Process View
The network for 'positive regulation of natural killer cell mediated cytotoxicity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity.
Name | Description | Probability | Func Analog Organism |
---|---|---|---|
Klrd1 | killer cell lectin-like receptor, subfamily D, member 1 | 0.266 | |
Cd2 | Cd2 molecule | 0.068 | |
Cd247 | Cd247 molecule | 0.059 | |
Gzmk | granzyme K | 0.057 | |
Prf1 | perforin 1 (pore forming protein) | 0.046 | |
Sh2d1a | SH2 domain protein 1A | 0.046 | |
Gimap4 | GTPase, IMAP family member 4 | 0.035 | |
Cd5 | Cd5 molecule | 0.035 | |
Apol3 | apolipoprotein L, 3 | 0.034 | |
Gzmb | granzyme B | 0.034 | |
Cd3g | CD3 molecule, gamma | 0.030 | |
Xcl1 | chemokine (C motif) ligand 1 | 0.030 | |
Mcpt8 | mast cell protease 8 | 0.024 | |
Ptprcap | protein tyrosine phosphatase, receptor type, C-associated protein | 0.021 | |
Arhgef15 | Rho guanine nucleotide exchange factor (GEF) 15 | 0.020 | |
Il2rb | interleukin 2 receptor, beta | 0.020 | |
Dcaf7 | DDB1 and CUL4 associated factor 7 | 0.020 | |
Ifit3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.017 | |
Unc45b | unc-45 homolog B (C. elegans) | 0.017 | |
Nkg7 | natural killer cell group 7 sequence | 0.017 | |
Gimap6 | GTPase, IMAP family member 6 | 0.017 | |
Tnfrsf14 | tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) | 0.016 | |
Cd8a | CD8a molecule | 0.015 | |
Zap70 | zeta-chain (TCR) associated protein kinase | 0.015 | |
Spn | sialophorin | 0.015 | |
Myc | myelocytomatosis oncogene | 0.015 | |
Tnfrsf12a | tumor necrosis factor receptor superfamily, member 12a | 0.014 | |
Txnrd1 | thioredoxin reductase 1 | 0.013 | |
Klrb1a | killer cell lectin-like receptor subfamily B, member 1A | 0.013 | |
Gimap5 | GTPase, IMAP family member 5 | 0.013 | |
Ptpn22 | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) | 0.012 | |
Cd96 | CD96 molecule | 0.012 | |
Ddr1 | discoidin domain receptor tyrosine kinase 1 | 0.012 | |
Sept1 | septin 1 | 0.012 | |
Rhoh | ras homolog gene family, member H | 0.012 | |
Klra5 | killer cell lectin-like receptor, subfamily A, member 5 | 0.012 | |
Gzma | granzyme A | 0.012 | |
Gzmc | granzyme C | 0.012 | |
Cdc2l5 | cell division cycle 2-like 5 (cholinesterase-related cell division controller) | 0.012 | |
Faim3 | Fas apoptotic inhibitory molecule 3 | 0.011 | |
Usp9x | ubiquitin specific peptidase 9, X-linked | 0.011 | |
Gimap1 | GTPase, IMAP family member 1 | 0.011 | |
Sox7 | SRY (sex determining region Y)-box 7 | 0.011 | |
P2ry10 | purinergic receptor P2Y, G-protein coupled, 10 | 0.010 |
Name | Description | Probability | Func Analog Organism |
---|---|---|---|
MLLT4 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 | 1.000 | |
CD84 | CD84 molecule | 0.998 | |
SLAMF1 | signaling lymphocytic activation molecule family member 1 | 0.997 | |
KLRD1 | killer cell lectin-like receptor subfamily D, member 1 | 0.991 | |
SH2D1A | SH2 domain containing 1A | 0.982 | |
PVRL4 | poliovirus receptor-related 4 | 0.915 | |
IL2RB | interleukin 2 receptor, beta | 0.900 | |
GZMK | granzyme K (granzyme 3; tryptase II) | 0.680 | |
SH2D1B | SH2 domain containing 1B | 0.628 | |
BCR | breakpoint cluster region | 0.589 | |
GBA | glucosidase, beta, acid | 0.472 | |
FYB | FYN binding protein | 0.412 | |
KLRK1 | killer cell lectin-like receptor subfamily K, member 1 | 0.386 | |
KLRC3 | killer cell lectin-like receptor subfamily C, member 3 | 0.371 | |
IL23A | interleukin 23, alpha subunit p19 | 0.309 | |
IFNG | interferon, gamma | 0.298 | |
RAB14 | RAB14, member RAS oncogene family | 0.211 | |
KLRC2 | killer cell lectin-like receptor subfamily C, member 2 | 0.188 | |
CD244 | CD244 molecule, natural killer cell receptor 2B4 | 0.174 | |
PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.172 | |
TJP1 | tight junction protein 1 (zona occludens 1) | 0.138 | |
FASLG | Fas ligand (TNF superfamily, member 6) | 0.086 | |
DOK1 | docking protein 1, 62kDa (downstream of tyrosine kinase 1) | 0.085 | |
CXCR6 | chemokine (C-X-C motif) receptor 6 | 0.081 | |
PRF1 | perforin 1 (pore forming protein) | 0.077 | |
NCSTN | nicastrin | 0.075 | |
BCAR1 | breast cancer anti-estrogen resistance 1 | 0.073 | |
CD2 | CD2 molecule | 0.073 | |
STAP2 | signal transducing adaptor family member 2 | 0.069 | |
INSR | insulin receptor | 0.068 | |
IL12A | interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) | 0.064 | |
INPP5D | inositol polyphosphate-5-phosphatase, 145kDa | 0.059 | |
CD3G | CD3g molecule, gamma (CD3-TCR complex) | 0.053 | |
ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | 0.050 | |
EPHB3 | EPH receptor B3 | 0.050 | |
KLRB1 | killer cell lectin-like receptor subfamily B, member 1 | 0.049 | |
TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | 0.046 | |
KLRG1 | killer cell lectin-like receptor subfamily G, member 1 | 0.043 | |
CCR5 | chemokine (C-C motif) receptor 5 | 0.040 | |
LMO2 | LIM domain only 2 (rhombotin-like 1) | 0.040 | |
JAK1 | Janus kinase 1 | 0.040 | |
IL18RAP | interleukin 18 receptor accessory protein | 0.039 | |
GNLY | granulysin | 0.035 | |
LY9 | lymphocyte antigen 9 | 0.034 | |
KLRC4 | killer cell lectin-like receptor subfamily C, member 4 | 0.033 | |
CD8A | CD8a molecule | 0.032 | |
KLRF1 | killer cell lectin-like receptor subfamily F, member 1 | 0.031 | |
CD247 | CD247 molecule | 0.030 | |
CD160 | CD160 molecule | 0.029 | |
GZMB | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) | 0.028 | |
EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.027 | |
ITK | IL2-inducible T-cell kinase | 0.026 | |
JAK2 | Janus kinase 2 | 0.026 | |
SRC | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 0.026 | |
PYHIN1 | pyrin and HIN domain family, member 1 | 0.025 | |
CRKL | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 0.025 | |
CD3E | CD3e molecule, epsilon (CD3-TCR complex) | 0.024 | |
GZMA | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | 0.022 | |
GNS | glucosamine (N-acetyl)-6-sulfatase | 0.022 | |
KLRC1 | killer cell lectin-like receptor subfamily C, member 1 | 0.021 | |
SH2D2A | SH2 domain containing 2A | 0.021 | |
XCL2 | chemokine (C motif) ligand 2 | 0.021 | |
IL12B | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | 0.019 | |
GPR65 | G protein-coupled receptor 65 | 0.018 | |
TXK | TXK tyrosine kinase | 0.017 | |
MRAS | muscle RAS oncogene homolog | 0.017 | |
CD96 | CD96 molecule | 0.017 | |
PRKCQ | protein kinase C, theta | 0.016 | |
LEPROT | leptin receptor overlapping transcript | 0.016 | |
GPR171 | G protein-coupled receptor 171 | 0.016 | |
CD80 | CD80 molecule | 0.015 | |
AGAP2 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 | 0.015 | |
CCL4 | chemokine (C-C motif) ligand 4 | 0.014 | |
CD28 | CD28 molecule | 0.014 | |
GPR18 | G protein-coupled receptor 18 | 0.014 | |
CD226 | CD226 molecule | 0.014 | |
STAT5B | signal transducer and activator of transcription 5B | 0.013 | |
CREG1 | cellular repressor of E1A-stimulated genes 1 | 0.013 | |
HEXB | hexosaminidase B (beta polypeptide) | 0.013 | |
CTSW | cathepsin W | 0.013 | |
ITM2B | integral membrane protein 2B | 0.013 | |
ATF7IP | activating transcription factor 7 interacting protein | 0.012 | |
HCST | hematopoietic cell signal transducer | 0.012 | |
TRAT1 | T cell receptor associated transmembrane adaptor 1 | 0.012 | |
SLAMF6 | SLAM family member 6 | 0.012 | |
TNFSF8 | tumor necrosis factor (ligand) superfamily, member 8 | 0.012 | |
ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 | 0.011 | |
CTLA4 | cytotoxic T-lymphocyte-associated protein 4 | 0.011 | |
EPHB2 | EPH receptor B2 | 0.011 | |
ICOS | inducible T-cell co-stimulator | 0.011 | |
LEPROTL1 | leptin receptor overlapping transcript-like 1 | 0.010 | |
IRF4 | interferon regulatory factor 4 | 0.010 | |
CD69 | CD69 molecule | 0.010 | |
CLINT1 | clathrin interactor 1 | 0.010 | |
CD3D | CD3d molecule, delta (CD3-TCR complex) | 0.010 | |
THEMIS | thymocyte selection associated | 0.010 | |
XCL1 | chemokine (C motif) ligand 1 | 0.010 | |
CLEC5A | C-type lectin domain family 5, member A | 0.010 |
Name | Description | Probability | Func Analog Organism |
---|---|---|---|
Klrk1 | killer cell lectin-like receptor subfamily K, member 1 | 0.952 | |
Klrc1 | killer cell lectin-like receptor subfamily C, member 1 | 0.913 | |
Klra9 | killer cell lectin-like receptor subfamily A, member 9 | 0.907 | |
Stat1 | signal transducer and activator of transcription 1 | 0.798 | |
Stat5b | signal transducer and activator of transcription 5B | 0.794 | |
Fasl | Fas ligand (TNF superfamily, member 6) | 0.711 | |
Icos | inducible T-cell co-stimulator | 0.696 | |
B2m | beta-2 microglobulin | 0.601 | |
Gzmk | granzyme K | 0.581 | |
H2-K1 | histocompatibility 2, K1, K region | 0.508 | |
Stat5a | signal transducer and activator of transcription 5A | 0.369 | |
Gzma | granzyme A | 0.348 | |
Gzmb | granzyme B | 0.318 | |
Xcl1 | chemokine (C motif) ligand 1 | 0.289 | |
Irf9 | interferon regulatory factor 9 | 0.283 | |
Klrd1 | killer cell lectin-like receptor, subfamily D, member 1 | 0.270 | |
Tapbp | TAP binding protein | 0.250 | |
Ncr1 | natural cytotoxicity triggering receptor 1 | 0.249 | |
Il18r1 | interleukin 18 receptor 1 | 0.229 | |
Il18rap | interleukin 18 receptor accessory protein | 0.219 | |
H2-Q7 | histocompatibility 2, Q region locus 7 | 0.187 | |
Itgax | integrin alpha X | 0.139 | |
H2-D1 | histocompatibility 2, D region locus 1 | 0.122 | |
Il10 | interleukin 10 | 0.112 | |
Klrb1b | killer cell lectin-like receptor subfamily B member 1B | 0.108 | |
Trim21 | tripartite motif-containing 21 | 0.100 | |
Klra8 | killer cell lectin-like receptor, subfamily A, member 8 | 0.100 | |
Klrb1c | killer cell lectin-like receptor subfamily B member 1C | 0.093 | |
Stat3 | signal transducer and activator of transcription 3 | 0.088 | |
Slamf1 | signaling lymphocytic activation molecule family member 1 | 0.086 | |
Cd244 | CD244 natural killer cell receptor 2B4 | 0.084 | |
Cd7 | CD7 antigen | 0.080 | |
Klrb1a | killer cell lectin-like receptor subfamily B member 1A | 0.079 | |
Klrg1 | killer cell lectin-like receptor subfamily G, member 1 | 0.074 | |
Ctsw | cathepsin W | 0.072 | |
Emr4 | EGF-like module containing, mucin-like, hormone receptor-like sequence 4 | 0.069 | |
Ctla4 | cytotoxic T-lymphocyte-associated protein 4 | 0.067 | |
Cd180 | CD180 antigen | 0.066 | |
Dpep3 | dipeptidase 3 | 0.063 | |
Ubd | ubiquitin D | 0.062 | |
Aoah | acyloxyacyl hydrolase | 0.058 | |
Il2rb | interleukin 2 receptor, beta chain | 0.056 | |
Klra5 | killer cell lectin-like receptor, subfamily A, member 5 | 0.055 | |
Pilra | paired immunoglobin-like type 2 receptor alpha | 0.055 | |
Itk | IL2-inducible T-cell kinase | 0.054 | |
Nfil3 | nuclear factor, interleukin 3, regulated | 0.053 | |
Slamf7 | SLAM family member 7 | 0.053 | |
BC147527 | cDNA sequence BC147527 | 0.051 | |
Nkg7 | natural killer cell group 7 sequence | 0.051 | |
Sh2d2a | SH2 domain protein 2A | 0.050 | |
Spna1 | spectrin alpha 1 | 0.049 | |
Ccr3 | chemokine (C-C motif) receptor 3 | 0.047 | |
Klra7 | killer cell lectin-like receptor, subfamily A, member 7 | 0.047 | |
Parp14 | poly (ADP-ribose) polymerase family, member 14 | 0.047 | |
Lepr | leptin receptor | 0.043 | |
Prf1 | perforin 1 (pore forming protein) | 0.042 | |
Bex6 | brain expressed gene 6 | 0.041 | |
H2-Q8 | histocompatibility 2, Q region locus 8 | 0.041 | |
H2-Eb1 | histocompatibility 2, class II antigen E beta | 0.040 | |
Ms4a1 | membrane-spanning 4-domains, subfamily A, member 1 | 0.040 | |
Pyhin1 | pyrin and HIN domain family, member 1 | 0.040 | |
Ctsb | cathepsin B | 0.038 | |
Cp | ceruloplasmin | 0.037 | |
Psmb9 | proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) | 0.035 | |
Tap2 | transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) | 0.035 | |
Gzmc | granzyme C | 0.035 | |
Cd160 | CD160 antigen | 0.034 | |
Gbp7 | guanylate binding protein 7 | 0.033 | |
Il6 | interleukin 6 | 0.032 | |
Lair1 | leukocyte-associated Ig-like receptor 1 | 0.032 | |
Cd96 | CD96 antigen | 0.031 | |
Irgm2 | immunity-related GTPase family M member 2 | 0.030 | |
Ctsd | cathepsin D | 0.030 | |
Fpr1 | formyl peptide receptor 1 | 0.029 | |
Il4ra | interleukin 4 receptor, alpha | 0.028 | |
Stat2 | signal transducer and activator of transcription 2 | 0.028 | |
Pilrb1 | paired immunoglobin-like type 2 receptor beta 1 | 0.027 | |
Klra2 | killer cell lectin-like receptor, subfamily A, member 2 | 0.027 | |
Ccr9 | chemokine (C-C motif) receptor 9 | 0.027 | |
Ear2 | eosinophil-associated, ribonuclease A family, member 2 | 0.026 | |
Cd3e | CD3 antigen, epsilon polypeptide | 0.025 | |
Il2ra | interleukin 2 receptor, alpha chain | 0.025 | |
Klra3 | killer cell lectin-like receptor, subfamily A, member 3 | 0.025 | |
H2-Q6 | histocompatibility 2, Q region locus 6 | 0.025 | |
Il6st | interleukin 6 signal transducer | 0.024 | |
Gbp2 | guanylate binding protein 2 | 0.024 | |
Il2 | interleukin 2 | 0.024 | |
Itgae | integrin alpha E, epithelial-associated | 0.024 | |
Plbd2 | phospholipase B domain containing 2 | 0.023 | |
Gcet2 | germinal center expressed transcript 2 | 0.023 | |
Itga4 | integrin alpha 4 | 0.023 | |
Ms4a4c | membrane-spanning 4-domains, subfamily A, member 4C | 0.023 | |
Rela | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 0.023 | |
Cd3g | CD3 antigen, gamma polypeptide | 0.023 | |
Irgm1 | immunity-related GTPase family M member 1 | 0.022 | |
Ccr5 | chemokine (C-C motif) receptor 5 | 0.022 | |
Pparg | peroxisome proliferator activated receptor gamma | 0.022 | |
Cxcr6 | chemokine (C-X-C motif) receptor 6 | 0.022 | |
Sh2d1b1 | SH2 domain protein 1B1 | 0.022 | |
AA408251 | expressed sequence AA408251 | 0.021 |