The network for 'response to axon injury' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to axon injury

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus.

NameDescriptionProbabilityFunc Analog Organism
Gstm1glutathione S-transferase mu 10.565
JunJun oncogene0.499
Lgals9lectin, galactoside-binding, soluble, 90.209
Ephx1epoxide hydrolase 1, microsomal0.154
Cox8acytochrome c oxidase subunit VIIIa0.152
Egr2early growth response 20.147
Anxa2annexin A20.134
Gadd45agrowth arrest and DNA-damage-inducible, alpha0.127
Plaurplasminogen activator, urokinase receptor0.121
Grm6glutamate receptor, metabotropic 60.115
Itgb1integrin, beta 10.114
Sncbsynuclein, beta0.113
S100a6S100 calcium binding protein A60.111
S100a10S100 calcium binding protein A100.105
Lgals5lectin, galactose binding, soluble 50.103
Pstpip1proline-serine-threonine phosphatase-interacting protein 10.101
Gjd2gap junction protein, delta 20.100
Foxa3forkhead box A30.100
Arf3ADP-ribosylation factor 30.098
Cd44Cd44 molecule0.097
Lgals3lectin, galactoside-binding, soluble, 30.094
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.083
Nmnat2nicotinamide nucleotide adenylyltransferase 20.082
C1qbcomplement component 1, q subcomponent, B chain0.082
Mycmyelocytomatosis oncogene0.078
Sstr2somatostatin receptor 20.078
Slc18a3solute carrier family 18 (vesicular acetylcholine), member 30.077
Tagln3transgelin 30.077
Zp3zona pellucida glycoprotein 3 (sperm receptor)0.076
Grb2growth factor receptor bound protein 20.076
Shox2short stature homeobox 20.072
Nr2f6nuclear receptor subfamily 2, group F, member 60.071
Gabrg3gamma-aminobutyric acid (GABA) A receptor, gamma 30.071
Myl6lmyosin, light polypeptide 6, alkali, smooth muscle and non-muscle-like0.069
Cd4Cd4 molecule0.068
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.068
Morf4l2mortality factor 4 like 20.068
Fis1fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)0.067
Cd151CD151 molecule (Raph blood group)0.066
Atf3activating transcription factor 30.066
Msx2msh homeobox 20.065
Gstp1glutathione S-transferase pi 10.065
Foxd3forkhead box D30.064
Klf6Kruppel-like factor 60.064
Mmp3matrix metallopeptidase 30.062
Ctsccathepsin C0.062
Stat6signal transducer and activator of transcription 60.061
RT1-DMaRT1 class II, locus DMa0.061
Lgals4lectin, galactoside-binding, soluble, 40.061
Bcat1branched chain aminotransferase 1, cytosolic0.059
Sgp158proline-rich glycoprotein (sgp158)0.059
Gria2glutamate receptor, ionotropic, AMPA 20.059
Thtyrosine hydroxylase0.057
Tspotranslocator protein0.056
Pla2g2aphospholipase A2, group IIA (platelets, synovial fluid)0.056
Spp1secreted phosphoprotein 10.056
Ctnna1catenin (cadherin associated protein), alpha 10.056
Haao3-hydroxyanthranilate 3,4-dioxygenase0.056
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.055
Dnase1l3deoxyribonuclease 1-like 30.054
Prl3d4prolactin family 3, subfamily d, member 40.054
Gpamglycerol-3-phosphate acyltransferase, mitochondrial0.053
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.053
Tstthiosulfate sulfurtransferase0.053
Marcksmyristoylated alanine rich protein kinase C substrate0.051
Arl11ADP-ribosylation factor-like 110.051
Dpysl3dihydropyrimidinase-like 30.051
Avparginine vasopressin0.051
Acadsacyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain0.050
Itgb7integrin, beta 70.050
Socs3suppressor of cytokine signaling 30.050
Tgfbr2transforming growth factor, beta receptor II0.050
G6pcglucose-6-phosphatase, catalytic subunit0.049
Slc29a2solute carrier family 29 (nucleoside transporters), member 20.049
Tnnt2troponin T type 2 (cardiac)0.049
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.049
Esr2estrogen receptor 2 (ER beta)0.049
Mmp9matrix metallopeptidase 90.048
Timp2TIMP metallopeptidase inhibitor 20.048
Timp1TIMP metallopeptidase inhibitor 10.048
Prdx2peroxiredoxin 20.047
Ctsscathepsin S0.047
Il6interleukin 60.047
Lyz2lysozyme 20.047
Vav1vav 1 guanine nucleotide exchange factor0.047
Btg2BTG family, member 20.046
Prkar1aprotein kinase, cAMP-dependent, regulatory, type I, alpha0.046
Shc3SHC (Src homology 2 domain containing) transforming protein 30.046
Il18interleukin 180.046
Gja5gap junction protein, alpha 50.046
Lin7blin-7 homolog b (C. elegans)0.046
S100a4S100 calcium-binding protein A40.045
Csf1colony stimulating factor 1 (macrophage)0.045
Crmp1collapsin response mediator protein 10.045
Nefmneurofilament, medium polypeptide0.045
Galgalanin prepropeptide0.044
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
scn8aasodium channel, voltage-gated, type VIII, alpha a0.745
mmp9matrix metalloproteinase 90.636
atoh1aatonal homolog 1a0.469
myf5myogenic factor 50.276
atoh1batonal homolog 1b0.266
bocbrother of CDO0.241
junbjun B proto-oncogene0.212
efna5bephrin A5b0.208
gad2glutamate decarboxylase 20.201
arnt2aryl hydrocarbon receptor nuclear translocator 20.185
ptf1apancreas specific transcription factor, 1a0.163
dpysl3dihydropyrimidinase-like 30.161
efnb1ephrin B10.143
alcamaactivated leukocyte cell adhesion molecule a0.134
LOC100000687signal peptide, CUB and EGF-like domain-containing protein 3-like0.131
ret1receptor tyrosine kinase0.131
slc17a6bsolute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6b0.125
slc17a7solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 70.114
slc1a2bsolute carrier family 1 (glial high affinity glutamate transporter), member 2b0.112
tnctenascin C0.110
neurog1neurogenin 10.109
neurod4neurogenic differentiation 40.105
socs3asuppressor of cytokine signaling 3a0.089
tbx18T-box 180.089
dlg2discs, large (Drosophila) homolog 20.088
atp2b2ATPase, Ca++ transporting, plasma membrane 20.086
otx2orthodenticle homolog 20.084
lamc1laminin, gamma 10.079
tbx2bT-box 2b0.078
appaamyloid beta (A4) precursor protein a0.078
c1qtnf4C1q and tumor necrosis factor related protein 40.076
drd2bdopamine receptor D2b0.075
dpysl4dihydropyrimidinase-like 40.073
gro1groucho 10.071
chrna7cholinergic receptor, nicotinic, alpha polypeptide 70.071
atf3activating transcription factor 30.067
tcf7l1atranscription factor 7-like 1a (T-cell specific, HMG-box)0.066
cntn2contactin 20.065
olig3oligodendrocyte transcription factor 30.057
jak1Janus kinase 10.056
cacnb1calcium channel, voltage-dependent, beta 1 subunit0.055
socs3bsuppressor of cytokine signaling 3b0.053
gadd45bbgrowth arrest and DNA-damage-inducible, beta b0.053
aldocaaldolase C, fructose-bisphosphate, a0.052
crxcone-rod homeobox0.052
sema3dsemaphorin 3d0.051
dag1dystroglycan 10.047
dpysl5adihydropyrimidinase-like 5a0.045
gata2aGATA-binding protein 2a0.045
jam2ajunctional adhesion molecule 2a0.045
otx5orthodenticle homolog 50.043
esrrgaestrogen-related receptor gamma a0.043
cpn1carboxypeptidase N, polypeptide 10.042
runx1runt-related transcription factor 10.041
top2btopoisomerase (DNA) II beta0.041
dusp2dual specificity phosphatase 20.040
pcp4aPurkinje cell protein 4a0.039
junbljun B proto-oncogene, like0.039
fosl2fos-like antigen 20.037
lama2laminin, alpha 20.037
matn4matrilin 40.036
m17IL-6 subfamily cytokine M170.036
copebcore promoter element binding protein0.035
irx4biroquois homeobox protein 4b0.034
spry1sprouty homolog 1 (Drosophila)0.034
gro2groucho 20.034
igfbp3insulin-like growth factor binding protein 30.034
chst11carbohydrate (chondroitin 4) sulfotransferase 110.033
myod1myogenic differentiation 10.033
cntn1acontactin 1a0.033
kif5aakinesin family member 5A, a0.032
tgif1TGFB-induced factor homeobox 10.032
insm1ainsulinoma-associated 1a0.032
sh3gl1bSH3-domain GRB2-like 1b0.032
pou3f2POU class 3 homeobox 20.032
cx39.9connexin 39.90.032
gpm6baglycoprotein M6Ba0.031
egr2bearly growth response 2b0.031
olfm2olfactomedin 20.030
foxg1aforkhead box G1a0.029
lmo1LIM domain only 10.028
dpysl2bdihydropyrimidinase-like 2b0.028
tada3ltranscriptional adaptor 3 (NGG1 homolog, yeast)-like0.028
six1bsine oculis homeobox homolog 1b0.027
cacna1abcalcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b0.027
gabra1gamma-aminobutyric acid (GABA) A receptor, alpha 10.027
lbx2ladybird homeobox homolog 2 (Drosophila)0.027
stc1lstanniocalcin 1, like0.026
lhx1bLIM homeobox 1b0.026
smad1MAD homolog 1 (Drosophila)0.026
evx1even-skipped homeobox 10.026
ephb4beph receptor B4b0.025
nxph1neurexophilin 10.025
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CaMKIICalcium/calmodulin-dependent protein kinase II0.661
Pi3K92ECG4141 gene product from transcript CG4141-RB0.403
Ras85DRas oncogene at 85D0.190
Rho1CG8416 gene product from transcript CG8416-RB0.097
p38bCG7393 gene product from transcript CG7393-RA0.089
CdsACDP diglyceride synthetase0.084
PtenCG5671 gene product from transcript CG5671-RB0.073
Lectin-galC1Galactose-specific C-type lectin0.070
aopanterior open0.053
Gr28bGustatory receptor 28b0.047
Nrx-IVNeurexin IV0.045
foxoforkhead box, sub-group O0.045
DscamDown syndrome cell adhesion molecule0.041
Aplip1APP-like protein interacting protein 10.038
Unc-76CG3981 gene product from transcript CG3981-RB0.036
M6CG7540 gene product from transcript CG7540-RA0.033
chicoCG5686 gene product from transcript CG5686-RB0.033
Ptp69DProtein tyrosine phosphatase 69D0.032
ewgerect wing0.030
Fkbp13CG9847 gene product from transcript CG9847-RC0.030
CG10641CG10641 gene product from transcript CG10641-RA0.029
drddrop dead0.029
jimCG11352 gene product from transcript CG11352-RB0.028
AnnXAnnexin X0.028
AblAbl tyrosine kinase0.026
LanB1CG7123 gene product from transcript CG7123-RA0.025
Spf45CG17540 gene product from transcript CG17540-RB0.025
chinmoChronologically inappropriate morphogenesis0.022
EphrinCG1862 gene product from transcript CG1862-RA0.021
S6kRPS6-p70-protein kinase0.021
pgant5polypeptide GalNAc transferase 50.021
gekgenghis khan0.021
HLHm5E(spl) region transcript m50.020
unc-104CG8566 gene product from transcript CG8566-RB0.019
Mekk1CG7717 gene product from transcript CG7717-RB0.019
CG6429CG6429 gene product from transcript CG6429-RA0.019
bshbrain-specific homeobox0.018
C15CG7937 gene product from transcript CG7937-RA0.018
PvrPDGF- and VEGF-receptor related0.018
myoglianinCG1838 gene product from transcript CG1838-RD0.017
eIF4Geukaryotic translation initiation factor 4G0.017
zfh1Zn finger homeodomain 10.016
mRpL24mitochondrial ribosomal protein L240.016
SaraSmad anchor for receptor activation0.016
Klp68DKinesin-like protein at 68D0.015
HsfHeat shock factor0.015
DAAMDishevelled Associated Activator of Morphogenesis0.014
Cdk5alphaCdk5 activator-like protein0.014
nrv1nervana 10.014
PdiProtein disulfide isomerase0.013
TrhTryptophan hydroxylase0.013
McrMacroglobulin complement-related0.012
DadDaughters against dpp0.012
kenken and barbie0.012
futschCG34387 gene product from transcript CG34387-RC0.012
NPFR1neuropeptide F receptor0.012
witwishful thinking0.012
Tsp96FTetraspanin 96F0.012
cwoclockwork orange0.012
Lgr3CG31096 gene product from transcript CG31096-RA0.012
Itp-r83AInositol 1,4,5,-tris-phosphate receptor0.012
unc-119CG1659 gene product from transcript CG1659-RA0.012
CrkCG1587 gene product from transcript CG1587-RC0.012
fogfolded gastrulation0.011
EcREcdysone receptor0.011
Cpr97EbCuticular protein 97Eb0.011
Su(dx)Suppressor of deltex0.011
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
JUNjun proto-oncogene0.996
EGFRepidermal growth factor receptor0.975
DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 300.953
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.894
DUSP1dual specificity phosphatase 10.889
FOSFBJ murine osteosarcoma viral oncogene homolog0.854
PTPN1protein tyrosine phosphatase, non-receptor type 10.815
CAV1caveolin 1, caveolae protein, 22kDa0.796
MAPK8mitogen-activated protein kinase 80.745
ATF2activating transcription factor 20.739
IGF1Rinsulin-like growth factor 1 receptor0.733
UCHL1ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)0.691
GSTM2glutathione S-transferase mu 2 (muscle)0.687
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.653
JUNBjun B proto-oncogene0.652
BCL2B-cell CLL/lymphoma 20.588
MAPK14mitogen-activated protein kinase 140.498
INSRinsulin receptor0.477
EFEMP2EGF containing fibulin-like extracellular matrix protein 20.428
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.381
FGFR1fibroblast growth factor receptor 10.374
MOBKL3MOB1, Mps One Binder kinase activator-like 3 (yeast)0.368
STRN3striatin, calmodulin binding protein 30.356
LAMC1laminin, gamma 1 (formerly LAMB2)0.348
NOSTRINnitric oxide synthase trafficker0.333
MAPK8IP1mitogen-activated protein kinase 8 interacting protein 10.326
MAPK1mitogen-activated protein kinase 10.303
THBS1thrombospondin 10.294
HSPA5heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)0.289
ATF3activating transcription factor 30.285
ADORA2Aadenosine A2a receptor0.281
RARAretinoic acid receptor, alpha0.260
NR4A1nuclear receptor subfamily 4, group A, member 10.258
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.257
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.247
ARRB1arrestin, beta 10.233
SOCS3suppressor of cytokine signaling 30.232
GSTM4glutathione S-transferase mu 40.229
MAPK10mitogen-activated protein kinase 100.225
SH3RF1SH3 domain containing ring finger 10.219
BCL2L11BCL2-like 11 (apoptosis facilitator)0.216
TIMP2TIMP metallopeptidase inhibitor 20.212
JAK2Janus kinase 20.210
ATF4activating transcription factor 4 (tax-responsive enhancer element B67)0.185
MAP2K4mitogen-activated protein kinase kinase 40.178
BAK1BCL2-antagonist/killer 10.170
MAP3K5mitogen-activated protein kinase kinase kinase 50.163
SLMAPsarcolemma associated protein0.156
CDK9cyclin-dependent kinase 90.155
CAV2caveolin 20.154
FAM40Afamily with sequence similarity 40, member A0.153
NCOA1nuclear receptor coactivator 10.151
PDCD10programmed cell death 100.150
JUNDjun D proto-oncogene0.137
IRF2BP1interferon regulatory factor 2 binding protein 10.136
FAT1FAT tumor suppressor homolog 1 (Drosophila)0.133
SNIP1Smad nuclear interacting protein 10.133
NGFnerve growth factor (beta polypeptide)0.129
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.128
EPORerythropoietin receptor0.128
CTTNBP2NLCTTNBP2 N-terminal like0.127
HMGA2high mobility group AT-hook 20.122
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.122
FAM40Bfamily with sequence similarity 40, member B0.118
PGRprogesterone receptor0.116
STK24serine/threonine kinase 240.111
IRS1insulin receptor substrate 10.109
TSC22D1TSC22 domain family, member 10.108
PTPN11protein tyrosine phosphatase, non-receptor type 110.107
LIFleukemia inhibitory factor (cholinergic differentiation factor)0.105
BIDBH3 interacting domain death agonist0.104
MAPK9mitogen-activated protein kinase 90.103
MED25mediator complex subunit 250.103
STAT5Asignal transducer and activator of transcription 5A0.101
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.100
STRNstriatin, calmodulin binding protein0.100
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.096
MYCNv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.095
EGR1early growth response 10.095
FGFR1OP2FGFR1 oncogene partner 20.094
NCF1neutrophil cytosolic factor 10.094
FGF1fibroblast growth factor 1 (acidic)0.093
ZNF512Bzinc finger protein 512B0.093
SH2B1SH2B adaptor protein 10.091
PFN1profilin 10.090
NR4A3nuclear receptor subfamily 4, group A, member 30.089
DDIT3DNA-damage-inducible transcript 30.087
MAPK3mitogen-activated protein kinase 30.087
FOSL1FOS-like antigen 10.086
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.086
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.085
NR4A2nuclear receptor subfamily 4, group A, member 20.085
FBXW7F-box and WD repeat domain containing 70.084
GSTM3glutathione S-transferase mu 3 (brain)0.084
BCL2L1BCL2-like 10.083
ETS2v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)0.081
STAT1signal transducer and activator of transcription 1, 91kDa0.080
APLP2amyloid beta (A4) precursor-like protein 20.078
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.078
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism