The network for 'replicative cell aging' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

replicative cell aging

The process associated with progression of the cell from its inception to the end of its lifespan that occurs as the cell continues cycles of growth and division.

NameDescriptionProbabilityFunc Analog Organism
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PRKAB1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.766
XRCC5X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)0.514
PRKAA1protein kinase, AMP-activated, alpha 1 catalytic subunit0.452
APLFaprataxin and PNKP like factor0.430
PRKAB2protein kinase, AMP-activated, beta 2 non-catalytic subunit0.340
CALM1calmodulin 1 (phosphorylase kinase, delta)0.265
H2AFXH2A histone family, member X0.255
RAD52RAD52 homolog (S. cerevisiae)0.206
RALBP1ralA binding protein 10.167
TERF2IPtelomeric repeat binding factor 2, interacting protein0.136
CHAF1Achromatin assembly factor 1, subunit A (p150)0.119
PDK1pyruvate dehydrogenase kinase, isozyme 10.115
BLMBloom syndrome, RecQ helicase-like0.112
PGAM1phosphoglycerate mutase 1 (brain)0.108
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.108
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.107
PPP6R2protein phosphatase 6, regulatory subunit 20.106
TMBIM6transmembrane BAX inhibitor motif containing 60.102
TOP3Atopoisomerase (DNA) III alpha0.096
WRNWerner syndrome, RecQ helicase-like0.092
RALAv-ral simian leukemia viral oncogene homolog A (ras related)0.092
STK4serine/threonine kinase 40.086
TERF2telomeric repeat binding factor 20.085
MUS81MUS81 endonuclease homolog (S. cerevisiae)0.080
SATB2SATB homeobox 20.075
XRCC4X-ray repair complementing defective repair in Chinese hamster cells 40.072
CABLES1Cdk5 and Abl enzyme substrate 10.069
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.065
KRT5keratin 50.063
ENO2enolase 2 (gamma, neuronal)0.057
TINF2TERF1 (TRF1)-interacting nuclear factor 20.056
PARP1poly (ADP-ribose) polymerase 10.055
NBNnibrin0.054
TXNthioredoxin0.049
PGK1phosphoglycerate kinase 10.048
DCLRE1BDNA cross-link repair 1B0.048
NEK6NIMA (never in mitosis gene a)-related kinase 60.046
RALGDSral guanine nucleotide dissociation stimulator0.040
RASSF1Ras association (RalGDS/AF-6) domain family member 10.039
HNRNPABheterogeneous nuclear ribonucleoprotein A/B0.037
PRKAG2protein kinase, AMP-activated, gamma 2 non-catalytic subunit0.036
APTXaprataxin0.035
SLC39A1solute carrier family 39 (zinc transporter), member 10.035
SLX4SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)0.034
ATP6V0CATPase, H+ transporting, lysosomal 16kDa, V0 subunit c0.033
RASSF5Ras association (RalGDS/AF-6) domain family member 50.032
PRKAA2protein kinase, AMP-activated, alpha 2 catalytic subunit0.030
SNX18sorting nexin 180.030
ANKRD28ankyrin repeat domain 280.029
RAP1ARAP1A, member of RAS oncogene family0.028
RIN1Ras and Rab interactor 10.028
TSPAN4tetraspanin 40.027
PAWRPRKC, apoptosis, WT1, regulator0.027
STARD7StAR-related lipid transfer (START) domain containing 70.027
VDAC1voltage-dependent anion channel 10.027
ABL2v-abl Abelson murine leukemia viral oncogene homolog 20.026
TNKStankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase0.026
KRT6Ckeratin 6C0.026
UBQLN1ubiquilin 10.025
MAP2K1mitogen-activated protein kinase kinase 10.025
PEBP1phosphatidylethanolamine binding protein 10.025
MRPL27mitochondrial ribosomal protein L270.024
RASSF2Ras association (RalGDS/AF-6) domain family member 20.023
PPP6R3protein phosphatase 6, regulatory subunit 30.023
EME1essential meiotic endonuclease 1 homolog 1 (S. pombe)0.023
PEBP4phosphatidylethanolamine-binding protein 40.022
MRPL53mitochondrial ribosomal protein L530.022
GMFBglia maturation factor, beta0.022
TUBA4Atubulin, alpha 4a0.021
GABARAPL2GABA(A) receptor-associated protein-like 20.020
NHEJ1nonhomologous end-joining factor 10.020
CD151CD151 molecule (Raph blood group)0.020
GCKRglucokinase (hexokinase 4) regulator0.020
CDV3CDV3 homolog (mouse)0.020
S1PR5sphingosine-1-phosphate receptor 50.020
NMNAT1nicotinamide nucleotide adenylyltransferase 10.020
PPIApeptidylprolyl isomerase A (cyclophilin A)0.020
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.020
NEDD9neural precursor cell expressed, developmentally down-regulated 90.019
PSEN2presenilin 2 (Alzheimer disease 4)0.018
RALBv-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)0.018
MOBKL1AMOB1, Mps One Binder kinase activator-like 1A (yeast)0.018
PDE4DIPphosphodiesterase 4D interacting protein0.018
GADD45Ggrowth arrest and DNA-damage-inducible, gamma0.017
TP73tumor protein p730.017
CHUKconserved helix-loop-helix ubiquitous kinase0.017
IGSF21immunoglobin superfamily, member 210.017
TPI1triosephosphate isomerase 10.017
SRIsorcin0.017
GNAI3guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 30.016
POLR2Lpolymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa0.016
ATMataxia telangiectasia mutated0.016
TAF2TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa0.016
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.016
DNAJB2DnaJ (Hsp40) homolog, subfamily B, member 20.016
FBXO4F-box protein 40.016
ALDOAaldolase A, fructose-bisphosphate0.015
SIRT1sirtuin 10.015
ARPC5actin related protein 2/3 complex, subunit 5, 16kDa0.015
SNX9sorting nexin 90.015
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Apcadenomatosis polyposis coli0.032
Prkab1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.017
Ptpn11protein tyrosine phosphatase, non-receptor type 110.017
Trp53transformation related protein 530.016
Grb2growth factor receptor bound protein 20.016
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.015
Egfrepidermal growth factor receptor0.015
Raf1v-raf-leukemia viral oncogene 10.015
Ptenphosphatase and tensin homolog0.012
Prkaa1protein kinase, AMP-activated, alpha 1 catalytic subunit0.012
Itgb1integrin beta 1 (fibronectin receptor beta)0.012
Adam17a disintegrin and metallopeptidase domain 170.011
BrafBraf transforming gene0.011
Nf1neurofibromatosis 10.011
Prkag1protein kinase, AMP-activated, gamma 1 non-catalytic subunit0.010
Shc1src homology 2 domain-containing transforming protein C10.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
SIR2Sir2p0.554
MIG1Mig1p0.387
CSR2Csr2p0.346
MMS22Mms22p0.222
DEF1Def1p0.209
SNF1Snf1p0.206
PHB2Phb2p0.182
MDS3Mds3p0.176
PHB1Phb1p0.167
SIP2Sip2p0.158
LAC1Lac1p0.152
FOB1Fob1p0.148
TOR2Tor2p0.139
TOF2Tof2p0.130
RFA1Rfa1p0.128
YAT1Yat1p0.124
MNN9Mnn9p0.122
HAL5Hal5p0.118
TRA1Tra1p0.114
NET1Net1p0.112
MOB1Mob1p0.111
NDI1Ndi1p0.105
CPR1Cpr1p0.104
RAS2Ras2p0.104
HHO1Hho1p0.104
POP2Pop2p0.103
HSP78Hsp78p0.095
HXT3Hxt3p0.092
YTA12Yta12p0.092
IRC8Irc8p0.091
LAG1Lag1p0.091
GIS1Gis1p0.091
SIN3Sin3p0.090
PEX5Pex5p0.085
EXO1Exo1p0.084
YKR075Chypothetical protein0.084
PUT2Put2p0.082
AVO1Avo1p0.081
DNM1Dnm1p0.081
BCY1Bcy1p0.081
HST1Hst1p0.080
LIP1Lip1p0.079
GIS4Gis4p0.079
HHT1Hht1p0.077
CDC6Cdc6p0.076
CRZ1Crz1p0.075
YDR026Chypothetical protein0.074
YPL014Whypothetical protein0.073
SFG1Sfg1p0.073
HOS4Hos4p0.072
RAD51Rad51p0.072
TRR1Trr1p0.070
PHO23Pho23p0.068
SLX4Slx4p0.066
RPD3Rpd3p0.065
TOS3Tos3p0.064
ROX1Rox1p0.064
RLM1Rlm1p0.064
PRR2Prr2p0.063
AGP2Agp2p0.062
RIM1Rim1p0.061
CDC4Cdc4p0.061
HXT1Hxt1p0.057
ADR1Adr1p0.056
YNL194Chypothetical protein0.056
GPH1Gph1p0.056
PUT3Put3p0.053
SCH9Sch9p0.053
BMH2Bmh2p0.053
GLN3Gln3p0.052
YKU70Yku70p0.051
ICY1Icy1p0.051
AHP1Ahp1p0.050
YDR506Chypothetical protein0.050
AFT1Aft1p0.049
LYS5Lys5p0.049
IRA1Ira1p0.049
SNT1Snt1p0.049
HXK2Hxk2p0.049
ACE2Ace2p0.048
YCL042Whypothetical protein0.047
PEX1Pex1p0.047
DNA2Dna2p0.046
SOD2Sod2p0.046
SNF4Snf4p0.046
NUP157Nup157p0.045
SAM2Sam2p0.045
UGA3Uga3p0.045
PET494Pet494p0.045
DCS2Dcs2p0.044
FPR1Fpr1p0.044
GPB2Gpb2p0.044
SGF73Sgf73p0.043
ALD6Ald6p0.043
GPI8Gpi8p0.043
GSF2Gsf2p0.042
APN1Apn1p0.042
CCT2Cct2p0.042
GIP2Gip2p0.042
YBR235Whypothetical protein0.042