The network for 'defecation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms


The expulsion of feces from the rectum.

NameDescriptionProbabilityFunc Analog Organism
Dlg4discs, large homolog 4 (Drosophila)0.736
Dsppdentin sialophosphoprotein0.549
Grm8glutamate receptor, metabotropic 80.549
Dlgap1discs, large (Drosophila) homolog-associated protein 10.536
Gabrg3gamma-aminobutyric acid (GABA) A receptor, gamma 30.529
Slc14a2solute carrier family 14 (urea transporter), member 20.503
Dlgap3discs, large (Drosophila) homolog-associated protein 30.490
B3gat1beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)0.390
Slc22a25solute carrier family 22, member 250.353
Cntfrciliary neurotrophic factor receptor0.342
Grin1glutamate receptor, ionotropic, N-methyl D-aspartate 10.333
Dccdeleted in colorectal carcinoma0.305
UncxUNC homeobox0.303
Gja6gap junction protein, alpha 60.299
St18suppression of tumorigenicity 180.295
Gad2glutamate decarboxylase 20.293
Crhr2corticotropin releasing hormone receptor 20.285
Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.257
Syn1synapsin I0.248
Atp2b4ATPase, Ca++ transporting, plasma membrane 40.247
Kcnh3potassium voltage-gated channel, subfamily H (eag-related), member 30.238
Csn1s1casein alpha s10.235
Gcnt3glucosaminyl (N-acetyl) transferase 3, mucin type0.234
FaslgFas ligand (TNF superfamily, member 6)0.232
Notch3Notch homolog 3 (Drosophila)0.219
Arhgef7Rho guanine nucleotide exchange factor (GEF7)0.219
Gjb4gap junction protein, beta 40.195
Gata4GATA binding protein 40.192
Foxa1forkhead box A10.177
Pspparotid secretory protein0.175
Gzmkgranzyme K0.174
Csf1colony stimulating factor 1 (macrophage)0.170
Sdc3syndecan 30.167
Nr1h4nuclear receptor subfamily 1, group H, member 40.164
Nkx6-1NK6 homeobox 10.162
Robo1roundabout homolog 1 (Drosophila)0.162
Sorcs3sortilin-related VPS10 domain containing receptor 30.151
MrgprfMAS-related GPR, member F0.148
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.145
Il9rinterleukin 9 receptor0.140
Slc8a3solute carrier family 8 (sodium/calcium exchanger), member 30.134
RGD1304952similar to RIKEN cDNA C530028O21 gene0.134
Magmyelin-associated glycoprotein0.133
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.131
Syt7synaptotagmin VII0.129
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.126
Cacna1bcalcium channel, voltage-dependent, N type, alpha 1B subunit0.126
Phox2apaired-like homeobox 2a0.120
FevFEV (ETS oncogene family)0.118
Atp2a3ATPase, Ca++ transporting, ubiquitous0.118
Gabrdgamma-aminobutyric acid (GABA) A receptor, delta0.115
Oprl1opiate receptor-like 10.114
Sh2d3cSH2 domain containing 3C0.112
Sstr3somatostatin receptor 30.110
Calcrcalcitonin receptor0.107
Slc4a1solute carrier family 4 (anion exchanger), member 10.107
Chrna4cholinergic receptor, nicotinic, alpha 40.107
Cox4i2cytochrome c oxidase subunit IV isoform 20.104
Olr1867olfactory receptor 18670.100
Nrxn3neurexin 30.100
Ompolfactory marker protein0.099
Snhg11small nucleolar RNA host gene 110.099
Fgf16fibroblast growth factor 160.090
Htr5a5-hydroxytryptamine (serotonin) receptor 5A0.090
Tacr3tachykinin receptor 30.090
Celsr3cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)0.089
Uhmk1U2AF homology motif (UHM) kinase 10.088
Htr3a5-hydroxytryptamine (serotonin) receptor 3a0.087
Dpp6dipeptidylpeptidase 60.084
Rims1regulating synaptic membrane exocytosis 10.084
Gucy2cguanylate cyclase 2C0.084
Neurod2neurogenic differentiation 20.082
Chmchoroideremia (Rab escort protein 1)0.081
Syt4synaptotagmin IV0.080
Spock2sparc/osteonectin, cwcv and kazal-like domains proteoglycan 20.080
Prlhrprolactin releasing hormone receptor0.080
Gng7guanine nucleotide binding protein (G protein), gamma 70.079
P2rx3purinergic receptor P2X, ligand-gated ion channel, 30.079
Csn2casein beta0.076
Cntn3contactin 3 (plasmacytoma associated)0.074
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.073
Cplx2complexin 20.073
Slc18a1solute carrier family 18 (vesicular monoamine), member 10.072
Shank1SH3 and multiple ankyrin repeat domains 10.071
Tnfsf4tumor necrosis factor (ligand) superfamily, member 40.069
Klrc1killer cell lectin-like receptor subfamily C, member 10.069
Olr1641olfactory receptor 16410.065
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.063
Mettl7bmethyltransferase like 7B0.063
Necab2N-terminal EF-hand calcium binding protein 20.062
Lrp3low density lipoprotein receptor-related protein 30.062
Magi2membrane associated guanylate kinase, WW and PDZ domain containing 20.062
Prkcgprotein kinase C, gamma0.060
Kcnn3potassium intermediate/small conductance calcium-activated channel, subfamily N, member 30.060
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.059
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
unc-9Protein UNC-90.045
unc-7Protein UNC-70.036
gtl-1Protein GTL-10.036
nlg-1Protein NLG-10.033
lin-11Protein LIN-110.029
mec-2Protein MEC-20.028
CELE_B0513.5Protein B0513.50.026
eps-8Protein EPS-80.025
F28E10.1Protein F28E10.10.025
unc-29Protein UNC-290.024
rgs-2Protein RGS-20.024
F31F7.1Protein F31F7.10.024
unc-38Protein UNC-380.023
rig-6Protein RIG-60.023
glr-5Protein GLR-50.022
F55H12.3Protein F55H12.30.022
glc-4Protein GLC-40.022
rgs-6Protein RGS-60.022
CELE_Y67A10A.9Protein Y67A10A.90.022
elt-6Protein ELT-60.021
pes-1Protein PES-10.021
inx-13Protein INX-130.021
F45E4.3Protein F45E4.30.021
cri-3Protein CRI-30.020
vab-3Protein VAB-30.020
unc-42Protein UNC-420.020
aex-3Protein AEX-30.020
lev-8Protein LEV-80.020
lev-1Protein LEV-10.019
F14F4.1Protein F14F4.10.019
mec-4Protein MEC-40.019
CELE_F52E1.13Protein F52E1.130.019
faah-1Protein FAAH-10.019
C13F10.6Protein C13F10.60.019
nhx-1Protein NHX-10.019
fshr-1Protein FSHR-10.019
unc-41Protein UNC-410.018
pha-4Protein PHA-40.018
sdz-28Protein SDZ-280.018
let-23Protein LET-230.018
prmt-3Protein PRMT-30.018
twk-18Protein TWK-180.017
ser-2Protein SER-20.017
syg-1Protein SYG-10.017
K10D3.4Protein K10D3.40.017
math-4Protein MATH-40.017
tra-1Protein TRA-10.017
ref-1Protein REF-10.017
tbc-16Protein TBC-160.016
C43H6.6Protein C43H6.60.016
hsp-12.2Protein HSP-12.20.016
CELE_Y105C5A.24Protein Y105C5A.240.016
uig-1Protein UIG-10.016
aqp-11Protein AQP-110.016
C18G1.3Protein C18G1.30.016
oac-59Protein OAC-590.016
T25B9.10Protein T25B9.100.016
unc-63Protein UNC-630.016
CELE_C31B8.7Protein C31B8.70.016
inx-4Protein INX-40.015
pqn-47Protein PQN-470.015
CELE_Y69H2.1Protein Y69H2.10.015
H10E21.5Protein H10E21.50.015
R03G8.3Protein R03G8.30.015
snt-5Protein SNT-50.015
frm-3Protein FRM-30.015
mec-18Protein MEC-180.015
clec-7Protein CLEC-70.015
vab-8Protein VAB-80.014
unc-122Protein UNC-1220.014
ZC247.2Protein ZC247.20.014
asp-6Protein ASP-60.014
C14C11.2Protein C14C11.20.014
lgc-39Protein LGC-390.014
H03A11.2Protein H03A11.20.014
R04E5.2Protein R04E5.20.014
nhr-2Protein NHR-20.014
aex-2Protein AEX-20.014
zag-1Protein ZAG-10.014
sto-5Protein STO-50.014
sox-3Protein SOX-30.014
C36E8.4Protein C36E8.40.014
pos-1Protein POS-10.014
best-23Protein BEST-230.013
che-3Protein CHE-30.013
H43E16.1Protein H43E16.10.013
efn-2Protein EFN-20.013
rig-3Protein RIG-30.013
pept-1Protein PEPT-10.013
trpa-1Protein TRPA-10.013
C48B6.9Protein C48B6.90.013
B0495.7Protein B0495.70.013
aex-1Protein AEX-10.013
eat-6Protein EAT-60.013
ida-1Protein IDA-10.013
T20D3.2Protein T20D3.20.013
daf-10Protein DAF-100.013
rpm-1Protein RPM-10.013
sad-1Protein SAD-10.013
F26F12.4Protein F26F12.40.013
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CG2862CG2862 gene product from transcript CG2862-RA0.019
CG14482CG14482 gene product from transcript CG14482-RA0.015
levyCG17280 gene product from transcript CG17280-RA0.014
Ssb-c31aSingle stranded-binding protein c31A0.013
RpL29Ribosomal protein L290.012
Ras85DRas oncogene at 85D0.011
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Lef1lymphoid enhancer binding factor 10.984
Klc1kinesin light chain 10.920
Tcf7transcription factor 7, T-cell specific0.806
Gli3GLI-Kruppel family member GLI30.756
Otx2orthodenticle homolog 2 (Drosophila)0.741
Mapk8mitogen-activated protein kinase 80.739
Rims2regulating synaptic membrane exocytosis 20.672
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.610
Rims1regulating synaptic membrane exocytosis 10.574
Fbxl20F-box and leucine-rich repeat protein 200.555
Grin2bglutamate receptor, ionotropic, NMDA2B (epsilon 2)0.531
Itpr3inositol 1,4,5-triphosphate receptor 30.478
Ctnnb1catenin (cadherin associated protein), beta 10.467
Stx1asyntaxin 1A (brain)0.446
Fgfr1fibroblast growth factor receptor 10.432
En1engrailed 10.416
Otx1orthodenticle homolog 1 (Drosophila)0.391
Mapk8ip2mitogen-activated protein kinase 8 interacting protein 20.383
Itpr2inositol 1,4,5-triphosphate receptor 20.358
Psen1presenilin 10.325
Pax2paired box gene 20.288
Gli2GLI-Kruppel family member GLI20.262
Kcnq1potassium voltage-gated channel, subfamily Q, member 10.260
Ctnna2catenin (cadherin associated protein), alpha 20.255
Snap25synaptosomal-associated protein 250.247
Usp9xubiquitin specific peptidase 9, X chromosome0.239
Stoml2stomatin (Epb7.2)-like 20.232
Ythdf3YTH domain family 30.228
Mrpl12mitochondrial ribosomal protein L120.227
Gsk3bglycogen synthase kinase 3 beta0.213
Ehd3EH-domain containing 30.210
Mapk8ip3mitogen-activated protein kinase 8 interacting protein 30.201
Nphp4nephronophthisis 4 (juvenile) homolog (human)0.201
Slc4a4solute carrier family 4 (anion exchanger), member 40.198
Dlgap1discs, large (Drosophila) homolog-associated protein 10.179
Shhsonic hedgehog0.175
Dus1ldihydrouridine synthase 1-like (S. cerevisiae)0.174
Krtap5-1keratin associated protein 5-10.165
Hsp90b1heat shock protein 90, beta (Grp94), member 10.163
Gria2glutamate receptor, ionotropic, AMPA2 (alpha 2)0.160
En2engrailed 20.160
Clstn1calsyntenin 10.159
Plcg1phospholipase C, gamma 10.159
Gpr27G protein-coupled receptor 270.153
Lrpprcleucine-rich PPR-motif containing0.151
Fjx1four jointed box 1 (Drosophila)0.151
Msx1homeobox, msh-like 10.150
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.149
Rnf208ring finger protein 2080.144
Arf6ADP-ribosylation factor 60.142
Fam19a5family with sequence similarity 19, member A50.140
Dab1disabled homolog 1 (Drosophila)0.140
Auts2autism susceptibility candidate 20.138
Emx1empty spiracles homolog 1 (Drosophila)0.134
Inainternexin neuronal intermediate filament protein, alpha0.134
Rapgef4Rap guanine nucleotide exchange factor (GEF) 40.131
Notch3Notch gene homolog 3 (Drosophila)0.130
Pip5k1cphosphatidylinositol-4-phosphate 5-kinase, type 1 gamma0.128
Timm23translocase of inner mitochondrial membrane 23 homolog (yeast)0.126
Arhgef1Rho guanine nucleotide exchange factor (GEF) 10.119
Wnt1wingless-related MMTV integration site 10.118
Bmp7bone morphogenetic protein 70.118
Pou4f2POU domain, class 4, transcription factor 20.118
Dlg2discs, large homolog 2 (Drosophila)0.113
Irs1insulin receptor substrate 10.113
Dpysl4dihydropyrimidinase-like 40.108
Gata3GATA binding protein 30.108
Gpr37G protein-coupled receptor 370.108
Ptch1patched homolog 10.107
Dctpp1dCTP pyrophosphatase 10.107
Tbx3T-box 30.106
Emx2empty spiracles homolog 2 (Drosophila)0.104
Samm50sorting and assembly machinery component 50 homolog (S. cerevisiae)0.104
Naa10N(alpha)-acetyltransferase 10, NatA catalytic subunitNalpha acetyltransferase 100.102
Clppcaseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli)0.100
Ascl1achaete-scute complex homolog 1 (Drosophila)0.099
Celsr2cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)0.099
LfngLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase0.096
Sv2bsynaptic vesicle glycoprotein 2 b0.094
Cdh2cadherin 20.093
Igf1rinsulin-like growth factor I receptor0.093
Vamp2vesicle-associated membrane protein 20.092
Dnm2dynamin 20.091
Gas1growth arrest specific 10.091
Pax6paired box gene 60.090
Sox11SRY-box containing gene 110.089
Msi1Musashi homolog 1(Drosophila)0.088
L1camL1 cell adhesion molecule0.087
Tbpl2TATA box binding protein like 20.087
Tnnt2troponin T2, cardiac0.087
Lrp6low density lipoprotein receptor-related protein 60.085
Peg3paternally expressed 30.084
Ciccapicua homolog (Drosophila)0.083
Ripply2ripply2 homolog (zebrafish)0.082
Scg2secretogranin II0.080
Apba2amyloid beta (A4) precursor protein-binding, family A, member 20.079
Pcmtd1protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 10.077
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism