The network for 'alpha beta t cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

alpha beta t cell differentiation

The process in which a precursor cell type acquires the specialized features of an alpha-beta T cell. An alpha-beta T cell is a T cell that expresses an alpha-beta T cell receptor complex.

NameDescriptionProbabilityFunc Analog Organism
Gimap4GTPase, IMAP family member 40.133
Apol3apolipoprotein L, 30.091
Ddr1discoidin domain receptor tyrosine kinase 10.086
Gja4gap junction protein, alpha 40.052
Hmha1histocompatibility (minor) HA-10.050
Cd37CD37 molecule0.048
Efnb1ephrin B10.047
Ceacam1carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)0.044
Cd5Cd5 molecule0.044
Itgb7integrin, beta 70.043
Tgfbr3transforming growth factor, beta receptor III0.038
Stat6signal transducer and activator of transcription 60.038
Hdac7histone deacetylase 70.034
Arhgap25Rho GTPase activating protein 250.032
Anpepalanyl (membrane) aminopeptidase0.031
Cd2Cd2 molecule0.030
Rps6ka1ribosomal protein S6 kinase polypeptide 10.029
Pecam1platelet/endothelial cell adhesion molecule 10.029
TekTEK tyrosine kinase, endothelial0.029
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.028
Tnfrsf14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.028
Rxraretinoid X receptor alpha0.027
Il2rginterleukin 2 receptor, gamma0.026
Spnsialophorin0.025
Sh2d1aSH2 domain protein 1A0.024
Map3k3mitogen activated protein kinase kinase kinase 30.023
Rhohras homolog gene family, member H0.023
Mapk7mitogen-activated protein kinase 70.023
Psd4pleckstrin and Sec7 domain containing 40.023
Ncr3natural cytotoxicity triggering receptor 30.022
Gpr4G protein-coupled receptor 40.022
Cd247Cd247 molecule0.020
Egfl7EGF-like-domain, multiple 70.020
Tfebtranscription factor EB0.020
Prkchprotein kinase C, eta0.019
Arhgap4Rho GTPase activating protein 40.018
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.018
LOC100364854similar to RIKEN cDNA A430107P09 gene-like0.018
Nficnuclear factor I/C0.018
Hdac1lhistone deacetylase 1-like0.018
Socs3suppressor of cytokine signaling 30.018
Psen1presenilin 10.017
Olr1469olfactory receptor Olr14690.017
Smad7SMAD family member 70.016
Nos3nitric oxide synthase 3, endothelial cell0.016
LOC363326hypothetical LOC3633260.016
Cskc-src tyrosine kinase0.015
Epn1Epsin 10.015
Plekhg2pleckstrin homology domain containing, family G (with RhoGef domain) member 20.015
Serpinb6bserine (or cysteine) peptidase inhibitor, clade B, member 6b0.015
TriobpTRIO and F-actin binding protein0.015
Jundjun D proto-oncogene0.015
Bin2bridging integrator 20.015
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.015
Podxlpodocalyxin-like0.014
Bak1BCL2-antagonist/killer 10.014
BtkBruton agammaglobulinemia tyrosine kinase0.014
Gata2GATA binding protein 20.014
Sdc3syndecan 30.014
Ptger4prostaglandin E receptor 4 (subtype EP4)0.014
Cd3gCD3 molecule, gamma0.013
Ctla2acytotoxic T lymphocyte-associated protein 2 alpha0.013
Hcsthematopoietic cell signal transducer0.013
Sept1septin 10.013
Nr2f6nuclear receptor subfamily 2, group F, member 60.013
Faim3Fas apoptotic inhibitory molecule 30.013
Arhgef15Rho guanine nucleotide exchange factor (GEF) 150.013
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.013
Cdc42bpbCDC42 binding protein kinase beta (DMPK-like)0.013
Ms4a1membrane-spanning 4-domains, subfamily A, member 10.012
Cd4Cd4 molecule0.012
Cnr2cannabinoid receptor 2 (macrophage)0.012
Wasf2WAS protein family, member 20.012
Gulogulonolactone (L-) oxidase0.012
Acap1ArfGAP with coiled-coil, ankyrin repeat and PH domains 10.012
Gpsm3G-protein signaling modulator 3 (AGS3-like, C. elegans)0.012
Trim25tripartite motif-containing 250.012
Ltblymphotoxin beta (TNF superfamily, member 3)0.012
Zfp36zinc finger protein 360.012
Cishcytokine inducible SH2-containing protein0.012
Tie1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.012
Scarf2scavenger receptor class F, member 20.011
Emcnendomucin0.011
Ralgdsral guanine nucleotide dissociation stimulator0.011
Ccl5chemokine (C-C motif) ligand 50.011
Sbno2strawberry notch homolog 2 (Drosophila)0.011
Lcklymphocyte-specific protein tyrosine kinase0.011
Lgals2lectin, galactoside-binding, soluble, 20.011
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.011
Ccdc69coiled-coil domain containing 690.011
GrapGRB2-related adaptor protein0.011
Ccl21chemokine (C-C motif) ligand 210.011
Cd69Cd69 molecule0.011
Prickle3prickle homolog 3 (Drosophila)0.011
Ptprcapprotein tyrosine phosphatase, receptor type, C-associated protein0.011
Dll4delta-like 4 (Drosophila)0.011
RT1-N3RT1 class Ib, locus N30.010
Klf13Kruppel-like factor 130.010
Actn4actinin alpha 40.010
Zap70zeta-chain (TCR) associated protein kinase0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.999
IL4Rinterleukin 4 receptor0.997
LCKlymphocyte-specific protein tyrosine kinase0.996
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.994
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.911
NCOR2nuclear receptor corepressor 20.877
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.862
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.753
SIN3ASIN3 homolog A, transcription regulator (yeast)0.738
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.729
BIRC3baculoviral IAP repeat containing 30.689
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.574
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.553
LIN9lin-9 homolog (C. elegans)0.443
ZAP70zeta-chain (TCR) associated protein kinase 70kDa0.329
CD247CD247 molecule0.320
NR2E3nuclear receptor subfamily 2, group E, member 30.316
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.312
RXRAretinoid X receptor, alpha0.294
NR0B1nuclear receptor subfamily 0, group B, member 10.259
BCL3B-cell CLL/lymphoma 30.238
TRAF1TNF receptor-associated factor 10.224
PPARAperoxisome proliferator-activated receptor alpha0.188
IL23Ainterleukin 23, alpha subunit p190.181
PMLpromyelocytic leukemia0.133
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.119
IL4interleukin 40.110
IL2RGinterleukin 2 receptor, gamma0.103
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.089
EP300E1A binding protein p3000.078
HDAC7histone deacetylase 70.078
CTBP1C-terminal binding protein 10.076
RUNX3runt-related transcription factor 30.070
VAV1vav 1 guanine nucleotide exchange factor0.069
PDZD11PDZ domain containing 110.065
TNFAIP3tumor necrosis factor, alpha-induced protein 30.064
SMAD4SMAD family member 40.064
SPRR2Asmall proline-rich protein 2A0.057
MEOX1mesenchyme homeobox 10.054
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.051
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.050
NFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta0.046
LIN54lin-54 homolog (C. elegans)0.046
HDAC4histone deacetylase 40.043
IL2RBinterleukin 2 receptor, beta0.042
CSNK1G1casein kinase 1, gamma 10.040
TNIP2TNFAIP3 interacting protein 20.038
IL6Rinterleukin 6 receptor0.037
CCR7chemokine (C-C motif) receptor 70.037
GRAP2GRB2-related adaptor protein 20.033
IKZF3IKAROS family zinc finger 3 (Aiolos)0.032
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.030
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.030
IL7Rinterleukin 7 receptor0.030
TBL1XR1transducin (beta)-like 1 X-linked receptor 10.030
PTPN6protein tyrosine phosphatase, non-receptor type 60.028
TRAF3TNF receptor-associated factor 30.028
HDAC9histone deacetylase 90.028
NFKBIZnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta0.027
TRAT1T cell receptor associated transmembrane adaptor 10.026
PRKCEprotein kinase C, epsilon0.026
PIAS1protein inhibitor of activated STAT, 10.026
LATlinker for activation of T cells0.025
ICAM1intercellular adhesion molecule 10.025
CD2CD2 molecule0.023
ARAFv-raf murine sarcoma 3611 viral oncogene homolog0.023
MED25mediator complex subunit 250.022
TGFB3transforming growth factor, beta 30.022
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.022
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.021
H2AFXH2A histone family, member X0.021
MAP3K8mitogen-activated protein kinase kinase kinase 80.021
PLCG1phospholipase C, gamma 10.021
BCL2L1BCL2-like 10.020
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.020
TGFB1transforming growth factor, beta 10.019
SKIv-ski sarcoma viral oncogene homolog (avian)0.019
HDAC5histone deacetylase 50.019
RBMX2RNA binding motif protein, X-linked 20.019
TNIP1TNFAIP3 interacting protein 10.018
RARAretinoic acid receptor, alpha0.018
IRF4interferon regulatory factor 40.017
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 20.017
E2F4E2F transcription factor 4, p107/p130-binding0.017
ZFP36zinc finger protein 36, C3H type, homolog (mouse)0.017
NLKnemo-like kinase0.017
ESR1estrogen receptor 10.017
PTPN22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.016
PLXND1plexin D10.016
CD3GCD3g molecule, gamma (CD3-TCR complex)0.015
RB1retinoblastoma 10.015
IL16interleukin 16 (lymphocyte chemoattractant factor)0.015
E2F1E2F transcription factor 10.015
TRAF3IP3TRAF3 interacting protein 30.015
ITGB1BP2integrin beta 1 binding protein (melusin) 20.014
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.014
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.013
CD7CD7 molecule0.013
CD6CD6 molecule0.013
SLASrc-like-adaptor0.013
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ikzf1IKAROS family zinc finger 11.000
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.997
Bcl2B-cell leukemia/lymphoma 20.997
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.997
Gli2GLI-Kruppel family member GLI20.996
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.995
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.992
Fgfr2fibroblast growth factor receptor 20.992
Tnftumor necrosis factor0.991
Pitx1paired-like homeodomain transcription factor 10.989
Ighimmunoglobulin heavy chain complex0.988
Tbx3T-box 30.988
Stat3signal transducer and activator of transcription 30.984
FasFas (TNF receptor superfamily member 6)0.977
Cd19CD19 antigen0.974
Lef1lymphoid enhancer binding factor 10.974
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.971
Socs1suppressor of cytokine signaling 10.968
Leprleptin receptor0.948
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.942
Ptenphosphatase and tensin homolog0.936
Jak2Janus kinase 20.934
Rag1recombination activating gene 10.927
Rargretinoic acid receptor, gamma0.926
Tnfaip3tumor necrosis factor, alpha-induced protein 30.922
Apcadenomatosis polyposis coli0.919
Stat5asignal transducer and activator of transcription 5A0.910
Zeb1zinc finger E-box binding homeobox 10.910
Sox9SRY-box containing gene 90.907
Ptprcprotein tyrosine phosphatase, receptor type, C0.906
Rxraretinoid X receptor alpha0.901
Pitx2paired-like homeodomain transcription factor 20.897
Cd40CD40 antigen0.870
Stat5bsignal transducer and activator of transcription 5B0.860
Smad4MAD homolog 4 (Drosophila)0.834
Fgf10fibroblast growth factor 100.834
Shhsonic hedgehog0.833
Runx1runt related transcription factor 10.826
Bcl6B-cell leukemia/lymphoma 60.819
Sfpi1SFFV proviral integration 10.818
Cd247CD247 antigen0.808
Stat6signal transducer and activator of transcription 60.791
Trp53transformation related protein 530.790
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.769
Gata4GATA binding protein 40.751
Csf2rb2colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)0.746
Socs3suppressor of cytokine signaling 30.741
Bcl3B-cell leukemia/lymphoma 30.735
Il2rbinterleukin 2 receptor, beta chain0.730
Map3k14mitogen-activated protein kinase kinase kinase 140.727
Ptpn11protein tyrosine phosphatase, non-receptor type 110.726
Ccl2chemokine (C-C motif) ligand 20.726
Kitkit oncogene0.702
Batf3basic leucine zipper transcription factor, ATF-like 30.693
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.684
Il2rginterleukin 2 receptor, gamma chain0.670
Gli3GLI-Kruppel family member GLI30.664
Abl1c-abl oncogene 1, non-receptor tyrosine kinase0.658
Pgrprogesterone receptor0.647
Foxp3forkhead box P30.635
Irf9interferon regulatory factor 90.631
Latlinker for activation of T cells0.623
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.621
Nf1neurofibromatosis 10.606
FynFyn proto-oncogene0.604
Creb1cAMP responsive element binding protein 10.582
Twist2twist homolog 2 (Drosophila)0.571
Irf8interferon regulatory factor 80.562
Cd28CD28 antigen0.550
Pxnpaxillin0.549
Ltalymphotoxin A0.534
Cishcytokine inducible SH2-containing protein0.529
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.523
Dysfdysferlin0.522
TcraT-cell receptor alpha chain0.521
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.517
Foxn1forkhead box N10.516
Bmp4bone morphogenetic protein 40.511
Hoxd13homeobox D130.503
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.500
Csf1colony stimulating factor 1 (macrophage)0.499
Ptgs2prostaglandin-endoperoxide synthase 20.493
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.484
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.481
Atxn1ataxin 10.469
Nodalnodal0.465
Stat2signal transducer and activator of transcription 20.464
Hhexhematopoietically expressed homeobox0.463
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.462
Pax2paired box gene 20.461
Il1binterleukin 1 beta0.459
Jak3Janus kinase 30.456
Prdm1PR domain containing 1, with ZNF domain0.446
Bmp2bone morphogenetic protein 20.444
Tgfbr3transforming growth factor, beta receptor III0.440
Col2a1collagen, type II, alpha 10.433
Csf2colony stimulating factor 2 (granulocyte-macrophage)0.430
Wt1Wilms tumor 1 homolog0.429
Batfbasic leucine zipper transcription factor, ATF-like0.427
Msx2homeobox, msh-like 20.422
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism