The network for 'actin crosslink formation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

actin crosslink formation

The process in which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes.

NameDescriptionProbabilityFunc Analog Organism
Actn1actinin, alpha 10.182
Iqgap1IQ motif containing GTPase activating protein 10.132
Myh9myosin, heavy chain 9, non-muscle0.121
Mylpfmyosin light chain, phosphorylatable, fast skeletal muscle0.097
Acta2smooth muscle alpha-actin0.081
Lmnalamin A0.078
Tpm2tropomyosin 2, beta0.078
Tagln2transgelin 20.071
Plxnb2plexin B20.070
AhnakAHNAK nucleoprotein0.064
Inainternexin neuronal intermediate filament protein, alpha0.054
Csrp1cysteine and glycine-rich protein 10.048
Tln1talin 10.047
Map4k4mitogen-activated protein kinase kinase kinase kinase 40.047
Magi2membrane associated guanylate kinase, WW and PDZ domain containing 20.045
Lamc1laminin, gamma 10.042
Atp2a1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.041
Snd1staphylococcal nuclease and tudor domain containing 10.037
Myl1myosin, light chain 10.037
LOC686323similar to thyroid receptor-interacting protein 60.033
Myl9myosin, light chain 9, regulatory0.033
Dlg3discs, large homolog 3 (Drosophila)0.031
Ckmcreatine kinase, muscle0.029
Myadmmyeloid-associated differentiation marker0.028
Ppp1r1aprotein phosphatase 1, regulatory (inhibitor) subunit 1A0.028
Mafkv-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)0.027
Cnksr3Cnksr family member 30.027
Acta1actin, alpha 1, skeletal muscle0.026
Cdh16cadherin 160.026
Pdzd4PDZ domain containing 40.026
Fam38afamily with sequence similarity 38, member A0.024
Dmgdhdimethylglycine dehydrogenase0.024
Pnmal2PNMA-like 20.022
Tnni2troponin I type 2 (skeletal, fast)0.021
Gprin1G protein-regulated inducer of neurite outgrowth 10.021
Flnafilamin A, alpha0.021
Fam129bfamily with sequence similarity 129, member B0.021
Vaspvasodilator-stimulated phosphoprotein0.021
Armcx2armadillo repeat containing, X-linked 20.020
Faahfatty acid amide hydrolase0.020
Slc27a2solute carrier family 27 (fatty acid transporter), member 20.020
Rtn1reticulon 10.019
Sncbsynuclein, beta0.019
Lin7blin-7 homolog b (C. elegans)0.019
Mcammelanoma cell adhesion molecule0.018
Flncfilamin C, gamma0.018
Nelfnasal embryonic LHRH factor0.018
Gneglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase0.018
Il4rainterleukin 4 receptor, alpha0.017
Gp1bbglycoprotein Ib (platelet), beta polypeptide0.017
Gprasp1G protein-coupled receptor associated sorting protein 10.016
Tuba1ctubulin, alpha 1C0.016
Kif5ckinesin family member 5C0.016
Actg2actin, gamma 2, smooth muscle, enteric0.015
Klkb1kallikrein B, plasma 10.015
Stx1bsyntaxin 1B0.015
Akap12A kinase (PRKA) anchor protein 120.015
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.015
Stmn3stathmin-like 30.015
Pcdha13protocadherin alpha 130.015
Tubb2btubulin, beta 2b0.015
Tspan7tetraspanin 70.014
Flnbfilamin, beta0.014
Nsg1neuron specific gene family member 10.014
Lppr3lipid phosphate phosphatase-related protein type 30.014
Elk3ELK3, ETS-domain protein0.014
Matkmegakaryocyte-associated tyrosine kinase0.014
Emilin1elastin microfibril interfacer 10.014
P2ry2purinergic receptor P2Y, G-protein coupled, 20.014
Hspb1heat shock protein 10.014
Traf4af1TRAF4 associated factor 10.014
Znf598zinc finger protein 5980.014
Trim35tripartite motif-containing 350.014
Dpysl5dihydropyrimidinase-like 50.013
L1camL1 cell adhesion molecule0.013
Cbln1cerebellin 1 precursor0.013
Spock2sparc/osteonectin, cwcv and kazal-like domains proteoglycan 20.013
Cnih2cornichon homolog 2 (Drosophila)0.012
Sfxn3sideroflexin 30.012
Zcchc12zinc finger, CCHC domain containing 120.012
Kynukynureninase (L-kynurenine hydrolase)0.012
Prkar1bprotein kinase, cAMP dependent regulatory, type I, beta0.012
Rilreversion induced LIM gene0.012
Marcksl1MARCKS-like 10.012
Myh7myosin, heavy chain 7, cardiac muscle, beta0.012
Mobkl2aMOB1, Mps One Binder kinase activator-like 2A (yeast)0.012
Map4microtubule-associated protein 40.012
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.012
Ces1ecarboxylesterase 1E0.012
Clip2CAP-GLY domain containing linker protein 20.011
Mvpmajor vault protein0.011
Nsg2neuron specific gene family member 20.011
Ptbp1polypyrimidine tract binding protein 10.011
Ncam1neural cell adhesion molecule 10.011
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
FN1fibronectin 10.683
FLNAfilamin A, alpha0.665
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.516
MYH9myosin, heavy chain 9, non-muscle0.470
WASF2WAS protein family, member 20.466
FLNBfilamin B, beta0.431
PSEN1presenilin 10.361
ACTN4actinin, alpha 40.300
PSEN2presenilin 2 (Alzheimer disease 4)0.177
SGCDsarcoglycan, delta (35kDa dystrophin-associated glycoprotein)0.121
SOS1son of sevenless homolog 1 (Drosophila)0.063
SGCGsarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)0.059
EPS8epidermal growth factor receptor pathway substrate 80.057
ACTN1actinin, alpha 10.056
TLN1talin 10.053
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.044
BAIAP2BAI1-associated protein 20.042
CASKcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.039
ABI1abl-interactor 10.033
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.026
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.026
FBLIM1filamin binding LIM protein 10.025
ITGB4integrin, beta 40.021
FHL2four and a half LIM domains 20.018
GULP1GULP, engulfment adaptor PTB domain containing 10.016
NCKAP1NCK-associated protein 10.015
ITGB5integrin, beta 50.015
ITGB7integrin, beta 70.013
ALDH7A1aldehyde dehydrogenase 7 family, member A10.012
PKP4plakophilin 40.012
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.012
XIRP1xin actin-binding repeat containing 10.011
ATN1atrophin 10.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism