The network for 'negative regulation of peptide hormone secretion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of peptide hormone secretion

Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.

NameDescriptionProbabilityFunc Analog Organism
Abcc8ATP-binding cassette, subfamily C (CFTR/MRP), member 80.155
Chrna7cholinergic receptor, nicotinic, alpha 70.070
Kcnh2potassium voltage-gated channel, subfamily H (eag-related), member 20.068
Grk4G protein-coupled receptor kinase 40.067
Phkg1phosphorylase kinase, gamma 10.064
Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.063
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.056
Sqlesqualene epoxidase0.052
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.049
Kcnj5potassium inwardly-rectifying channel, subfamily J, member 50.049
Hivep2human immunodeficiency virus type I enhancer binding protein 20.047
Lepleptin0.044
Iappislet amyloid polypeptide0.044
Sox17SRY (sex determining region Y)-box 170.043
Gsg1lGSG1-like0.041
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.039
Avparginine vasopressin0.039
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.039
Camk2gcalcium/calmodulin-dependent protein kinase II gamma0.036
Begainbrain-enriched guanylate kinase-associated0.035
Dhrs7cdehydrogenase/reductase (SDR family) member 7C0.035
Rxrgretinoid X receptor gamma0.035
Notch3Notch homolog 3 (Drosophila)0.034
Apoa4apolipoprotein A-IV0.034
Sc4molsterol-C4-methyl oxidase-like0.033
HhipHedgehog-interacting protein0.033
Unc5aunc-5 homolog A (C. elegans)0.032
Kcnk3potassium channel, subfamily K, member 30.031
Sdc3syndecan 30.031
Hrh2histamine receptor H 20.030
Trhr2thyrotropin releasing hormone receptor 20.030
Atp2a3ATPase, Ca++ transporting, ubiquitous0.030
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.029
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.029
Slc18a3solute carrier family 18 (vesicular acetylcholine), member 30.029
Asgr1asialoglycoprotein receptor 10.029
Prlhrprolactin releasing hormone receptor0.028
Cortcortistatin0.027
Mef2dmyocyte enhancer factor 2D0.027
Cmklr1chemokine-like receptor 10.027
Cacng4calcium channel, voltage-dependent, gamma subunit 40.027
Grpgastrin releasing peptide0.027
Drd1adopamine receptor D1A0.026
Ghrgrowth hormone receptor0.026
Hrh3histamine receptor H30.026
Obp3alpha-2u globulin PGCL40.026
Il9interleukin 90.026
Gnb3guanine nucleotide binding protein (G protein), beta polypeptide 30.025
Crhbpcorticotropin releasing hormone binding protein0.025
Lhbluteinizing hormone beta0.024
LOC100360919Immunoglobulin lambda-like polypeptide 1-like0.024
Gh1growth hormone 10.024
Dmrta1DMRT-like family A10.024
Pecam1platelet/endothelial cell adhesion molecule 10.024
Rhorhodopsin0.024
SeboxSEBOX homeobox0.024
Glp1rglucagon-like peptide 1 receptor0.024
Foxd4forkhead box D40.023
Dccdeleted in colorectal carcinoma0.023
Enpepglutamyl aminopeptidase0.023
Gpr1G protein-coupled receptor 10.023
Mipmajor intrinsic protein of lens fiber0.023
Mpp2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)0.023
Cyp51cytochrome P450, family 510.023
Magohmago-nashi homolog, proliferation-associated (Drosophila)0.023
Acrv1acrosomal vesicle protein 10.022
Grin1glutamate receptor, ionotropic, N-methyl D-aspartate 10.022
Grm7glutamate receptor, metabotropic 70.022
Fat2FAT tumor suppressor homolog 2 (Drosophila)0.022
LOC100360587hypothetical protein LOC1003605870.022
Rab3bRAB3B, member RAS oncogene family0.022
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 10.022
Gabrr1gamma-aminobutyric acid (GABA) receptor, rho 10.021
Adra2cadrenergic, alpha-2C-, receptor0.021
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.021
Gpr6G protein-coupled receptor 60.021
Grifingalectin-related inter-fiber protein0.020
Mep1ameprin 1 alpha0.020
Pik3r1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.020
VgfVGF nerve growth factor inducible0.020
Prl2a1Prolactin family 2, subfamily a, member 10.020
Ppyr1pancreatic polypeptide receptor 10.020
Lifrleukemia inhibitory factor receptor alpha0.020
Cyp2c11cytochrome P450, subfamily 2, polypeptide 110.019
Krt31keratin 310.019
Nrg2neuregulin 20.019
Grb2growth factor receptor bound protein 20.019
Cntfrciliary neurotrophic factor receptor0.019
Acat3acetyl-Coenzyme A acetyltransferase 30.019
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.018
Pfkfb46-phosphofructo-2-kinase/fructose-2,6-biphosphatase 40.018
Thrspthyroid hormone responsive0.018
Tpcr12putative olfactory receptor0.018
A2bp1ataxin 2 binding protein 10.018
Neurod2neurogenic differentiation 20.018
Grm5glutamate receptor, metabotropic 50.017
Rhbdl1rhomboid, veinlet-like 1 (Drosophila)0.017
Eporerythropoietin receptor0.017
Slc8a3solute carrier family 8 (sodium/calcium exchanger), member 30.017
Grm6glutamate receptor, metabotropic 60.017
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
IppInositol polyphosphate 1-phosphatase0.129
DatDopamine N acetyltransferase0.112
Irk3Inwardly rectifying potassium channel 30.069
myoglianinCG1838 gene product from transcript CG1838-RD0.069
ActbetaActivin-beta0.057
GABA-B-R2metabotropic GABA-B receptor subtype 20.057
Plc21CPhospholipase C at 21C0.044
cv-2crossveinless 20.042
svrsilver0.036
Pde8Phosphodiesterase 80.035
foxoforkhead box, sub-group O0.032
rutrutabaga0.030
SNF4AgammaSNF4/AMP-activated protein kinase gamma subunit0.028
Gadd45CG11086 gene product from transcript CG11086-RA0.027
Irk2Inwardly rectifying potassium channel 20.026
5-HT1BSerotonin receptor 1B0.023
HDAC4CG1770 gene product from transcript CG1770-RE0.023
cln3CG5582 gene product from transcript CG5582-RA0.022
rho-5rhomboid-50.021
cnkconnector enhancer of ksr0.021
dncdunce0.021
CG42574CG42574 gene product from transcript CG42574-RE0.020
TbhTyramine beta hydroxylase0.020
trbltribbles0.020
mttmangetout0.019
CG42369CG42369 gene product from transcript CG42369-RA0.019
tldtolloid0.019
NPFR1neuropeptide F receptor0.019
ShawShaker cognate w0.018
KCNQKCNQ potassium channel0.018
GABA-B-R3metabotropic GABA-B receptor subtype 30.018
Glut1Glucose transporter 10.018
rlrolled0.018
Eaat1Excitatory amino acid transporter 10.017
trktrunk0.017
SmoxSmad on X0.017
HLH106Helix loop helix protein 1060.016
CG10200CG10200 gene product from transcript CG10200-RB0.016
CG34139CG34139 gene product from transcript CG34139-RD0.016
Fer2LCHFerritin 2 light chain homologue0.016
Atg9Autophagy-specific gene 90.016
eyeyeless0.016
EfrER GDP-fucose transporter0.015
Eip63F-1Ecdysone-induced protein 63F 10.015
SlnSilnoon0.015
Nmdar1NMDA receptor 10.015
CG12001CG12001 gene product from transcript CG12001-RA0.015
drddrop dead0.015
nudECG8104 gene product from transcript CG8104-RB0.015
klgklingon0.015
CG33289CG33289 gene product from transcript CG33289-RA0.015
qtcquick-to-court0.015
CG8907CG8907 gene product from transcript CG8907-RA0.015
lillililliputian0.014
shfshifted0.014
egreiger0.014
beat-Icbeaten path Ic0.014
CG42629CG42629 gene product from transcript CG42629-RB0.014
nubnubbin0.014
Doc2Dorsocross20.013
tsgtwisted gastrulation0.013
CG10426CG10426 gene product from transcript CG10426-RA0.013
pdfrPDF receptor0.013
pumpumilio0.013
jebjelly belly0.013
timtimeless0.013
HERC2CG11734 gene product from transcript CG11734-RC0.013
netCG11450 gene product from transcript CG11450-RB0.013
CG13636CG13636 gene product from transcript CG13636-RB0.013
witwishful thinking0.012
Pka-R2cAMP-dependent protein kinase R20.012
RFeSPRieske iron-sulfur protein0.012
dnr1defense repressor 10.012
Spn77BaSerpin 77Ba0.012
Ac76EAdenylyl cyclase 76E0.012
sloslowpoke0.012
CG1265CG1265 gene product from transcript CG1265-RB0.012
GLazGlial Lazarillo0.011
CG16884CG16884 gene product from transcript CG16884-RA0.011
Pdp1PAR-domain protein 10.011
nordCG30418 gene product from transcript CG30418-RA0.011
tauCG31057 gene product from transcript CG31057-RA0.011
otuovarian tumor0.011
beat-Iabeaten path Ia0.011
tkvthickveins0.011
PGRP-LFPeptidoglycan recognition protein LF0.011
InRInsulin-like receptor0.011
TequilaCG4821 gene product from transcript CG4821-RE0.011
Octbeta2RCG33976 gene product from transcript CG33976-RA0.011
bab2CG9102 gene product from transcript CG9102-RA0.011
Gr28bGustatory receptor 28b0.011
unc-104CG8566 gene product from transcript CG8566-RB0.010
beben0.010
Nmdar2NMDA receptor 20.010
Ac3CG1506 gene product from transcript CG1506-RA0.010
Ilp2Insulin-like peptide 20.010
S6kIIRPS6-protein kinase-II0.010
bynbrachyenteron0.010
RicRas which interacts with Calmodulin0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
GRB10growth factor receptor-bound protein 100.749
LIN7Blin-7 homolog B (C. elegans)0.668
KCNE1potassium voltage-gated channel, Isk-related family, member 10.643
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.417
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.392
VAC14Vac14 homolog (S. cerevisiae)0.375
INSRinsulin receptor0.324
MPDZmultiple PDZ domain protein0.305
CRHR1corticotropin releasing hormone receptor 10.292
GABBR1gamma-aminobutyric acid (GABA) B receptor, 10.249
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.119
ZNF746zinc finger protein 7460.101
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.098
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.097
BMPR1Bbone morphogenetic protein receptor, type IB0.079
PTPN1protein tyrosine phosphatase, non-receptor type 10.073
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.059
KCNJ5potassium inwardly-rectifying channel, subfamily J, member 50.047
ABCC8ATP-binding cassette, sub-family C (CFTR/MRP), member 80.047
NSFN-ethylmaleimide-sensitive factor0.046
MED15mediator complex subunit 150.041
GAB1GRB2-associated binding protein 10.039
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.035
KCNJ11potassium inwardly-rectifying channel, subfamily J, member 110.034
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.032
IRS1insulin receptor substrate 10.032
CHRNA4cholinergic receptor, nicotinic, alpha 40.031
MTNR1Amelatonin receptor 1A0.030
ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 10.027
KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)0.026
GPR6G protein-coupled receptor 60.024
PPP3R1protein phosphatase 3, regulatory subunit B, alpha0.023
ARRDC3arrestin domain containing 30.022
KCNJ16potassium inwardly-rectifying channel, subfamily J, member 160.021
GJD2gap junction protein, delta 2, 36kDa0.021
SH3GL3SH3-domain GRB2-like 30.020
RASGRF1Ras protein-specific guanine nucleotide-releasing factor 10.019
DRD2dopamine receptor D20.018
DLGAP2discs, large (Drosophila) homolog-associated protein 20.017
NOGnoggin0.017
KCNJ3potassium inwardly-rectifying channel, subfamily J, member 30.017
BMP8Abone morphogenetic protein 8a0.016
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.016
NCOR1nuclear receptor corepressor 10.016
SREBF2sterol regulatory element binding transcription factor 20.015
NPY2Rneuropeptide Y receptor Y20.014
SH2B1SH2B adaptor protein 10.014
GPR50G protein-coupled receptor 500.014
ATP2B2ATPase, Ca++ transporting, plasma membrane 20.014
SSTR3somatostatin receptor 30.012
KCNJ10potassium inwardly-rectifying channel, subfamily J, member 100.012
TBC1D10ATBC1 domain family, member 10A0.012
IRS2insulin receptor substrate 20.011
GAD2glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)0.011
WNT2wingless-type MMTV integration site family member 20.011
HTR2A5-hydroxytryptamine (serotonin) receptor 2A0.011
AVPR1Barginine vasopressin receptor 1B0.011
PLEKHA1pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 10.010
PXMP2peroxisomal membrane protein 2, 22kDa0.010
SLC6A5solute carrier family 6 (neurotransmitter transporter, glycine), member 50.010
DLGAP1discs, large (Drosophila) homolog-associated protein 10.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Lepleptin0.970
Esr1estrogen receptor 1 (alpha)0.868
Tgfb1transforming growth factor, beta 10.829
Ptenphosphatase and tensin homolog0.824
Leprleptin receptor0.809
Ptpn11protein tyrosine phosphatase, non-receptor type 110.737
Nos3nitric oxide synthase 3, endothelial cell0.692
Apcadenomatosis polyposis coli0.561
Ghrgrowth hormone receptor0.526
Fshrfollicle stimulating hormone receptor0.526
LOC100048884novel member of the major urinary protein (Mup) gene family0.490
Insrinsulin receptor0.455
Tgfbr2transforming growth factor, beta receptor II0.412
Esr2estrogen receptor 2 (beta)0.367
Fstfollistatin0.365
Cyp19a1cytochrome P450, family 19, subfamily a, polypeptide 10.299
Mup10major urinary protein 100.281
Mup19major urinary protein 190.272
Prlrprolactin receptor0.258
Amhr2anti-Mullerian hormone type 2 receptor0.255
Gata4GATA binding protein 40.247
Trp53transformation related protein 530.226
Kiss1KiSS-1 metastasis-suppressor0.226
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.222
Cav1caveolin 1, caveolae protein0.221
Nr3c1nuclear receptor subfamily 3, group C, member 10.212
Vegfavascular endothelial growth factor A0.210
Mup9major urinary protein 90.201
Pim3proviral integration site 30.186
Ldlrlow density lipoprotein receptor0.173
Arandrogen receptor0.168
Irs2insulin receptor substrate 20.166
Mup8major urinary protein 80.164
Plin1perilipin 10.130
Tgfbr1transforming growth factor, beta receptor I0.128
Mup12major urinary protein 120.126
Mup1major urinary protein 10.126
Nf1neurofibromatosis 10.123
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.107
Pim2proviral integration site 20.106
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.106
Pomcpro-opiomelanocortin-alpha0.103
Nos2nitric oxide synthase 2, inducible0.097
Mup13major urinary protein 130.096
Mup3major urinary protein 30.092
Mup17major urinary protein 170.092
Mup14major urinary protein 140.091
LOC100048885major urinary protein LOC1000488850.084
Pim1proviral integration site 10.082
Mup2major urinary protein 20.079
Mup7major urinary protein 70.076
Mup15major urinary protein 150.076
Ncoa3nuclear receptor coactivator 30.074
Prkg1protein kinase, cGMP-dependent, type I0.074
Ppargperoxisome proliferator activated receptor gamma0.073
Mup11major urinary protein 110.071
Ctnnb1catenin (cadherin associated protein), beta 10.068
Nos1nitric oxide synthase 1, neuronal0.068
Igf1insulin-like growth factor 10.064
Lhcgrluteinizing hormone/choriogonadotropin receptor0.064
Drd2dopamine receptor D20.062
Cdkn1bcyclin-dependent kinase inhibitor 1B0.059
Sfrp2secreted frizzled-related protein 20.059
Apoeapolipoprotein E0.057
Pnpla2patatin-like phospholipase domain containing 20.055
U46068cDNA sequence U460680.054
Ern2endoplasmic reticulum (ER) to nucleus signalling 20.052
Csf1colony stimulating factor 1 (macrophage)0.048
Crhcorticotropin releasing hormone0.046
Mstnmyostatin0.046
Svs5seminal vesicle secretory protein 50.043
Shc1src homology 2 domain-containing transforming protein C10.042
Smad4MAD homolog 4 (Drosophila)0.042
WwoxWW domain-containing oxidoreductase0.040
Cideccell death-inducing DFFA-like effector c0.040
Nodalnodal0.040
Mup5major urinary protein 50.040
Smad3MAD homolog 3 (Drosophila)0.038
Gata6GATA binding protein 60.036
Mup4major urinary protein 40.036
Gja1gap junction protein, alpha 10.036
Sik3SIK family kinase 30.036
Col1a1collagen, type I, alpha 10.035
Klk1b26kallikrein 1-related petidase b260.033
Bmpr1abone morphogenetic protein receptor, type 1A0.032
Adipoqadiponectin, C1Q and collagen domain containing0.031
Pck1phosphoenolpyruvate carboxykinase 1, cytosolic0.031
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.031
Cyp11b1cytochrome P450, family 11, subfamily b, polypeptide 10.030
Mbl1mannose-binding lectin (protein A) 10.029
Inhbainhibin beta-A0.028
Vav2vav 2 oncogene0.028
Cd70CD70 antigen0.027
En1engrailed 10.026
Rxraretinoid X receptor alpha0.026
Accn5amiloride-sensitive cation channel 5, intestinal0.025
Egfrepidermal growth factor receptor0.025
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.024
Jag1jagged 10.024
Htr45 hydroxytryptamine (serotonin) receptor 40.023
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism