The network for 'negative regulation of autophagy' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of autophagy

Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.

NameDescriptionProbabilityFunc Analog Organism
Rpl10aribosomal protein L10A0.044
Atp5hATP synthase, H+ transporting, mitochondrial F0 complex, subunit d0.025
Rpl18aribosomal protein L18A0.024
Sdhbsuccinate dehydrogenase complex, subunit B, iron sulfur (Ip)0.022
Atp5oATP synthase, H+ transporting, mitochondrial F1 complex, O subunit0.021
Rps21ribosomal protein S210.020
Rpl31ribosomal protein L310.020
Rps8ribosomal protein S80.017
Sdhdsuccinate dehydrogenase complex, subunit D, integral membrane protein0.017
Nacanascent polypeptide-associated complex alpha subunit0.016
Rpl23aribosomal protein L23a0.016
Uqcrfs1ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 10.016
Ndufa8NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 80.016
Rpl8ribosomal protein L80.016
Psmb1proteasome (prosome, macropain) subunit, beta type 10.015
Psmc5proteasome (prosome, macropain) 26S subunit, ATPase, 50.015
Rpl5ribosomal protein L50.015
Eif3ieukaryotic translation initiation factor 3, subunit I0.015
Npm1nucleophosmin (nucleolar phosphoprotein B23, numatrin)0.015
Park7Parkinson disease (autosomal recessive, early onset) 70.014
Ndufb10NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 100.014
LOC10036049160S ribosomal protein L13-like0.014
Psmc1proteasome (prosome, macropain) 26S subunit, ATPase, 10.014
Cct2chaperonin containing TCP1, subunit 2 (beta)0.014
Cct3chaperonin containing Tcp1, subunit 3 (gamma)0.014
Ndufa13NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 130.014
Psma2proteasome (prosome, macropain) subunit, alpha type 20.014
Rpl4ribosomal protein L40.014
Cct5chaperonin containing Tcp1, subunit 5 (epsilon)0.014
Rps3ribosomal protein S30.013
Rpl7aribosomal protein L7a0.013
Eif3meukaryotic translation initiation factor 3, subunit M0.013
Mrpl27mitochondrial ribosomal protein L270.013
Rps2ribosomal protein S20.013
Eif3s6ipeukaryotic translation initiation factor 3, subunit 6 interacting protein0.013
Ndufs7NADH dehydrogenase (ubiquinone) Fe-S protein 70.013
Eif3geukaryotic translation initiation factor 3, subunit G0.013
Rpl3ribosomal protein L30.012
Atp5a1ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle0.012
Mrpl13mitochondrial ribosomal protein L130.012
Psmd6proteasome (prosome, macropain) 26S subunit, non-ATPase, 60.012
Rpl9ribosomal protein L90.012
Psmc2proteasome (prosome, macropain) 26S subunit, ATPase 20.012
Chmp2achromatin modifying protein 2A0.012
Mrps23mitochondrial ribosomal protein S230.012
Vps28vacuolar protein sorting 28 homolog (S. cerevisiae)0.012
Prmt1protein arginine methyltransferase 10.012
CnbpCCHC-type zinc finger, nucleic acid binding protein0.012
Mdh2malate dehydrogenase 2, NAD (mitochondrial)0.012
Rps11ribosomal protein S110.012
Atp5jATP synthase, H+ transporting, mitochondrial F0 complex, subunit F60.012
Rps9ribosomal protein S90.012
Atp5c1ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 10.011
Rpl6ribosomal protein L60.011
S100a10S100 calcium binding protein A100.011
Rps5ribosomal protein S50.011
Ndufv1NADH dehydrogenase (ubiquinone) flavoprotein 10.011
LOC688869similar to cytochrome c oxidase, subunit VIb polypeptide 10.011
Rps27ribosomal protein S270.011
Idh3Bisocitrate dehydrogenase 3 (NAD+) beta0.011
Aprtadenine phosphoribosyl transferase0.011
Cops6COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)0.011
Atp5lATP synthase, H+ transporting, mitochondrial F0 complex, subunit G0.010
Hsd17b10hydroxysteroid (17-beta) dehydrogenase 100.010
Gnb2l1guanine nucleotide binding protein (G protein), beta polypeptide 2 like 10.010
Rpl28ribosomal protein L280.010
Eif3deukaryotic translation initiation factor 3, subunit D0.010
RGD1303003homolog of zebrafish ES10.010
Ndufb6NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 60.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
igf1rbinsulin-like growth factor 1b receptor0.799
vps39vacuolar protein sorting 39 homolog (S. cerevisiae)0.306
mapk1mitogen-activated protein kinase 10.304
lppLIM domain containing preferred translocation partner in lipoma0.262
mapk3mitogen-activated protein kinase 30.226
insrbinsulin receptor b0.212
tm9sf2transmembrane 9 superfamily member 20.194
vdravitamin D receptor a0.169
tob1atransducer of ERBB2, 1a0.160
terttelomerase reverse transcriptase0.154
xbp1X-box binding protein 10.150
zbtb4zinc finger and BTB domain containing 40.127
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.114
gro2groucho 20.110
mapk6mitogen-activated protein kinase 60.099
furinafurin (paired basic amino acid cleaving enzyme) a0.097
tmed10transmembrane emp24-like trafficking protein 10 (yeast)0.092
slc24a5solute carrier family 24, member 50.088
pafah1b1bplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b0.086
slc45a2solute carrier family 45, member 20.083
cdiptCDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)0.082
gnb1aguanine nucleotide binding protein (G protein), beta polypeptide 1a0.077
antxr2aanthrax toxin receptor 2a0.076
hdac4histone deacetylase 40.073
wnt10awingless-type MMTV integration site family, member 10a0.067
nadl1.2neural adhesion molecule L1.20.066
nrg1neuregulin 10.064
ldb1aLIM-domain binding factor 1a0.063
prkar1aaprotein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a0.062
fgf20afibroblast growth factor 20a0.058
mical3flavoprotein oxidoreductase MICAL30.057
ext2exostoses (multiple) 20.056
nrasneuroblastoma RAS viral (v-ras) oncogene homolog0.055
aplp2amyloid beta (A4) precursor-like protein 20.055
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.054
mapk14amitogen-activated protein kinase 14a0.054
srprsignal recognition particle receptor (docking protein)0.053
mxi1max interacting protein0.052
atp2b4ATPase, Ca++ transporting, plasma membrane 40.052
ripk2receptor-interacting serine-threonine kinase 20.051
tfe3atranscription factor binding to IGHM enhancer 3a0.051
atp6v0d1ATPase, H+ transporting, V0 subunit D isoform 10.050
gpr126G protein-coupled receptor 1260.050
cdh1cadherin 1, epithelial0.049
sec61al2Sec61 alpha like 20.048
rnd1lRho family GTPase 1 like0.047
tram1translocating chain-associating membrane protein 10.046
gclmglutamate-cysteine ligase, modifier subunit0.046
mibmind bomb0.042
foxo3aforkhead box O3A0.041
rhoaaras homolog gene family, member Aa0.040
acsl1acyl-CoA synthetase long-chain family member 10.040
ccnhcyclin H0.039
dusp4dual specificity phosphatase 40.038
kcnh2potassium voltage-gated channel, subfamily H (eag-related), member 20.037
lass2LAG1 homolog, ceramide synthase 2 (S. cerevisiae)0.036
adrb2aadrenergic receptor, beta 2a0.036
acvr1bactivin A receptor, type IB0.035
cldn12claudin 120.035
bmp16bone morphogenetic protein 160.034
gfergrowth factor, augmenter of liver regeneration (ERV1 homolog, S. cerevisiae)0.034
sec24dSEC24 family, member D (S. cerevisiae)0.034
sdc2syndecan 20.033
prkciprotein kinase C, iota0.033
baxabcl2-associated X protein, a0.033
ccng1cyclin G10.032
bonbonnie and clyde0.031
ptpn1protein tyrosine phosphatase, non-receptor type 10.031
h1mlinker histone H1M0.031
tbx1T-box 10.030
kdm4blysine (K)-specific demethylase 4B0.030
tm9sf3transmembrane 9 superfamily member 30.029
tm9sf4transmembrane 9 superfamily protein member 40.029
crb2acrumbs homolog 2a0.028
pafah1b1aplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit a0.028
ptpn13protein tyrosine phosphatase, non-receptor type 130.027
thrbthyroid hormone receptor beta0.027
cecr1acat eye syndrome chromosome region, candidate 1a0.027
cry2acryptochrome 2a0.026
nrg2aneuregulin 2a0.026
tgfb1atransforming growth factor, beta 1a0.026
ccnt2acyclin T2a0.025
crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.025
brd2abromodomain-containing 2a0.025
dctn1adynactin 1a0.025
atp6v0caATPase, H+ transporting, lysosomal, V0 subunit c, a0.024
hprt1hypoxanthine phosphoribosyltransferase 10.024
kif3bkinesin family member 3B0.024
aldh18a1aldehyde dehydrogenase 18 family, member A10.024
gsk3bglycogen synthase kinase 3 beta0.024
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
MadMothers against dpp0.995
Ras85DRas oncogene at 85D0.989
PtenCG5671 gene product from transcript CG5671-RB0.979
phlpole hole0.957
Pi3K92ECG4141 gene product from transcript CG4141-RB0.910
RhebCG1081 gene product from transcript CG1081-RA0.691
Akt1CG4006 gene product from transcript CG4006-RA0.600
Stat92ESignal-transducer and activator of transcription protein at 92E0.522
Xbp1X box binding protein-10.428
drkdownstream of receptor kinase0.359
S6kRPS6-p70-protein kinase0.255
gbbglass bottom boat0.246
Pk61CProtein kinase 61C0.179
jebjelly belly0.166
Atg1Autophagy-specific gene 10.146
chicoCG5686 gene product from transcript CG5686-RB0.135
Srp54kSignal recognition particle protein 54k0.134
CblCG7037 gene product from transcript CG7037-RB0.119
CaMKIICalcium/calmodulin-dependent protein kinase II0.106
Spase18-21Spase 18/21-subunit0.089
InRInsulin-like receptor0.085
sosine oculis0.081
kibrakibra ortholog0.077
EcREcdysone receptor0.077
SmoxSmad on X0.073
Aats-trpTryptophanyl-tRNA synthetase0.073
Arf79FADP ribosylation factor 79F0.072
unc-104CG8566 gene product from transcript CG8566-RB0.071
SrpRbetaSignal recognition particle receptor beta0.071
Plc21CPhospholipase C at 21C0.069
Sec61alphaCG9539 gene product from transcript CG9539-RA0.057
CdsACDP diglyceride synthetase0.057
PknProtein kinase related to protein kinase N0.053
Rab7Rab-protein 70.053
myoglianinCG1838 gene product from transcript CG1838-RD0.049
CG7220CG7220 gene product from transcript CG7220-RD0.049
SbfSET domain binding factor0.047
Rab11Rab-protein 110.047
CG6490CG6490 gene product from transcript CG6490-RB0.044
cbscentrosomin's beautiful sister0.044
Gp150CG5820 gene product from transcript CG5820-RA0.043
trioCG18214 gene product from transcript CG18214-RA0.040
SaraSmad anchor for receptor activation0.039
svpseven up0.039
EgfrEpidermal growth factor receptor0.039
Atg8aAutophagy-specific gene 8a0.037
Nrx-1Neurexin 10.037
foxoforkhead box, sub-group O0.037
PTP-ERProtein tyrosine phosphatase-ERK/Enhancer of Ras10.037
Ent1Equilibrative nucleoside transporter 10.035
Lk6CG17342 gene product from transcript CG17342-RA0.034
PvrPDGF- and VEGF-receptor related0.033
DadDaughters against dpp0.033
Pabp2CG2163 gene product from transcript CG2163-RA0.032
CSN4COP9 complex homolog subunit 40.032
Gap1GTPase-activating protein 10.031
TctpTranslationally controlled tumor protein0.031
eyaeyes absent0.031
Sc2CG10849 gene product from transcript CG10849-RA0.031
WASpCG1520 gene product from transcript CG1520-RA0.030
Sec61gammaCG14214 gene product from transcript CG14214-RA0.030
VhaM8.9CG8444 gene product from transcript CG8444-RA0.029
AlkCG8250 gene product from transcript CG8250-RA0.029
CG5885CG5885 gene product from transcript CG5885-RA0.029
Syt4Synaptotagmin 40.029
Ard1Arrest defective 10.028
MSBPmembrane steroid binding protein0.026
HcfHost cell factor0.026
TorTarget of rapamycin0.025
ManfMesencephalic astrocyte-derived neurotrophic factor0.025
Fer2LCHFerritin 2 light chain homologue0.024
Bre1CG10542 gene product from transcript CG10542-RA0.024
Elp3Elongator complex protein 30.024
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.955
FKBP1AFK506 binding protein 1A, 12kDa0.673
MAP2K1mitogen-activated protein kinase kinase 10.602
MTORmechanistic target of rapamycin (serine/threonine kinase)0.373
AKT1v-akt murine thymoma viral oncogene homolog 10.235
PTPN23protein tyrosine phosphatase, non-receptor type 230.131
MAPK1mitogen-activated protein kinase 10.099
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.096
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.091
NOXA1NADPH oxidase activator 10.068
RPTORregulatory associated protein of MTOR, complex 10.055
UBE3Aubiquitin protein ligase E3A0.054
GOLT1Bgolgi transport 1B0.043
APPamyloid beta (A4) precursor protein0.041
LATlinker for activation of T cells0.039
MPDZmultiple PDZ domain protein0.034
ARHGEF12Rho guanine nucleotide exchange factor (GEF) 120.031
PDCD6programmed cell death 60.030
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.029
BRAFv-raf murine sarcoma viral oncogene homolog B10.029
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.028
RXRAretinoid X receptor, alpha0.026
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.025
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.025
PDPK13-phosphoinositide dependent protein kinase-10.024
CDC14BCDC14 cell division cycle 14 homolog B (S. cerevisiae)0.022
CDC42EP4CDC42 effector protein (Rho GTPase binding) 40.022
CDC37cell division cycle 37 homolog (S. cerevisiae)0.018
CDCP1CUB domain containing protein 10.017
RASSF1Ras association (RalGDS/AF-6) domain family member 10.017
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.016
IGSF21immunoglobin superfamily, member 210.016
ARRDC3arrestin domain containing 30.015
PARD6Gpar-6 partitioning defective 6 homolog gamma (C. elegans)0.015
RASSF5Ras association (RalGDS/AF-6) domain family member 50.015
MAPK3mitogen-activated protein kinase 30.014
MDM2Mdm2 p53 binding protein homolog (mouse)0.014
SH3RF1SH3 domain containing ring finger 10.014
HPS6Hermansky-Pudlak syndrome 60.014
PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans)0.014
THBS1thrombospondin 10.014
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.013
TTC3tetratricopeptide repeat domain 30.013
GMFBglia maturation factor, beta0.013
SPRR2Asmall proline-rich protein 2A0.013
RALAv-ral simian leukemia viral oncogene homolog A (ras related)0.012
CCDC115coiled-coil domain containing 1150.012
SMAD7SMAD family member 70.012
MAPKAPK2mitogen-activated protein kinase-activated protein kinase 20.012
PEBP1phosphatidylethanolamine binding protein 10.012
USP54ubiquitin specific peptidase 540.012
BLOC1S2biogenesis of lysosomal organelles complex-1, subunit 20.012
PEBP4phosphatidylethanolamine-binding protein 40.012
PICK1protein interacting with PRKCA 10.011
IRS1insulin receptor substrate 10.011
KSR1kinase suppressor of ras 10.011
EGFRepidermal growth factor receptor0.011
PTK2BPTK2B protein tyrosine kinase 2 beta0.011
GNAI3guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 30.010
UBE2E1ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)0.010
RALGDSral guanine nucleotide dissociation stimulator0.010
CALM1calmodulin 1 (phosphorylase kinase, delta)0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.966
Ptenphosphatase and tensin homolog0.830
Grb10growth factor receptor bound protein 100.175
Tgfbr2transforming growth factor, beta receptor II0.154
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.145
Trp53transformation related protein 530.130
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.125
Raf1v-raf-leukemia viral oncogene 10.111
RictorRPTOR independent companion of MTOR, complex 20.087
Apcadenomatosis polyposis coli0.080
BrafBraf transforming gene0.068
Mapkap1mitogen-activated protein kinase associated protein 10.055
Mapk14mitogen-activated protein kinase 140.041
Mdm2transformed mouse 3T3 cell double minute 20.031
Mdm4transformed mouse 3T3 cell double minute 40.029
Ppargperoxisome proliferator activated receptor gamma0.027
Shc1src homology 2 domain-containing transforming protein C10.025
Nos3nitric oxide synthase 3, endothelial cell0.024
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.023
Abca1ATP-binding cassette, sub-family A (ABC1), member 10.019
Cdx2caudal type homeobox 20.018
Atp2a2ATPase, Ca++ transporting, cardiac muscle, slow twitch 20.018
Fgfr2fibroblast growth factor receptor 20.017
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.017
Mapk1mitogen-activated protein kinase 10.016
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.015
Cdkn2acyclin-dependent kinase inhibitor 2A0.015
Mapk3mitogen-activated protein kinase 30.014
Rint1RAD50 interactor 10.013
Rptorregulatory associated protein of MTOR, complex 10.012
Smad4MAD homolog 4 (Drosophila)0.012
Irs2insulin receptor substrate 20.012
Rxraretinoid X receptor alpha0.012
Mecp2methyl CpG binding protein 20.012
Atf2activating transcription factor 20.012
Rararetinoic acid receptor, alpha0.011
Rfwd2ring finger and WD repeat domain 20.011
Csf2colony stimulating factor 2 (granulocyte-macrophage)0.011
Egfrepidermal growth factor receptor0.011
Foxo3forkhead box O30.011
Vegfavascular endothelial growth factor A0.010
Bcl6B-cell leukemia/lymphoma 60.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
YPL260Whypothetical protein0.052
YMR102Chypothetical protein0.014
YPL014Whypothetical protein0.012
YNL134Chypothetical protein0.010