.972
Hoxa13homeobox A130.971
Prrx1paired related homeobox 10.962
Fgf10fibroblast growth factor 100.961
Ctnnb1catenin (cadherin associated protein), beta 10.956
Tbx5T-box 50.940
Fgfr1fibroblast growth factor receptor 10.940
Vangl2vang-like 2 (van gogh, Drosophila)0.899
Rxraretinoid X receptor alpha0.895
Trp63transformation related protein 630.889
Zfpm2zinc finger protein, multitype 20.889
Twist2twist homolog 2 (Drosophila)0.888
Rarbretinoic acid receptor, beta0.887
Ptpn11protein tyrosine phosphatase, non-receptor type 110.887
Fgfr3fibroblast growth factor receptor 30.886
Hoxd11homeobox D110.879
Ptch1patched homolog 10.870
Psen1presenilin 10.864
Nos3nitric oxide synthase 3, endothelial cell0.860
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.839
Smad6MAD homolog 6 (Drosophila)0.833
Foxf1aforkhead box F1a0.816
Itgb1integrin beta 1 (fibronectin receptor beta)0.807
Zeb1zinc finger E-box binding homeobox 10.794
Hoxd13homeobox D130.792
Tbx2T-box 20.780
Apcadenomatosis polyposis coli0.731
Tcf21transcription factor 210.721
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.701
Msx2homeobox, msh-like 20.696
Pitx1paired-like homeodomain transcription factor 10.662
Ntrk3neurotrophic tyrosine kinase, receptor, type 30.661
Fgf3fibroblast growth factor 30.656
Rargretinoic acid receptor, gamma0.655
Gdf5growth differentiation factor 50.653
Bdnfbrain derived neurotrophic factor0.641
Otx2orthodenticle homolog 2 (Drosophila)0.627
Hoxa11homeobox A110.609
Tbx15T-box 150.599
Ptenphosphatase and tensin homolog0.582
Gdnfglial cell line derived neurotrophic factor0.578
Chd7chromodomain helicase DNA binding protein 70.570
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.564
Gata5GATA binding protein 50.544
Hspg2perlecan (heparan sulfate proteoglycan 2)0.540
Pou5f1POU domain, class 5, transcription factor 10.530
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.528
Alx4aristaless-like homeobox 40.528
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.525
Gscgoosecoid homeobox0.516
Sall4sal-like 4 (Drosophila)0.513
Sox2SRY-box containing gene 20.509
Acvr1activin A receptor, type 10.492
Bmp5bone morphogenetic protein 50.485
Pou3f3POU domain, class 3, transcription factor 30.484
Gbx2gastrulation brain homeobox 20.468
Msx1homeobox, msh-like 10.464
Lhx1LIM homeobox protein 10.455
Epha4Eph receptor A40.454
Dlx5distal-less homeobox 50.452
Vegfavascular endothelial growth factor A0.447
Gsk3bglycogen synthase kinase 3 beta0.447
Lrp6low density lipoprotein receptor-related protein 60.437
Egfrepidermal growth factor receptor0.430
Mesp1mesoderm posterior 10.421
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.419
Lmx1aLIM homeobox transcription factor 1 alpha0.390
Nfatc2nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 20.389
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism