The network for 'regulation of natural killer cell mediated cytotoxicity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of natural killer cell mediated cytotoxicity

Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity.

NameDescriptionProbabilityFunc Analog Organism
RT1-EC2RT1 class Ib, locus EC20.987
Klrd1killer cell lectin-like receptor, subfamily D, member 10.596
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.539
RT1-CE12RT1 class I, locus CE120.294
Tap1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.197
Mmp12matrix metallopeptidase 120.124
Gzmbgranzyme B0.120
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.105
Nkg7natural killer cell group 7 sequence0.082
Rt1.aaMHC class I RT1.Aa alpha-chain0.057
Prf1perforin 1 (pore forming protein)0.052
Cd2Cd2 molecule0.047
Klrb1akiller cell lectin-like receptor subfamily B, member 1A0.041
Lgals3bplectin, galactoside-binding, soluble, 3 binding protein0.039
Gzmkgranzyme K0.037
Klra5killer cell lectin-like receptor, subfamily A, member 50.035
Sellselectin L0.032
Oas1a2'-5' oligoadenylate synthetase 1A0.032
RT1-S3RT1 class Ib, locus S30.030
Klra17killer cell lectin-like receptor, subfamily A, member 170.029
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.025
Cd8aCD8a molecule0.021
LOC100364500RT1 class I, locus CE11-like0.019
Neurl3neuralized homolog 3 (Drosophila)0.017
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.017
Cd247Cd247 molecule0.016
Ccr2chemokine (C-C motif) receptor 20.015
Mcpt8mast cell protease 80.014
Gimap4GTPase, IMAP family member 40.013
RT1-M3-1RT1 class Ib, locus M3, gene 10.013
Kmokynurenine 3-monooxygenase (kynurenine 3-hydroxylase)0.013
RT1-ClRT1 class Ib, locus Cl0.013
Ccl5chemokine (C-C motif) ligand 50.013
Apcsamyloid P component, serum0.012
Cxcl10chemokine (C-X-C motif) ligand 100.012
Arhgap15Rho GTPase activating protein 150.011
Apol3apolipoprotein L, 30.011
Zcwpw1zinc finger, CW-type with PWWP domain 10.010
Irf1interferon regulatory factor 10.010
Il7rinterleukin 7 receptor0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
im:7141132im:71411320.089
zgc:101598zgc:1015980.051
defbl3defensin, beta-like 30.041
fxr2fragile X mental retardation, autosomal homolog 20.036
itln1intelectin 10.036
sb:cb134sb:cb1340.035
fbln4fibulin 40.029
eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.026
itln3intelectin 30.025
fcho2FCH domain only 20.025
jhdm1dajumonji C domain containing histone demethylase 1 homolog Da (S. cerevisiae)0.024
sb:cb429sb:cb4290.022
tlr22toll-like receptor 220.021
tnfrsf18tumor necrosis factor receptor superfamily, member 180.020
wu:fb80e01wu:fb80e010.019
cry1acryptochrome 1a0.018
zgc:112992zgc:1129920.018
slc12a3solute carrier family 12 (sodium/chloride transporters), member 30.017
dmrt1doublesex and mab-3 related transcription factor 10.017
ppp2r5eaprotein phosphatase 2, regulatory subunit B', epsilon isoform a0.016
im:7135980im:71359800.016
tlr4bbtoll-like receptor 4b, duplicate b0.015
nitr13novel immune-type receptor 130.015
lppLIM domain containing preferred translocation partner in lipoma0.014
gsk3bglycogen synthase kinase 3 beta0.014
zgc:172101zgc:1721010.014
nitr8novel immune-type receptor 80.014
LOC555739serine/threonine-protein kinase LMTK1-like0.013
oxsr1aoxidative-stress responsive 1a0.013
im:7152557im:71525570.013
wacaWW domain containing adaptor with coiled-coil a0.013
wnt10bwingless-type MMTV integration site family, member 10b0.013
kpna3karyopherin (importin) alpha 30.012
ip6k2inositol hexaphosphate kinase 20.012
atp2b4ATPase, Ca++ transporting, plasma membrane 40.012
nitr12novel immune-type receptor 120.012
arl4aaADP-ribosylation factor-like 4aa0.011
sipa1l1signal-induced proliferation-associated 1 like 10.011
cx39.9connexin 39.90.011
npy4rneuropeptide Y receptor Y40.011
hegheart of glass0.011
smarca2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.011
angptl3angiopoietin-like 30.011
nitr4anovel immune-type receptor 4a0.011
sult1st4sulfotransferase family 1, cytosolic sulfotransferase 40.011
tlr9toll-like receptor 90.011
znf148zinc finger protein 1480.010
gatsl2GATS protein-like 20.010
frylfurry homolog-like (Drosophila)0.010
phrf1PHD and ring finger domains 10.010
LOC569720rho GTPase-activating protein 32-like0.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
B2Mbeta-2-microglobulin1.000
HLA-Amajor histocompatibility complex, class I, A1.000
HLA-Cmajor histocompatibility complex, class I, C1.000
HLA-Bmajor histocompatibility complex, class I, B1.000
HLA-Gmajor histocompatibility complex, class I, G1.000
TAP1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)1.000
HLA-Fmajor histocompatibility complex, class I, F0.999
HLA-Emajor histocompatibility complex, class I, E0.998
KLRD1killer cell lectin-like receptor subfamily D, member 10.993
TAPBPTAP binding protein (tapasin)0.990
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.984
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.981
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.906
PILRApaired immunoglobin-like type 2 receptor alpha0.895
IL2RBinterleukin 2 receptor, beta0.805
SLAMF1signaling lymphocytic activation molecule family member 10.623
PTPN6protein tyrosine phosphatase, non-receptor type 60.595
ITM2Bintegral membrane protein 2B0.495
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.474
TAP2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.473
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.461
GBAglucosidase, beta, acid0.408
PSMB8proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)0.344
SIGLEC7sialic acid binding Ig-like lectin 70.248
PTAFRplatelet-activating factor receptor0.235
HK3hexokinase 3 (white cell)0.234
KLRK1killer cell lectin-like receptor subfamily K, member 10.208
LILRA1leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 10.207
IL23Ainterleukin 23, alpha subunit p190.198
GZMKgranzyme K (granzyme 3; tryptase II)0.175
IFNGinterferon, gamma0.174
ARRB2arrestin, beta 20.166
GZMBgranzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)0.132
GNLYgranulysin0.127
INSRinsulin receptor0.119
PRF1perforin 1 (pore forming protein)0.111
KLRC3killer cell lectin-like receptor subfamily C, member 30.106
KLRC2killer cell lectin-like receptor subfamily C, member 20.105
PVRL2poliovirus receptor-related 2 (herpesvirus entry mediator B)0.089
CD33CD33 molecule0.073
BTN3A1butyrophilin, subfamily 3, member A10.073
PGCPplasma glutamate carboxypeptidase0.070
LILRA2leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 20.066
NKG7natural killer cell group 7 sequence0.055
HEXBhexosaminidase B (beta polypeptide)0.054
CMKLR1chemokine-like receptor 10.050
IL18RAPinterleukin 18 receptor accessory protein0.048
NCSTNnicastrin0.046
CXCR6chemokine (C-X-C motif) receptor 60.045
PIK3R5phosphoinositide-3-kinase, regulatory subunit 50.043
MAP3K5mitogen-activated protein kinase kinase kinase 50.042
PTPN1protein tyrosine phosphatase, non-receptor type 10.042
KLRG1killer cell lectin-like receptor subfamily G, member 10.042
STAP2signal transducing adaptor family member 20.042
HCSThematopoietic cell signal transducer0.041
BTN3A2butyrophilin, subfamily 3, member A20.040
CCL5chemokine (C-C motif) ligand 50.038
SIGLEC9sialic acid binding Ig-like lectin 90.037
PSAPprosaposin0.037
KIR3DL2killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 20.036
CCL4chemokine (C-C motif) ligand 40.036
MAPK10mitogen-activated protein kinase 100.036
KLRC4killer cell lectin-like receptor subfamily C, member 40.035
CD160CD160 molecule0.035
RAB14RAB14, member RAS oncogene family0.035
TJP1tight junction protein 1 (zona occludens 1)0.035
XCL2chemokine (C motif) ligand 20.034
ARRB1arrestin, beta 10.034
GNAQguanine nucleotide binding protein (G protein), q polypeptide0.033
KLRF1killer cell lectin-like receptor subfamily F, member 10.033
FPR2formyl peptide receptor 20.033
EPORerythropoietin receptor0.033
HFEhemochromatosis0.032
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.032
CD84CD84 molecule0.032
BTN3A3butyrophilin, subfamily 3, member A30.032
IL12Ainterleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)0.031
AOAHacyloxyacyl hydrolase (neutrophil)0.031
GZMAgranzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)0.031
CD226CD226 molecule0.030
LAIR1leukocyte-associated immunoglobulin-like receptor 10.030
NLRP3NLR family, pyrin domain containing 30.029
TXKTXK tyrosine kinase0.029
LILRA3leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 30.028
CD3GCD3g molecule, gamma (CD3-TCR complex)0.028
FTH1ferritin, heavy polypeptide 10.028
HCP5HLA complex P50.026
GZMHgranzyme H (cathepsin G-like 2, protein h-CCPX)0.026
TBX21T-box 210.026
EMR1egf-like module containing, mucin-like, hormone receptor-like 10.026
SIRPB1signal-regulatory protein beta 10.025
NPC2Niemann-Pick disease, type C20.025
PYHIN1pyrin and HIN domain family, member 10.025
TNFRSF12Atumor necrosis factor receptor superfamily, member 12A0.024
KIR2DL2killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2 and killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 20.023
KIR3DL1killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 10.023
TAPBPLTAP binding protein-like0.022
PSMB9proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)0.021
LILRB4leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 40.021
CTSWcathepsin W0.021
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
H2-K1histocompatibility 2, K1, K region0.986
TapbpTAP binding protein0.981
H2-D1histocompatibility 2, D region locus 10.965
Klrk1killer cell lectin-like receptor subfamily K, member 10.937
Slamf1signaling lymphocytic activation molecule family member 10.907
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.855
Klra9killer cell lectin-like receptor subfamily A, member 90.844
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.827
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.745
Klrd1killer cell lectin-like receptor, subfamily D, member 10.644
Irf9interferon regulatory factor 90.602
Klrc1killer cell lectin-like receptor subfamily C, member 10.589
H2-Q7histocompatibility 2, Q region locus 70.585
B2mbeta-2 microglobulin0.556
Gzmagranzyme A0.485
FaslFas ligand (TNF superfamily, member 6)0.424
Stat1signal transducer and activator of transcription 10.357
Trim21tripartite motif-containing 210.352
Tap1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.316
Gzmkgranzyme K0.288
Il6interleukin 60.288
H2-Q6histocompatibility 2, Q region locus 60.258
Gbp2guanylate binding protein 20.248
Irgm2immunity-related GTPase family M member 20.247
ItkIL2-inducible T-cell kinase0.217
Xcl1chemokine (C motif) ligand 10.201
Klra7killer cell lectin-like receptor, subfamily A, member 70.197
Igtpinterferon gamma induced GTPase0.192
Gzmbgranzyme B0.181
H2-Q8histocompatibility 2, Q region locus 80.181
Gbp7guanylate binding protein 70.156
Irf1interferon regulatory factor 10.153
Psmb10proteasome (prosome, macropain) subunit, beta type 100.148
Ncr1natural cytotoxicity triggering receptor 10.136
Pyhin1pyrin and HIN domain family, member 10.135
Parp14poly (ADP-ribose) polymerase family, member 140.127
Klra3killer cell lectin-like receptor, subfamily A, member 30.115
Il18rapinterleukin 18 receptor accessory protein0.086
Irgm1immunity-related GTPase family M member 10.085
Stat2signal transducer and activator of transcription 20.084
Arrb1arrestin, beta 10.084
Klrb1bkiller cell lectin-like receptor subfamily B member 1B0.082
Cd7CD7 antigen0.081
AW112010expressed sequence AW1120100.078
Slamf7SLAM family member 70.069
BC147527cDNA sequence BC1475270.067
Il18r1interleukin 18 receptor 10.067
Nkg7natural killer cell group 7 sequence0.066
Ifi35interferon-induced protein 350.065
Stat4signal transducer and activator of transcription 40.064
Klrg1killer cell lectin-like receptor subfamily G, member 10.064
Tgtp2T-cell specific GTPase 20.062
Ccr9chemokine (C-C motif) receptor 90.059
Gbp3guanylate binding protein 30.057
Klrb1ckiller cell lectin-like receptor subfamily B member 1C0.056
Cd84CD84 antigen0.055
Klrb1fkiller cell lectin-like receptor subfamily B member 1F0.055
H2-Q5histocompatibility 2, Q region locus 50.054
Il2rainterleukin 2 receptor, alpha chain0.053
Tnfsf10tumor necrosis factor (ligand) superfamily, member 100.053
Cxcl9chemokine (C-X-C motif) ligand 90.050
Iigp1interferon inducible GTPase 10.048
Emr4EGF-like module containing, mucin-like, hormone receptor-like sequence 40.047
Ccr3chemokine (C-C motif) receptor 30.047
Ctswcathepsin W0.046
Cd160CD160 antigen0.045
Pilrb1paired immunoglobin-like type 2 receptor beta 10.045
Cd180CD180 antigen0.044
NmiN-myc (and STAT) interactor0.044
Lgals3bplectin, galactoside-binding, soluble, 3 binding protein0.044
Il4rainterleukin 4 receptor, alpha0.044
Ccl5chemokine (C-C motif) ligand 50.043
Prf1perforin 1 (pore forming protein)0.042
Aoahacyloxyacyl hydrolase0.042
Cd244CD244 natural killer cell receptor 2B40.042
Parp10poly (ADP-ribose) polymerase family, member 100.041
Icosinducible T-cell co-stimulator0.039
H2-Eb1histocompatibility 2, class II antigen E beta0.039
Klra8killer cell lectin-like receptor, subfamily A, member 80.039
Parp9poly (ADP-ribose) polymerase family, member 90.038
Ifi47interferon gamma inducible protein 470.037
Kmokynurenine 3-monooxygenase (kynurenine 3-hydroxylase)0.036
Zfp36zinc finger protein 360.036
Cxcr6chemokine (C-X-C motif) receptor 60.036
Gbp1guanylate binding protein 10.035
Uba7ubiquitin-like modifier activating enzyme 70.035
Cd3gCD3 antigen, gamma polypeptide0.035
Klrb1akiller cell lectin-like receptor subfamily B member 1A0.033
FcrlaFc receptor-like A0.033
Slfn1schlafen 10.032
Itgaxintegrin alpha X0.031
Cd2CD2 antigen0.030
Il10interleukin 100.030
C920025E04RikRIKEN cDNA C920025E04 gene0.030
Bex6brain expressed gene 60.030
Sh2d2aSH2 domain protein 2A0.029
Klra5killer cell lectin-like receptor, subfamily A, member 50.029
Slamf6SLAM family member 60.029
Klra17killer cell lectin-like receptor, subfamily A, member 170.029
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.028
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism