The network for 'heart valve morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

heart valve morphogenesis

The process in which the structure of a heart valve is generated and organized.

NameDescriptionProbabilityFunc Analog Organism
Olr1469olfactory receptor Olr14690.219
Efnb1ephrin B10.170
Olr1523olfactory receptor 15230.099
Olr1701olfactory receptor 17010.076
Tcfe2atranscription factor E2a0.075
Btg2BTG family, member 20.069
RT1-DOaRT1 class II, locus DOa0.061
Mllt4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.059
Sox13SRY (sex determining region Y)-box 130.057
Smad7SMAD family member 70.042
Unc5bunc-5 homolog B (C. elegans)0.041
Olr825olfactory receptor 8250.041
RGD1564327similar to integrin alpha 80.036
Thbdthrombomodulin0.033
Hes1hairy and enhancer of split 1 (Drosophila)0.032
Rai14retinoic acid induced 140.031
FosFBJ osteosarcoma oncogene0.031
RGD1565591similar to Ski protein0.027
Emp1epithelial membrane protein 10.026
Nfibnuclear factor I/B0.026
Nr2f2nuclear receptor subfamily 2, group F, member 20.025
Srrm2serine/arginine repetitive matrix 20.025
Golga1golgi autoantigen, golgin subfamily a, 10.024
Nfixnuclear factor I/X (CCAAT-binding transcription factor)0.023
Ptpn14protein tyrosine phosphatase, non-receptor type 140.023
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.023
Kdrkinase insert domain receptor0.023
Ddr1discoidin domain receptor tyrosine kinase 10.023
Notch2Notch homolog 2 (Drosophila)0.022
Ptgirprostaglandin I2 (prostacyclin) receptor (IP)0.022
Col8a1collagen, type VIII, alpha 10.021
Sox17SRY (sex determining region Y)-box 170.021
Myh11myosin, heavy chain 11, smooth muscle0.020
Junbjun B proto-oncogene0.020
Tpcr12putative olfactory receptor0.020
Jubjub, ajuba homolog (Xenopus laevis)0.020
RbpmsRNA binding protein with multiple splicing0.019
Cdc42ep1CDC42 effector protein (Rho GTPase binding) 10.019
Smosmoothened homolog (Drosophila)0.019
Rtf1Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.019
Nfianuclear factor I/A0.019
Map4k4mitogen-activated protein kinase kinase kinase kinase 40.019
Tgfb3transforming growth factor, beta 30.019
Admadrenomedullin0.019
Cald1caldesmon 10.018
Npr1natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)0.018
Wt1Wilms tumor 10.018
Egfl7EGF-like-domain, multiple 70.018
Ergv-ets erythroblastosis virus E26 oncogene homolog (avian)0.017
Myo1cmyosin IC0.017
Prdm2PR domain containing 2, with ZNF domain0.016
Olr1404olfactory receptor 14040.016
Egr2early growth response 20.016
Cybrd1cytochrome b reductase 10.015
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.015
Ralgdsral guanine nucleotide dissociation stimulator0.015
F13a1coagulation factor XIII, A1 polypeptide0.015
Dll1delta-like 1 (Drosophila)0.015
LOC100360919Immunoglobulin lambda-like polypeptide 1-like0.015
Prkd3protein kinase D30.014
Ets1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.014
Tcf4transcription factor 40.014
Zfp36zinc finger protein 360.014
Fgfr4fibroblast growth factor receptor 40.014
Cnn1calponin 1, basic, smooth muscle0.014
Tceb3transcription elongation factor B (SIII), polypeptide 30.013
Rps6ka1ribosomal protein S6 kinase polypeptide 10.013
RGD1306636hypothetical LOC2934980.013
Megf6multiple EGF-like-domains 60.013
Hyal2hyaluronoglucosaminidase 20.013
Cnpy2canopy 2 homolog (zebrafish)0.013
Dlc1deleted in liver cancer 10.013
Phf12PHD finger protein 120.013
Rnase1ribonuclease, RNase A family, 1 (pancreatic)0.013
Nos3nitric oxide synthase 3, endothelial cell0.013
Megf10multiple EGF-like domains 100.013
Enpp1ectonucleotide pyrophosphatase/phosphodiesterase 10.012
Mgllmonoglyceride lipase0.012
Kank1KN motif and ankyrin repeat domains 10.012
Crygfcrystallin, gamma F0.012
Egr1early growth response 10.012
Itpr3inositol 1,4,5-triphosphate receptor, type 30.012
Foxp1forkhead box P10.012
Myo1amyosin IA0.012
Cpsf7cleavage and polyadenylation specific factor 70.012
Bbxbobby sox homolog (Drosophila)0.012
Esm1endothelial cell-specific molecule 10.011
Lamc1laminin, gamma 10.011
Plekhg2pleckstrin homology domain containing, family G (with RhoGef domain) member 20.011
Timp3TIMP metallopeptidase inhibitor 30.011
Grb10growth factor receptor bound protein 100.011
Irs1insulin receptor substrate 10.011
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.011
Crispld2cysteine-rich secretory protein LCCL domain containing 20.011
Casp2caspase 20.011
F2rcoagulation factor II (thrombin) receptor0.011
RradRas-related associated with diabetes0.011
Pou5f2POU domain class 5, transcription factor 20.011
CblbCas-Br-M (murine) ecotropic retroviral transforming sequence b0.011
Rararetinoic acid receptor, alpha0.011
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tbx5aT-box 5a0.960
tbx1T-box 10.945
hand2heart and neural crest derivatives expressed transcript 20.937
tbx20T-box 200.912
fli1afriend leukemia integration 1a0.763
gata6GATA-binding protein 60.759
tal1T-cell acute lymphocytic leukemia 10.746
bmp4bone morphogenetic protein 40.719
mef2cbmyocyte enhancer factor 2cb0.710
ptch1patched 10.565
jag1bjagged 1b0.511
fn1fibronectin 10.482
tbx16T-box gene 160.419
hhexhematopoietically expressed homeobox0.404
bmp2bbone morphogenetic protein 2b0.396
neo1neogenin 10.355
cdh2cadherin 2, neuronal0.329
nkx2.5NK2 transcription factor related 50.308
lft2lefty20.304
nfatc1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 10.280
gsnagelsolin a0.250
gli2aGLI-Kruppel family member GLI2a0.234
pkd2polycystic kidney disease 20.207
tpm4tropomyosin 40.197
wnt5bwingless-type MMTV integration site family, member 5b0.183
dlcdeltaC0.159
wnt11rwingless-type MMTV integration site family, member 11, related0.158
gata2aGATA-binding protein 2a0.152
tbx18T-box 180.152
tgfb3transforming growth factor, beta 30.145
tbx5bT-box 5b0.137
tfap2atranscription factor AP-2 alpha0.123
jag1ajagged 1a0.103
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.099
smosmoothened homolog (Drosophila)0.099
shhasonic hedgehog a0.096
hnf1baHNF1 homeobox Ba0.087
lamc1laminin, gamma 10.086
oepone-eyed pinhead0.086
gli1GLI-Kruppel family member 10.083
hapln1ahyaluronan and proteoglycan link protein 1a0.083
kdrlkinase insert domain receptor like0.080
dlddeltaD0.080
lamb1alaminin, beta 1a0.079
alcamaactivated leukocyte cell adhesion molecule a0.079
tgfb2transforming growth factor, beta 20.078
fibinfin bud initiation factor0.077
has2hyaluronan synthase 20.077
mibmind bomb0.076
crip2cysteine-rich protein 20.074
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.072
myl7myosin, light polypeptide 7, regulatory0.070
hspb7heat shock protein family, alpha-crystallin-related, b70.070
fgf8afibroblast growth factor 8 a0.069
tnni1btroponin I, skeletal, slow b0.066
mmp14amatrix metalloproteinase 14a (membrane-inserted)0.062
her7hairy and enhancer of split related-70.061
tbx2aT-box gene 2a0.058
wu:fv91b12wu:fv91b120.057
dlbdeltaB0.056
LOC566708FL cytokine receptor-like0.055
mef2camyocyte enhancer factor 2ca0.054
gata3GATA-binding protein 30.052
dlx2adistal-less homeobox gene 2a0.052
runx1runt-related transcription factor 10.050
mmp2matrix metalloproteinase 20.049
bambiaBMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a0.049
fgfr4fibroblast growth factor receptor 40.049
robo3roundabout homolog 30.048
zgc:158603zgc:1586030.048
cdx4caudal type homeo box transcription factor 40.044
slc12a2solute carrier family 12 (potassium/chloride transporters), member 20.043
foxa1forkhead box A10.043
flot2aflotillin 2a0.042
notch3notch homolog 30.041
wnt11wingless-type MMTV integration site family, member 110.041
osr2odd-skipped related 2 (Drosophila)0.041
notch1bnotch homolog 1b0.041
ntlano tail a0.041
plagl2pleiomorphic adenoma gene-like 20.040
her1hairy-related 10.039
aldh1a2aldehyde dehydrogenase 1 family, member A20.038
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.038
wlswntless homolog (Drosophila)0.036
wnt2bbwingless-type MMTV integration site family, member 2Bb0.035
gatsl2GATS protein-like 20.035
fgf17fibroblast growth factor 170.034
rbm24aRNA binding motif protein 24a0.032
sec23aSec23 homolog A (S. cerevisiae)0.032
lmo2LIM domain only 2 (rhombotin-like 1)0.032
lhx1aLIM homeobox 1a0.032
rereaarginine-glutamic acid dipeptide (RE) repeats a0.030
tll1tolloid-like 10.030
flncbfilamin C, gamma b (actin binding protein 280)0.029
irx3airoquois homeobox protein 3a0.029
pax2apaired box gene 2a0.028
ctgfconnective tissue growth factor0.028
vmhcventricular myosin heavy chain0.028
foxn4forkhead box N40.028
col27a1acollagen, type XXVII, alpha 1a0.028
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
JAG1jagged 11.000
NOTCH1notch 10.982
NOTCH3notch 30.954
BMPR1Abone morphogenetic protein receptor, type IA0.770
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.623
FSTL1follistatin-like 10.351
BMP2bone morphogenetic protein 20.318
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.301
FKBP1AFK506 binding protein 1A, 12kDa0.263
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.152
SMAD7SMAD family member 70.138
TGFB1transforming growth factor, beta 10.132
GATA4GATA binding protein 40.090
GDF5growth differentiation factor 50.079
SMAD3SMAD family member 30.073
SMAD2SMAD family member 20.066
NOTCH2notch 20.063
SMURF2SMAD specific E3 ubiquitin protein ligase 20.058
GATA1GATA binding protein 1 (globin transcription factor 1)0.055
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.054
TGFBR1transforming growth factor, beta receptor 10.053
TBX5T-box 50.050
TGFB3transforming growth factor, beta 30.048
SKILSKI-like oncogene0.047
DLL1delta-like 1 (Drosophila)0.043
ACVR1activin A receptor, type I0.040
ENGendoglin0.038
CTGFconnective tissue growth factor0.038
SETD8SET domain containing (lysine methyltransferase) 80.036
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.032
SMAD1SMAD family member 10.029
JAG2jagged 20.025
EPAS1endothelial PAS domain protein 10.022
SMAD4SMAD family member 40.020
PRKG1protein kinase, cGMP-dependent, type I0.019
CXXC5CXXC finger protein 50.019
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.019
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.018
MAML1mastermind-like 1 (Drosophila)0.017
ZEB2zinc finger E-box binding homeobox 20.016
CTNNBIP1catenin, beta interacting protein 10.015
HAND2heart and neural crest derivatives expressed 20.014
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.014
SPRED1sprouty-related, EVH1 domain containing 10.014
TAL1T-cell acute lymphocytic leukemia 10.013
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.012
EFNB2ephrin-B20.012
SMAD6SMAD family member 60.012
GATA2GATA binding protein 20.012
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.011
NRP1neuropilin 10.011
EGFL7EGF-like-domain, multiple 70.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)1.000
Gata4GATA binding protein 41.000
Shhsonic hedgehog0.999
Tbx3T-box 30.999
Gli3GLI-Kruppel family member GLI30.999
Jag1jagged 10.998
Pax3paired box gene 30.998
Pitx2paired-like homeodomain transcription factor 20.997
Efnb2ephrin B20.997
Hand1heart and neural crest derivatives expressed transcript 10.997
Prrx1paired related homeobox 10.993
Tgfb2transforming growth factor, beta 20.992
Notch1Notch gene homolog 1 (Drosophila)0.991
Hand2heart and neural crest derivatives expressed transcript 20.988
Fgfr2fibroblast growth factor receptor 20.980
Foxc1forkhead box C10.975
Sox9SRY-box containing gene 90.971
Pax2paired box gene 20.971
Nodalnodal0.966
Pitx1paired-like homeodomain transcription factor 10.958
Bmp4bone morphogenetic protein 40.940
Gli2GLI-Kruppel family member GLI20.918
Hoxa1homeobox A10.901
Msx1homeobox, msh-like 10.899
Ptf1apancreas specific transcription factor, 1a0.899
Smad6MAD homolog 6 (Drosophila)0.897
Fgfr1fibroblast growth factor receptor 10.896
Meox2mesenchyme homeobox 20.880
Fgf8fibroblast growth factor 80.857
Tbx1T-box 10.851
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.849
Sox11SRY-box containing gene 110.847
Otx2orthodenticle homolog 2 (Drosophila)0.841
Smad4MAD homolog 4 (Drosophila)0.802
Foxc2forkhead box C20.791
Ctnnb1catenin (cadherin associated protein), beta 10.778
Fgf10fibroblast growth factor 100.768
Snai1snail homolog 1 (Drosophila)0.768
Zic3zinc finger protein of the cerebellum 30.767
Foxg1forkhead box G10.745
Apcadenomatosis polyposis coli0.739
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.715
Ascl1achaete-scute complex homolog 1 (Drosophila)0.712
Hey2hairy/enhancer-of-split related with YRPW motif 20.681
Nos3nitric oxide synthase 3, endothelial cell0.626
Bmpr1abone morphogenetic protein receptor, type 1A0.612
Neurod1neurogenic differentiation 10.582
Hey1hairy/enhancer-of-split related with YRPW motif 10.537
Sox2SRY-box containing gene 20.527
Zfpm2zinc finger protein, multitype 20.521
Prrx2paired related homeobox 20.494
Runx2runt related transcription factor 20.478
Foxh1forkhead box H10.445
Smad3MAD homolog 3 (Drosophila)0.440
Sox4SRY-box containing gene 40.435
Dll4delta-like 4 (Drosophila)0.434
Efna2ephrin A20.431
Hoxa13homeobox A130.429
Vangl2vang-like 2 (van gogh, Drosophila)0.428
Ror2receptor tyrosine kinase-like orphan receptor 20.409
Rxraretinoid X receptor alpha0.402
Hes5hairy and enhancer of split 5 (Drosophila)0.389
Hspg2perlecan (heparan sulfate proteoglycan 2)0.373
Zeb1zinc finger E-box binding homeobox 10.364
Gata1GATA binding protein 10.333
Gscgoosecoid homeobox0.333
Fgfr3fibroblast growth factor receptor 30.327
Hoxa10homeobox A100.325
Fstfollistatin0.308
Alx4aristaless-like homeobox 40.282
Chd7chromodomain helicase DNA binding protein 70.260
Mef2cmyocyte enhancer factor 2C0.254
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.253
Hdac7histone deacetylase 70.245
Ptenphosphatase and tensin homolog0.243
Tcfap2atranscription factor AP-2, alpha0.231
Smad1MAD homolog 1 (Drosophila)0.224
Hhexhematopoietically expressed homeobox0.215
Mesp1mesoderm posterior 10.213
Ntf3neurotrophin 30.210
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.208
Hoxa11homeobox A110.204
Dlx5distal-less homeobox 50.199
Lef1lymphoid enhancer binding factor 10.189
Notch3Notch gene homolog 3 (Drosophila)0.183
Ctgfconnective tissue growth factor0.181
Neurog2neurogenin 20.181
Pax9paired box gene 90.180
Ptpn11protein tyrosine phosphatase, non-receptor type 110.176
Wt1Wilms tumor 1 homolog0.172
Dlx2distal-less homeobox 20.170
Pax6paired box gene 60.164
Ptpn14protein tyrosine phosphatase, non-receptor type 140.162
Fgf18fibroblast growth factor 180.150
Gata6GATA binding protein 60.150
Eya1eyes absent 1 homolog (Drosophila)0.147
Twist2twist homolog 2 (Drosophila)0.146
Smad2MAD homolog 2 (Drosophila)0.144
Ephb2Eph receptor B20.144
Sox17SRY-box containing gene 170.141
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism