The network for 'catecholamine biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

catecholamine biosynthetic process

The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.

NameDescriptionProbabilityFunc Analog Organism
Colqcollagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase0.187
Kcnj1potassium inwardly-rectifying channel, subfamily J, member 10.113
Cyp2a1cytochrome P450, family 2, subfamily a, polypeptide 10.111
Ugt2bUDP glycosyltransferase 2 family, polypeptide B0.081
Abcc6ATP-binding cassette, subfamily C (CFTR/MRP), member 60.066
Olr1701olfactory receptor 17010.064
Sult1c3sulfotransferase family, cytosolic, 1C, member 30.061
Akr1c18aldo-keto reductase family 1, member C180.048
Cyp3a2cytochrome P450, family 3, subfamily a, polypeptide 20.046
Cyp2f4cytochrome P450, family 2, subfamily f, polypeptide 40.044
Trhr2thyrotropin releasing hormone receptor 20.041
Olr1867olfactory receptor 18670.035
Slc14a2solute carrier family 14 (urea transporter), member 20.034
Fgbfibrinogen beta chain0.034
A1i3alpha-1-inhibitor III0.033
Cyp1a2cytochrome P450, family 1, subfamily a, polypeptide 20.031
Cyp27b1cytochrome P450, family 27, subfamily b, polypeptide 10.031
Crygfcrystallin, gamma F0.029
Cyp2b3cytochrome P450, family 2, subfamily b, polypeptide 30.028
Foxa1forkhead box A10.028
Cyp2b2cytochrome P450, family 2, subfamily b, polypeptide 20.028
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.026
Cyp2d2cytochrome P450, family 2, subfamily d, polypeptide 20.025
Pfkfb26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 20.024
Rxrgretinoid X receptor gamma0.023
Hoxa2homeo box A20.023
LOC494499LOC494499 protein0.022
Cyp2c23cytochrome P450, family 2, subfamily c, polypeptide 230.021
Sult1c2sulfotransferase family, cytosolic, 1C, member 20.019
Rftn2raftlin family member 20.019
Ncr1natural cytotoxicity triggering receptor 10.019
Gnmtglycine N-methyltransferase0.019
Cyp2d3cytochrome P450, family 2, subfamily d, polypeptide 30.019
Ugt2b1UDP glucuronosyltransferase 2 family, polypeptide B10.018
Cyp3a23/3a1cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 10.018
P2rx2purinergic receptor P2X, ligand-gated ion channel, 20.018
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.018
Tgfbr3transforming growth factor, beta receptor III0.017
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.017
Cyp2c22cytochrome P450, family 2, subfamily c, polypeptide 220.017
Gja6gap junction protein, alpha 60.016
Igsf1immunoglobulin superfamily, member 10.016
Tubtubby homolog (mouse)0.015
Cyp2c12cytochrome P450, family 2, subfamily c, polypeptide 120.015
Cyp2b1cytochrome P450, family 2, subfamily b, polypeptide 10.015
FevFEV (ETS oncogene family)0.015
Fdxrferredoxin reductase0.015
P2rx3purinergic receptor P2X, ligand-gated ion channel, 30.014
Cyp4a8cytochrome P450, family 4, subfamily a, polypeptide 80.014
Insrrinsulin receptor-related receptor0.014
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.014
Zfp37zinc finger protein 370.014
Klkb1kallikrein B, plasma 10.013
Agtr2angiotensin II receptor, type 20.013
Pon1paraoxonase 10.013
Cyp4a10cytochrome P450, family 4, subfamily a, polypeptide 100.013
Olr1078olfactory receptor 10780.012
Car5acarbonic anhydrase 5a, mitochondrial0.012
Cyp2d4cytochrome P450, family 2, subfamily d, polypeptide 40.012
Azgp1alpha-2-glycoprotein 1, zinc-binding0.011
Ugt2b37UDP-glucuronosyltransferase 2 family, member 370.011
Cyp2c13cytochrome P450, family 2, subfamily c, polypeptide 130.011
Il8rainterleukin 8 receptor, alpha0.011
Pigrpolymeric immunoglobulin receptor0.011
Cyp3a18cytochrome P450, family 3, subfamily a, polypeptide 180.011
Lhcgrluteinizing hormone/choriogonadotropin receptor0.011
Akr1c14aldo-keto reductase family 1, member C140.011
G6pcglucose-6-phosphatase, catalytic subunit0.010
LOC246267resection-induced TPI (rs11)0.010
Otcornithine carbamoyltransferase0.010
F9coagulation factor IX0.010
Cyp2e1cytochrome P450, family 2, subfamily e, polypeptide 10.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
cat-2Protein CAT-20.454
cat-1Protein CAT-10.286
cat-4Protein CAT-40.104
cyp-35A3Protein CYP-35A30.035
dat-1Protein DAT-10.031
cyp-35A2Protein CYP-35A20.024
tbb-4Protein TBB-40.021
ugt-22Protein UGT-220.020
cyp-35A5Protein CYP-35A50.020
pes-1Protein PES-10.020
cyp-35C1Protein CYP-35C10.020
C39D10.7Protein C39D10.70.019
CELE_F02H6.3Protein F02H6.30.018
hlh-14Protein HLH-140.015
ceh-13Protein CEH-130.015
crls-1Protein CRLS-10.015
CELE_C29F7.2Protein C29F7.20.013
C43F9.5Protein C43F9.50.013
nlp-16Protein NLP-160.012
C44C1.5Protein C44C1.50.012
ZC449.2Protein ZC449.20.012
F38B2.2Protein F38B2.20.012
daf-11Protein DAF-110.012
CELE_T04A8.7Protein T04A8.70.011
basl-1Protein BASL-10.011
cyp-35B2Protein CYP-35B20.010
K02A6.2Protein K02A6.20.010
cyp-29A2Protein CYP-29A20.010
bbs-1Protein BBS-10.010
lin-32Protein LIN-320.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
mitfamicrophthalmia-associated transcription factor a0.858
sox10SRY-box containing gene 100.608
ddcdopa decarboxylase0.563
slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.418
ednrb1endothelin receptor B0.369
dlx5adistal-less homeobox gene 5a0.319
kitakit receptor a0.288
thtyrosine hydroxylase0.219
csf1racolony stimulating factor 1 receptor, a0.171
pmelapremelanosome protein a0.161
aox3aldehyde oxidase 30.145
ptch1patched 10.140
dlx2adistal-less homeobox gene 2a0.133
nos1nitric oxide synthase 1 (neuronal)0.121
cyp19a1bcytochrome P450, family 19, subfamily A, polypeptide 1b0.117
ebf3early B-cell factor 30.093
edn1endothelin 10.090
adcyap1r1adenylate cyclase activating polypeptide 1 (pituitary) receptor type I0.089
runx3runt-related transcription factor 30.086
lmx1b.1LIM homeobox transcription factor 1, beta 10.084
prox1prospero-related homeobox gene 10.081
sst1.1somatostatin 1, tandem duplicate 10.080
lhx2bLIM homeobox 2b0.079
htr1aa5-hydroxytryptamine (serotonin) receptor 1A a0.079
pax7apaired box gene 7a0.076
gstt1aglutathione S-transferase theta 1a0.073
col9a2procollagen, type IX, alpha 20.066
ltkleukocyte tyrosine kinase0.065
ascl1aachaete-scute complex-like 1a (Drosophila)0.064
crhbpcorticotropin releasing hormone binding protein0.063
phox2bpaired-like homeobox 2b0.053
gch2GTP cyclohydrolase 20.052
opn4aopsin 4a (melanopsin)0.051
gcm2glial cells missing homolog 2 (Drosophila)0.050
evx1even-skipped homeobox 10.048
foxi3bforkhead box I3b0.047
lhx5LIM homeobox 50.045
vps39vacuolar protein sorting 39 homolog (S. cerevisiae)0.045
stmn4stathmin-like 40.044
slc24a5solute carrier family 24, member 50.040
atp1a1a.2ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide0.039
pnp4apurine nucleoside phosphorylase 4a0.039
mpp5amembrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a)0.038
otpaorthopedia homolog a0.038
gad1bglutamate decarboxylase 1b0.038
maomonoamine oxidase0.036
crhcorticotropin releasing hormone0.036
slc45a2solute carrier family 45, member 20.035
sox9aSRY-box containing gene 9a0.035
tbx5aT-box 5a0.035
tyrp1tyrosinase-related protein 10.035
dctdopachrome tautomerase0.034
nr4a2bnuclear receptor subfamily 4, group A, member 2b0.034
fgf10afibroblast growth factor 10a0.034
trpm7transient receptor potential cation channel, subfamily M, member 70.034
cadm1bcell adhesion molecule 1b0.034
dlx1adistal-less homeobox gene 1a0.033
plp1aproteolipid protein 1a0.033
gnrh3gonadotropin-releasing hormone 30.031
dlx2bdistal-less homeobox gene 2b0.030
arandrogen receptor0.030
runx1runt-related transcription factor 10.030
mecomMDS1 and EVI1 complex locus0.030
dlx6adistal-less homeobox gene 6a0.030
cnr1cannabinoid receptor 10.030
uxs1UDP-glucuronic acid decarboxylase 10.029
esr1estrogen receptor 10.029
sim1asingle-minded homolog 1a (Drosophila)0.028
gata1aGATA binding protein 1a0.028
emx2empty spiracles homeobox 20.028
elavl3ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)0.027
stmn2bstathmin-like 2b0.027
lef1lymphocyte enhancer binding factor 10.027
dbhdopamine beta hydroxylase0.027
tph2tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)0.026
th2tyrosine hydroxylase 20.026
phox2apaired-like homeobox 2a0.026
tgfb3transforming growth factor, beta 30.026
plxna4plexin A40.025
nme4non-metastatic cells 4, protein expressed in0.025
hbbe3hemoglobin beta embryonic-30.025
desmadesmin a0.025
tbx20T-box 200.025
rag1recombination activating gene 10.025
hcrthypocretin (orexin) neuropeptide precursor0.024
tbx4T-box 40.024
prom1bprominin 1 b0.024
barhl2BarH-like 20.024
flncbfilamin C, gamma b (actin binding protein 280)0.024
penkbproenkephalin b0.024
irx5airoquois homeobox protein 5a0.023
fhl2afour and a half LIM domains 2a0.023
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
DdcDopa decarboxylase0.391
DopRDopamine receptor0.145
VAChTCG32848 gene product from transcript CG32848-RA0.132
Spn28DSerpin 28D0.112
ia2CG31795 gene product from transcript CG31795-RD0.100
Kr-h1Kruppel homolog 10.097
Mmp1Matrix metalloproteinase 10.086
HandCG18144 gene product from transcript CG18144-RA0.078
Eip74EFEcdysone-induced protein 74EF0.070
TrpA1Transient receptor potential A10.063
AlkCG8250 gene product from transcript CG8250-RA0.060
norpAno receptor potential A0.057
NPFR1neuropeptide F receptor0.057
kkvkrotzkopf verkehrt0.049
TbhTyramine beta hydroxylase0.048
highikaru genki0.042
RdlResistant to dieldrin0.042
fhfrataxin homolog0.041
stumpsCG31317 gene product from transcript CG31317-RC0.041
Adgf-AAdenosine deaminase-related growth factor A0.038
Rh5Rhodopsin 50.036
cpocouch potato0.035
Mlp84BMuscle LIM protein at 84B0.035
Ork1Open rectifier K[+] channel 10.033
nanarrow abdomen0.033
TimpTissue inhibitor of metalloproteases0.032
ShawShaker cognate w0.029
jingCG9397 gene product from transcript CG9397-RI0.028
Hr46Hormone receptor-like in 460.027
CG32834CG32834 gene product from transcript CG32834-RB0.026
HmgcrHMG Coenzyme A reductase0.026
Eaat1Excitatory amino acid transporter 10.025
VGATVesicular GABA Transporter0.025
SnapSoluble NSF attachment protein0.025
Nmdar1NMDA receptor 10.024
tauCG31057 gene product from transcript CG31057-RA0.024
CG3239CG3239 gene product from transcript CG3239-RB0.023
cwoclockwork orange0.023
drddrop dead0.023
Syt1Synaptotagmin 10.022
myoglianinCG1838 gene product from transcript CG1838-RD0.022
CCSCG17753 gene product from transcript CG17753-RA0.022
Pvf2PDGF- and VEGF-related factor 20.022
oddodd skipped0.022
nabCG33545 gene product from transcript CG33545-RC0.022
Gadd45CG11086 gene product from transcript CG11086-RA0.021
CG3597CG3597 gene product from transcript CG3597-RA0.020
l(1)G0144lethal (1) G01440.020
ImpIGF-II mRNA-binding protein0.020
CG13253CG13253 gene product from transcript CG13253-RB0.020
CG8709CG8709 gene product from transcript CG8709-RK0.020
CG9897CG9897 gene product from transcript CG9897-RA0.019
OambOctopamine receptor in mushroom bodies0.019
Spn77BaSerpin 77Ba0.019
PhKgammaPhosphorylase kinase gamma0.019
CG17181CG17181 gene product from transcript CG17181-RA0.019
PapssPAPS synthetase0.018
Sld5CG14549 gene product from transcript CG14549-RA0.018
CG16756CG16756 gene product from transcript CG16756-RA0.018
pdfrPDF receptor0.017
CG5018CG5018 gene product from transcript CG5018-RA0.017
DhDiuretic hormone0.017
Cyp301a1CG8587 gene product from transcript CG8587-RA0.017
PGRP-SC2CG14745 gene product from transcript CG14745-RA0.017
onecutCG1922 gene product from transcript CG1922-RA0.016
Glut1Glucose transporter 10.016
nonAno on or off transient A0.016
pdm2POU domain protein 20.016
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PDZD11PDZ domain containing 110.342
MAPTmicrotubule-associated protein tau0.115
SOD1superoxide dismutase 1, soluble0.035
SNCAIPsynuclein, alpha interacting protein0.034
EGR3early growth response 30.031
PSMB1proteasome (prosome, macropain) subunit, beta type, 10.025
APPamyloid beta (A4) precursor protein0.023
PRDX1peroxiredoxin 10.022
DOCK7dedicator of cytokinesis 70.020
HSPA1Bheat shock 70kDa protein 1B0.017
FOSBFBJ murine osteosarcoma viral oncogene homolog B0.015
URODuroporphyrinogen decarboxylase0.014
DAD1defender against cell death 10.014
NR4A3nuclear receptor subfamily 4, group A, member 30.013
NME1-NME2NME1-NME2 readthrough0.013
SPTBN1spectrin, beta, non-erythrocytic 10.013
SLC1A2solute carrier family 1 (glial high affinity glutamate transporter), member 20.013
LRRK2leucine-rich repeat kinase 20.012
NDUFA4NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa0.012
PDE4DIPphosphodiesterase 4D interacting protein0.012
PRDX6peroxiredoxin 60.012
PHOX2Apaired-like homeobox 2a0.011
CYP2C9cytochrome P450, family 2, subfamily C, polypeptide 90.011
LDHBlactate dehydrogenase B0.011
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.934
Neurod1neurogenic differentiation 10.880
Gata4GATA binding protein 40.623
Pax6paired box gene 60.567
Ptf1apancreas specific transcription factor, 1a0.443
Neurog2neurogenin 20.382
Vegfavascular endothelial growth factor A0.304
Neurod4neurogenic differentiation 40.267
Nhlh1nescient helix loop helix 10.266
Shhsonic hedgehog0.231
Isl1ISL1 transcription factor, LIM/homeodomain0.224
Ascl1achaete-scute complex homolog 1 (Drosophila)0.223
Nkx2-2NK2 transcription factor related, locus 2 (Drosophila)0.199
Hand1heart and neural crest derivatives expressed transcript 10.197
Tgfbr2transforming growth factor, beta receptor II0.187
Gata6GATA binding protein 60.187
Kitkit oncogene0.178
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.162
Lhx3LIM homeobox protein 30.162
Acvr1activin A receptor, type 10.149
Hoxa1homeobox A10.139
Hand2heart and neural crest derivatives expressed transcript 20.134
Pitx2paired-like homeodomain transcription factor 20.120
Mesp1mesoderm posterior 10.114
Nos3nitric oxide synthase 3, endothelial cell0.100
Foxc2forkhead box C20.098
Pax3paired box gene 30.097
Gata1GATA binding protein 10.093
Kitlkit ligand0.088
Drd2dopamine receptor D20.087
Fbn1fibrillin 10.083
Tcfap2atranscription factor AP-2, alpha0.078
Tal1T-cell acute lymphocytic leukemia 10.073
MecomMDS1 and EVI1 complex locus0.073
Chrnb2cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)0.071
Lgr5leucine rich repeat containing G protein coupled receptor 50.064
Ece1endothelin converting enzyme 10.060
Onecut1one cut domain, family member 10.057
Neurog3neurogenin 30.052
Mitfmicrophthalmia-associated transcription factor0.051
Tgfbr1transforming growth factor, beta receptor I0.044
Pdx1pancreatic and duodenal homeobox 10.043
Fshrfollicle stimulating hormone receptor0.041
Sox4SRY-box containing gene 40.040
Crb2crumbs homolog 2 (Drosophila)0.039
Nf1neurofibromatosis 10.037
Rspo2R-spondin 2 homolog (Xenopus laevis)0.037
Pou4f2POU domain, class 4, transcription factor 20.035
Fgf8fibroblast growth factor 80.035
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.035
Cyp19a1cytochrome P450, family 19, subfamily a, polypeptide 10.034
Kiss1KiSS-1 metastasis-suppressor0.033
En1engrailed 10.032
Sox10SRY-box containing gene 100.032
Gbx2gastrulation brain homeobox 20.032
Zfpm2zinc finger protein, multitype 20.032
Prph2peripherin 20.032
Nkx2-9NK2 transcription factor related, locus 9 (Drosophila)0.031
Sox2SRY-box containing gene 20.030
Ebf3early B-cell factor 30.029
Nos1nitric oxide synthase 1, neuronal0.028
RhagRhesus blood group-associated A glycoprotein0.028
Gnrhrgonadotropin releasing hormone receptor0.027
Wfikkn2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.026
Galr1galanin receptor 10.026
Cplx1complexin 10.025
Tyrp1tyrosinase-related protein 10.025
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.024
Gypaglycophorin A0.023
Prox1prospero-related homeobox 10.023
Unc79unc-79 homolog (C. elegans)0.022
Jag1jagged 10.021
Cdkn2acyclin-dependent kinase inhibitor 2A0.021
Six6sine oculis-related homeobox 6 homolog (Drosophila)0.021
Irs2insulin receptor substrate 20.020
Cbfa2t3core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)0.020
Rit2Ras-like without CAAX 20.020
Ank1ankyrin 1, erythroid0.020
Moxd2monooxygenase, DBH-like 20.019
Fgf15fibroblast growth factor 150.019
FosFBJ osteosarcoma oncogene0.019
Gpr50G-protein-coupled receptor 500.019
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.019
Emx1empty spiracles homolog 1 (Drosophila)0.019
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.019
Ren1renin 1 structural0.019
Vdrvitamin D receptor0.018
Ncam2neural cell adhesion molecule 20.018
Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.018
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.018
Chrna7cholinergic receptor, nicotinic, alpha polypeptide 70.018
Arxaristaless related homeobox0.018
RorbRAR-related orphan receptor beta0.018
Kcnq1potassium voltage-gated channel, subfamily Q, member 10.018
Eya1eyes absent 1 homolog (Drosophila)0.017
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism