The network for 'low density lipoprotein particle clearance' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

low density lipoprotein particle clearance

The process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.

NameDescriptionProbabilityFunc Analog Organism
LOC100364265ribosomal protein L19-like0.178
Cd36CD36 molecule (thrombospondin receptor)0.010
Fabp4fatty acid binding protein 4, adipocyte0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
C1QAcomplement component 1, q subcomponent, A chain0.731
C1QCcomplement component 1, q subcomponent, C chain0.706
RBFOX1RNA binding protein, fox-1 homolog (C. elegans) 10.278
PCBP1poly(rC) binding protein 10.276
RBFOX2RNA binding protein, fox-1 homolog (C. elegans) 20.157
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.153
APOA1apolipoprotein A-I0.127
HNRNPA0heterogeneous nuclear ribonucleoprotein A00.121
KHDRBS1KH domain containing, RNA binding, signal transduction associated 10.118
PTBP2polypyrimidine tract binding protein 20.100
HNRNPH2heterogeneous nuclear ribonucleoprotein H2 (H')0.072
U2AF2U2 small nuclear RNA auxiliary factor 20.055
LDLRlow density lipoprotein receptor0.045
ANKFY1ankyrin repeat and FYVE domain containing 10.040
CIRBPcold inducible RNA binding protein0.033
HNRNPH3heterogeneous nuclear ribonucleoprotein H3 (2H9)0.032
DDX5DEAD (Asp-Glu-Ala-Asp) box polypeptide 50.030
DKK1dickkopf homolog 1 (Xenopus laevis)0.027
LRRK2leucine-rich repeat kinase 20.026
PCSK9proprotein convertase subtilisin/kexin type 90.026
QKIquaking homolog, KH domain RNA binding (mouse)0.024
HNRNPH1heterogeneous nuclear ribonucleoprotein H1 (H)0.024
SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesin0.023
DDX17DEAD (Asp-Glu-Ala-Asp) box polypeptide 170.021
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.019
PDIA3protein disulfide isomerase family A, member 30.019
RBMXRNA binding motif protein, X-linked0.019
PCBP2poly(rC) binding protein 20.018
C1QBcomplement component 1, q subcomponent, B chain0.018
TRAF5TNF receptor-associated factor 50.017
PRKCZprotein kinase C, zeta0.016
STON2stonin 20.015
MICALL1MICAL-like 10.014
ATXN1ataxin 10.014
FYNFYN oncogene related to SRC, FGR, YES0.014
MARCOmacrophage receptor with collagenous structure0.013
RHOGras homolog gene family, member G (rho G)0.012
MTAPmethylthioadenosine phosphorylase0.012
APOBapolipoprotein B (including Ag(x) antigen)0.011
APOEapolipoprotein E0.011
HNRNPUheterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)0.011
TOP1topoisomerase (DNA) I0.011
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Apoeapolipoprotein E0.908
Dab1disabled homolog 1 (Drosophila)0.836
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.539
Npc1Niemann Pick type C10.371
Bcl2B-cell leukemia/lymphoma 20.350
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.268
Mapk8ip1mitogen-activated protein kinase 8 interacting protein 10.208
Abca1ATP-binding cassette, sub-family A (ABC1), member 10.199
Mapk8ip2mitogen-activated protein kinase 8 interacting protein 20.167
Tbx3T-box 30.149
Apoa1apolipoprotein A-I0.148
Cav1caveolin 1, caveolae protein0.133
Ppargperoxisome proliferator activated receptor gamma0.111
Lrp1low density lipoprotein receptor-related protein 10.107
Gsk3bglycogen synthase kinase 3 beta0.102
Lrp8low density lipoprotein receptor-related protein 8, apolipoprotein e receptor0.087
Scd1stearoyl-Coenzyme A desaturase 10.087
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.081
Ldlrlow density lipoprotein receptor0.072
Axin1axin 10.071
Vegfavascular endothelial growth factor A0.068
Flt1FMS-like tyrosine kinase 10.064
Nphs2nephrosis 2 homolog, podocin (human)0.059
Crtc3CREB regulated transcription coactivator 30.044
Klf15Kruppel-like factor 150.040
Sertad2SERTA domain containing 20.039
Hsd3b7hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 70.037
Lpin1lipin 10.036
Fgfr3fibroblast growth factor receptor 30.033
Appamyloid beta (A4) precursor protein0.031
Vldlrvery low density lipoprotein receptor0.028
Hnrnph2heterogeneous nuclear ribonucleoprotein H20.027
Kcnj10potassium inwardly-rectifying channel, subfamily J, member 100.022
Ror2receptor tyrosine kinase-like orphan receptor 20.022
Lcatlecithin cholesterol acyltransferase0.022
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.021
Ehd4EH-domain containing 40.021
Vkorc1vitamin K epoxide reductase complex, subunit 10.021
Lrp5low density lipoprotein receptor-related protein 50.021
Pick1protein interacting with C kinase 10.020
Sqlesqualene epoxidase0.020
Agtr1aangiotensin II receptor, type 1a0.019
Hsd11b1hydroxysteroid 11-beta dehydrogenase 10.019
Osbpl8oxysterol binding protein-like 80.018
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.018
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.018
Mesdc2mesoderm development candidate 20.018
Lpllipoprotein lipase0.017
Smad6MAD homolog 6 (Drosophila)0.017
Lsslanosterol synthase0.017
Pofut1protein O-fucosyltransferase 10.017
Ddx5DEAD (Asp-Glu-Ala-Asp) box polypeptide 50.017
Psen1presenilin 10.016
Lrp6low density lipoprotein receptor-related protein 60.016
Myo1cmyosin IC0.015
Ptprbprotein tyrosine phosphatase, receptor type, B0.015
Ltbrlymphotoxin B receptor0.015
Cdh5cadherin 50.015
Sc4molsterol-C4-methyl oxidase-like0.015
Hmgcs13-hydroxy-3-methylglutaryl-Coenzyme A synthase 10.015
Gjb2gap junction protein, beta 20.015
Vangl2vang-like 2 (van gogh, Drosophila)0.014
Foxa2forkhead box A20.014
Cbx3chromobox homolog 3 (Drosophila HP1 gamma)0.014
Fabp4fatty acid binding protein 4, adipocyte0.014
Agtr2angiotensin II receptor, type 20.014
Foxa3forkhead box A30.013
Dhcr2424-dehydrocholesterol reductase0.013
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.013
Apaf1apoptotic peptidase activating factor 10.013
Srsf3serine/arginine-rich splicing factor 30.012
Ccl2chemokine (C-C motif) ligand 20.012
Cyp51cytochrome P450, family 510.012
Sox11SRY-box containing gene 110.012
Dkk1dickkopf homolog 1 (Xenopus laevis)0.012
Igfbp4insulin-like growth factor binding protein 40.012
Efemp2epidermal growth factor-containing fibulin-like extracellular matrix protein 20.012
Hnf4ahepatic nuclear factor 4, alpha0.012
H6pdhexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)0.011
Ehd3EH-domain containing 30.011
Txnipthioredoxin interacting protein0.011
Hnrnpdheterogeneous nuclear ribonucleoprotein D0.011
Dok1docking protein 10.011
Myl12bmyosin, light chain 12B, regulatory0.011
Egfrepidermal growth factor receptor0.010
Fn1fibronectin 10.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism