The network for 'positive regulation of synaptic plasticity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of synaptic plasticity

A process that increases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.

NameDescriptionProbabilityFunc Analog Organism
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.222
Mmp3matrix metallopeptidase 30.204
Calcbcalcitonin-related polypeptide, beta0.183
Racgap1Rac GTPase-activating protein 10.160
Mmp12matrix metallopeptidase 120.131
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.124
Ccnb1cyclin B10.118
Mmp13matrix metallopeptidase 130.099
Hrasls5HRAS-like suppressor family, member 50.091
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.076
Il6interleukin 60.070
Pipprolactin induced protein0.065
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.059
Top2atopoisomerase (DNA) II alpha0.058
C1qtnf5C1q and tumor necrosis factor related protein 50.054
Mmp9matrix metallopeptidase 90.052
Plk1polo-like kinase 1 (Drosophila)0.049
Arhgap10Rho GTPase activating protein 100.048
Ibspintegrin-binding sialoprotein0.047
Cd80Cd80 molecule0.047
Pttg1pituitary tumor-transforming 10.046
LOC689399hypothetical protein LOC6893990.044
MrgprfMAS-related GPR, member F0.043
Cacnb3calcium channel, voltage-dependent, beta 3 subunit0.041
Ltbp3latent transforming growth factor beta binding protein 30.040
Cdca3cell division cycle associated 30.040
Vipvasoactive intestinal peptide0.038
Htr2b5-hydroxytryptamine (serotonin) receptor 2B0.038
Cdk1cyclin-dependent kinase 10.037
Ugt1a7cUDP glucuronosyltransferase 1 family, polypeptide A7C0.035
Slc6a5solute carrier family 6 (neurotransmitter transporter, glycine), member 50.034
Csf3colony stimulating factor 3 (granulocyte)0.033
Col12a1collagen, type XII, alpha 10.031
Accn3amiloride-sensitive cation channel 30.030
Nr4a3nuclear receptor subfamily 4, group A, member 30.029
Fbln5fibulin 50.029
Tfectranscription factor EC0.029
Plauplasminogen activator, urokinase0.028
Tacr1tachykinin receptor 10.028
Fam38bfamily with sequence similarity 38, member B0.028
Ube2cubiquitin-conjugating enzyme E2C0.028
Ccl4chemokine (C-C motif) ligand 40.027
Olfml2bolfactomedin-like 2B0.026
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.025
Ccl11chemokine (C-C motif) ligand 110.025
Egr2early growth response 20.024
Ccr1chemokine (C-C motif) receptor 10.024
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.023
Foxe3forkhead box E30.023
Gabrg3gamma-aminobutyric acid (GABA) A receptor, gamma 30.022
Fmodfibromodulin0.022
Selpselectin P0.022
Kifc1kinesin family member C10.022
Bst1bone marrow stromal cell antigen 10.022
Cercamcerebral endothelial cell adhesion molecule0.021
Figfc-fos induced growth factor0.021
Cenptcentromere protein T0.021
Glycam1glycosylation dependent cell adhesion molecule 10.020
Elnelastin0.020
Gng8guanine nucleotide binding protein (G protein), gamma 80.020
Klrc1killer cell lectin-like receptor subfamily C, member 10.020
Cspg4chondroitin sulfate proteoglycan 40.020
Mmp7matrix metallopeptidase 70.020
Sfrp4secreted frizzled-related protein 40.019
Esr2estrogen receptor 2 (ER beta)0.019
Kif18bkinesin family member 18B0.018
Crisp1cysteine-rich secretory protein 10.018
Mybphmyosin binding protein H0.018
Seleselectin E0.018
RGD1561143similar to cell surface receptor FDFACT0.018
Sprr3small proline-rich protein 30.018
Nox1NADPH oxidase 10.018
Pgfplacental growth factor0.018
Ptpn7protein tyrosine phosphatase, non-receptor type 70.018
Reg3gregenerating islet-derived 3 gamma0.018
Eregepiregulin0.017
Bfsp1beaded filament structural protein 10.017
Sval1seminal vesicle antigen-like 10.017
LOC686539similar to immunoglobulin superfamily containing leucine-rich repeat0.017
Traf4af1TRAF4 associated factor 10.017
Slc24a6solute carrier family 24 (sodium/potassium/calcium exchanger), member 60.017
Col5a1collagen, type V, alpha 10.017
Fosl1fos-like antigen 10.016
Kcnj8potassium inwardly-rectifying channel, subfamily J, member 80.016
Col1a1collagen, type I, alpha 10.016
Stxbp2syntaxin binding protein 20.016
Cpa3carboxypeptidase A3, mast cell0.016
Dock8dedicator of cytokinesis 80.016
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.016
Mcm5minichromosome maintenance complex component 50.016
Ascl2achaete-scute complex homolog 2 (Drosophila)0.015
Tgfb1i1transforming growth factor beta 1 induced transcript 10.015
Vom1r101vomeronasal 1 receptor 1010.015
Espl1extra spindle pole bodies homolog 1 (S. cerevisiae)0.015
VgfVGF nerve growth factor inducible0.014
Bcat1branched chain aminotransferase 1, cytosolic0.014
Neurl3neuralized homolog 3 (Drosophila)0.014
Dlgap5discs, large (Drosophila) homolog-associated protein 50.014
Chiachitinase, acidic0.014
Gabrr1gamma-aminobutyric acid (GABA) receptor, rho 10.014
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Neurod1neurogenic differentiation 10.998
Ascl1achaete-scute complex homolog 1 (Drosophila)0.994
Neurod4neurogenic differentiation 40.982
Pax6paired box gene 60.935
Neurog2neurogenin 20.933
Neurog3neurogenin 30.874
Otx2orthodenticle homolog 2 (Drosophila)0.868
Isl1ISL1 transcription factor, LIM/homeodomain0.867
Shhsonic hedgehog0.757
Hand2heart and neural crest derivatives expressed transcript 20.674
Onecut1one cut domain, family member 10.606
Hand1heart and neural crest derivatives expressed transcript 10.604
Tcfap2atranscription factor AP-2, alpha0.587
Gata1GATA binding protein 10.579
MecomMDS1 and EVI1 complex locus0.549
Nhlh1nescient helix loop helix 10.547
Ptf1apancreas specific transcription factor, 1a0.449
Msx1homeobox, msh-like 10.427
Insm1insulinoma-associated 10.422
Lhx3LIM homeobox protein 30.372
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.370
Mab21l2mab-21-like 2 (C. elegans)0.364
Nr5a1nuclear receptor subfamily 5, group A, member 10.342
Ilkintegrin linked kinase0.340
Foxd4forkhead box D40.334
Gpr50G-protein-coupled receptor 500.333
Lhx5LIM homeobox protein 50.332
Efna2ephrin A20.307
Gdf11growth differentiation factor 110.306
Dkk1dickkopf homolog 1 (Xenopus laevis)0.292
Bub1bbudding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)0.274
Kcnq2potassium voltage-gated channel, subfamily Q, member 20.258
Prph2peripherin 20.243
Chrnb2cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)0.242
Pou4f2POU domain, class 4, transcription factor 20.236
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.235
Tlx3T-cell leukemia, homeobox 30.234
Alx3aristaless-like homeobox 30.228
Hoxb1homeobox B10.227
Hoxd13homeobox D130.216
Nkx3-2NK3 homeobox 20.214
Nos2nitric oxide synthase 2, inducible0.211
Mmp24matrix metallopeptidase 240.210
Mmp9matrix metallopeptidase 90.210
Hba-xhemoglobin X, alpha-like embryonic chain in Hba complex0.207
Neurod2neurogenic differentiation 20.206
Il6interleukin 60.203
Trim10tripartite motif-containing 100.203
Pdx1pancreatic and duodenal homeobox 10.202
Il10interleukin 100.190
Pitx1paired-like homeodomain transcription factor 10.181
Elavl4ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)0.179
Mxd3Max dimerization protein 30.179
Tbrachyury0.179
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.176
Col9a1collagen, type IX, alpha 10.175
Tlr4toll-like receptor 40.168
Chrna3cholinergic receptor, nicotinic, alpha polypeptide 30.163
Tcf15transcription factor 150.162
Dlx2distal-less homeobox 20.162
Slc4a1solute carrier family 4 (anion exchanger), member 10.161
Sox11SRY-box containing gene 110.161
Prrx2paired related homeobox 20.157
Fgf15fibroblast growth factor 150.154
Ncanneurocan0.153
Six6sine oculis-related homeobox 6 homolog (Drosophila)0.152
Snai1snail homolog 1 (Drosophila)0.148
Gata4GATA binding protein 40.145
Dccdeleted in colorectal carcinoma0.145
Prphperipherin0.145
Pitx2paired-like homeodomain transcription factor 20.140
Hbb-bh1hemoglobin Z, beta-like embryonic chain0.134
Dab1disabled homolog 1 (Drosophila)0.132
Pou3f2POU domain, class 3, transcription factor 20.132
Six3sine oculis-related homeobox 3 homolog (Drosophila)0.132
Pax3paired box gene 30.131
Rspo2R-spondin 2 homolog (Xenopus laevis)0.131
Gypaglycophorin A0.127
RhagRhesus blood group-associated A glycoprotein0.126
Nkx1-2NK1 transcription factor related, locus 2 (Drosophila)0.126
Hbb-yhemoglobin Y, beta-like embryonic chain0.125
Ebf2early B-cell factor 20.122
Glra1glycine receptor, alpha 1 subunit0.122
Ebf3early B-cell factor 30.121
Vsx2visual system homeobox 20.121
Gfra3glial cell line derived neurotrophic factor family receptor alpha 30.120
Gscgoosecoid homeobox0.119
Hoxd3homeobox D30.117
Hoxa10homeobox A100.117
Foxd2forkhead box D20.113
Epxeosinophil peroxidase0.109
Ank1ankyrin 1, erythroid0.109
Emx1empty spiracles homolog 1 (Drosophila)0.109
En1engrailed 10.108
Platplasminogen activator, tissue0.106
Plauplasminogen activator, urokinase0.104
Col22a1collagen, type XXII, alpha 10.104
Sim2single-minded homolog 2 (Drosophila)0.103
Stmn4stathmin-like 40.103
Hoxb7homeobox B70.100
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism