The network for 'regulation of catalytic activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of catalytic activity

Any process that modulates the activity of an enzyme.

NameDescriptionProbabilityFunc Analog Organism
JunJun oncogene0.621
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.608
Junbjun B proto-oncogene0.605
Zfp36zinc finger protein 360.569
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.552
Hsph1heat shock 105/110 protein 10.518
Utrnutrophin0.503
Ccnd1cyclin D10.499
Calcrlcalcitonin receptor-like0.498
Epas1endothelial PAS domain protein 10.492
Pip4k2bphosphatidylinositol-5-phosphate 4-kinase, type II, beta0.458
Arpc1bactin related protein 2/3 complex, subunit 1B0.447
Tgfb1transforming growth factor, beta 10.426
Clic4chloride intracellular channel 40.406
Creb1cAMP responsive element binding protein 10.397
Homer3homer homolog 3 (Drosophila)0.393
Sirpasignal-regulatory protein alpha0.385
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.385
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.384
Dact3dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)0.381
Cd40lgCD40 ligand0.380
Fgfr1Fibroblast growth factor receptor 10.377
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.352
Sdc3syndecan 30.352
Adam17ADAM metallopeptidase domain 170.351
FosFBJ osteosarcoma oncogene0.348
Rhoaras homolog gene family, member A0.339
Drd2dopamine receptor D20.339
Myo1bmyosin Ib0.339
Dusp1dual specificity phosphatase 10.337
Avparginine vasopressin0.332
Nrp2neuropilin 20.322
Cmklr1chemokine-like receptor 10.313
Ripk3receptor-interacting serine-threonine kinase 30.310
Rgs12regulator of G-protein signaling 120.309
Ptpn18protein tyrosine phosphatase, non-receptor type 180.305
Anxa2annexin A20.304
Tle4transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)0.302
Ifitm3interferon induced transmembrane protein 30.297
Slc9a1solute carrier family 9 (sodium/hydrogen exchanger), member 10.295
Lnpepleucyl/cystinyl aminopeptidase0.291
Exoc5exocyst complex component 50.287
Spink1serine peptidase inhibitor, Kazal type 10.285
Klf6Kruppel-like factor 60.284
Kcna3potassium voltage-gated channel, shaker-related subfamily, member 30.284
Ppp1r9bprotein phosphatase 1, regulatory subunit 9B0.283
Rup2urinary protein 20.283
Hspa1aheat shock 70kD protein 1A0.281
Lphn2latrophilin 20.278
Cd48Cd48 molecule0.278
Gna12guanine nucleotide binding protein (G protein) alpha 120.278
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.277
Mpeg1macrophage expressed 10.276
Id3inhibitor of DNA binding 30.276
Il1r1interleukin 1 receptor, type I0.276
Cdc42bpbCDC42 binding protein kinase beta (DMPK-like)0.275
Golph3golgi phosphoprotein 3 (coat-protein)0.275
Hckhemopoietic cell kinase0.273
Agap3ArfGAP with GTPase domain, ankyrin repeat and PH domain 30.272
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.268
Htr2b5-hydroxytryptamine (serotonin) receptor 2B0.268
Olr416olfactory receptor 4160.267
Vimvimentin0.267
Tgfbr2transforming growth factor, beta receptor II0.267
Dnaja1DnaJ (Hsp40) homolog, subfamily A, member 10.265
Trib1tribbles homolog 1 (Drosophila)0.265
Slc6a6solute carrier family 6 (neurotransmitter transporter, taurine), member 60.264
Pik3r2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.264
C3complement component 30.264
Abcc8ATP-binding cassette, subfamily C (CFTR/MRP), member 80.263
Dnajb1DnaJ (Hsp40) homolog, subfamily B, member 10.263
Ccr5chemokine (C-C motif) receptor 50.261
Csnk1a1casein kinase 1, alpha 10.258
Btg2BTG family, member 20.257
Gabrb3gamma-aminobutyric acid (GABA) A receptor, beta 30.256
Ddr1discoidin domain receptor tyrosine kinase 10.256
Kcng2potassium voltage-gated channel, subfamily G, member 20.253
Agtr1aangiotensin II receptor, type 1a0.253
RGD1308350similar to hypothetical protein MGC132510.252
Fgafibrinogen alpha chain0.251
Sept3septin 30.249
Acvr1activin A receptor, type I0.249
Dynlt1dynein light chain Tctex-type 10.247
Slc25a3solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 30.247
Fkbp1aFK506 binding protein 1a0.243
Dynll1dynein light chain LC8-type 10.242
Hivep2human immunodeficiency virus type I enhancer binding protein 20.241
KitlgKIT ligand0.238
Il8rainterleukin 8 receptor, alpha0.236
Homer1homer homolog 1 (Drosophila)0.235
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.235
Adrb1adrenergic, beta-1-, receptor0.234
Procprotein C0.234
Map3k8mitogen-activated protein kinase kinase kinase 80.234
Jak2Janus kinase 20.233
Scn7asodium channel, voltage-gated, type VII, alpha0.230
Vcanversican0.230
Fgf18fibroblast growth factor 180.230
Pik3r3phosphoinositide-3-kinase, regulatory subunit 3 (gamma)0.230
S100a8S100 calcium binding protein A80.228
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
nlg-1Protein NLG-10.433
sur-2Protein SUR-20.288
mbk-2Protein MBK-20.284
nhr-45Protein NHR-450.270
vab-3Protein VAB-30.244
skn-1Protein SKN-10.237
xpo-1Protein XPO-10.219
mpk-1Protein MPK-10.212
plk-1Protein PLK-10.195
par-3Protein PAR-30.172
egl-8Protein EGL-80.162
inx-3Protein INX-30.156
C11E4.6Protein C11E4.60.146
pkc-3Protein PKC-30.139
egl-18Protein EGL-180.137
mcm-2Protein MCM-20.130
fln-2Protein FLN-20.129
egal-1Protein EGAL-10.127
sqv-4Protein SQV-40.125
tbb-1Protein TBB-10.124
unc-43Protein UNC-430.120
bar-1Protein BAR-10.116
unc-53Protein UNC-530.113
tmc-2Protein TMC-20.111
mrck-1Protein MRCK-10.109
lag-1Protein LAG-10.103
nhr-6Protein NHR-60.102
zyg-9Protein ZYG-90.101
CELE_W02D7.5Protein W02D7.50.101
sem-5Protein SEM-50.100
scc-3Protein SCC-30.099
unc-79Protein UNC-790.096
magi-1Protein MAGI-10.096
ttx-1Protein TTX-10.095
sma-6Protein SMA-60.091
icd-1Protein ICD-10.090
fut-3Protein FUT-30.089
icp-1Protein ICP-10.087
par-5Protein PAR-50.087
mec-2Protein MEC-20.087
tol-1Protein TOL-10.087
atg-2Protein ATG-20.085
mes-3Protein MES-30.085
npp-23Protein NPP-230.085
C48B6.3Protein C48B6.30.084
smp-1Protein SMP-10.084
cyc-1Protein CYC-10.084
rps-2Protein RPS-20.083
plc-1Protein PLC-10.083
pup-2Protein PUP-20.083
unc-15Protein UNC-150.083
daf-21Protein DAF-210.082
unc-26Protein UNC-260.081
kle-2Protein KLE-20.079
C49A1.10Protein C49A1.100.078
bet-2Protein BET-20.077
lin-36Protein LIN-360.076
kal-1Protein KAL-10.076
unc-71Protein UNC-710.075
F39B2.1Protein F39B2.10.075
inx-13Protein INX-130.075
rhgf-2Protein RHGF-20.075
itr-1Protein ITR-10.074
C28H8.1Protein C28H8.10.073
atp-2Protein ATP-20.073
mel-26Protein MEL-260.072
cam-1Protein CAM-10.072
F52A8.1Protein F52A8.10.072
atx-3Protein ATX-30.072
egg-6Protein EGG-60.072
inx-1Protein INX-10.072
gei-18Protein GEI-180.071
dnj-16Protein DNJ-160.071
atg-11Protein ATG-110.070
W05F2.6Protein W05F2.60.070
dars-1Protein DARS-10.070
dpf-3Protein DPF-30.070
imb-2Protein IMB-20.070
rskn-1Protein RSKN-10.069
dpy-21Protein DPY-210.069
sup-17Protein SUP-170.069
mig-38Protein MIG-380.069
cct-4Protein CCT-40.069
F49D11.10Protein F49D11.100.069
unc-47Protein UNC-470.068
sel-8Protein SEL-80.068
cks-1Protein CKS-10.068
csn-1Protein CSN-10.066
pig-1Protein PIG-10.066
pdr-1Protein PDR-10.065
unc-52Protein UNC-520.065
chc-1Protein CHC-10.065
F29B9.11Protein F29B9.110.065
daf-6Protein DAF-60.064
F28B3.1Protein F28B3.10.064
eps-8Protein EPS-80.063
mom-2Protein MOM-20.062
zyg-1Protein ZYG-10.062
ten-1Protein TEN-10.062
ergo-1Protein ERGO-10.062
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
wnt2bbwingless-type MMTV integration site family, member 2Bb0.815
spry4sprouty (Drosophila) homolog 40.611
cx43connexin 430.548
gro1groucho 10.330
fgf3fibroblast growth factor 30.323
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.304
fosv-fos FBJ murine osteosarcoma viral oncogene homolog0.281
pitx3paired-like homeodomain transcription factor 30.270
thtyrosine hydroxylase0.256
appbamyloid beta (A4) precursor protein b0.232
dag1dystroglycan 10.219
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.199
fn1fibronectin 10.192
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.191
foxa2forkhead box A20.190
adra2cadrenergic, alpha-2C-, receptor0.184
socs3asuppressor of cytokine signaling 3a0.183
gata5GATA-binding protein 50.177
bmp1abone morphogenetic protein 1a0.177
fabp2fatty acid binding protein 2, intestinal0.177
penkaproenkephalin a0.176
twist1atwist1a0.176
rarabretinoic acid receptor, alpha b0.176
spry2sprouty homolog 20.173
sox11aSRY-box containing gene 11a0.166
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.161
eif3haeukaryotic translation initiation factor 3, subunit H, a0.160
lmx1b.1LIM homeobox transcription factor 1, beta 10.159
cyp19a1acytochrome P450, family 19, subfamily A, polypeptide 1a0.157
junjun proto-oncogene0.155
plcg1phospholipase C, gamma 10.154
wnt5bwingless-type MMTV integration site family, member 5b0.151
plxnb2aplexin b2a0.150
wnt1wingless-type MMTV integration site family, member 10.149
tgfb3transforming growth factor, beta 30.145
mycbp2MYC binding protein 20.143
bhmtbetaine-homocysteine methyltransferase0.142
avplarginine vasopressin-like0.141
wt1bwilms tumor 1b0.140
atf3activating transcription factor 30.136
dip2cDIP2 disco-interacting protein 2 homolog C (Drosophila)0.136
bidaBH3 interacting domain death agonist0.132
terttelomerase reverse transcriptase0.132
gadd45bbgrowth arrest and DNA-damage-inducible, beta b0.130
cyp19a1bcytochrome P450, family 19, subfamily A, polypeptide 1b0.129
ighmimmunoglobulin heavy constant mu and immunoglobulin heavy constant mu0.127
oxtloxytocin-like0.126
crhcorticotropin releasing hormone0.124
mgaMAX gene associated0.123
dzip1DAZ interacting protein 10.121
her6hairy-related 60.121
dkk1bdickkopf 1b0.120
nadl1.2neural adhesion molecule L1.20.120
ghragrowth hormone receptor a0.120
inspreproinsulin0.119
wu:fb58e05wu:fb58e050.117
cebpdCCAAT/enhancer binding protein (C/EBP), delta0.117
sox11bSRY-box containing gene 11b0.116
fgfr1afibroblast growth factor receptor 1a0.116
shhasonic hedgehog a0.114
wnt8bwingless-type MMTV integration site family, member 8b0.114
ascl1aachaete-scute complex-like 1a (Drosophila)0.113
fbp1bfructose-1,6-bisphosphatase 1b0.112
flhfloating head0.110
adra2badrenergic, alpha-2B-, receptor0.108
sec23aSec23 homolog A (S. cerevisiae)0.108
egr1early growth response 10.106
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.105
fzd7bfrizzled homolog 7b0.105
zbtb4zinc finger and BTB domain containing 40.104
tnfrsfatumor necrosis factor receptor superfamily, member a0.103
prkciprotein kinase C, iota0.102
adrb2aadrenergic receptor, beta 2a0.102
sfrp5secreted frizzled-related protein 50.101
junbjun B proto-oncogene0.100
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.099
gpc4glypican 40.097
sulf1sulfatase 10.097
pak1p21/Cdc42/Rac1-activated kinase 10.095
rrasrelated RAS viral (r-ras) oncogene homolog0.095
sox7SRY-box containing gene 70.095
ptrfbpolymerase I and transcript release factor b0.095
LOC566708FL cytokine receptor-like0.094
mstnbmyostatin b0.094
otpaorthopedia homolog a0.093
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.092
calcrlacalcitonin receptor-like a0.092
foxp2forkhead box P20.091
smyhc2slow myosin heavy chain 20.090
ccng1cyclin G10.090
rnd3aRho family GTPase 3a0.090
wnt10awingless-type MMTV integration site family, member 10a0.089
pvrl1bpoliovirus receptor-related 1b0.088
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.088
lef1lymphocyte enhancer binding factor 10.087
hmgb2bhigh-mobility group box 2b0.086
disp1dispatched homolog 1 (Drosophila)0.085
cdh1cadherin 1, epithelial0.085
ywhaqbtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b0.085
si:dkeyp-22b2.3si:dkeyp-22b2.30.084
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
rlrolled0.975
Ras85DRas oncogene at 85D0.924
Akt1CG4006 gene product from transcript CG4006-RA0.910
Rac1CG2248 gene product from transcript CG2248-RA0.870
shnschnurri0.806
twstwins0.763
Pi3K92ECG4141 gene product from transcript CG4141-RB0.748
Rac2CG8556 gene product from transcript CG8556-RA0.693
Stat92ESignal-transducer and activator of transcription protein at 92E0.681
StimStromal interaction molecule0.624
rheaCG6831 gene product from transcript CG6831-RA0.616
flwflapwing0.610
Src42ASrc oncogene at 42A0.598
KhcKinesin heavy chain0.572
par-1CG8201 gene product from transcript CG8201-RA0.560
Sra-1specifically Rac1-associated protein 10.546
rokRho-kinase0.526
p120ctnAdherens junction protein p1200.523
CakiCalcium/calmodulin-dependent protein kinase0.514
Dcr-2Dicer-20.493
dncdunce0.489
Atg1Autophagy-specific gene 10.481
fzfrizzled0.481
enaenabled0.465
dysdysfusion0.456
ShawShaker cognate w0.454
pucpuckered0.451
Liprin-alphaCG11199 gene product from transcript CG11199-RB0.447
Cip4CG15015 gene product from transcript CG15015-RA0.437
EgfrEpidermal growth factor receptor0.428
S6kIIRPS6-protein kinase-II0.422
nmonemo0.415
Fmr1CG6203 gene product from transcript CG6203-RC0.415
Rho1CG8416 gene product from transcript CG8416-RB0.410
slprslipper0.408
CycACyclin A0.404
Pk61CProtein kinase 61C0.394
MerMerlin0.385
Sin3ACG8815 gene product from transcript CG8815-RC0.377
kuzkuzbanian0.377
slmbsupernumerary limbs0.375
AblAbl tyrosine kinase0.372
Smg1CG32743 gene product from transcript CG32743-RA0.371
tkvthickveins0.364
spasspastin0.364
PknProtein kinase related to protein kinase N0.360
G-ialpha65AG protein alphai subunit 65A0.349
CkIIalphaCasein kinase II alpha subunit0.343
hephemipterous0.343
Dap160Dynamin associated protein 1600.336
PtenCG5671 gene product from transcript CG5671-RB0.332
CaMKIICalcium/calmodulin-dependent protein kinase II0.327
rutrutabaga0.322
bazbazooka0.318
prosprospero0.317
CycECyclin E0.315
chicchickadee0.314
Plc21CPhospholipase C at 21C0.311
bonbonus0.310
S6kRPS6-p70-protein kinase0.307
Uba1Ubiquitin activating enzyme 10.303
nejnejire0.295
neurneuralized0.291
cazcabeza0.285
HLHmdeltaE(spl) region transcript mdelta0.282
jarjaguar0.280
maskmultiple ankyrin repeats single KH domain0.280
foxoforkhead box, sub-group O0.276
InRInsulin-like receptor0.269
numbCG3779 gene product from transcript CG3779-RB0.264
AGO2Argonaute 20.264
PakPAK-kinase0.264
Ras64BRas oncogene at 64B0.262
eyeyeless0.260
mbtmushroom bodies tiny0.253
drkdownstream of receptor kinase0.245
RhoBTBCG5701 gene product from transcript CG5701-RA0.243
dmdiminutive0.242
tsrtwinstar0.240
RhebCG1081 gene product from transcript CG1081-RA0.239
RbfRetinoblastoma-family protein0.233
ththread0.231
fogfolded gastrulation0.226
stcksteamer duck0.225
msnmisshapen0.222
eIF-4EEukaryotic initiation factor 4E0.219
Su(H)Suppressor of Hairless0.218
CblCG7037 gene product from transcript CG7037-RB0.214
G-oalpha47AG protein oalpha 47A0.213
CG9339CG9339 gene product from transcript CG9339-RG0.213
wtswarts0.212
trbltribbles0.211
EcREcdysone receptor0.210
ykiyorkie0.209
babobaboon0.208
Cul-3Cullin-30.208
cindrCIN85 and CD2AP orthologue0.205
Sema-2aCG4700 gene product from transcript CG4700-RC0.204
SaraSmad anchor for receptor activation0.199
Sas-4CG10061 gene product from transcript CG10061-RA0.199
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
CKS1Cks1p0.774
SIC1Sic1p0.740
NBP2Nbp2p0.593
STE11Ste11p0.590
STE4Ste4p0.587
ROM2Rom2p0.559
SLT2Slt2p0.559
NAP1Nap1p0.550
HSL1Hsl1p0.505
HSP82Hsp82p0.488
PBS2Pbs2p0.453
CLB3Clb3p0.440
MYO5Myo5p0.426
CDC12Cdc12p0.388
STI1Sti1p0.381
TOR1Tor1p0.376
DBF2Dbf2p0.323
SDS22Sds22p0.322
SSK2Ssk2p0.321
PCL9Pcl9p0.318
YME1Yme1p0.304
RHO1Rho1p0.293
CDC48Cdc48p0.288
RAS2Ras2p0.280
FAR1Far1p0.278
CDC28Cdc28p0.263
MKK1Mkk1p0.259
SSN8Ssn8p0.250
TSC11Tsc11p0.244
CDC24Cdc24p0.239
GPH1Gph1p0.238
MOB2Mob2p0.236
CAK1Cak1p0.233
SSK1Ssk1p0.229
CLN3Cln3p0.226
PRK1Prk1p0.223
SHO1Sho1p0.222
GLC7Glc7p0.219
CLB2Clb2p0.215
AHP1Ahp1p0.210
BCK2Bck2p0.206
RAD53Rad53p0.206
YPT53Ypt53p0.203
MRC1Mrc1p0.201
SWE1Swe1p0.200
RPP1BRpp1bp0.197
CDC20Cdc20p0.195
CLB4Clb4p0.192
CDC6Cdc6p0.191
CRZ1Crz1p0.190
PSK1Psk1p0.190
CRN1Crn1p0.189
STE20Ste20p0.188
TRS65Trs65p0.187
CYK3Cyk3p0.184
ABP1Abp1p0.181
CLB5Clb5p0.180
GLC8Glc8p0.180
MPS1Mps1p0.180
GYL1Gyl1p0.178
GCS1Gcs1p0.176
MSG5Msg5p0.176
CIN8Cin8p0.176
PPH21Pph21p0.175
RDH54Rdh54p0.174
DPB2Dpb2p0.172
PHO85Pho85p0.171
GAL83Gal83p0.167
TPS1Tps1p0.165
BFR1Bfr1p0.162
MSB3Msb3p0.162
RLM1Rlm1p0.160
RAD59Rad59p0.160
SLA2Sla2p0.160
SIP1Sip1p0.159
TSR1Tsr1p0.158
CCT4Cct4p0.158
ATG18Atg18p0.158
LCB4Lcb4p0.155
PMS1Pms1p0.152
MOB1Mob1p0.151
NYV1Nyv1p0.150
MSH3Msh3p0.150
ASK10Ask10p0.149
CDC4Cdc4p0.149
SUI3Sui3p0.147
RAD52Rad52p0.147
SOD1Sod1p0.146
CHK1Chk1p0.145
COT1Cot1p0.145
UFO1Ufo1p0.145
PAM1Pam1p0.144
GDS1Gds1p0.143
PIN4Pin4p0.140
AIM20Aim20p0.140
NPL4Npl4p0.140
STE5Ste5p0.139
ATG3Atg3p0.139
VAC8Vac8p0.138
ERP5Erp5p0.138