The network for 'positive regulation of natural killer cell mediated cytotoxicity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of natural killer cell mediated cytotoxicity

Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity.

NameDescriptionProbabilityFunc Analog Organism
Klrd1killer cell lectin-like receptor, subfamily D, member 10.266
Cd2Cd2 molecule0.068
Cd247Cd247 molecule0.059
Gzmkgranzyme K0.057
Prf1perforin 1 (pore forming protein)0.046
Sh2d1aSH2 domain protein 1A0.046
Gimap4GTPase, IMAP family member 40.035
Cd5Cd5 molecule0.035
Apol3apolipoprotein L, 30.034
Gzmbgranzyme B0.034
Cd3gCD3 molecule, gamma0.030
Xcl1chemokine (C motif) ligand 10.030
Mcpt8mast cell protease 80.024
Ptprcapprotein tyrosine phosphatase, receptor type, C-associated protein0.021
Arhgef15Rho guanine nucleotide exchange factor (GEF) 150.020
Il2rbinterleukin 2 receptor, beta0.020
Dcaf7DDB1 and CUL4 associated factor 70.020
Ifit3interferon-induced protein with tetratricopeptide repeats 30.017
Unc45bunc-45 homolog B (C. elegans)0.017
Nkg7natural killer cell group 7 sequence0.017
Gimap6GTPase, IMAP family member 60.017
Tnfrsf14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.016
Cd8aCD8a molecule0.015
Zap70zeta-chain (TCR) associated protein kinase0.015
Spnsialophorin0.015
Mycmyelocytomatosis oncogene0.015
Tnfrsf12atumor necrosis factor receptor superfamily, member 12a0.014
Txnrd1thioredoxin reductase 10.013
Klrb1akiller cell lectin-like receptor subfamily B, member 1A0.013
Gimap5GTPase, IMAP family member 50.013
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.012
Cd96CD96 molecule0.012
Ddr1discoidin domain receptor tyrosine kinase 10.012
Sept1septin 10.012
Rhohras homolog gene family, member H0.012
Klra5killer cell lectin-like receptor, subfamily A, member 50.012
Gzmagranzyme A0.012
Gzmcgranzyme C0.012
Cdc2l5cell division cycle 2-like 5 (cholinesterase-related cell division controller)0.012
Faim3Fas apoptotic inhibitory molecule 30.011
Usp9xubiquitin specific peptidase 9, X-linked0.011
Gimap1GTPase, IMAP family member 10.011
Sox7SRY (sex determining region Y)-box 70.011
P2ry10purinergic receptor P2Y, G-protein coupled, 100.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 41.000
CD84CD84 molecule0.998
SLAMF1signaling lymphocytic activation molecule family member 10.997
KLRD1killer cell lectin-like receptor subfamily D, member 10.991
SH2D1ASH2 domain containing 1A0.982
PVRL4poliovirus receptor-related 40.915
IL2RBinterleukin 2 receptor, beta0.900
GZMKgranzyme K (granzyme 3; tryptase II)0.680
SH2D1BSH2 domain containing 1B0.628
BCRbreakpoint cluster region0.589
GBAglucosidase, beta, acid0.472
FYBFYN binding protein0.412
KLRK1killer cell lectin-like receptor subfamily K, member 10.386
KLRC3killer cell lectin-like receptor subfamily C, member 30.371
IL23Ainterleukin 23, alpha subunit p190.309
IFNGinterferon, gamma0.298
RAB14RAB14, member RAS oncogene family0.211
KLRC2killer cell lectin-like receptor subfamily C, member 20.188
CD244CD244 molecule, natural killer cell receptor 2B40.174
PTPN1protein tyrosine phosphatase, non-receptor type 10.172
TJP1tight junction protein 1 (zona occludens 1)0.138
FASLGFas ligand (TNF superfamily, member 6)0.086
DOK1docking protein 1, 62kDa (downstream of tyrosine kinase 1)0.085
CXCR6chemokine (C-X-C motif) receptor 60.081
PRF1perforin 1 (pore forming protein)0.077
NCSTNnicastrin0.075
BCAR1breast cancer anti-estrogen resistance 10.073
CD2CD2 molecule0.073
STAP2signal transducing adaptor family member 20.069
INSRinsulin receptor0.068
IL12Ainterleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)0.064
INPP5Dinositol polyphosphate-5-phosphatase, 145kDa0.059
CD3GCD3g molecule, gamma (CD3-TCR complex)0.053
ASAH1N-acylsphingosine amidohydrolase (acid ceramidase) 10.050
EPHB3EPH receptor B30.050
KLRB1killer cell lectin-like receptor subfamily B, member 10.049
TNFRSF12Atumor necrosis factor receptor superfamily, member 12A0.046
KLRG1killer cell lectin-like receptor subfamily G, member 10.043
CCR5chemokine (C-C motif) receptor 50.040
LMO2LIM domain only 2 (rhombotin-like 1)0.040
JAK1Janus kinase 10.040
IL18RAPinterleukin 18 receptor accessory protein0.039
GNLYgranulysin0.035
LY9lymphocyte antigen 90.034
KLRC4killer cell lectin-like receptor subfamily C, member 40.033
CD8ACD8a molecule0.032
KLRF1killer cell lectin-like receptor subfamily F, member 10.031
CD247CD247 molecule0.030
CD160CD160 molecule0.029
GZMBgranzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)0.028
EPB41L3erythrocyte membrane protein band 4.1-like 30.027
ITKIL2-inducible T-cell kinase0.026
JAK2Janus kinase 20.026
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.026
PYHIN1pyrin and HIN domain family, member 10.025
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.025
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.024
GZMAgranzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)0.022
GNSglucosamine (N-acetyl)-6-sulfatase0.022
KLRC1killer cell lectin-like receptor subfamily C, member 10.021
SH2D2ASH2 domain containing 2A0.021
XCL2chemokine (C motif) ligand 20.021
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.019
GPR65G protein-coupled receptor 650.018
TXKTXK tyrosine kinase0.017
MRASmuscle RAS oncogene homolog0.017
CD96CD96 molecule0.017
PRKCQprotein kinase C, theta0.016
LEPROTleptin receptor overlapping transcript0.016
GPR171G protein-coupled receptor 1710.016
CD80CD80 molecule0.015
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 20.015
CCL4chemokine (C-C motif) ligand 40.014
CD28CD28 molecule0.014
GPR18G protein-coupled receptor 180.014
CD226CD226 molecule0.014
STAT5Bsignal transducer and activator of transcription 5B0.013
CREG1cellular repressor of E1A-stimulated genes 10.013
HEXBhexosaminidase B (beta polypeptide)0.013
CTSWcathepsin W0.013
ITM2Bintegral membrane protein 2B0.013
ATF7IPactivating transcription factor 7 interacting protein0.012
HCSThematopoietic cell signal transducer0.012
TRAT1T cell receptor associated transmembrane adaptor 10.012
SLAMF6SLAM family member 60.012
TNFSF8tumor necrosis factor (ligand) superfamily, member 80.012
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor (GEF) 60.011
CTLA4cytotoxic T-lymphocyte-associated protein 40.011
EPHB2EPH receptor B20.011
ICOSinducible T-cell co-stimulator0.011
LEPROTL1leptin receptor overlapping transcript-like 10.010
IRF4interferon regulatory factor 40.010
CD69CD69 molecule0.010
CLINT1clathrin interactor 10.010
CD3DCD3d molecule, delta (CD3-TCR complex)0.010
THEMISthymocyte selection associated0.010
XCL1chemokine (C motif) ligand 10.010
CLEC5AC-type lectin domain family 5, member A0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Klrk1killer cell lectin-like receptor subfamily K, member 10.952
Klrc1killer cell lectin-like receptor subfamily C, member 10.913
Klra9killer cell lectin-like receptor subfamily A, member 90.907
Stat1signal transducer and activator of transcription 10.798
Stat5bsignal transducer and activator of transcription 5B0.794
FaslFas ligand (TNF superfamily, member 6)0.711
Icosinducible T-cell co-stimulator0.696
B2mbeta-2 microglobulin0.601
Gzmkgranzyme K0.581
H2-K1histocompatibility 2, K1, K region0.508
Stat5asignal transducer and activator of transcription 5A0.369
Gzmagranzyme A0.348
Gzmbgranzyme B0.318
Xcl1chemokine (C motif) ligand 10.289
Irf9interferon regulatory factor 90.283
Klrd1killer cell lectin-like receptor, subfamily D, member 10.270
TapbpTAP binding protein0.250
Ncr1natural cytotoxicity triggering receptor 10.249
Il18r1interleukin 18 receptor 10.229
Il18rapinterleukin 18 receptor accessory protein0.219
H2-Q7histocompatibility 2, Q region locus 70.187
Itgaxintegrin alpha X0.139
H2-D1histocompatibility 2, D region locus 10.122
Il10interleukin 100.112
Klrb1bkiller cell lectin-like receptor subfamily B member 1B0.108
Trim21tripartite motif-containing 210.100
Klra8killer cell lectin-like receptor, subfamily A, member 80.100
Klrb1ckiller cell lectin-like receptor subfamily B member 1C0.093
Stat3signal transducer and activator of transcription 30.088
Slamf1signaling lymphocytic activation molecule family member 10.086
Cd244CD244 natural killer cell receptor 2B40.084
Cd7CD7 antigen0.080
Klrb1akiller cell lectin-like receptor subfamily B member 1A0.079
Klrg1killer cell lectin-like receptor subfamily G, member 10.074
Ctswcathepsin W0.072
Emr4EGF-like module containing, mucin-like, hormone receptor-like sequence 40.069
Ctla4cytotoxic T-lymphocyte-associated protein 40.067
Cd180CD180 antigen0.066
Dpep3dipeptidase 30.063
Ubdubiquitin D0.062
Aoahacyloxyacyl hydrolase0.058
Il2rbinterleukin 2 receptor, beta chain0.056
Klra5killer cell lectin-like receptor, subfamily A, member 50.055
Pilrapaired immunoglobin-like type 2 receptor alpha0.055
ItkIL2-inducible T-cell kinase0.054
Nfil3nuclear factor, interleukin 3, regulated0.053
Slamf7SLAM family member 70.053
BC147527cDNA sequence BC1475270.051
Nkg7natural killer cell group 7 sequence0.051
Sh2d2aSH2 domain protein 2A0.050
Spna1spectrin alpha 10.049
Ccr3chemokine (C-C motif) receptor 30.047
Klra7killer cell lectin-like receptor, subfamily A, member 70.047
Parp14poly (ADP-ribose) polymerase family, member 140.047
Leprleptin receptor0.043
Prf1perforin 1 (pore forming protein)0.042
Bex6brain expressed gene 60.041
H2-Q8histocompatibility 2, Q region locus 80.041
H2-Eb1histocompatibility 2, class II antigen E beta0.040
Ms4a1membrane-spanning 4-domains, subfamily A, member 10.040
Pyhin1pyrin and HIN domain family, member 10.040
Ctsbcathepsin B0.038
Cpceruloplasmin0.037
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.035
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.035
Gzmcgranzyme C0.035
Cd160CD160 antigen0.034
Gbp7guanylate binding protein 70.033
Il6interleukin 60.032
Lair1leukocyte-associated Ig-like receptor 10.032
Cd96CD96 antigen0.031
Irgm2immunity-related GTPase family M member 20.030
Ctsdcathepsin D0.030
Fpr1formyl peptide receptor 10.029
Il4rainterleukin 4 receptor, alpha0.028
Stat2signal transducer and activator of transcription 20.028
Pilrb1paired immunoglobin-like type 2 receptor beta 10.027
Klra2killer cell lectin-like receptor, subfamily A, member 20.027
Ccr9chemokine (C-C motif) receptor 90.027
Ear2eosinophil-associated, ribonuclease A family, member 20.026
Cd3eCD3 antigen, epsilon polypeptide0.025
Il2rainterleukin 2 receptor, alpha chain0.025
Klra3killer cell lectin-like receptor, subfamily A, member 30.025
H2-Q6histocompatibility 2, Q region locus 60.025
Il6stinterleukin 6 signal transducer0.024
Gbp2guanylate binding protein 20.024
Il2interleukin 20.024
Itgaeintegrin alpha E, epithelial-associated0.024
Plbd2phospholipase B domain containing 20.023
Gcet2germinal center expressed transcript 20.023
Itga4integrin alpha 40.023
Ms4a4cmembrane-spanning 4-domains, subfamily A, member 4C0.023
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.023
Cd3gCD3 antigen, gamma polypeptide0.023
Irgm1immunity-related GTPase family M member 10.022
Ccr5chemokine (C-C motif) receptor 50.022
Ppargperoxisome proliferator activated receptor gamma0.022
Cxcr6chemokine (C-X-C motif) receptor 60.022
Sh2d1b1SH2 domain protein 1B10.022
AA408251expressed sequence AA4082510.021
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism