The network for 'regulation of smoothened signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of smoothened signaling pathway

Any process that modulates the frequency, rate or extent of smoothened signaling.

NameDescriptionProbabilityFunc Analog Organism
Adam10ADAM metallopeptidase domain 100.073
Dynll1dynein light chain LC8-type 10.059
Ppp3r1protein phosphatase 3, regulatory subunit B, alpha isoform0.056
Myo1bmyosin Ib0.050
Unc5bunc-5 homolog B (C. elegans)0.045
Tcf12transcription factor 120.038
Gja1gap junction protein, alpha 10.034
RragaRas-related GTP binding A0.033
Taok1TAO kinase 10.032
Tgfb2transforming growth factor, beta 20.032
Mapk9mitogen-activated protein kinase 90.032
Pctk2PCTAIRE protein kinase 20.031
Slc30a1solute carrier family 30 (zinc transporter), member 10.030
Snx3sorting nexin 30.027
Marcksl1MARCKS-like 10.027
Nek9NIMA (never in mitosis gene a)- related kinase 90.027
RGD1562987similar to cDNA sequence BC0311810.027
Atf2activating transcription factor 20.027
Atp6v0a1ATPase, H+ transporting, lysosomal V0 subunit A10.026
Dnm1ldynamin 1-like0.025
Eif4a2eukaryotic translation initiation factor 4A, isoform 20.025
Prkar1aprotein kinase, cAMP-dependent, regulatory, type I, alpha0.025
Ppp1r2protein phosphatase 1, regulatory (inhibitor) subunit 20.024
Gna12guanine nucleotide binding protein (G protein) alpha 120.024
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.023
Rnf4ring finger protein 40.023
Map4k4mitogen-activated protein kinase kinase kinase kinase 40.022
Fam65afamily with sequence similarity 65, member A0.022
XiapX-linked inhibitor of apoptosis0.022
Tomm20translocase of outer mitochondrial membrane 20 homolog (yeast)0.022
Metmet proto-oncogene0.021
Sult5a1sulfotransferase family 5A, member 10.021
Golph3golgi phosphoprotein 3 (coat-protein)0.021
Csnk1g3casein kinase 1, gamma 30.021
Spcs1signal peptidase complex subunit 1 homolog (S. cerevisiae)0.020
Ccr5chemokine (C-C motif) receptor 50.020
Mllt4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.020
Fam49bfamily with sequence similarity 49, member B0.020
Dmddystrophin0.020
Ppp2cbprotein phosphatase 2, catalytic subunit, beta isoform0.020
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.020
Ptp4a1protein tyrosine phosphatase type IVA, member 10.020
Soat1sterol O-acyltransferase 10.019
Strnstriatin, calmodulin binding protein0.019
Calcrlcalcitonin receptor-like0.019
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.019
Mapre1microtubule-associated protein, RP/EB family, member 10.019
Ube2g1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)0.019
Ptpn12protein tyrosine phosphatase, non-receptor type 120.018
Mtx2metaxin 20.018
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.018
Arl5aADP-ribosylation factor-like 5A0.018
Nop10NOP10 ribonucleoprotein homolog (yeast)0.018
Mapre3microtubule-associated protein, RP/EB family, member 30.018
Flt1FMS-related tyrosine kinase 10.018
Apcadenomatous polyposis coli0.018
CblCas-Br-M (murine) ecotropic retroviral transforming sequence0.018
Utrnutrophin0.018
Trim23tripartite motif-containing 230.018
Amphamphiphysin0.017
Clec11aC-type lectin domain family 11, member a0.017
Psen1presenilin 10.017
Polr2gpolymerase (RNA) II (DNA directed) polypeptide G0.017
Wdfy1WD repeat and FYVE domain containing 10.017
Mpp2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)0.017
Dnaja2DnaJ (Hsp40) homolog, subfamily A, member 20.017
Cugbp2CUG triplet repeat, RNA binding protein 20.017
Pak2p21 protein (Cdc42/Rac)-activated kinase 20.017
Rab14RAB14, member RAS oncogene family0.017
Actr6ARP6 actin-related protein 6 homolog (yeast)0.016
Arf1ADP-ribosylation factor 10.016
Wbp2WW domain binding protein 20.016
Exoc5exocyst complex component 50.016
VapaVAMP (vesicle-associated membrane protein)-associated protein A0.016
Foxp4forkhead box P40.016
Igfbp5insulin-like growth factor binding protein 50.015
Elf1E74-like factor 10.015
Obp3alpha-2u globulin PGCL40.015
Cyth1cytohesin 10.015
Dnajb1DnaJ (Hsp40) homolog, subfamily B, member 10.015
Col8a1collagen, type VIII, alpha 10.015
Gnai1guanine nucleotide binding protein (G protein), alpha inhibiting 10.015
Acvr1activin A receptor, type I0.015
Ppp2caprotein phosphatase 2, catalytic subunit, alpha isoform0.015
Atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.015
Capn6calpain 60.015
Nckap1NCK-associated protein 10.014
Prnpprion protein0.014
Sec23aSec23 homolog A (S. cerevisiae)0.014
Atp6v1b2ATPase, H transporting, lysosomal V1 subunit B20.014
Dynlrb1dynein light chain roadblock-type 10.014
Arntaryl hydrocarbon receptor nuclear translocator0.014
Smad7SMAD family member 70.014
Arhgap28Rho GTPase activating protein 280.014
Pax8paired box 80.014
Gdf11growth differentiation factor 110.014
Sdcbpsyndecan binding protein0.014
Dlg4discs, large homolog 4 (Drosophila)0.014
Gpr176G protein-coupled receptor 1760.014
NsfN-ethylmaleimide-sensitive factor0.014
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
ptch2patched 20.882
shhasonic hedgehog a0.846
zic1zic family member 1 (odd-paired homolog, Drosophila)0.809
foxa1forkhead box A10.669
fn1fibronectin 10.656
gli1GLI-Kruppel family member 10.629
ihhaIndian hedgehog homolog a0.591
lhx2bLIM homeobox 2b0.488
zic4zic family member 40.415
mibmind bomb0.413
cc2d2acoiled-coil and C2 domain containing 2A0.400
flhfloating head0.376
zic3zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)0.326
gli2aGLI-Kruppel family member GLI2a0.275
rspo3R-spondin 3 homolog (Xenopus laevis)0.220
twist1atwist1a0.214
extl3exostoses (multiple)-like 30.196
bmp1abone morphogenetic protein 1a0.192
ephb4beph receptor B4b0.175
gli3GLI-Kruppel family member GLI30.163
ccdc40coiled-coil domain containing 400.158
chrndcholinergic receptor, nicotinic, delta polypeptide0.154
guk1guanylate kinase 10.147
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.136
pde6cphosphodiesterase 6C, cGMP-specific, cone, alpha prime0.135
bmp2bbone morphogenetic protein 2b0.134
tbx1T-box 10.125
rereaarginine-glutamic acid dipeptide (RE) repeats a0.121
ift52intraflagellar transport protein 520.118
znf503zinc finger protein 5030.109
smad5MAD homolog 5 (Drosophila)0.105
ift88intraflagellar transport 88 homolog0.098
wnt5bwingless-type MMTV integration site family, member 5b0.082
ptch1patched 10.080
ptk2.1protein tyrosine kinase 2a0.080
szlsizzled0.080
twist3twist30.079
disp1dispatched homolog 1 (Drosophila)0.076
gnat2guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 20.075
smosmoothened homolog (Drosophila)0.075
chdchordin0.073
pdgfaaplatelet-derived growth factor alpha a0.066
gc3guanylyl cyclase 30.064
gro2groucho 20.063
osr2odd-skipped related 2 (Drosophila)0.062
sox11aSRY-box containing gene 11a0.061
zic5zic family member 5 (odd-paired homolog, Drosophila)0.059
dmddystrophin0.059
ift57intraflagellar transport protein 570.058
restRE1-silencing transcription factor0.056
lect1leukocyte cell derived chemotaxin 10.056
nog1noggin 10.053
col2a1acollagen type II, alpha-1a0.052
pax9paired box gene 90.052
marcksl1MARCKS-like 10.052
cyp2p10cytochrome P450, family 2, subfamily P, polypeptide 100.052
unc45aunc-45 homolog A (C. elegans)0.050
ndr2nodal-related 20.048
per3period homolog 3 (Drosophila)0.047
zgc:55936zgc:559360.047
dvl3dishevelled, dsh homolog 3 (Drosophila)0.045
bocbrother of CDO0.043
cluap1clusterin associated protein 10.042
rbp4lretinol binding protein 4, like0.042
khdrbs1bKH domain containing, RNA binding, signal transduction associated 1b0.040
plod2procollagen-lysine, 2-oxoglutarate 5-dioxygenase 20.040
aanat2arylalkylamine N-acetyltransferase0.040
crxcone-rod homeobox0.037
sox19bSRY-box containing gene 19b0.036
axin2axin 2 (conductin, axil)0.035
sox11bSRY-box containing gene 11b0.035
neo1neogenin 10.034
nkx2.9NK2 transcription factor related, locus 9 (Drosophila)0.034
ntn2netrin 20.034
uxs1UDP-glucuronic acid decarboxylase 10.034
ripply1ripply10.033
tll1tolloid-like 10.033
hoxa11bhomeo box A11b0.033
loxl2blysyl oxidase-like 2b0.032
opn1lw1opsin 1 (cone pigments), long-wave-sensitive, 10.031
prrx1bpaired related homeobox 1b0.030
etv5aets variant 5a0.030
kif17kinesin family member 170.030
rhorhodopsin0.029
zgc:55573zgc:555730.029
fzd8bfrizzled homolog 8b0.029
wnt3wingless-type MMTV integration site family, member 30.028
tbx24T-box 240.027
fbln4fibulin 40.027
wdr45lwdr45 like0.027
pcdh18aprotocadherin 18a0.026
pwp2hPWP2 periodic tryptophan protein homolog (yeast)0.026
epha4aeph receptor A4a0.026
smad9MAD homolog 9 (Drosophila)0.026
zic2bzic family member 2 (odd-paired homolog, Drosophila) b0.026
opn1sw1opsin 1 (cone pigments), short-wave-sensitive 10.025
bmp16bone morphogenetic protein 160.025
col7a1lcollagen type VII alpha 1-like0.025
barhl2BarH-like 20.025
wnt3awingless-type MMTV integration site family, member 3A0.025
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
coscosta0.451
cicubitus interruptus0.429
snssticks and stones0.258
hbshibris0.212
ttvtout-velu0.183
Ext2CG8433 gene product from transcript CG8433-RA0.167
smosmoothened0.154
botvbrother of tout-velu0.149
hhhedgehog0.132
panpangolin0.126
Pka-C1cAMP-dependent protein kinase 10.120
Sulf1Sulfated0.118
fforked0.092
Gp150CG5820 gene product from transcript CG5820-RA0.085
fufused0.084
araaraucan0.079
pgant3polypeptide GalNAc transferase 30.062
Cul-3Cullin-30.059
fyfuzzy0.055
fzfrizzled0.053
UbxUltrabithorax0.047
inx3innexin 30.047
wdbwiderborst0.046
wlswntless0.046
PknProtein kinase related to protein kinase N0.046
rstroughest0.045
NotumCG13076 gene product from transcript CG13076-RB0.043
jebjelly belly0.041
twitwist0.040
sflsulfateless0.039
netCG11450 gene product from transcript CG11450-RB0.039
nocno ocelli0.039
Klp64DKinesin-like protein at 64D0.039
rempAreduced mechanoreceptor potential A0.038
towtarget of wingless0.038
pkprickle0.038
ykiyorkie0.038
vvlventral veins lacking0.038
emcextra macrochaetae0.037
Bre1CG10542 gene product from transcript CG10542-RA0.036
CG9772CG9772 gene product from transcript CG9772-RB0.036
linlines0.036
bnlbranchless0.036
EloAElongin A0.036
Akt1CG4006 gene product from transcript CG4006-RA0.035
Pkd2Polycystic kidney disease gene-20.034
Wnt2Wnt oncogene analog 20.033
SsdpSequence-specific single-stranded DNA-binding protein0.032
dppdecapentaplegic0.032
sdscalloped0.032
binbiniou0.031
boibrother of iHog0.031
sglsugarless0.030
knknot0.030
Wnt4Wnt oncogene analog 40.027
mib1mind bomb 10.027
rolsrolling pebbles0.026
PGRP-LCPeptidoglycan recognition protein LC0.026
mirrmirror0.025
dallydivision abnormally delayed0.025
Pp2B-14DProtein phosphatase 2B at 14D0.025
HLH54FCG5005 gene product from transcript CG5005-RA0.025
frtzfritz0.025
lftlowfat0.025
kniknirps0.025
CG10200CG10200 gene product from transcript CG10200-RB0.024
egreiger0.023
wgwingless0.023
flrflare0.023
fngfringe0.023
simsingle-minded0.023
ftfat0.022
nrv2nervana 20.022
nkdnaked cuticle0.022
hthhomothorax0.021
Irk2Inwardly rectifying potassium channel 20.021
nompCno mechanoreceptor potential C0.021
CG11299CG11299 gene product from transcript CG11299-RA0.021
lunaCG33473 gene product from transcript CG33473-RB0.021
CG9238CG9238 gene product from transcript CG9238-RA0.020
IrInwardly rectifying potassium channel0.020
IndyI'm not dead yet0.020
OdsHOds-site homeobox0.020
pnrpannier0.020
nctnicastrin0.020
CG32372CG32372 gene product from transcript CG32372-RA0.020
krzkurtz0.019
zipzipper0.019
mewmultiple edematous wings0.019
nompAno mechanoreceptor potential A0.019
CG15730CG15730 gene product from transcript CG15730-RA0.019
cswcorkscrew0.019
elBelbow B0.019
CG3308CG3308 gene product from transcript CG3308-RA0.019
enengrailed0.019
ininturned0.019
UbqnUbiquilin0.019
G-oalpha47AG protein oalpha 47A0.018
apapterous0.018
CSN7COP9 complex homolog subunit 70.018
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.892
APCadenomatous polyposis coli0.563
SUFUsuppressor of fused homolog (Drosophila)0.506
BTRCbeta-transducin repeat containing0.379
GLI1GLI family zinc finger 10.313
FGF1fibroblast growth factor 1 (acidic)0.181
FBXW11F-box and WD repeat domain containing 110.174
CUL1cullin 10.129
NR0B1nuclear receptor subfamily 0, group B, member 10.108
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.059
CSNK2Bcasein kinase 2, beta polypeptide0.055
SKP1S-phase kinase-associated protein 10.054
ZAP70zeta-chain (TCR) associated protein kinase 70kDa0.037
SMOsmoothened homolog (Drosophila)0.033
PTCH1patched 10.027
CD247CD247 molecule0.027
CDC34cell division cycle 34 homolog (S. cerevisiae)0.025
GSK3Bglycogen synthase kinase 3 beta0.024
PRKAR1Aprotein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)0.024
NFYAnuclear transcription factor Y, alpha0.021
LCKlymphocyte-specific protein tyrosine kinase0.021
FGF10fibroblast growth factor 100.018
STRN3striatin, calmodulin binding protein 30.016
PRKACAprotein kinase, cAMP-dependent, catalytic, alpha0.014
ARRB1arrestin, beta 10.014
ARandrogen receptor0.013
NUB1negative regulator of ubiquitin-like proteins 10.013
RCN3reticulocalbin 3, EF-hand calcium binding domain0.013
TCF4transcription factor 40.012
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.012
AKAP11A kinase (PRKA) anchor protein 110.011
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Gli3GLI-Kruppel family member GLI31.000
Gli2GLI-Kruppel family member GLI20.999
Ctnnb1catenin (cadherin associated protein), beta 10.998
Shhsonic hedgehog0.995
Fgfr3fibroblast growth factor receptor 30.993
Pax3paired box gene 30.986
Prrx1paired related homeobox 10.978
Smosmoothened homolog (Drosophila)0.972
Ptch1patched homolog 10.970
Foxc1forkhead box C10.955
Retret proto-oncogene0.953
Nognoggin0.941
Bmp7bone morphogenetic protein 70.939
Fgf10fibroblast growth factor 100.922
Msx1homeobox, msh-like 10.920
Dlx5distal-less homeobox 50.892
Fgfr1fibroblast growth factor receptor 10.892
Mks1Meckel syndrome, type 10.836
Sox9SRY-box containing gene 90.790
Otx2orthodenticle homolog 2 (Drosophila)0.788
Rarbretinoic acid receptor, beta0.780
Sall4sal-like 4 (Drosophila)0.779
Nr0b1nuclear receptor subfamily 0, group B, member 10.706
Twist2twist homolog 2 (Drosophila)0.698
Cdoncell adhesion molecule-related/down-regulated by oncogenes0.679
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.670
Bmp4bone morphogenetic protein 40.668
Pou3f3POU domain, class 3, transcription factor 30.664
Lmx1aLIM homeobox transcription factor 1 alpha0.658
Rspo2R-spondin 2 homolog (Xenopus laevis)0.653
Msx2homeobox, msh-like 20.640
Lhx1LIM homeobox protein 10.640
Pax2paired box gene 20.627
Gbx2gastrulation brain homeobox 20.623
Ahi1Abelson helper integration site 10.619
Otx1orthodenticle homolog 1 (Drosophila)0.584
Pax8paired box gene 80.580
Sox2SRY-box containing gene 20.575
Fgf8fibroblast growth factor 80.550
Htthuntingtin0.536
Lmx1bLIM homeobox transcription factor 1 beta0.487
Dkk1dickkopf homolog 1 (Xenopus laevis)0.480
Wnt5awingless-related MMTV integration site 5A0.478
Pkdccprotein kinase domain containing, cytoplasmic0.474
Prrx2paired related homeobox 20.473
BmperBMP-binding endothelial regulator0.467
Eya1eyes absent 1 homolog (Drosophila)0.461
Gli1GLI-Kruppel family member GLI10.459
Ror2receptor tyrosine kinase-like orphan receptor 20.443
Nkx2-1NK2 homeobox 10.425
Insm1insulinoma-associated 10.411
En1engrailed 10.404
Adra1aadrenergic receptor, alpha 1a0.388
Gscgoosecoid homeobox0.386
Ascl1achaete-scute complex homolog 1 (Drosophila)0.375
Wnt3awingless-related MMTV integration site 3A0.353
Gsk3bglycogen synthase kinase 3 beta0.347
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.325
Rargretinoic acid receptor, gamma0.321
Zic2zinc finger protein of the cerebellum 20.313
Hoxd11homeobox D110.312
Wnt10bwingless related MMTV integration site 10b0.306
Alx4aristaless-like homeobox 40.290
Gdnfglial cell line derived neurotrophic factor0.283
Atxn1ataxin 10.277
Efsembryonal Fyn-associated substrate0.276
NanogNanog homeobox0.275
Pax6paired box gene 60.275
Psen1presenilin 10.274
Lrp6low density lipoprotein receptor-related protein 60.271
Pax9paired box gene 90.266
Emx2empty spiracles homolog 2 (Drosophila)0.265
Tgfb2transforming growth factor, beta 20.265
Mn1meningioma 10.261
Tbx15T-box 150.260
Nodalnodal0.257
Mitfmicrophthalmia-associated transcription factor0.250
Pdx1pancreatic and duodenal homeobox 10.246
Evc2Ellis van Creveld syndrome 2 homolog (human)0.242
Chrdchordin0.237
Apcadenomatosis polyposis coli0.235
Ift88intraflagellar transport 88 homolog (Chlamydomonas)0.232
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform0.230
Tcf21transcription factor 210.230
Kdm2blysine (K)-specific demethylase 2B0.221
Nrtnneurturin0.220
Zic3zinc finger protein of the cerebellum 30.219
Lhx3LIM homeobox protein 30.218
Megf8multiple EGF-like-domains 80.211
Kif3akinesin family member 3A0.207
Acanaggrecan0.206
Sox3SRY-box containing gene 30.205
Nkx2-2NK2 transcription factor related, locus 2 (Drosophila)0.199
Rnf2ring finger protein 20.187
Fgfr2fibroblast growth factor receptor 20.185
Wdr19WD repeat domain 190.177
Fzd1frizzled homolog 1 (Drosophila)0.173
Gas1growth arrest specific 10.172
Six3sine oculis-related homeobox 3 homolog (Drosophila)0.166
Zic1zinc finger protein of the cerebellum 10.165
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism