The network for 'response to cocaine' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to cocaine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant.

NameDescriptionProbabilityFunc Analog Organism
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.869
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.557
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.491
Chrna1cholinergic receptor, nicotinic, alpha 1 (muscle)0.427
Grm1glutamate receptor, metabotropic 10.402
Cckarcholecystokinin A receptor0.264
Npy5rneuropeptide Y receptor Y50.249
Slc30a2solute carrier family 30 (zinc transporter), member 20.249
Slc6a11solute carrier family 6 (neurotransmitter transporter, GABA), member 110.230
Hrh4histamine receptor H40.228
Drd1adopamine receptor D1A0.192
Dccdeleted in colorectal carcinoma0.191
Gata4GATA binding protein 40.189
FevFEV (ETS oncogene family)0.189
Vipvasoactive intestinal peptide0.185
Ompolfactory marker protein0.185
Htr75-hydroxytryptamine (serotonin) receptor 70.177
Hrh3histamine receptor H30.176
Hsd3b5hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 50.174
Kcnh7potassium voltage-gated channel, subfamily H (eag-related), member 70.172
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.169
Gad2glutamate decarboxylase 20.165
Akr1c18aldo-keto reductase family 1, member C180.164
Avpr1barginine vasopressin receptor 1B0.162
Lim2lens intrinsic membrane protein 20.162
UncxUNC homeobox0.161
Ctsjcathepsin J0.160
Fxyd4FXYD domain-containing ion transport regulator 40.158
Chrna6cholinergic receptor, nicotinic, alpha 60.151
Chrna7cholinergic receptor, nicotinic, alpha 70.149
N5DNA binding protein N50.147
Grik1glutamate receptor, ionotropic, kainate 10.146
Pspparotid secretory protein0.144
Slc16a8solute carrier family 16, member 8 (monocarboxylic acid transporter 3)0.144
Gfra2GDNF family receptor alpha 20.143
Clstn3calsyntenin 30.138
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.137
Notch3Notch homolog 3 (Drosophila)0.137
Magmyelin-associated glycoprotein0.131
Rgs8regulator of G-protein signaling 80.130
Gpr12G protein-coupled receptor 120.127
Slc8a3solute carrier family 8 (sodium/calcium exchanger), member 30.125
Mamdc4MAM domain containing 40.125
FosFBJ osteosarcoma oncogene0.122
RGD1562618similar to RIKEN cDNA 6030419C18 gene0.121
RGD1564664similar to LOC387763 protein0.118
Slc6a18solute carrier family 6, member 180.117
Chrngcholinergic receptor, nicotinic, gamma0.116
Egr2early growth response 20.116
Dlg4discs, large homolog 4 (Drosophila)0.114
Ptafrplatelet-activating factor receptor0.114
Slc8a2solute carrier family 8 (sodium/calcium exchanger), member 20.112
Olr1641olfactory receptor 16410.110
Olr287olfactory receptor 2870.110
Slc14a2solute carrier family 14 (urea transporter), member 20.110
Atp7bATPase, Cu++ transporting, beta polypeptide0.110
Spt1salivary protein 10.107
Htr5a5-hydroxytryptamine (serotonin) receptor 5A0.103
Cpne9copine family member IX0.101
Crhcorticotropin releasing hormone0.097
Catsper2cation channel, sperm associated 20.095
Arandrogen receptor0.094
Gabrr3gamma-aminobutyric acid (GABA) receptor, rho 30.093
Insrrinsulin receptor-related receptor0.092
Col10a1collagen, type X, alpha 10.091
Csf1colony stimulating factor 1 (macrophage)0.091
Junbjun B proto-oncogene0.090
Slc32a1solute carrier family 32 (GABA vesicular transporter), member 10.089
Arpp21cAMP-regulated phosphoprotein 210.088
Egr1early growth response 10.087
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.087
Grpgastrin releasing peptide0.087
Nr4a3nuclear receptor subfamily 4, group A, member 30.085
Olr226olfactory receptor 2260.085
Gabbr1gamma-aminobutyric acid (GABA) B receptor 10.084
Tacr2tachykinin receptor 20.084
Cnga3cyclic nucleotide gated channel alpha 30.084
Impg2interphotoreceptor matrix proteoglycan 20.083
Celsr3cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)0.083
Akp3alkaline phosphatase 3, intestine, not Mn requiring0.083
Oprl1opiate receptor-like 10.081
Slc18a3solute carrier family 18 (vesicular acetylcholine), member 30.080
Scn10asodium channel, voltage-gated, type X, alpha subunit0.080
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 10.079
Prlhrprolactin releasing hormone receptor0.078
Glra1glycine receptor, alpha 10.078
Thtyrosine hydroxylase0.078
Prss1protease, serine, 1 (trypsin 1)0.077
RT1-A3RT1 class I, locus A30.076
Grik3glutamate receptor, ionotropic, kainate 30.076
Sstr5somatostatin receptor 50.076
Grid2glutamate receptor, ionotropic, delta 20.075
Avparginine vasopressin0.074
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CG13253CG13253 gene product from transcript CG13253-RB0.021
jebjelly belly0.020
CG42629CG42629 gene product from transcript CG42629-RB0.020
TbhTyramine beta hydroxylase0.016
Vap-33-1CG5014 gene product from transcript CG5014-RB0.012
Octbeta2RCG33976 gene product from transcript CG33976-RA0.012
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
DLG4discs, large homolog 4 (Drosophila)0.935
IRS1insulin receptor substrate 10.681
ESR1estrogen receptor 10.604
AKAP1A kinase (PRKA) anchor protein 10.527
CSNK1Ecasein kinase 1, epsilon0.442
UCHL1ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)0.385
BCAR1breast cancer anti-estrogen resistance 10.350
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.322
UHRF1ubiquitin-like with PHD and ring finger domains 10.281
CRHcorticotropin releasing hormone0.281
CRHR1corticotropin releasing hormone receptor 10.239
CAMK2Acalcium/calmodulin-dependent protein kinase II alpha0.237
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.225
GRB10growth factor receptor-bound protein 100.212
VAC14Vac14 homolog (S. cerevisiae)0.192
MCCmutated in colorectal cancers0.174
DVL2dishevelled, dsh homolog 2 (Drosophila)0.170
ADORA2Aadenosine A2a receptor0.154
DNMT3ADNA (cytosine-5-)-methyltransferase 3 alpha0.152
AXIN1axin 10.141
KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)0.137
NCOR2nuclear receptor corepressor 20.132
DYNC1I1dynein, cytoplasmic 1, intermediate chain 10.115
BADBCL2-associated agonist of cell death0.111
HSPH1heat shock 105kDa/110kDa protein 10.107
DNMT3BDNA (cytosine-5-)-methyltransferase 3 beta0.101
GRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.100
ARHGEF1Rho guanine nucleotide exchange factor (GEF) 10.095
IRS2insulin receptor substrate 20.094
JDP2Jun dimerization protein 20.092
BAK1BCL2-antagonist/killer 10.090
PER1period homolog 1 (Drosophila)0.089
DLGAP1discs, large (Drosophila) homolog-associated protein 10.086
BCL2L1BCL2-like 10.084
MDM2Mdm2 p53 binding protein homolog (mouse)0.081
FAM110Afamily with sequence similarity 110, member A0.079
ARHGEF12Rho guanine nucleotide exchange factor (GEF) 120.079
BCL6B-cell CLL/lymphoma 60.077
NR1H2nuclear receptor subfamily 1, group H, member 20.076
DVL1dishevelled, dsh homolog 1 (Drosophila)0.075
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.073
GRIN2Cglutamate receptor, ionotropic, N-methyl D-aspartate 2C0.068
CASP7caspase 7, apoptosis-related cysteine peptidase0.067
FAM110Cfamily with sequence similarity 110, member C0.065
KCNA4potassium voltage-gated channel, shaker-related subfamily, member 40.065
ACACAacetyl-CoA carboxylase alpha0.059
EGR3early growth response 30.057
HES1hairy and enhancer of split 1, (Drosophila)0.055
BBS10Bardet-Biedl syndrome 100.055
PRKACBprotein kinase, cAMP-dependent, catalytic, beta0.054
SNAI1snail homolog 1 (Drosophila)0.054
RNF144Bring finger protein 144B0.053
NR4A1nuclear receptor subfamily 4, group A, member 10.053
TAOK1TAO kinase 10.053
ANXA4annexin A40.053
BCL2L11BCL2-like 11 (apoptosis facilitator)0.051
BCL2B-cell CLL/lymphoma 20.049
CADM4cell adhesion molecule 40.048
HSPA9heat shock 70kDa protein 9 (mortalin)0.047
CUEDC2CUE domain containing 20.047
DVL3dishevelled, dsh homolog 3 (Drosophila)0.046
MBD1methyl-CpG binding domain protein 10.045
IER2immediate early response 20.045
PPARAperoxisome proliferator-activated receptor alpha0.044
GTF3C1general transcription factor IIIC, polypeptide 1, alpha 220kDa0.044
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.042
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.041
NRIP1nuclear receptor interacting protein 10.039
CDK5R1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.039
RALYLRALY RNA binding protein-like0.038
SKILSKI-like oncogene0.038
FYNFYN oncogene related to SRC, FGR, YES0.038
GABRG2gamma-aminobutyric acid (GABA) A receptor, gamma 20.037
HIPK2homeodomain interacting protein kinase 20.036
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.036
SPRR2Asmall proline-rich protein 2A0.036
GHRgrowth hormone receptor0.036
GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O0.035
CHRNA4cholinergic receptor, nicotinic, alpha 40.035
GRIN1glutamate receptor, ionotropic, N-methyl D-aspartate 10.034
AKAP2A kinase (PRKA) anchor protein 20.034
NLGN1neuroligin 10.032
IRF2BP1interferon regulatory factor 2 binding protein 10.032
LDHBlactate dehydrogenase B0.032
GAB2GRB2-associated binding protein 20.032
APPamyloid beta (A4) precursor protein0.032
SLC9A3solute carrier family 9 (sodium/hydrogen exchanger), member 30.031
PITPNM1phosphatidylinositol transfer protein, membrane-associated 10.030
PDCD6IPprogrammed cell death 6 interacting protein0.029
PTK2PTK2 protein tyrosine kinase 20.028
EGFRepidermal growth factor receptor0.028
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.028
MAPTmicrotubule-associated protein tau0.027
CCKBRcholecystokinin B receptor0.027
MAP2microtubule-associated protein 20.027
ZMYND8zinc finger, MYND-type containing 80.027
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.027
HUWE1HECT, UBA and WWE domain containing 10.026
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)1.000
Drd2dopamine receptor D21.000
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.999
Mef2dmyocyte enhancer factor 2D0.963
Nos1nitric oxide synthase 1, neuronal0.959
Chrnb4cholinergic receptor, nicotinic, beta polypeptide 40.865
Ppargperoxisome proliferator activated receptor gamma0.861
Drd1adopamine receptor D1A0.852
Chrnb2cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)0.728
Emx1empty spiracles homolog 1 (Drosophila)0.656
Grin2bglutamate receptor, ionotropic, NMDA2B (epsilon 2)0.639
Grm1glutamate receptor, metabotropic 10.627
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.610
Lhx3LIM homeobox protein 30.581
Htr5a5-hydroxytryptamine (serotonin) receptor 5A0.538
Homer1homer homolog 1 (Drosophila)0.476
Leprleptin receptor0.458
Pnpla2patatin-like phospholipase domain containing 20.457
Chrna3cholinergic receptor, nicotinic, alpha polypeptide 30.326
Shank2SH3/ankyrin domain gene 20.317
Arandrogen receptor0.292
Plcg1phospholipase C, gamma 10.277
Esr1estrogen receptor 1 (alpha)0.251
Npy2rneuropeptide Y receptor Y20.250
Prkacaprotein kinase, cAMP dependent, catalytic, alpha0.247
Dlgap1discs, large (Drosophila) homolog-associated protein 10.220
Insrinsulin receptor0.219
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.209
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.200
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.196
Kiss1KiSS-1 metastasis-suppressor0.189
Ncor2nuclear receptor co-repressor 20.170
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.147
Npy1rneuropeptide Y receptor Y10.138
Dlg2discs, large homolog 2 (Drosophila)0.137
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.134
Per1period homolog 1 (Drosophila)0.132
Kcnq2potassium voltage-gated channel, subfamily Q, member 20.128
Nf1neurofibromatosis 10.122
Chrna4cholinergic receptor, nicotinic, alpha polypeptide 40.118
Rp1retinitis pigmentosa 1 (human)0.115
Chrna6cholinergic receptor, nicotinic, alpha polypeptide 60.115
Cckbrcholecystokinin B receptor0.111
Kcna1potassium voltage-gated channel, shaker-related subfamily, member 10.108
Crhr1corticotropin releasing hormone receptor 10.107
Shc3src homology 2 domain-containing transforming protein C30.100
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.095
Grb10growth factor receptor bound protein 100.087
Oprk1opioid receptor, kappa 10.087
Ins2insulin II0.086
Adrb2adrenergic receptor, beta 20.084
Nr3c1nuclear receptor subfamily 3, group C, member 10.082
Foxd2forkhead box D20.082
Adra2badrenergic receptor, alpha 2b0.081
Grik2glutamate receptor, ionotropic, kainate 2 (beta 2)0.081
Kcnma1potassium large conductance calcium-activated channel, subfamily M, alpha member 10.080
Cnr1cannabinoid receptor 1 (brain)0.074
Nab2Ngfi-A binding protein 20.072
Htr45 hydroxytryptamine (serotonin) receptor 40.072
Grin2aglutamate receptor, ionotropic, NMDA2A (epsilon 1)0.071
Pitx3paired-like homeodomain transcription factor 30.068
Hrh1histamine receptor H10.067
Chrna10cholinergic receptor, nicotinic, alpha polypeptide 100.067
Esr2estrogen receptor 2 (beta)0.066
Gjd2gap junction protein, delta 20.060
Stk32bserine/threonine kinase 32B0.059
Gpr26G protein-coupled receptor 260.058
Pgrprogesterone receptor0.057
Cyp19a1cytochrome P450, family 19, subfamily a, polypeptide 10.054
Ptgs2prostaglandin-endoperoxide synthase 20.053
Gpr12G-protein coupled receptor 120.050
Epha6Eph receptor A60.048
Npy5rneuropeptide Y receptor Y50.048
Igf2rinsulin-like growth factor 2 receptor0.047
Kcnv1potassium channel, subfamily V, member 10.044
Mef2cmyocyte enhancer factor 2C0.044
Irs2insulin receptor substrate 20.044
WwoxWW domain-containing oxidoreductase0.043
Atp4aATPase, H+/K+ exchanging, gastric, alpha polypeptide0.043
Zp1zona pellucida glycoprotein 10.042
Mc3rmelanocortin 3 receptor0.041
Adcyap1adenylate cyclase activating polypeptide 10.041
Dlg4discs, large homolog 4 (Drosophila)0.041
Sstr1somatostatin receptor 10.040
Chrm1cholinergic receptor, muscarinic 1, CNS0.040
Nxph1neurexophilin 10.039
B3gat1beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)0.038
Trpc5transient receptor potential cation channel, subfamily C, member 50.038
Sstr4somatostatin receptor 40.037
Opn1swopsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)0.037
Cacng2calcium channel, voltage-dependent, gamma subunit 20.035
Glra1glycine receptor, alpha 1 subunit0.034
Rs1retinoschisis (X-linked, juvenile) 1 (human)0.034
Myod1myogenic differentiation 10.033
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.033
Adra1aadrenergic receptor, alpha 1a0.033
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism