The network for 'negative regulation of cardiac muscle tissue growth' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cardiac muscle tissue growth

Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle growth.

NameDescriptionProbabilityFunc Analog Organism
LOC100362824caveolin 2-like0.980
Cav1caveolin 1, caveolae protein0.739
Cav2caveolin 20.595
Adam10ADAM metallopeptidase domain 100.290
Emp1epithelial membrane protein 10.161
Timp3TIMP metallopeptidase inhibitor 30.109
Nek9NIMA (never in mitosis gene a)- related kinase 90.083
Serpine2serine (or cysteine) peptidase inhibitor, clade E, member 20.071
Nos3nitric oxide synthase 3, endothelial cell0.069
Olr37olfactory receptor 370.060
Pecam1platelet/endothelial cell adhesion molecule 10.059
Ehd2EH-domain containing 20.056
Cald1caldesmon 10.050
Jak1Janus kinase 10.045
Dnah2dynein, axonemal, heavy chain 20.044
Dusp7dual specificity phosphatase 70.041
Nedd4neural precursor cell expressed, developmentally down-regulated 40.040
Dlg4discs, large homolog 4 (Drosophila)0.038
Arntaryl hydrocarbon receptor nuclear translocator0.035
Dnase1deoxyribonuclease I0.035
Efemp1EGF-containing fibulin-like extracellular matrix protein 10.033
Lamc1laminin, gamma 10.033
Smad7SMAD family member 70.033
KitlgKIT ligand0.033
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.031
Galnt1UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)0.030
Hspb2heat shock protein beta 20.030
Tnni2troponin I type 2 (skeletal, fast)0.029
Gpr4G protein-coupled receptor 40.027
Dhrs7cdehydrogenase/reductase (SDR family) member 7C0.027
Cdh5cadherin 50.027
Mef2dmyocyte enhancer factor 2D0.027
Cd9CD9 molecule0.026
Vegfavascular endothelial growth factor A0.026
Slc6a20solute carrier family 6 (proline IMINO transporter), member 200.026
Camkk2calcium/calmodulin-dependent protein kinase kinase 2, beta0.025
Itga6integrin, alpha 60.024
Ppardperoxisome proliferator-activated receptor delta0.023
Gja4gap junction protein, alpha 40.023
Ptpn12protein tyrosine phosphatase, non-receptor type 120.023
Tcf12transcription factor 120.023
Gja5gap junction protein, alpha 50.023
Fbln5fibulin 50.022
Megf6multiple EGF-like-domains 60.022
Tns1tensin 10.022
Notch2Notch homolog 2 (Drosophila)0.022
Rap1aRAP1A, member of RAS oncogene family0.022
Sdprserum deprivation response0.021
RradRas-related associated with diabetes0.021
Ppicpeptidylprolyl isomerase C0.021
Prrx1paired related homeobox 10.020
Sp1Sp1 transcription factor0.020
Gse1genetic suppressor element 10.020
Pdgfbplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.019
Npr1natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)0.019
Abcc2ATP-binding cassette, subfamily C (CFTR/MRP), member 20.019
Fabp6fatty acid binding protein 6, ileal0.019
LOC100360403ATP-binding cassette, sub-family C, member 9-like0.019
Sstr4somatostatin receptor 40.018
Casq1calsequestrin 1 (fast-twitch, skeletal muscle)0.018
Myo1cmyosin IC0.018
Rnase4ribonuclease, RNase A family 40.017
Ptprgprotein tyrosine phosphatase, receptor type, G0.017
Fkbp10FK506 binding protein 100.017
Icam2intercellular adhesion molecule 20.017
Tgfbr1transforming growth factor, beta receptor 10.017
Pgam2phosphoglycerate mutase 2 (muscle)0.017
Ckmt2creatine kinase, mitochondrial 2, sarcomeric0.017
Olr1701olfactory receptor 17010.017
Tie1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.016
Fgfr1Fibroblast growth factor receptor 10.016
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.016
St3gal3ST3 beta-galactoside alpha-2,3-sialyltransferase 30.016
Pls3plastin 3 (T-isoform)0.016
Nxph4neurexophilin 40.016
Add3adducin 3 (gamma)0.016
Hrchistidine rich calcium binding protein0.016
Dlc1deleted in liver cancer 10.016
Arsbarylsulfatase B0.015
Tubtubby homolog (mouse)0.015
Aoc3amine oxidase, copper containing 3 (vascular adhesion protein 1)0.015
Mapre3microtubule-associated protein, RP/EB family, member 30.015
Il9interleukin 90.015
Efnb1ephrin B10.015
Cyb5r3cytochrome b5 reductase 30.015
Agtr2angiotensin II receptor, type 20.015
Ddr2discoidin domain receptor tyrosine kinase 20.015
Prkcaprotein kinase C, alpha0.014
Anpepalanyl (membrane) aminopeptidase0.014
Enpp1ectonucleotide pyrophosphatase/phosphodiesterase 10.014
Jag2jagged 20.014
Myo1bmyosin Ib0.014
Kcnj13potassium inwardly-rectifying channel, subfamily J, member 130.014
Col15a1collagen, type XV, alpha 10.014
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.014
Cox8bcytochrome c oxidase, subunit VIIIb0.014
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.626
MDM2Mdm2 p53 binding protein homolog (mouse)0.426
STK3serine/threonine kinase 30.257
HDAC1histone deacetylase 10.160
YAP1Yes-associated protein 10.148
TGFB1transforming growth factor, beta 10.130
KRT5keratin 50.086
WWOXWW domain containing oxidoreductase0.056
MOBKL1BMOB1, Mps One Binder kinase activator-like 1B (yeast)0.055
SATB2SATB homeobox 20.050
GATA4GATA binding protein 40.044
STK4serine/threonine kinase 40.038
RASSF3Ras association (RalGDS/AF-6) domain family member 30.037
RASSF5Ras association (RalGDS/AF-6) domain family member 50.032
AXIN1axin 10.032
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.029
RASSF1Ras association (RalGDS/AF-6) domain family member 10.029
KRT6Ckeratin 6C0.028
DEAF1deformed epidermal autoregulatory factor 1 (Drosophila)0.027
TP73tumor protein p730.027
TP53BP2tumor protein p53 binding protein, 20.023
MOBKL1AMOB1, Mps One Binder kinase activator-like 1A (yeast)0.022
TGFB3transforming growth factor, beta 30.022
BMP7bone morphogenetic protein 70.022
PTPN14protein tyrosine phosphatase, non-receptor type 140.022
TGFBR1transforming growth factor, beta receptor 10.021
AMOTL1angiomotin like 10.021
FSTL1follistatin-like 10.020
BMP2bone morphogenetic protein 20.019
S1PR5sphingosine-1-phosphate receptor 50.019
SMAD7SMAD family member 70.019
HNRNPCL1heterogeneous nuclear ribonucleoprotein C-like 10.018
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.017
TBX5T-box 50.016
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.015
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.015
PPP1R13Bprotein phosphatase 1, regulatory (inhibitor) subunit 13B0.014
LATS1LATS, large tumor suppressor, homolog 1 (Drosophila)0.014
TEAD1TEA domain family member 1 (SV40 transcriptional enhancer factor)0.013
AMOTL2angiomotin like 20.012
RCOR1REST corepressor 10.012
SNX9sorting nexin 90.012
DAXXdeath-domain associated protein0.011
GJC2gap junction protein, gamma 2, 47kDa0.011
NR2E3nuclear receptor subfamily 2, group E, member 30.011
NRP1neuropilin 10.011
UACAuveal autoantigen with coiled-coil domains and ankyrin repeats0.011
TFAP2Atranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha)0.010
TGFBR3transforming growth factor, beta receptor III0.010
SLMAPsarcolemma associated protein0.010
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.659
Scn5asodium channel, voltage-gated, type V, alpha0.316
Tbx3T-box 30.182
Hcn4hyperpolarization-activated, cyclic nucleotide-gated K+ 40.127
Fgfr2fibroblast growth factor receptor 20.088
Ctnnb1catenin (cadherin associated protein), beta 10.087
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.081
Ptpn11protein tyrosine phosphatase, non-receptor type 110.057
Apcadenomatosis polyposis coli0.052
Gja5gap junction protein, alpha 50.045
Efemp2epidermal growth factor-containing fibulin-like extracellular matrix protein 20.039
Ighmbp2immunoglobulin mu binding protein 20.038
Trp63transformation related protein 630.034
Sox2SRY-box containing gene 20.034
Jag1jagged 10.033
Shhsonic hedgehog0.031
Cdh5cadherin 50.028
Ryr2ryanodine receptor 2, cardiac0.028
Vegfavascular endothelial growth factor A0.028
Axin1axin 10.027
Tgfbr1transforming growth factor, beta receptor I0.024
Zfp932zinc finger protein 9320.024
Trp53transformation related protein 530.024
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.022
Pitx2paired-like homeodomain transcription factor 20.020
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.019
Hand2heart and neural crest derivatives expressed transcript 20.019
Bmpr1abone morphogenetic protein receptor, type 1A0.018
Foxc2forkhead box C20.018
Gja1gap junction protein, alpha 10.017
Egfrepidermal growth factor receptor0.017
Gata4GATA binding protein 40.016
Sox9SRY-box containing gene 90.015
Pax3paired box gene 30.014
Bmp4bone morphogenetic protein 40.014
Emx1empty spiracles homolog 1 (Drosophila)0.014
Tgfb2transforming growth factor, beta 20.013
Mta2metastasis-associated gene family, member 20.013
BrafBraf transforming gene0.013
Psen1presenilin 10.013
Hey2hairy/enhancer-of-split related with YRPW motif 20.013
Itgb1integrin beta 1 (fibronectin receptor beta)0.012
Tbx5T-box 50.012
Nos3nitric oxide synthase 3, endothelial cell0.011
Ntf3neurotrophin 30.011
Robo4roundabout homolog 4 (Drosophila)0.010
Loxlysyl oxidase0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism