The network for 'cellular macromolecule localization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular macromolecule localization

Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.

NameDescriptionProbabilityFunc Analog Organism
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.933
Gria2glutamate receptor, ionotropic, AMPA 20.687
Mapre1microtubule-associated protein, RP/EB family, member 10.664
Rap1bRAP1B, member of RAS oncogene family0.603
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.599
Mapk1mitogen activated protein kinase 10.584
Myadmmyeloid-associated differentiation marker0.507
S100a10S100 calcium binding protein A100.505
Rhoaras homolog gene family, member A0.488
Pfn1profilin 10.478
Cltcclathrin, heavy chain (Hc)0.431
Zranb2zinc finger, RAN-binding domain containing 20.429
Actr3ARP3 actin-related protein 3 homolog (yeast)0.399
Hsph1heat shock 105/110 protein 10.369
Grin2aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.332
Cops7aCOP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)0.303
RragaRas-related GTP binding A0.302
Arpc1bactin related protein 2/3 complex, subunit 1B0.298
Capza2capping protein (actin filament) muscle Z-line, alpha 20.265
Pip4k2bphosphatidylinositol-5-phosphate 4-kinase, type II, beta0.255
Atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.249
Appamyloid beta (A4) precursor protein0.227
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.219
Tpm3tropomyosin 3, gamma0.217
Rtn4reticulon 40.216
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.215
Psmc1proteasome (prosome, macropain) 26S subunit, ATPase, 10.212
Anxa2annexin A20.209
Kctd13potassium channel tetramerisation domain containing 130.208
Stip1stress-induced phosphoprotein 10.206
Kif1bkinesin family member 1B0.202
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.198
Ppp2caprotein phosphatase 2, catalytic subunit, alpha isoform0.197
Dlg1discs, large homolog 1 (Drosophila)0.196
Calm2calmodulin 20.196
Grin1glutamate receptor, ionotropic, N-methyl D-aspartate 10.196
Gabarapl2GABA(A) receptor-associated protein like 20.194
Cdc42cell division cycle 42 (GTP binding protein)0.193
Arf1ADP-ribosylation factor 10.191
Itgb1integrin, beta 10.188
Ppp3r1protein phosphatase 3, regulatory subunit B, alpha isoform0.187
Grip2glutamate receptor interacting protein 20.187
Ppp2r2cprotein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform0.183
Wdr1WD repeat domain 10.183
Kcna3potassium voltage-gated channel, shaker-related subfamily, member 30.181
Nap1l1nucleosome assembly protein 1-like 10.176
Anxa4annexin A40.175
Col3a1collagen, type III, alpha 10.174
Rhobras homolog gene family, member B0.174
Tcof1Treacher Collins-Franceschetti syndrome 1 homolog (human)0.172
Sumo1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)0.170
Jak2Janus kinase 20.167
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform0.163
Snx6sorting nexin 60.162
Psma2proteasome (prosome, macropain) subunit, alpha type 20.159
Nlgn3neuroligin 30.159
Acta2smooth muscle alpha-actin0.157
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.156
Nrxn3neurexin 30.155
Zfand6zinc finger, AN1-type domain 60.155
Kcnd2potassium voltage-gated channel, Shal-related subfamily, member 20.154
Arpc2actin related protein 2/3 complex, subunit 20.154
Csf3colony stimulating factor 3 (granulocyte)0.152
Rhocras homolog gene family, member C0.151
Cap1CAP, adenylate cyclase-associated protein 1 (yeast)0.149
Actr2ARP2 actin-related protein 2 homolog (yeast)0.149
Stxbp1syntaxin binding protein 10.148
Khdrbs1KH domain containing, RNA binding, signal transduction associated 10.148
Ube2g1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)0.146
Stx12syntaxin 120.141
Nrxn1neurexin 10.141
Synj1synaptojanin 10.140
Atp2b1ATPase, Ca++ transporting, plasma membrane 10.137
Mpripmyosin phosphatase Rho interacting protein0.137
Apbb1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.134
LOC100362824caveolin 2-like0.133
Eif4a2eukaryotic translation initiation factor 4A, isoform 20.133
Cdc37cell division cycle 37 homolog (S. cerevisiae)0.131
Dlgap3discs, large (Drosophila) homolog-associated protein 30.131
Ctnnd2catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)0.131
Stx1asyntaxin 1A (brain)0.130
Pkiaprotein kinase (cAMP-dependent, catalytic) inhibitor alpha0.129
Rab7aRAB7A, member RAS oncogene family0.128
Jak1Janus kinase 10.127
Sirpasignal-regulatory protein alpha0.127
Akt1s1AKT1 substrate 1 (proline-rich)0.127
Pitpnaphosphatidylinositol transfer protein, alpha0.125
Atp6v0a1ATPase, H+ transporting, lysosomal V0 subunit A10.124
Dnm1ldynamin 1-like0.123
Pdcd6programmed cell death 60.123
Dpysl3dihydropyrimidinase-like 30.123
LOC100362155cysteine and histidine rich 10.122
Clic1chloride intracellular channel 10.121
Caskcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.120
Syt4synaptotagmin IV0.120
Dnajb1DnaJ (Hsp40) homolog, subfamily B, member 10.119
Ywhaqtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.119
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
mpk-1Protein MPK-10.537
par-5Protein PAR-50.335
atn-1Protein ATN-10.307
zyg-8Protein ZYG-80.302
D1081.8Protein D1081.80.273
npp-7Protein NPP-70.238
goa-1Protein GOA-10.224
flh-1Protein FLH-10.224
dnj-12Protein DNJ-120.177
unc-52Protein UNC-520.166
imb-2Protein IMB-20.163
stam-1Protein STAM-10.156
daf-3Protein DAF-30.148
nphp-4Protein NPHP-40.147
sem-5Protein SEM-50.145
ftt-2Protein FTT-20.144
egl-44Protein EGL-440.141
cpt-1Protein CPT-10.139
baf-1Protein BAF-10.139
hcp-4Protein HCP-40.137
F33H2.3Protein F33H2.30.137
spc-1Protein SPC-10.135
dsh-2Protein DSH-20.133
unc-9Protein UNC-90.125
hsp-1Protein HSP-10.123
lin-25Protein LIN-250.122
ZK418.9Protein ZK418.90.120
npp-20Protein NPP-200.111
glp-1Protein GLP-10.106
arl-8Protein ARL-80.105
zfp-1Protein ZFP-10.103
rab-1Protein RAB-10.102
sad-1Protein SAD-10.101
syg-1Protein SYG-10.101
snr-1Protein SNR-10.100
ntl-4Protein NTL-40.099
pdl-1Protein PDL-10.099
egl-8Protein EGL-80.098
egal-1Protein EGAL-10.097
mbk-2Protein MBK-20.097
cls-2Protein CLS-20.097
gei-17Protein GEI-170.096
sop-3Protein SOP-30.096
spr-5Protein SPR-50.093
mtr-4Protein MTR-40.091
ajm-1Protein AJM-10.091
rab-3Protein RAB-30.089
swsn-4Protein SWSN-40.089
F32B5.7Protein F32B5.70.087
F33H1.4Protein F33H1.40.085
npp-9Protein NPP-90.084
csnk-1Protein CSNK-10.083
rpn-1Protein RPN-10.083
unc-83Protein UNC-830.082
F10G8.8Protein F10G8.80.082
unc-10Protein UNC-100.081
hif-1Protein HIF-10.080
T01C3.2Protein T01C3.20.079
ain-1Protein AIN-10.079
mig-2Protein MIG-20.079
crn-5Protein CRN-50.079
rpn-3Protein RPN-30.078
unc-108Protein UNC-1080.078
T14B1.1Protein T14B1.10.078
lron-3Protein LRON-30.078
ess-2Protein ESS-20.077
cab-1Protein CAB-10.077
H43E16.1Protein H43E16.10.077
F56D2.6Protein F56D2.60.077
rpt-5Protein RPT-50.075
unc-85Protein UNC-850.074
glo-4Protein GLO-40.074
unc-59Protein UNC-590.074
let-502Protein LET-5020.074
cmd-1Protein CMD-10.073
Y43H11AL.1Protein Y43H11AL.10.073
hmp-1Protein HMP-10.073
eat-18Protein EAT-180.073
ldb-1Protein LDB-10.073
mig-15Protein MIG-150.072
lin-23Protein LIN-230.071
hmg-1.2Protein HMG-1.20.071
ZK858.6Protein ZK858.60.071
chaf-1Protein CHAF-10.070
let-60Protein LET-600.069
spd-5Protein SPD-50.069
pha-4Protein PHA-40.069
pdi-3Protein PDI-30.069
nap-1Protein NAP-10.068
npl-4.2Protein NPL-4.20.068
lag-1Protein LAG-10.068
swsn-1Protein SWSN-10.067
bbs-8Protein BBS-80.067
ttm-4Protein TTM-40.067
ubl-5Protein UBL-50.066
lin-37Protein LIN-370.066
sma-1Protein SMA-10.066
dcr-1Protein DCR-10.065
dpy-30Protein DPY-300.065
mel-11Protein MEL-110.064
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
nanos3nanos homolog 30.292
cdh1cadherin 1, epithelial0.169
nkx2.2aNK2 transcription factor related 2a0.168
pitx3paired-like homeodomain transcription factor 30.166
smad1MAD homolog 1 (Drosophila)0.148
igf1rainsulin-like growth factor 1a receptor0.142
ccna2cyclin A20.135
alcambactivated leukocyte cell adhesion molecule b0.134
flot2aflotillin 2a0.131
sept2septin 20.127
arpc5aactin related protein 2/3 complex, subunit 5A0.123
ddx46DEAD (Asp-Glu-Ala-Asp) box polypeptide 460.122
wnt11rwingless-type MMTV integration site family, member 11, related0.118
metmet proto-oncogene (hepatocyte growth factor receptor)0.117
shhbsonic hedgehog b0.108
lama2laminin, alpha 20.107
hspa4aheat shock protein 4a0.106
dag1dystroglycan 10.097
pak2ap21 (CDKN1A)-activated kinase 2a0.094
tcf7transcription factor 7 (T-cell specific, HMG-box)0.090
efnb2aephrin B2a0.085
acvr1bactivin A receptor, type IB0.084
lamb2laminin, beta 2 (laminin S)0.082
rangap1Ran GTPase activating protein 10.081
pkd2polycystic kidney disease 20.079
hsp90a.1heat shock protein 90-alpha 10.078
nf1aneurofibromin 1a0.077
ptenbphosphatase and tensin homolog B (mutated in multiple advanced cancers 1)0.075
lama4laminin, alpha 40.075
cxcr4achemokine (C-X-C motif) receptor 4a0.071
sumo2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)0.068
mtpmicrosomal triglyceride transfer protein0.068
snai1asnail homolog 1a (Drosophila)0.067
arl6ADP-ribosylation factor-like 60.066
acvr1lactivin A receptor, type I like0.064
ptch2patched 20.063
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.062
fgf3fibroblast growth factor 30.061
rag1recombination activating gene 10.061
ap2a1adaptor-related protein complex 2, alpha 1 subunit0.060
lamc1laminin, gamma 10.059
calb2bcalbindin 2b, (calretinin)0.057
krt8keratin 80.057
rap1bRAS related protein 1b0.056
rab1aRAB1A, member RAS oncogene family0.056
ilkintegrin linked kinase0.056
itgb1b.2integrin, beta 1b.20.055
ahctf1AT hook containing transcription factor 10.055
sulf1sulfatase 10.055
flncbfilamin C, gamma b (actin binding protein 280)0.054
pabpc1apoly A binding protein, cytoplasmic 1 a0.054
cadcarbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase0.053
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.053
sarsseryl-tRNA synthetase0.053
arnt2aryl hydrocarbon receptor nuclear translocator 20.052
pcnaproliferating cell nuclear antigen0.052
ef1aelongation factor 1-alpha0.051
unc45bunc-45 homolog B (C. elegans)0.050
tmem2transmembrane protein 20.050
hsp90a.2heat shock protein 90-alpha 20.050
mef2camyocyte enhancer factor 2ca0.048
csnk1dacasein kinase 1, delta a0.048
fzd7bfrizzled homolog 7b0.047
myod1myogenic differentiation 10.047
csrp1acysteine and glycine-rich protein 1a0.047
cntn1acontactin 1a0.046
bocbrother of CDO0.046
muskmuscle, skeletal, receptor tyrosine kinase0.044
cd63Cd63 antigen0.044
bmp1abone morphogenetic protein 1a0.044
pwp2hPWP2 periodic tryptophan protein homolog (yeast)0.043
foxa2forkhead box A20.043
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.042
LOC100535549cytoplasmic polyadenylation element-binding protein 4-like0.042
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.042
ilf2interleukin enhancer binding factor 20.042
cntn1bcontactin 1b0.041
gnaiaguanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a0.041
dlg2discs, large (Drosophila) homolog 20.040
yap1Yes-associated protein 10.040
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.037
ywhabatyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a0.037
cxcr4bchemokine (C-X-C motif), receptor 4b0.037
aplnraapelin receptor a0.036
fbn2bfibrillin 2b0.036
ptgs1prostaglandin-endoperoxide synthase 10.036
ppp2cbprotein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform0.036
dcun1d5DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae)0.035
copacoatomer protein complex, subunit alpha0.035
igf1rbinsulin-like growth factor 1b receptor0.035
sncgbsynuclein, gamma b (breast cancer-specific protein 1)0.035
per3period homolog 3 (Drosophila)0.035
arpc4actin related protein 2/3 complex, subunit 40.035
cul1acullin 1a0.034
rhoabras homolog gene family, member Ab0.034
dkk1bdickkopf 1b0.033
ube2iubiquitin-conjugating enzyme E2I0.033
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Rab11Rab-protein 110.998
TER94CG2331 gene product from transcript CG2331-RA0.988
par-6CG5884 gene product from transcript CG5884-RA0.983
eyaeyes absent0.972
aPKCatypical protein kinase C0.971
MadMothers against dpp0.970
Rab5Rab-protein 50.967
Ras85DRas oncogene at 85D0.955
cpbcapping protein beta0.950
cpacapping protein alpha0.942
BicDBicaudal D0.917
DlicDynein light intermediate chain0.910
Cdc42CG12530 gene product from transcript CG12530-RA0.907
rheaCG6831 gene product from transcript CG6831-RA0.898
Hel25EHelicase at 25E0.887
RhebCG1081 gene product from transcript CG1081-RA0.871
gbbglass bottom boat0.854
cicubitus interruptus0.836
Act5CActin 5C0.832
aspabnormal spindle0.825
slmbsupernumerary limbs0.823
Pi3K92ECG4141 gene product from transcript CG4141-RB0.812
KhcKinesin heavy chain0.765
sqhspaghetti squash0.754
Pp2B-14DProtein phosphatase 2B at 14D0.713
Fs(2)KetFemale sterile (2) Ketel0.700
Pi3K21BCG2699 gene product from transcript CG2699-RA0.684
spn-Espindle E0.678
fogfolded gastrulation0.669
phlpole hole0.636
l(2)gllethal (2) giant larvae0.617
Hrb27CHeterogeneous nuclear ribonucleoprotein at 27C0.615
sosine oculis0.609
magomago nashi0.608
beta4GalNAcTACG8536 gene product from transcript CG8536-RA0.604
Pka-C1cAMP-dependent protein kinase 10.572
LamCLamin C0.570
tacctransforming acidic coiled-coil protein0.561
aopanterior open0.555
MybMyb oncogene-like0.549
Npc1aNiemann-Pick type C-1a0.544
Aats-trpTryptophanyl-tRNA synthetase0.540
Ets97DEts at 97D0.523
RASSF8CG5053 gene product from transcript CG5053-RA0.515
Vps36Vacuolar protein sorting 360.514
ninaEneither inactivation nor afterpotential E0.512
Rac1CG2248 gene product from transcript CG2248-RA0.507
stcksteamer duck0.497
ebiCG4063 gene product from transcript CG4063-RA0.497
sas-6spindle assembly abnormal 60.489
mspsmini spindles0.484
Sir2CG5216 gene product from transcript CG5216-RA0.484
Atg1Autophagy-specific gene 10.471
sinaseven in absentia0.465
Rab6Rab-protein 60.464
l(3)01239lethal (3) 012390.464
Pp1-87BProtein phosphatase 1 at 87B0.455
TSG101tumor suppressor protein 1010.451
l(1)dd4lethal (1) discs degenerate 40.449
dallydivision abnormally delayed0.445
Tif-IACG3278 gene product from transcript CG3278-RA0.424
Src64BSrc oncogene at 64B0.423
pitaCG3941 gene product from transcript CG3941-RA0.418
shotshort stop0.417
Vap-33-1CG5014 gene product from transcript CG5014-RB0.416
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism