The network for 'modification dependent macromolecule catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

modification dependent macromolecule catabolic process

The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule.

NameDescriptionProbabilityFunc Analog Organism
Psma3proteasome (prosome, macropain) subunit, alpha type 30.990
Psma5proteasome (prosome, macropain) subunit, alpha type 50.986
Dnaja2DnaJ (Hsp40) homolog, subfamily A, member 20.981
Psmb3proteasome (prosome, macropain) subunit, beta type 30.956
Psma7proteasome (prosome, macropain) subunit, alpha type 70.887
Psma4proteasome (prosome, macropain) subunit, alpha type 40.882
Psmc2proteasome (prosome, macropain) 26S subunit, ATPase 20.839
Psmb2proteasome (prosome, macropain) subunit, beta type 20.808
Psmc1proteasome (prosome, macropain) 26S subunit, ATPase, 10.731
Psmb6proteasome (prosome, macropain) subunit, beta type 60.602
Psma2proteasome (prosome, macropain) subunit, alpha type 20.491
Psmd13proteasome (prosome, macropain) 26S subunit, non-ATPase, 130.460
Psmd6proteasome (prosome, macropain) 26S subunit, non-ATPase, 60.387
Psmc3proteasome (prosome, macropain) 26S subunit, ATPase 30.377
Psme2proteasome (prosome, macropain) activator subunit 20.368
Nsfl1cNSFL1 (p97) cofactor (p47)0.322
CnbpCCHC-type zinc finger, nucleic acid binding protein0.298
Psmb7proteasome (prosome, macropain) subunit, beta type 70.279
Ppp1cbprotein phosphatase 1, catalytic subunit, beta isoform0.271
Eef2eukaryotic translation elongation factor 20.270
Psmb1proteasome (prosome, macropain) subunit, beta type 10.262
Psmb10proteasome (prosome, macropain) subunit, beta type 100.202
Psmb4proteasome (prosome, macropain) subunit, beta type 40.182
Golph3golgi phosphoprotein 3 (coat-protein)0.178
Psmc4proteasome (prosome, macropain) 26S subunit, ATPase, 40.174
Psmc5proteasome (prosome, macropain) 26S subunit, ATPase, 50.173
Ptges3prostaglandin E synthase 3 (cytosolic)0.147
Ndfip2Nedd4 family interacting protein 20.142
Cwc15CWC15 spliceosome-associated protein homolog (S. cerevisiae)0.124
Zfand5zinc finger, AN1-type domain 50.120
Psmb5proteasome (prosome, macropain) subunit, beta type 50.120
Psma1proteasome (prosome, macropain) subunit, alpha type 10.119
Phaxphosphorylated adaptor for RNA export0.115
Rab21RAB21, member RAS oncogene family0.107
Dnajb9DnaJ (Hsp40) homolog, subfamily B, member 90.103
Txnrd1thioredoxin reductase 10.102
Psma6proteasome (prosome, macropain) subunit, alpha type 60.101
Rad23bRAD23 homolog B (S. cerevisiae)0.098
Csnk1dcasein kinase 1, delta0.095
Hsph1heat shock 105/110 protein 10.091
Psmd4proteasome (prosome, macropain) 26S subunit, non-ATPase, 40.089
Psmd7proteasome (prosome, macropain) 26S subunit, non-ATPase, 70.087
Nploc4nuclear protein localization 4 homolog (S. cerevisiae)0.082
Dnajb11DnaJ (Hsp40) homolog, subfamily B, member 110.082
Manfmesencephalic astrocyte-derived neurotrophic factor0.080
Rnf146ring finger protein 1460.076
Gorasp2golgi reassembly stacking protein 20.076
Psmd2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.072
Pdia4protein disulfide isomerase family A, member 40.068
Psmd3proteasome (prosome, macropain) 26S subunit, non-ATPase, 30.065
Vcpvalosin-containing protein0.062
Mapre1microtubule-associated protein, RP/EB family, member 10.060
Cdc37cell division cycle 37 homolog (S. cerevisiae)0.057
Syngr2synaptogyrin 20.052
Usp47ubiquitin specific peptidase 470.049
Ubcubiquitin C0.048
LOC100366237prefoldin subunit 4-like0.047
Ppp1r2protein phosphatase 1, regulatory (inhibitor) subunit 20.046
Psmd1proteasome (prosome, macropain) 26S subunit, non-ATPase, 10.045
Pompproteasome maturation protein0.044
Ufd1lubiquitin fusion degradation 1 like (yeast)0.043
Ptp4a1protein tyrosine phosphatase type IVA, member 10.042
Ppm1bprotein phosphatase 1B, magnesium dependent, beta isoform0.041
Cmtm6CKLF-like MARVEL transmembrane domain containing 60.041
Hprt1hypoxanthine phosphoribosyltransferase 10.040
Cops5COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)0.040
Hk1hexokinase 10.039
Cdk7cyclin-dependent kinase 70.039
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.039
Cand1cullin-associated and neddylation-dissociated 10.039
Dnaja1DnaJ (Hsp40) homolog, subfamily A, member 10.039
Txnl1thioredoxin-like 10.038
Psmd14proteasome (prosome, macropain) 26S subunit, non-ATPase, 140.037
Rbbp7retinoblastoma binding protein 70.034
Oaz1ornithine decarboxylase antizyme 10.034
Irf1interferon regulatory factor 10.033
Lgals3bplectin, galactoside-binding, soluble, 3 binding protein0.033
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.032
Higd1aHIG1 hypoxia inducible domain family, member 1A0.032
Acyp2acylphosphatase 2, muscle type0.032
Ube2d2ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)0.031
Eif5aeukaryotic translation initiation factor 5A0.031
Ube2iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.030
Rgs19regulator of G-protein signaling 190.029
Rab11aRAB11a, member RAS oncogene family0.028
Pctk2PCTAIRE protein kinase 20.028
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.028
Creld2cysteine-rich with EGF-like domains 20.027
Dlg1discs, large homolog 1 (Drosophila)0.027
Usp14ubiquitin specific peptidase 140.026
St13suppression of tumorigenicity 130.026
Mgat2mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase0.026
Clns1achloride channel, nucleotide-sensitive, 1A0.025
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.024
Csnk2bcasein kinase 2, beta polypeptide0.024
Rnf2ring finger protein 20.024
Rnf19aring finger protein 19A0.023
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
pas-4Protein PAS-40.846
rpt-2Protein RPT-20.724
rpt-3Protein RPT-30.712
pbs-6Protein PBS-60.638
rpn-12Protein RPN-120.566
rpt-5Protein RPT-50.496
rpn-3Protein RPN-30.446
rpn-7Protein RPN-70.415
npl-4.2Protein NPL-4.20.374
pas-6Protein PAS-60.341
cul-1Protein CUL-10.307
rpn-10Protein RPN-100.306
rpn-6.1Protein RPN-6.10.268
pbs-5Protein PBS-50.250
rpn-5Protein RPN-50.233
hgrs-1Protein HGRS-10.231
pbs-7Protein PBS-70.226
pbs-3Protein PBS-30.224
K08E3.5Protein K08E3.50.203
pbs-2Protein PBS-20.191
mig-5Protein MIG-50.189
bub-1Protein BUB-10.180
mdf-2Protein MDF-20.169
rpn-9Protein RPN-90.153
taf-5Protein TAF-50.152
imb-2Protein IMB-20.148
rnr-1Protein RNR-10.144
atx-3Protein ATX-30.142
pas-2Protein PAS-20.139
dpy-30Protein DPY-300.136
pbs-4Protein PBS-40.136
tba-2Protein TBA-20.129
pas-1Protein PAS-10.124
cdc-48.2Protein CDC-48.20.122
rpn-1Protein RPN-10.121
egl-18Protein EGL-180.117
E04D5.1Protein E04D5.10.114
rpt-4Protein RPT-40.108
T20B12.7Protein T20B12.70.107
rpn-2Protein RPN-20.103
app-1Protein APP-10.101
F53B7.3Protein F53B7.30.101
pbs-1Protein PBS-10.096
hda-1Protein HDA-10.094
npl-4.1Protein NPL-4.10.094
T22F3.2Protein T22F3.20.084
his-42Protein HIS-420.082
asb-1Protein ASB-10.081
klp-16Protein KLP-160.080
T07F10.3Protein T07F10.30.075
CELE_C24H12.5Protein C24H12.50.072
zen-4Protein ZEN-40.066
gei-11Protein GEI-110.066
pup-2Protein PUP-20.064
F25B3.6Protein F25B3.60.063
klp-19Protein KLP-190.061
puf-7Protein PUF-70.060
syx-17Protein SYX-170.057
ubxn-1Protein UBXN-10.056
hcp-1Protein HCP-10.056
pgl-1Protein PGL-10.055
rod-1Protein ROD-10.055
ima-2Protein IMA-20.052
C31E10.6Protein C31E10.60.051
rpn-8Protein RPN-80.051
nduf-2.2Protein NDUF-2.20.050
taf-9Protein TAF-90.050
B0454.9Protein B0454.90.050
D1081.8Protein D1081.80.049
spas-1Protein SPAS-10.049
rpl-11.1Protein RPL-11.10.049
R11A8.7Protein R11A8.70.048
F46F11.6Protein F46F11.60.048
CELE_K08F4.1Protein K08F4.10.048
F37A4.1Protein F37A4.10.045
M106.3Protein M106.30.045
rsd-2Protein RSD-20.045
tbb-2Protein TBB-20.044
mcm-2Protein MCM-20.044
spn-4Protein SPN-40.044
rpt-6Protein RPT-60.043
rpn-11Protein RPN-110.043
syx-5Protein SYX-50.043
tba-1Protein TBA-10.043
C13F10.5Protein C13F10.50.042
atg-3Protein ATG-30.042
cpg-8Protein CPG-80.041
rha-1Protein RHA-10.041
CELE_B0334.5Protein B0334.50.041
ZK1010.2Protein ZK1010.20.040
mex-3Protein MEX-30.039
asd-1Protein ASD-10.039
rfc-2Protein RFC-20.039
spk-1Protein SPK-10.039
gyg-2Protein GYG-20.039
sas-5Protein SAS-50.039
pas-5Protein PAS-50.038
sel-9Protein SEL-90.038
pap-1Protein PAP-10.038
mcm-6Protein MCM-60.038
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
psmd6proteasome (prosome, macropain) 26S subunit, non-ATPase, 60.967
psmb1proteasome (prosome, macropain) subunit, beta type, 10.957
psmd4bproteasome (prosome, macropain) 26S subunit, non-ATPase, 4b0.853
psma6aproteasome (prosome, macropain) subunit, alpha type, 6a0.823
psmb7proteasome (prosome, macropain) subunit, beta type, 70.805
psma8proteasome (prosome, macropain) subunit, alpha type, 80.797
psmb4proteasome (prosome, macropain) subunit, beta type, 40.789
psmd12proteasome (prosome, macropain) 26S subunit, non-ATPase, 120.766
psmb3proteasome (prosome, macropain) subunit, beta type, 30.764
psmc6proteasome (prosome, macropain) 26S subunit, ATPase, 60.732
adrm1badhesion regulating molecule 1b0.676
psmd1proteasome (prosome, macropain) 26S subunit, non-ATPase, 10.641
ube2d1ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)0.613
psmc2proteasome (prosome, macropain) 26S subunit, ATPase 20.610
psmd13proteasome (prosome, macropain) 26S subunit, non-ATPase, 130.580
ccnb1cyclin B10.574
psmc1bproteasome (prosome, macropain) 26S subunit, ATPase, 1b0.566
tia1lcytotoxic granule-associated RNA binding protein 1, like0.498
wnt4awingless-type MMTV integration site family, member 4a0.489
psma4proteasome (prosome, macropain) subunit, alpha type, 40.477
chukconserved helix-loop-helix ubiquitous kinase0.474
vcpvalosin containing protein0.455
rab1aRAB1A, member RAS oncogene family0.441
hspa5heat shock protein 50.436
bc2putative breast adenocarcinoma marker0.434
ywhabbtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b0.418
psma2proteasome (prosome, macropain) subunit, alpha type, 20.408
cdt1chromatin licensing and DNA replication factor 10.399
psmc4proteasome (prosome, macropain) 26S subunit, ATPase, 40.399
mcts1malignant T cell amplified sequence 10.399
psmb2proteasome (prosome, macropain) subunit, beta type, 20.384
ck2bcasein kinase 2 beta0.378
eif1beukaryotic translation initiation factor 1B0.363
psmc5proteasome (prosome, macropain) 26S subunit, ATPase, 50.357
psma1proteasome (prosome, macropain) subunit, alpha type, 10.356
kif23kinesin family member 230.351
tsc22d2TSC22 domain family 2 and TSC22 domain family, member 20.351
aurkbaurora kinase B0.345
pdlim4PDZ and LIM domain 40.322
lancl1LanC antibiotic synthetase component C-like 1 (bacterial)0.321
ihhaIndian hedgehog homolog a0.307
hspa4bheat shock protein 4b0.301
plk1polo-like kinase 1 (Drosophila)0.297
ccnb2cyclin B20.295
chmp4bchromatin modifying protein 4B0.293
baxabcl2-associated X protein, a0.285
dnm1ldynamin 1-like0.274
gps1G protein pathway suppressor 10.272
arpp19acAMP-regulated phosphoprotein 19a0.267
sumo1SMT3 suppressor of mif two 3 homolog 1 (yeast)0.264
psmd11bproteasome (prosome, macropain) 216S subunit, non-ATPase, 11b0.263
psmb5proteasome (prosome, macropain) subunit, beta type, 50.254
psma5proteasome (prosome, macropain) subunit, alpha type,50.252
pdia4protein disulfide isomerase associated 40.251
sirt1sirtuin (silent mating type information regulation 2 homolog) 10.250
smarcb1aSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1a0.247
psmd11aproteasome (prosome, macropain) 216S subunit, non-ATPase, 11a0.246
cnot6CCR4-NOT transcription complex, subunit 60.242
dnajc3DnaJ (Hsp40) homolog, subfamily C, member 30.240
tmem93transmembrane protein 930.240
fliiflightless I homolog (Drosophila)0.239
ddx42DEAD (Asp-Glu-Ala-Asp) box polypeptide 420.236
bsdc1BSD domain containing 10.231
tacc3transforming, acidic coiled-coil containing protein 30.229
dusp1dual specificity phosphatase 10.222
syap1synapse associated protein 10.220
syvn1synovial apoptosis inhibitor 1, synoviolin0.218
psmc1aproteasome (prosome, macropain) 26S subunit, ATPase, 1a0.217
crklv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.216
ube2q2ubiquitin-conjugating enzyme E2Q family member 20.214
maxmyc-associated factor X0.213
rae1RAE1 RNA export 1 homolog (S. pombe)0.213
tnpo3transportin 30.212
usp5ubiquitin specific protease 50.212
srsf11serine/arginine-rich splicing factor 110.210
faf2Fas associated factor family member 20.208
dirc2disrupted in renal carcinoma 20.207
fbxw2F-box and WD repeat domain containing 20.206
exoc3exocyst complex component 30.205
arf2ADP-ribosylation factor 20.202
ccnecyclin E0.200
capn2bcalpain 2, (m/II) large subunit b0.197
psmb11proteasome (prosome, macropain) subunit, beta type, 110.196
kdm5clysine (K)-specific demethylase 5C0.192
psmd2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.185
hirip5HIRA interacting protein 50.184
zfand5bzinc finger, AN1-type domain 5b0.183
ube2g2ubiquitin-conjugating enzyme E2G 20.182
orc1origin recognition complex, subunit 10.180
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Rpt3CG16916 gene product from transcript CG16916-RA0.980
Prosbeta2Proteasome beta2 subunit0.969
Pros29Proteasome 29kD subunit0.958
Mov34CG3416 gene product from transcript CG3416-RA0.950
Rpn9CG10230 gene product from transcript CG10230-RB0.947
Rpt1CG1341 gene product from transcript CG1341-RA0.942
Prosbeta1Proteasome beta1 subunit0.933
Rpn1CG7762 gene product from transcript CG7762-RA0.931
tefutelomere fusion0.923
CG13349CG13349 gene product from transcript CG13349-RA0.922
Rpn11CG18174 gene product from transcript CG18174-RA0.915
Pros25Proteasome 25kD subunit0.907
Rpn2CG11888 gene product from transcript CG11888-RA0.903
Prosalpha5Proteasome alpha5 subunit0.893
Pp1-87BProtein phosphatase 1 at 87B0.890
Pros26.4Proteasome 26S subunit subunit 4 ATPase0.889
CG12321CG12321 gene product from transcript CG12321-RA0.846
Rpn6Proteasome p44.5 subunit0.845
Prosalpha7Proteasome alpha7 subunit0.837
Uba1Ubiquitin activating enzyme 10.825
CG8979CG8979 gene product from transcript CG8979-RC0.748
CycBCyclin B0.745
Pros26Proteasome 26kD subunit0.739
Pros28.1Proteasome 28kD subunit 10.705
Prosbeta3Proteasome beta3 subunit0.693
TER94CG2331 gene product from transcript CG2331-RA0.686
CG17331CG17331 gene product from transcript CG17331-RA0.686
Rpn3Regulatory particle non-ATPase 30.615
Rpt4CG3455 gene product from transcript CG3455-RA0.603
Rpn5CG1100 gene product from transcript CG1100-RA0.590
Rpn12CG4157 gene product from transcript CG4157-RA0.563
hydhyperplastic discs0.561
dcodiscs overgrown0.555
Rpn7CG5378 gene product from transcript CG5378-RA0.540
Pros35Proteasome 35kD subunit0.532
Prosbeta7Proteasome beta7 subunit0.527
Prosbeta5Proteasome beta5 subunit0.527
Fcp1CG12252 gene product from transcript CG12252-RA0.502
Pros54Proteasome 54kD subunit0.474
Tbp-1Tat-binding protein-10.459
Pros45CG1489 gene product from transcript CG1489-RA0.447
ncdnon-claret disjunctional0.392
lqfliquid facets0.382
IncenpInner centromere protein0.378
UbcD2Ubiquitin conjugating enzyme 20.372
CG2046CG2046 gene product from transcript CG2046-RA0.369
cpacapping protein alpha0.368
CycECyclin E0.365
Vap-33-1CG5014 gene product from transcript CG5014-RB0.348
Uch-L3Ubiquitin C-terminal hydrolase0.330
cdc23CG2508 gene product from transcript CG2508-RA0.320
Mgat1UDP-GlcNAc:a-3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I0.318
Cap-GCG34438 gene product from transcript CG34438-RF0.313
CG11347CG11347 gene product from transcript CG11347-RE0.309
poloCG12306 gene product from transcript CG12306-RA0.305
Tak1TGF-beta activated kinase 10.303
CG7375CG7375 gene product from transcript CG7375-RA0.295
CSN5COP9 complex homolog subunit 50.290
CycDCyclin D0.289
Top1Topoisomerase 10.287
CSN7COP9 complex homolog subunit 70.280
CG32581CG32581 gene product from transcript CG32581-RB0.274
SaraSmad anchor for receptor activation0.268
skpACG16983 gene product from transcript CG16983-RD0.262
smt3CG4494 gene product from transcript CG4494-RA0.260
p47CG11139 gene product from transcript CG11139-RA0.255
Ras85DRas oncogene at 85D0.253
Pi3K92ECG4141 gene product from transcript CG4141-RB0.245
jubAjuba LIM protein0.241
CG5384CG5384 gene product from transcript CG5384-RA0.235
Ufd1-likeUbiquitin fusion-degradation 1-like0.235
CG4673CG4673 gene product from transcript CG4673-RB0.229
mspsmini spindles0.229
CG8974CG8974 gene product from transcript CG8974-RD0.228
Nipped-ACG33554 gene product from transcript CG33554-RE0.222
RYBPRing and YY1 Binding Protein0.221
Atg6Autophagy-specific gene 60.216
Rab1Rab-protein 10.216
Akt1CG4006 gene product from transcript CG4006-RA0.211
CycGCyclin G0.211
Tip60CG6121 gene product from transcript CG6121-RA0.208
Rcd1Reduction in Cnn dots 10.204
Prp8pre-mRNA processing factor 80.202
piepineapple eye0.199
dupdouble parked0.189
TSG101tumor suppressor protein 1010.188
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
UBCubiquitin C1.000
UBE2D3ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)1.000
RNF11ring finger protein 111.000
PSMD4proteasome (prosome, macropain) 26S subunit, non-ATPase, 41.000
VCPvalosin containing protein1.000
PSMA6proteasome (prosome, macropain) subunit, alpha type, 61.000
SMAD2SMAD family member 21.000
CUL3cullin 31.000
PSMA7proteasome (prosome, macropain) subunit, alpha type, 71.000
PSMA2proteasome (prosome, macropain) subunit, alpha type, 21.000
UBE2V1ubiquitin-conjugating enzyme E2 variant 11.000
TP53tumor protein p531.000
UBE2D2ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)1.000
PSMA1proteasome (prosome, macropain) subunit, alpha type, 10.999
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.999
SKP1S-phase kinase-associated protein 10.999
UBE2Nubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)0.999
COPS5COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)0.998
SMURF2SMAD specific E3 ubiquitin protein ligase 20.998
CDC20cell division cycle 20 homolog (S. cerevisiae)0.998
RB1retinoblastoma 10.998
CUL1cullin 10.998
PSMD14proteasome (prosome, macropain) 26S subunit, non-ATPase, 140.997
PSMA4proteasome (prosome, macropain) subunit, alpha type, 40.997
BTRCbeta-transducin repeat containing0.997
FBXW11F-box and WD repeat domain containing 110.996
PSMB1proteasome (prosome, macropain) subunit, beta type, 10.995
PSMD1proteasome (prosome, macropain) 26S subunit, non-ATPase, 10.994
CDC27cell division cycle 27 homolog (S. cerevisiae)0.992
PSMA3proteasome (prosome, macropain) subunit, alpha type, 30.991
SYVN1synovial apoptosis inhibitor 1, synoviolin0.991
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.991
RNF111ring finger protein 1110.991
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.990
PSME3proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)0.990
PSMB7proteasome (prosome, macropain) subunit, beta type, 70.990
XIAPX-linked inhibitor of apoptosis0.990
HSPA5heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)0.990
UBQLN1ubiquilin 10.989
RNF5ring finger protein 50.989
MDM2Mdm2 p53 binding protein homolog (mouse)0.988
UBE2D1ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)0.986
PLK1polo-like kinase 10.986
PSMC5proteasome (prosome, macropain) 26S subunit, ATPase, 50.982
SMAD4SMAD family member 40.978
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.978
PSMC1proteasome (prosome, macropain) 26S subunit, ATPase, 10.975
CUL2cullin 20.973
PSMC3proteasome (prosome, macropain) 26S subunit, ATPase, 30.973
ARIH2ariadne homolog 2 (Drosophila)0.970
PSMC6proteasome (prosome, macropain) 26S subunit, ATPase, 60.968
SKP2S-phase kinase-associated protein 2 (p45)0.967
UBE2Bubiquitin-conjugating enzyme E2B (RAD6 homolog)0.966
BRCA1breast cancer 1, early onset0.966
EXOSC3exosome component 30.965
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.965
TRAF6TNF receptor-associated factor 60.963
BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast)0.961
PTK2PTK2 protein tyrosine kinase 20.961
POMPproteasome maturation protein0.959
PSMC2proteasome (prosome, macropain) 26S subunit, ATPase, 20.955
UHRF2ubiquitin-like with PHD and ring finger domains 20.953
CCNB1cyclin B10.952
STUB1STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase0.948
ZNRF1zinc and ring finger 10.945
PSMB4proteasome (prosome, macropain) subunit, beta type, 40.942
UFD1Lubiquitin fusion degradation 1 like (yeast)0.939
SMAD7SMAD family member 70.938
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 20.935
TRIM39tripartite motif containing 390.930
PSMC4proteasome (prosome, macropain) 26S subunit, ATPase, 40.928
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.926
MARCH7membrane-associated ring finger (C3HC4) 70.925
PSMB2proteasome (prosome, macropain) subunit, beta type, 20.921
MDM4Mdm4 p53 binding protein homolog (mouse)0.914
CKS1BCDC28 protein kinase regulatory subunit 1B0.913
PSMB6proteasome (prosome, macropain) subunit, beta type, 60.912
PSMD12proteasome (prosome, macropain) 26S subunit, non-ATPase, 120.909
ANAPC11anaphase promoting complex subunit 110.902
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.893
SMAD5SMAD family member 50.890
HDAC1histone deacetylase 10.889
GSK3Bglycogen synthase kinase 3 beta0.884
CCNA2cyclin A20.883
MAP3K5mitogen-activated protein kinase kinase kinase 50.883
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.876
AMFRautocrine motility factor receptor0.875
YY1YY1 transcription factor0.866
DCUN1D1DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)0.866
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.864
PSMA5proteasome (prosome, macropain) subunit, alpha type, 50.859
CDK2cyclin-dependent kinase 20.849
TRIM43tripartite motif containing 430.834
PSMD6proteasome (prosome, macropain) 26S subunit, non-ATPase, 60.832
OTUB1OTU domain, ubiquitin aldehyde binding 10.832
FAF2Fas associated factor family member 20.832
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.830
ANAPC4anaphase promoting complex subunit 40.830
HSPA8heat shock 70kDa protein 80.829
FBXW7F-box and WD repeat domain containing 70.820
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 531.000
Ctnnb1catenin (cadherin associated protein), beta 11.000
Mdm2transformed mouse 3T3 cell double minute 20.999
Psma7proteasome (prosome, macropain) subunit, alpha type 70.997
Vcpvalosin containing protein0.997
Axin1axin 10.996
Per2period homolog 2 (Drosophila)0.996
Psen1presenilin 10.991
Psma1proteasome (prosome, macropain) subunit, alpha type 10.991
Psma2proteasome (prosome, macropain) subunit, alpha type 20.989
Psma5proteasome (prosome, macropain) subunit, alpha type 50.988
Gsk3bglycogen synthase kinase 3 beta0.987
Psmb6proteasome (prosome, macropain) subunit, beta type 60.986
Psmd4proteasome (prosome, macropain) 26S subunit, non-ATPase, 40.979
Clockcircadian locomotor output cycles kaput0.976
Per1period homolog 1 (Drosophila)0.975
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.971
Ranbp9RAN binding protein 90.959
Cry2cryptochrome 2 (photolyase-like)0.943
Ncoa3nuclear receptor coactivator 30.915
Mdm4transformed mouse 3T3 cell double minute 40.910
Psma3proteasome (prosome, macropain) subunit, alpha type 30.907
Rnf111ring finger 1110.899
Psmc3proteasome (prosome, macropain) 26S subunit, ATPase 30.899
Apcadenomatosis polyposis coli0.886
Psmb7proteasome (prosome, macropain) subunit, beta type 70.885
Ccnb1cyclin B10.882
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.875
Psmc2proteasome (prosome, macropain) 26S subunit, ATPase 20.872
Cdk1cyclin-dependent kinase 10.859
Ptenphosphatase and tensin homolog0.856
Usp9xubiquitin specific peptidase 9, X chromosome0.852
Psma6proteasome (prosome, macropain) subunit, alpha type 60.836
Gli3GLI-Kruppel family member GLI30.830
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.826
Appamyloid beta (A4) precursor protein0.801
Mbd3methyl-CpG binding domain protein 30.797
Zfand5zinc finger, AN1-type domain 50.782
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.782
Hdac6histone deacetylase 60.775
Tax1bp1Tax1 (human T-cell leukemia virus type I) binding protein 10.747
Cul3cullin 30.734
Arid1bAT rich interactive domain 1B (SWI-like)0.727
Pax2paired box gene 20.721
Psmd14proteasome (prosome, macropain) 26S subunit, non-ATPase, 140.711
Arrb1arrestin, beta 10.694
Cops5COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana)0.693
Cul4acullin 4A0.692
Smad7MAD homolog 7 (Drosophila)0.689
Csnk1ecasein kinase 1, epsilon0.683
Rnf2ring finger protein 20.683
Yap1yes-associated protein 10.674
Nedd4neural precursor cell expressed, developmentally down-regulated 40.666
Arhgef7Rho guanine nucleotide exchange factor (GEF7)0.644
Cry1cryptochrome 1 (photolyase-like)0.631
Pias2protein inhibitor of activated STAT 20.630
Pompproteasome maturation protein0.625
Ube2v1ubiquitin-conjugating enzyme E2 variant 10.624
Fzr1fizzy/cell division cycle 20 related 1 (Drosophila)0.624
Fgfr1fibroblast growth factor receptor 10.619
Trp73transformation related protein 730.617
Ccne1cyclin E10.615
Birc5baculoviral IAP repeat-containing 50.614
Dvl1dishevelled, dsh homolog 1 (Drosophila)0.601
Banf1barrier to autointegration factor 10.591
Dyrk1adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a0.585
Psmb3proteasome (prosome, macropain) subunit, beta type 30.581
Rnf19aring finger protein 19A0.579
Psmb5proteasome (prosome, macropain) subunit, beta type 50.578
Psmd3proteasome (prosome, macropain) 26S subunit, non-ATPase, 30.572
Arntlaryl hydrocarbon receptor nuclear translocator-like0.571
Traf6TNF receptor-associated factor 60.566
Psmd6proteasome (prosome, macropain) 26S subunit, non-ATPase, 60.565
Aampangio-associated migratory protein0.547
Rbl2retinoblastoma-like 20.545
Setdb1SET domain, bifurcated 10.544
Gnb2guanine nucleotide binding protein (G protein), beta 20.542
Cdk4cyclin-dependent kinase 40.538
Socs1suppressor of cytokine signaling 10.538
Cul1cullin 10.536
Pcnaproliferating cell nuclear antigen0.527
Psma4proteasome (prosome, macropain) subunit, alpha type 40.514
Mgea5meningioma expressed antigen 5 (hyaluronidase)0.505
Ppp1caprotein phosphatase 1, catalytic subunit, alpha isoform0.503
Cdk2cyclin-dependent kinase 20.501
Bcl2B-cell leukemia/lymphoma 20.498
Smurf2SMAD specific E3 ubiquitin protein ligase 20.489
Arrb2arrestin, beta 20.486
Agap3ArfGAP with GTPase domain, ankyrin repeat and PH domain 30.485
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.477
Glrx3glutaredoxin 30.471
Skp1aS-phase kinase-associated protein 1A0.459
Anapc2anaphase promoting complex subunit 20.459
Iqcb1IQ calmodulin-binding motif containing 10.455
Phf1PHD finger protein 10.454
Add1adducin 1 (alpha)0.454
Tab3TGF-beta activated kinase 1/MAP3K7 binding protein 30.447
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
YMR258Chypothetical protein0.477
YLR352Whypothetical protein0.476