The network for 'somatic stem cell maintenance' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

somatic stem cell maintenance

Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line.

NameDescriptionProbabilityFunc Analog Organism
Nek9NIMA (never in mitosis gene a)- related kinase 90.341
Eif2c2eukaryotic translation initiation factor 2C, 20.172
Nfixnuclear factor I/X (CCAAT-binding transcription factor)0.098
Bbxbobby sox homolog (Drosophila)0.051
Dlg4discs, large homolog 4 (Drosophila)0.049
Tgfbr2transforming growth factor, beta receptor II0.046
Axin1axin 10.040
Adam10ADAM metallopeptidase domain 100.038
Zfp91zinc finger protein 910.037
Igfbp5insulin-like growth factor binding protein 50.036
Ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.035
Rararetinoic acid receptor, alpha0.034
Mcm5minichromosome maintenance complex component 50.033
Nfibnuclear factor I/B0.031
Atf2activating transcription factor 20.031
Gata3GATA binding protein 30.029
Pacs1phosphofurin acidic cluster sorting protein 10.027
Acyp2acylphosphatase 2, muscle type0.027
TriobpTRIO and F-actin binding protein0.026
LfngLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase0.026
Cd4Cd4 molecule0.026
Sema6bsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B0.025
Notch1Notch homolog 1, translocation-associated (Drosophila)0.024
Tfebtranscription factor EB0.024
Aanatarylalkylamine N-acetyltransferase0.024
Abcc1ATP-binding cassette, subfamily C (CFTR/MRP), member 10.023
Klf13Kruppel-like factor 130.023
Twist1twist homolog 1 (Drosophila)0.022
Flt1FMS-related tyrosine kinase 10.022
Acvr1activin A receptor, type I0.021
Lig3ligase III, DNA, ATP-dependent0.021
Ccnd2cyclin D20.021
Rps6ka1ribosomal protein S6 kinase polypeptide 10.021
Hes1hairy and enhancer of split 1 (Drosophila)0.019
Nr2f2nuclear receptor subfamily 2, group F, member 20.019
Prkceprotein kinase C, epsilon0.019
Slc6a6solute carrier family 6 (neurotransmitter transporter, taurine), member 60.019
Ednrbendothelin receptor type B0.018
Foxp4forkhead box P40.018
Gna15guanine nucleotide binding protein, alpha 150.018
Dlgap4discs, large homolog-associated protein 4 (Drosophila)0.017
Casp2caspase 20.017
Itgb4integrin, beta 40.016
Itpr2inositol 1,4,5-triphosphate receptor, type 20.016
Atp2a3ATPase, Ca++ transporting, ubiquitous0.016
Tcp11l2t-complex 11 (mouse) like 20.016
Gsk3bglycogen synthase kinase 3 beta0.016
Lbrlamin B receptor0.016
Adrm1adhesion regulating molecule 10.016
Tcf4transcription factor 40.016
Lman1lectin, mannose-binding, 10.016
Cdk2cyclin dependent kinase 20.015
Cpdcarboxypeptidase D0.015
Smad7SMAD family member 70.015
Sec14l1SEC14-like 1 (S. cerevisiae)0.015
Top2atopoisomerase (DNA) II alpha0.015
Rgs19regulator of G-protein signaling 190.015
Taok2TAO kinase 20.014
Atp1b2ATPase, Na+/K+ transporting, beta 2 polypeptide0.014
Myo1cmyosin IC0.014
Mapk9mitogen-activated protein kinase 90.014
Tceb3transcription elongation factor B (SIII), polypeptide 30.014
Npap60nuclear pore associated protein0.014
Nrasneuroblastoma ras oncogene0.014
Fgf16fibroblast growth factor 160.014
Wdfy1WD repeat and FYVE domain containing 10.014
Lrch4leucine-rich repeats and calponin homology (CH) domain containing 40.014
Clic4chloride intracellular channel 40.014
Nfianuclear factor I/A0.014
Igf2insulin-like growth factor 20.014
Chac2ChaC, cation transport regulator homolog 2 (E. coli)0.014
Slit3slit homolog 3 (Drosophila)0.014
Atp2b1ATPase, Ca++ transporting, plasma membrane 10.013
Tpcr12putative olfactory receptor0.013
Pou2f3POU class 2 homeobox 30.013
Tob1transducer of ErbB-2.10.013
Irs1insulin receptor substrate 10.013
Gipc1GIPC PDZ domain containing family, member 10.013
Mgllmonoglyceride lipase0.013
Chd4chromodomain helicase DNA binding protein 40.013
Creb3l1cAMP responsive element binding protein 3-like 10.013
Creb1cAMP responsive element binding protein 10.013
Tspyl1TSPY-like 10.013
Rph3alrabphilin 3A-like (without C2 domains)0.013
Mllt4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.012
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.012
Mtx2metaxin 20.012
Nkx2-1NK2 homeobox 10.012
Hdac7histone deacetylase 70.012
Kctd15potassium channel tetramerisation domain containing 150.012
Gse1genetic suppressor element 10.012
Mfsd10major facilitator superfamily domain containing 100.012
Cep78centrosomal protein 780.012
Rasa1RAS p21 protein activator (GTPase activating protein) 10.012
Myo1bmyosin Ib0.012
Nficnuclear factor I/C0.012
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
wlswntless homolog (Drosophila)0.926
notch3notch homolog 30.897
bmp4bone morphogenetic protein 40.888
bocbrother of CDO0.882
gata3GATA-binding protein 30.751
tbx1T-box 10.747
wnt5bwingless-type MMTV integration site family, member 5b0.715
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.710
pax2apaired box gene 2a0.652
fn1fibronectin 10.633
cdh2cadherin 2, neuronal0.598
six4bsine oculis homeobox homolog 4b0.592
eya1eyes absent homolog 10.572
jag1bjagged 1b0.535
fgf3fibroblast growth factor 30.533
osr2odd-skipped related 2 (Drosophila)0.396
sox3SRY-box containing gene 30.380
shhasonic hedgehog a0.366
foxi1forkhead box I10.358
tcf7l1atranscription factor 7-like 1a (T-cell specific, HMG-box)0.324
jag2jagged 20.322
ndr2nodal-related 20.311
tbx5aT-box 5a0.297
gli1GLI-Kruppel family member 10.281
wnt3wingless-type MMTV integration site family, member 30.275
wnt2bbwingless-type MMTV integration site family, member 2Bb0.275
bmp2bbone morphogenetic protein 2b0.274
cdoncell adhesion molecule-related/down-regulated by oncogenes0.262
flt4fms-related tyrosine kinase 40.258
pax8paired box gene 80.256
pbx4pre-B-cell leukemia transcription factor 40.254
wnt9awingless-type MMTV integration site family, member 9A0.244
notch2notch homolog 20.244
lmx1b.1LIM homeobox transcription factor 1, beta 10.232
foxi3aforkhead box I3a0.230
rbfox2RNA binding protein, fox-1 homolog (C. elegans) 20.226
chst11carbohydrate (chondroitin 4) sulfotransferase 110.219
sox9aSRY-box containing gene 9a0.219
mmp2matrix metalloproteinase 20.217
krt4keratin 40.216
fzd7bfrizzled homolog 7b0.212
neo1neogenin 10.208
ascl1aachaete-scute complex-like 1a (Drosophila)0.192
tbx2bT-box 2b0.186
ptprsaprotein tyrosine phosphatase, receptor type, s, a0.184
fzd7afrizzled homolog 7a0.180
mibmind bomb0.175
flhfloating head0.175
sox2SRY-box containing gene 20.165
pea3ETS-domain transcription factor pea30.163
efnb2aephrin B2a0.163
ednraendothelin receptor type A0.155
mgaMAX gene associated0.151
nova2neuro-oncological ventral antigen 20.149
sulf1sulfatase 10.146
gli2aGLI-Kruppel family member GLI2a0.145
znf503zinc finger protein 5030.143
tcf21transcription factor 210.139
fgfr4fibroblast growth factor receptor 40.133
ventventral expressed homeobox0.124
mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.121
dnmt8DNA (cytosine-5-)-methyltransferase 80.119
fgf17fibroblast growth factor 170.117
bonbonnie and clyde0.117
tp53tumor protein p530.117
ythdf1YTH domain family, member 10.114
akt2v-akt murine thymoma viral oncogene homolog 20.111
gpc4glypican 40.111
cdh1cadherin 1, epithelial0.110
dnmt4DNA (cytosine-5-)-methyltransferase 40.106
wnt2bawingless-type MMTV integration site family, member 2Ba0.106
mecomMDS1 and EVI1 complex locus0.106
vangl2vang-like 2 (van gogh, Drosophila)0.106
cdt1chromatin licensing and DNA replication factor 10.105
ephb4beph receptor B4b0.104
spry4sprouty (Drosophila) homolog 40.103
id3inhibitor of DNA binding 30.102
wnt8awingless-type MMTV integration site family, member 8a0.102
bmpr1aabone morphogenetic protein receptor, type 1aa0.100
slit3slit (Drosophila) homolog 30.097
cfl2lcofilin 2, like0.094
gli3GLI-Kruppel family member GLI30.094
zfp36l1azinc finger protein 36, C3H type-like 1a0.092
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.091
nrarpbnotch-regulated ankyrin repeat protein b0.090
sox32SRY-box containing gene 320.089
foxi3bforkhead box I3b0.089
sox11aSRY-box containing gene 11a0.088
col8a1acollagen, type VIII, alpha 1a0.087
tp53bp2tumor protein p53 binding protein, 20.085
hnf1bbHNF1 homeobox Bb0.084
pou3f3bPOU class 3 homeobox 3b0.083
fzd10frizzled homolog 100.082
tnfsf10l3tumor necrosis factor (ligand) superfamily, member 10 like 30.082
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
MadMothers against dpp0.989
emcextra macrochaetae0.708
osaCG7467 gene product from transcript CG7467-RD0.589
rapretina aberrant in pattern0.524
fz2frizzled 20.414
DadDaughters against dpp0.384
cicubitus interruptus0.373
EgfrEpidermal growth factor receptor0.311
E(spl)Enhancer of split0.299
l(2)gllethal (2) giant larvae0.230
aopanterior open0.194
Tsc1CG6147 gene product from transcript CG6147-RA0.156
gcmglial cells missing0.144
mbcmyoblast city0.119
eyaeyes absent0.114
bowlbrother of odd with entrails limited0.078
Sin3ACG8815 gene product from transcript CG8815-RC0.077
m2E(spl) region transcript m20.077
malphaE(spl) region transcript malpha0.076
Abd-BAbdominal B0.073
bratbrain tumor0.070
vvlventral veins lacking0.067
amosabsent MD neurons and olfactory sensilla0.056
HLHmgammaE(spl) region transcript mgamma0.046
stumpsCG31317 gene product from transcript CG31317-RC0.044
Su(H)Suppressor of Hairless0.039
Su(z)12CG8013 gene product from transcript CG8013-RA0.036
HLHm5E(spl) region transcript m50.031
ebiCG4063 gene product from transcript CG4063-RA0.031
HLHm7E(spl) region transcript m70.030
Btk29ABtk family kinase at 29A0.027
ewgerect wing0.024
Rab11Rab-protein 110.024
Myd88CG2078 gene product from transcript CG2078-RA0.023
HLHmbetaE(spl) region transcript mbeta0.022
Ras85DRas oncogene at 85D0.022
SceSex combs extra0.021
slp1sloppy paired 10.020
Cdk4Cyclin-dependent kinase 40.019
opaodd paired0.018
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SMAD4SMAD family member 41.000
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa1.000
AXIN1axin 11.000
CSNK1Ecasein kinase 1, epsilon0.999
POU3F2POU class 3 homeobox 20.999
NOTCH1notch 10.999
TAL1T-cell acute lymphocytic leukemia 10.999
SMAD7SMAD family member 70.998
SMAD2SMAD family member 20.991
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.989
JAG1jagged 10.988
SP1Sp1 transcription factor0.987
EP300E1A binding protein p3000.985
PAX3paired box 30.974
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.967
CDK2cyclin-dependent kinase 20.967
TRIM33tripartite motif containing 330.964
SMAD3SMAD family member 30.962
DVL1dishevelled, dsh homolog 1 (Drosophila)0.958
FOXD3forkhead box D30.956
LMO4LIM domain only 40.952
INSRinsulin receptor0.947
APLFaprataxin and PNKP like factor0.926
RLIMring finger protein, LIM domain interacting0.902
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.879
BMP7bone morphogenetic protein 70.877
SOX2SRY (sex determining region Y)-box 20.876
DVL3dishevelled, dsh homolog 3 (Drosophila)0.876
NKX2-1NK2 homeobox 10.873
HCFC1host cell factor C1 (VP16-accessory protein)0.871
PTCH1patched 10.839
SOX10SRY (sex determining region Y)-box 100.832
RUNX1runt-related transcription factor 10.817
POU5F1POU class 5 homeobox 10.817
SKP1S-phase kinase-associated protein 10.803
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.801
SMAD1SMAD family member 10.790
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.747
GSK3Bglycogen synthase kinase 3 beta0.746
FGF1fibroblast growth factor 1 (acidic)0.737
CTNNBIP1catenin, beta interacting protein 10.723
IL4Rinterleukin 4 receptor0.703
APCadenomatous polyposis coli0.659
CREBBPCREB binding protein0.644
FBLN1fibulin 10.626
UHRF2ubiquitin-like with PHD and ring finger domains 20.621
AMMECR1Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 10.615
HIC1hypermethylated in cancer 10.613
DDB1damage-specific DNA binding protein 1, 127kDa0.598
HNF1AHNF1 homeobox A0.596
MYOD1myogenic differentiation 10.583
GATA2GATA binding protein 20.522
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.520
WWP2WW domain containing E3 ubiquitin protein ligase 20.519
MCCmutated in colorectal cancers0.488
WT1Wilms tumor 10.430
C20orf20chromosome 20 open reading frame 200.425
POU3F3POU class 3 homeobox 30.418
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.391
BTRCbeta-transducin repeat containing0.372
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.371
MEOX2mesenchyme homeobox 20.369
NFIXnuclear factor I/X (CCAAT-binding transcription factor)0.368
XRCC4X-ray repair complementing defective repair in Chinese hamster cells 40.347
ASCL1achaete-scute complex homolog 1 (Drosophila)0.347
SOX11SRY (sex determining region Y)-box 110.343
YAP1Yes-associated protein 10.338
CCND1cyclin D10.335
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.334
CDK6cyclin-dependent kinase 60.332
GLIS2GLIS family zinc finger 20.327
JAG2jagged 20.325
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.322
STAP2signal transducing adaptor family member 20.319
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.319
GABPAGA binding protein transcription factor, alpha subunit 60kDa0.314
E2F1E2F transcription factor 10.306
MARCKSL1MARCKS-like 10.306
MAML1mastermind-like 1 (Drosophila)0.305
ATXN1Lataxin 1-like0.302
DCP1ADCP1 decapping enzyme homolog A (S. cerevisiae)0.292
NR4A1nuclear receptor subfamily 4, group A, member 10.292
KITLGKIT ligand0.290
FERMT2fermitin family member 20.287
CADM4cell adhesion molecule 40.282
SKIv-ski sarcoma viral oncogene homolog (avian)0.264
TCF12transcription factor 120.252
SPENspen homolog, transcriptional regulator (Drosophila)0.252
NCOA2nuclear receptor coactivator 20.248
DMAP1DNA methyltransferase 1 associated protein 10.234
TAOK1TAO kinase 10.229
ATF7IPactivating transcription factor 7 interacting protein0.224
BBS10Bardet-Biedl syndrome 100.210
KSR1kinase suppressor of ras 10.207
HDAC4histone deacetylase 40.205
SOX1SRY (sex determining region Y)-box 10.205
CXXC5CXXC finger protein 50.201
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.200
CTNND1catenin (cadherin-associated protein), delta 10.199
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Fgfr2fibroblast growth factor receptor 20.999
Shhsonic hedgehog0.999
Gli3GLI-Kruppel family member GLI30.995
Fgf8fibroblast growth factor 80.995
Pax3paired box gene 30.994
Otx2orthodenticle homolog 2 (Drosophila)0.994
Lef1lymphoid enhancer binding factor 10.989
Hes1hairy and enhancer of split 1 (Drosophila)0.982
Rargretinoic acid receptor, gamma0.976
Fgfr1fibroblast growth factor receptor 10.972
Ctnnb1catenin (cadherin associated protein), beta 10.960
Hand1heart and neural crest derivatives expressed transcript 10.955
Bmp4bone morphogenetic protein 40.950
Vangl2vang-like 2 (van gogh, Drosophila)0.937
Pax6paired box gene 60.925
Msx1homeobox, msh-like 10.922
Bmp7bone morphogenetic protein 70.919
Msx2homeobox, msh-like 20.916
Rararetinoic acid receptor, alpha0.909
Alx4aristaless-like homeobox 40.908
Tbx3T-box 30.899
Gli2GLI-Kruppel family member GLI20.893
Pax2paired box gene 20.891
Emx2empty spiracles homolog 2 (Drosophila)0.885
Ror2receptor tyrosine kinase-like orphan receptor 20.884
Wnt3awingless-related MMTV integration site 3A0.875
Rb1retinoblastoma 10.868
Sox2SRY-box containing gene 20.864
Pitx2paired-like homeodomain transcription factor 20.861
Sall4sal-like 4 (Drosophila)0.860
Notch1Notch gene homolog 1 (Drosophila)0.859
Apcadenomatosis polyposis coli0.830
Emx1empty spiracles homolog 1 (Drosophila)0.825
Trp63transformation related protein 630.796
Dkk1dickkopf homolog 1 (Xenopus laevis)0.796
Smad6MAD homolog 6 (Drosophila)0.786
Pou5f1POU domain, class 5, transcription factor 10.768
Dlx5distal-less homeobox 50.721
Tal1T-cell acute lymphocytic leukemia 10.719
Dvl2dishevelled 2, dsh homolog (Drosophila)0.716
Sfrp2secreted frizzled-related protein 20.711
Meox2mesenchyme homeobox 20.699
Trp53transformation related protein 530.699
Foxc1forkhead box C10.697
Lhx1LIM homeobox protein 10.697
Stat5bsignal transducer and activator of transcription 5B0.697
Tcf21transcription factor 210.686
Six3sine oculis-related homeobox 3 homolog (Drosophila)0.684
Hoxd13homeobox D130.679
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.678
Ptch1patched homolog 10.674
Nf1neurofibromatosis 10.644
Tcfap2atranscription factor AP-2, alpha0.633
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.620
Tgfatransforming growth factor alpha0.617
Hes5hairy and enhancer of split 5 (Drosophila)0.617
Hand2heart and neural crest derivatives expressed transcript 20.617
Eya1eyes absent 1 homolog (Drosophila)0.605
Prrx1paired related homeobox 10.593
Zeb1zinc finger E-box binding homeobox 10.588
Gdf5growth differentiation factor 50.579
Dll1delta-like 1 (Drosophila)0.572
Pax8paired box gene 80.559
Dvl3dishevelled 3, dsh homolog (Drosophila)0.544
Pou3f3POU domain, class 3, transcription factor 30.531
Foxf1aforkhead box F1a0.511
Tbx2T-box 20.499
Yap1yes-associated protein 10.492
Tead2TEA domain family member 20.461
Tbx1T-box 10.460
Foxc2forkhead box C20.457
Smad7MAD homolog 7 (Drosophila)0.454
Hoxd11homeobox D110.435
Rxraretinoid X receptor alpha0.417
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.408
Pkd1polycystic kidney disease 1 homolog0.405
Zfp362zinc finger protein 3620.403
Runx1runt related transcription factor 10.385
Alx3aristaless-like homeobox 30.384
Fgf3fibroblast growth factor 30.384
Sox7SRY-box containing gene 70.372
Fgf18fibroblast growth factor 180.372
Snai1snail homolog 1 (Drosophila)0.371
Bmp2bone morphogenetic protein 20.371
Cdkn1bcyclin-dependent kinase inhibitor 1B0.369
Smad3MAD homolog 3 (Drosophila)0.364
Fgf10fibroblast growth factor 100.358
Lmx1aLIM homeobox transcription factor 1 alpha0.346
NrkNik related kinase0.345
Smad1MAD homolog 1 (Drosophila)0.344
Ldb1LIM domain binding 10.342
Cbfa2t3core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)0.340
Vangl1vang-like 1 (van gogh, Drosophila)0.339
Cdx2caudal type homeobox 20.339
Shesrc homology 2 domain-containing transforming protein E0.338
Gscgoosecoid homeobox0.334
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.333
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism