The network for 'cell cell signaling' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cell cell signaling

Any process that mediates the transfer of information from one cell to another.

NameDescriptionProbabilityFunc Analog Organism
Gabrb3gamma-aminobutyric acid (GABA) A receptor, beta 30.983
Gria2glutamate receptor, ionotropic, AMPA 20.982
Syn1synapsin I0.974
Grm7glutamate receptor, metabotropic 70.967
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.960
Gng7guanine nucleotide binding protein (G protein), gamma 70.955
Kcnq3potassium voltage-gated channel, KQT-like subfamily, member 30.942
Dlg4discs, large homolog 4 (Drosophila)0.930
Unc5aunc-5 homolog A (C. elegans)0.899
Nrxn3neurexin 30.895
Syn2synapsin II0.888
Dlgap1discs, large (Drosophila) homolog-associated protein 10.866
B3gat1beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)0.866
Neurod2neurogenic differentiation 20.863
Snap25synaptosomal-associated protein 250.858
Kcnt1potassium channel, subfamily T, member 10.847
Htr75-hydroxytryptamine (serotonin) receptor 70.835
Rgs9regulator of G-protein signaling 90.835
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.822
Myt1lmyelin transcription factor 1-like0.820
Gria1glutamate receptor, ionotropic, AMPA 10.818
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.810
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.800
Syt4synaptotagmin IV0.792
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.791
Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.778
Stx1bsyntaxin 1B0.771
Grik1glutamate receptor, ionotropic, kainate 10.742
Avparginine vasopressin0.733
Hcrtr1hypocretin (orexin) receptor 10.730
Prkcgprotein kinase C, gamma0.724
Arandrogen receptor0.723
Akr1c18aldo-keto reductase family 1, member C180.685
Slc1a1solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 10.682
Adam2ADAM metallopeptidase domain 20.677
Thtyrosine hydroxylase0.674
Atp6v0a1ATPase, H+ transporting, lysosomal V0 subunit A10.672
Kcnc3potassium voltage gated channel, Shaw-related subfamily, member 30.667
Nrcamneuronal cell adhesion molecule0.661
Oprm1opioid receptor, mu 10.657
Prkceprotein kinase C, epsilon0.652
Sstr2somatostatin receptor 20.650
Pitx3paired-like homeodomain 30.648
Kcnc2potassium voltage gated channel, Shaw-related subfamily, member 20.642
Chrna7cholinergic receptor, nicotinic, alpha 70.640
Mapk10mitogen activated protein kinase 100.634
Nlgn3neuroligin 30.634
Gabrb1gamma-aminobutyric acid (GABA) A receptor, beta 10.632
Prkcaprotein kinase C, alpha0.631
FevFEV (ETS oncogene family)0.631
Grin2aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.630
Foxe3forkhead box E30.629
Cacna1bcalcium channel, voltage-dependent, N type, alpha 1B subunit0.626
Snap91synaptosomal-associated protein 910.625
Lin7blin-7 homolog b (C. elegans)0.609
Gcm1glial cells missing homolog 1 (Drosophila)0.608
Kcnj9potassium inwardly-rectifying channel, subfamily J, member 90.604
Vsnl1visinin-like 10.603
Adra2aadrenergic, alpha-2A-, receptor0.601
CamkvCaM kinase-like vesicle-associated0.601
Hk1hexokinase 10.600
Pde1bphosphodiesterase 1B, calmodulin-dependent0.599
Chrngcholinergic receptor, nicotinic, gamma0.598
Ednrbendothelin receptor type B0.593
Anxa2annexin A20.592
Sh3gl2SH3-domain GRB2-like 20.590
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.585
Begainbrain-enriched guanylate kinase-associated0.584
Il12binterleukin 12B0.580
Accn1amiloride-sensitive cation channel 1, neuronal0.580
Kcnd3potassium voltage-gated channel, Shal-related subfamily, member 30.579
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.578
Foxe1forkhead box E1 (thyroid transcription factor 2)0.577
Atp1b2ATPase, Na+/K+ transporting, beta 2 polypeptide0.576
Anxa1annexin A10.574
Zg16zymogen granule protein 160.573
Rgs8regulator of G-protein signaling 80.572
Atp2b3ATPase, Ca++ transporting, plasma membrane 30.571
Slc5a5solute carrier family 5 (sodium iodide symporter), member 50.570
Kalrnkalirin, RhoGEF kinase0.566
Dlgap2discs, large (Drosophila) homolog-associated protein 20.564
Magi2membrane associated guanylate kinase, WW and PDZ domain containing 20.564
Hrkharakiri, BCL2 interacting protein (contains only BH3 domain)0.561
Tmod2tropomodulin 20.548
Prss1protease, serine, 1 (trypsin 1)0.546
Rin1Ras and Rab interactor 10.544
Syt1synaptotagmin I0.544
VgfVGF nerve growth factor inducible0.539
St8sia3ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 30.530
Grid1glutamate receptor, ionotropic, delta 10.530
Gabra1gamma-aminobutyric acid (GABA) A receptor, alpha 10.529
Slc18a3solute carrier family 18 (vesicular acetylcholine), member 30.529
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
unc-9Protein UNC-90.997
hif-1Protein HIF-10.902
egl-30Protein EGL-300.826
rig-6Protein RIG-60.821
vab-3Protein VAB-30.728
nhr-67Protein NHR-670.706
goa-1Protein GOA-10.702
dbl-1Protein DBL-10.700
lin-11Protein LIN-110.675
pdfr-1Protein PDFR-10.661
unc-86Protein UNC-860.642
unc-53Protein UNC-530.630
unc-38Protein UNC-380.601
C06G3.6Protein C06G3.60.573
mrp-1Protein MRP-10.545
CELE_C56A3.6Protein C56A3.60.536
egl-36Protein EGL-360.527
nlg-1Protein NLG-10.523
gar-3Protein GAR-30.504
glr-5Protein GLR-50.456
unc-54Protein UNC-540.433
pxf-1Protein PXF-10.426
plc-1Protein PLC-10.422
hlh-2Protein HLH-20.407
pkg-1Protein PKG-10.401
inx-12Protein INX-120.386
inx-3Protein INX-30.384
R13A5.9Protein R13A5.90.383
unc-7Protein UNC-70.371
egl-27Protein EGL-270.368
ace-3Protein ACE-30.368
let-756Protein LET-7560.361
let-23Protein LET-230.355
slo-1Protein SLO-10.349
unc-104Protein UNC-1040.347
F54E4.3Protein F54E4.30.342
unc-6Protein UNC-60.333
madd-4Protein MADD-40.318
unc-79Protein UNC-790.318
unc-73Protein UNC-730.314
egl-3Protein EGL-30.294
egl-5Protein EGL-50.272
sng-1Protein SNG-10.271
glp-1Protein GLP-10.267
inx-13Protein INX-130.266
sta-1Protein STA-10.264
klc-2Protein KLC-20.263
F49C12.9Protein F49C12.90.261
egl-15Protein EGL-150.256
num-1Protein NUM-10.245
cyp-35C1Protein CYP-35C10.245
dpff-1Protein DPFF-10.241
C34F6.9Protein C34F6.90.239
F55H12.3Protein F55H12.30.237
spc-1Protein SPC-10.235
egl-13Protein EGL-130.221
plc-2Protein PLC-20.220
faah-1Protein FAAH-10.215
unc-26Protein UNC-260.211
unc-103Protein UNC-1030.204
nhr-45Protein NHR-450.201
unc-43Protein UNC-430.199
ain-1Protein AIN-10.198
pes-7Protein PES-70.194
cyp-35A3Protein CYP-35A30.193
glc-4Protein GLC-40.193
glr-1Protein GLR-10.189
C34D10.2Protein C34D10.20.189
sem-5Protein SEM-50.188
unc-47Protein UNC-470.188
lev-8Protein LEV-80.179
exc-5Protein EXC-50.179
sto-5Protein STO-50.178
fsn-1Protein FSN-10.178
unc-60Protein UNC-600.176
ttm-2Protein TTM-20.174
CELE_Y37A1B.17Protein Y37A1B.170.174
kcc-1Protein KCC-10.171
Y43E12A.2Protein Y43E12A.20.169
rsa-1Protein RSA-10.168
stn-1Protein STN-10.167
ser-2Protein SER-20.166
prkl-1Protein PRKL-10.163
acr-16Protein ACR-160.160
polk-1Protein POLK-10.160
CELE_W05H12.1Protein W05H12.10.160
unc-10Protein UNC-100.160
vpr-1Protein VPR-10.157
gld-1Protein GLD-10.155
cat-1Protein CAT-10.155
zyg-8Protein ZYG-80.153
hmr-1Protein HMR-10.153
dat-1Protein DAT-10.152
M01A8.2Protein M01A8.20.152
ark-1Protein ARK-10.152
F28E10.1Protein F28E10.10.152
tag-303Protein TAG-3030.149
gdi-1Protein GDI-10.149
cmd-1Protein CMD-10.149
adt-2Protein ADT-20.149
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
gli2aGLI-Kruppel family member GLI2a0.895
wnt8bwingless-type MMTV integration site family, member 8b0.880
pax8paired box gene 80.625
pax6apaired box gene 6a0.617
kal1aKallmann syndrome 1a sequence0.611
myod1myogenic differentiation 10.507
wnt1wingless-type MMTV integration site family, member 10.481
hnf1baHNF1 homeobox Ba0.471
efnb2aephrin B2a0.468
otpaorthopedia homolog a0.432
lhx1aLIM homeobox 1a0.427
rarabretinoic acid receptor, alpha b0.393
gli1GLI-Kruppel family member 10.383
ascl1aachaete-scute complex-like 1a (Drosophila)0.377
myf5myogenic factor 50.375
otpborthopedia homolog b0.373
phox2apaired-like homeobox 2a0.372
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.348
nsfaN-ethylmaleimide-sensitive factor a0.344
flhfloating head0.340
gad2glutamate decarboxylase 20.320
esr2aestrogen receptor 2a0.318
tal1T-cell acute lymphocytic leukemia 10.309
pou3f1POU class 3 homeobox 10.307
notum3notum 30.304
bocbrother of CDO0.302
atp1a3aATPase, Na+/K+ transporting, alpha 3a polypeptide0.296
dab1adisabled homolog 1a (Drosophila)0.286
sox10SRY-box containing gene 100.284
ptgs1prostaglandin-endoperoxide synthase 10.274
foxa2forkhead box A20.254
pax2apaired box gene 2a0.253
slc1a2bsolute carrier family 1 (glial high affinity glutamate transporter), member 2b0.252
pax7apaired box gene 7a0.247
alcambactivated leukocyte cell adhesion molecule b0.242
nanos3nanos homolog 30.239
raraaretinoic acid receptor, alpha a0.238
vsx1visual system homeobox 1 homolog, chx10-like0.230
ndrg4N-myc downstream regulated gene 40.225
nlgn1neuroligin 10.220
leprleptin receptor0.218
smad1MAD homolog 1 (Drosophila)0.215
egr1early growth response 10.206
dkk1bdickkopf 1b0.202
tgfb3transforming growth factor, beta 30.198
mibmind bomb0.197
dccdeleted in colorectal carcinoma0.195
col15a1bcollagen, type XV, alpha 1b0.187
wlswntless homolog (Drosophila)0.184
osr1odd-skipped related 1 (Drosophila)0.180
jag2jagged 20.178
bdnfbrain-derived neurotrophic factor0.178
arnt2aryl hydrocarbon receptor nuclear translocator 20.170
sncgbsynuclein, gamma b (breast cancer-specific protein 1)0.168
gperG protein-coupled estrogen receptor 10.165
egr2bearly growth response 2b0.164
nrg2aneuregulin 2a0.164
evx1even-skipped homeobox 10.161
foxp2forkhead box P20.159
gria3bglutamate receptor, ionotrophic, AMPA 3b0.158
wnt5bwingless-type MMTV integration site family, member 5b0.156
zic1zic family member 1 (odd-paired homolog, Drosophila)0.149
wnt3awingless-type MMTV integration site family, member 3A0.146
pcdh19protocadherin 190.144
gja3gap junction protein, alpha 30.141
pvalb7parvalbumin 70.141
gfra1bgdnf family receptor alpha 1b0.136
sec23aSec23 homolog A (S. cerevisiae)0.135
pcdh8protocadherin 80.133
ptenbphosphatase and tensin homolog B (mutated in multiple advanced cancers 1)0.131
dusp6dual specificity phosphatase 60.131
cyfip2cytoplasmic FMR1 interacting protein 20.130
atp1b1bATPase, Na+/K+ transporting, beta 1b polypeptide0.129
tfap2btranscription factor AP-2 beta0.128
gria2aglutamate receptor, ionotropic, AMPA 2a0.128
dmbx1adiencephalon/mesencephalon homeobox 1a0.127
roraaRAR-related orphan receptor A, paralog a0.127
snai1asnail homolog 1a (Drosophila)0.126
acvr2aactivin receptor IIa0.122
ndr2nodal-related 20.119
nrg1neuregulin 10.119
tbx1T-box 10.115
irx4airoquois homeobox protein 4a0.115
ncs1aneuronal calcium sensor 1a0.115
etv2ets variant gene 20.115
eng2aengrailed 2a0.114
smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.113
nf1aneurofibromin 1a0.111
rapsnreceptor-associated protein of the synapse, 43kD0.109
lama2laminin, alpha 20.106
bmp7abone morphogenetic protein 7a0.106
tshbthyroid stimulating hormone, beta subunit0.105
gria1aglutamate receptor, ionotropic, AMPA 1a0.105
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.104
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
GRB2growth factor receptor-bound protein 21.000
DLG4discs, large homolog 4 (Drosophila)1.000
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.999
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.998
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.998
MDM2Mdm2 p53 binding protein homolog (mouse)0.996
CREBBPCREB binding protein0.993
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.988
EGFRepidermal growth factor receptor0.979
KCNJ4potassium inwardly-rectifying channel, subfamily J, member 40.961
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.960
FGFR1fibroblast growth factor receptor 10.959
CSNK2A1casein kinase 2, alpha 1 polypeptide0.958
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.956
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.955
PSEN1presenilin 10.948
DRD2dopamine receptor D20.943
LRRK2leucine-rich repeat kinase 20.940
PDX1pancreatic and duodenal homeobox 10.939
GABBR2gamma-aminobutyric acid (GABA) B receptor, 20.937
PTPN11protein tyrosine phosphatase, non-receptor type 110.918
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.906
NEDD4neural precursor cell expressed, developmentally down-regulated 40.903
CASKcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.897
CRHR1corticotropin releasing hormone receptor 10.893
FGFR2fibroblast growth factor receptor 20.879
ESR1estrogen receptor 10.873
KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)0.863
MAPK1mitogen-activated protein kinase 10.851
GSK3Bglycogen synthase kinase 3 beta0.841
EPS15epidermal growth factor receptor pathway substrate 150.838
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.832
ABCC8ATP-binding cassette, sub-family C (CFTR/MRP), member 80.832
GRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.829
SNAP25synaptosomal-associated protein, 25kDa0.814
ACTL6Bactin-like 6B0.807
VAMP3vesicle-associated membrane protein 3 (cellubrevin)0.791
SHC1SHC (Src homology 2 domain containing) transforming protein 10.782
JAG1jagged 10.779
GRIN2Cglutamate receptor, ionotropic, N-methyl D-aspartate 2C0.772
IGF1Rinsulin-like growth factor 1 receptor0.751
NR4A1nuclear receptor subfamily 4, group A, member 10.751
FOXD3forkhead box D30.746
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.743
CSNK1Ecasein kinase 1, epsilon0.737
TEKTEK tyrosine kinase, endothelial0.726
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.717
CDK5R2cyclin-dependent kinase 5, regulatory subunit 2 (p39)0.704
APPamyloid beta (A4) precursor protein0.693
MYOD1myogenic differentiation 10.692
KCNB1potassium voltage-gated channel, Shab-related subfamily, member 10.690
SOX1SRY (sex determining region Y)-box 10.685
DLGAP1discs, large (Drosophila) homolog-associated protein 10.678
SNTA1syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)0.674
KCNQ2potassium voltage-gated channel, KQT-like subfamily, member 20.673
SLC9A3solute carrier family 9 (sodium/hydrogen exchanger), member 30.665
ATP2B2ATPase, Ca++ transporting, plasma membrane 20.658
RAB1ARAB1A, member RAS oncogene family0.642
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.637
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.637
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.636
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.629
NAPAN-ethylmaleimide-sensitive factor attachment protein, alpha0.628
CAMK2Acalcium/calmodulin-dependent protein kinase II alpha0.628
SH3GL2SH3-domain GRB2-like 20.617
GAD2glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)0.617
PAX3paired box 30.613
CABP1calcium binding protein 10.588
SORBS3sorbin and SH3 domain containing 30.586
GRIA2glutamate receptor, ionotropic, AMPA 20.581
FGF8fibroblast growth factor 8 (androgen-induced)0.580
KRT8keratin 80.580
RFC5replication factor C (activator 1) 5, 36.5kDa0.579
SSTR2somatostatin receptor 20.569
GRIA1glutamate receptor, ionotropic, AMPA 10.569
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.563
FGF1fibroblast growth factor 1 (acidic)0.554
SMAD4SMAD family member 40.553
CCR5chemokine (C-C motif) receptor 50.552
HOXD12homeobox D120.552
NEUROD2neurogenic differentiation 20.552
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.551
EPS8epidermal growth factor receptor pathway substrate 80.551
OCRLoculocerebrorenal syndrome of Lowe0.543
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.542
SH3KBP1SH3-domain kinase binding protein 10.541
ITSN1intersectin 1 (SH3 domain protein)0.534
TAL1T-cell acute lymphocytic leukemia 10.532
SMAD2SMAD family member 20.524
ORC2origin recognition complex, subunit 20.519
LBX1ladybird homeobox 10.517
SNAP23synaptosomal-associated protein, 23kDa0.517
DNM1dynamin 10.511
PYYpeptide YY0.509
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.502
PTPN1protein tyrosine phosphatase, non-receptor type 10.494
CAPNS1calpain, small subunit 10.493
PRKCAprotein kinase C, alpha0.464
MAPTmicrotubule-associated protein tau0.462
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism