The network for 'vitamin d biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

vitamin d biosynthetic process

The chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3).

NameDescriptionProbabilityFunc Analog Organism
Cyp3a18cytochrome P450, family 3, subfamily a, polypeptide 180.493
Ugt2bUDP glycosyltransferase 2 family, polypeptide B0.285
Il6interleukin 60.107
LOC293989cytochrome P450-like0.097
Cyp2a2cytochrome P450, family 2, subfamily a, polypeptide 20.087
Cyp3a23/3a1cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 10.068
Abcb11ATP-binding cassette, subfamily B (MDR/TAP), member 110.063
Il1ainterleukin 1 alpha0.063
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.061
Cyp1a1cytochrome P450, family 1, subfamily a, polypeptide 10.056
Ccl4chemokine (C-C motif) ligand 40.054
Cyp4f1cytochrome P450, family 4, subfamily f, polypeptide 10.043
Sult1b1sulfotransferase family, cytosolic, 1B, member 10.041
LOC494499LOC494499 protein0.039
Stat3signal transducer and activator of transcription 30.036
Akr1c18aldo-keto reductase family 1, member C180.035
Cyp2b1cytochrome P450, family 2, subfamily b, polypeptide 10.035
Sult1c3sulfotransferase family, cytosolic, 1C, member 30.035
Selpselectin P0.032
Ugt2b5UDP glucuronosyltransferase 2 family, polypeptide B50.031
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.031
Sult2a1sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 10.030
Slc9a3solute carrier family 9 (sodium/hydrogen exchanger), member 30.027
Sult1c2sulfotransferase family, cytosolic, 1C, member 20.027
Gjb3gap junction protein, beta 30.027
Ccl20chemokine (C-C motif) ligand 200.025
Cyp2a1cytochrome P450, family 2, subfamily a, polypeptide 10.025
Gabregamma-aminobutyric acid (GABA) A receptor, epsilon0.024
Cyp4a10cytochrome P450, family 4, subfamily a, polypeptide 100.021
Sult1e1sulfotransferase family 1E, estrogen-preferring, member 10.020
Cyp2d3cytochrome P450, family 2, subfamily d, polypeptide 30.020
Cyp2c22cytochrome P450, family 2, subfamily c, polypeptide 220.019
Apobapolipoprotein B0.018
Fut1fucosyltransferase 10.018
Gja5gap junction protein, alpha 50.017
LOC100360403ATP-binding cassette, sub-family C, member 9-like0.017
Hipk3homeodomain interacting protein kinase 30.017
Prss3protease, serine, 30.016
Hoxb8homeo box B80.015
Omdosteomodulin0.015
Galnt5UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)0.015
Cyp2d2cytochrome P450, family 2, subfamily d, polypeptide 20.015
Accn5amiloride-sensitive cation channel 5, intestinal0.014
Il2rbinterleukin 2 receptor, beta0.014
Birc3baculoviral IAP repeat-containing 30.014
Ptpn14protein tyrosine phosphatase, non-receptor type 140.014
Insl3insulin-like 30.014
Cst8cystatin 8 (cystatin-related epididymal specific)0.014
Mc5rmelanocortin 5 receptor0.014
Brd1bromodomain containing 10.013
Ccl3chemokine (C-C motif) ligand 30.013
Cdkn2acyclin-dependent kinase inhibitor 2A0.013
KlKlotho0.013
Spink1serine peptidase inhibitor, Kazal type 10.013
Nr5a2nuclear receptor subfamily 5, group A, member 20.013
Irf1interferon regulatory factor 10.013
Adhfe1alcohol dehydrogenase, iron containing, 10.013
Clcn5chloride channel 50.013
Nr0b2nuclear receptor subfamily 0, group B, member 20.012
Obp3alpha-2u globulin PGCL40.012
Hsd3b5hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 50.012
Fut9fucosyltransferase 9 (alpha (1,3) fucosyltransferase)0.012
LOC290595hypothetical gene supported by AF1520020.012
Dmgdhdimethylglycine dehydrogenase0.012
Cyp3a9cytochrome P450, family 3, subfamily a, polypeptide 90.012
Tnftumor necrosis factor (TNF superfamily, member 2)0.012
Cyp2c13cytochrome P450, family 2, subfamily c, polypeptide 130.012
Cyp3a2cytochrome P450, family 3, subfamily a, polypeptide 20.012
Reg3gregenerating islet-derived 3 gamma0.012
As3mtarsenic (+3 oxidation state) methyltransferase0.012
Dpyddihydropyrimidine dehydrogenase0.011
Cyp2d4cytochrome P450, family 2, subfamily d, polypeptide 40.011
Fabp9fatty acid binding protein 9, testis0.011
Ceacam10carcinoembryonic antigen-related cell adhesion molecule 100.011
Ugt2b37UDP-glucuronosyltransferase 2 family, member 370.011
Pbsnprobasin0.011
Pfkfb16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 10.011
Alox5arachidonate 5-lipoxygenase0.011
Exosc6exosome component 60.011
Svs3aseminal vesicle secretory protein 3A0.011
Cybrd1cytochrome b reductase 10.011
Mcpt8mast cell protease 80.011
Sval1seminal vesicle antigen-like 10.011
Sult5a1sulfotransferase family 5A, member 10.011
Clca4chloride channel accessory 40.010
Abcc2ATP-binding cassette, subfamily C (CFTR/MRP), member 20.010
Ms4a8amembrane-spanning 4-domains, subfamily A, member 8A0.010
Dnase1deoxyribonuclease I0.010
Ces1fcarboxylesterase 1F0.010
Fat2FAT tumor suppressor homolog 2 (Drosophila)0.010
Lhcgrluteinizing hormone/choriogonadotropin receptor0.010
Prl8a4prolactin family 8, subfamily a, member 40.010
Il1rapinterleukin 1 receptor accessory protein0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.987
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.924
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.866
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.846
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.627
BCL3B-cell CLL/lymphoma 30.475
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.321
IL1R1interleukin 1 receptor, type I0.235
RXRAretinoid X receptor, alpha0.092
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.083
NFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta0.072
JUBjub, ajuba homolog (Xenopus laevis)0.054
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.029
HRhairless homolog (mouse)0.025
ICAM1intercellular adhesion molecule 10.025
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.020
IL1R2interleukin 1 receptor, type II0.018
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.018
IL1RNinterleukin 1 receptor antagonist0.017
TRAF1TNF receptor-associated factor 10.015
EGR1early growth response 10.014
TNIP1TNFAIP3 interacting protein 10.011
CYP3A7cytochrome P450, family 3, subfamily A, polypeptide 70.011
NOTCH1notch 10.011
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Cyp2c38cytochrome P450, family 2, subfamily c, polypeptide 380.983
Cyp2c29cytochrome P450, family 2, subfamily c, polypeptide 290.981
Cyp3a11cytochrome P450, family 3, subfamily a, polypeptide 110.979
Cps1carbamoyl-phosphate synthetase 10.972
Otcornithine transcarbamylase0.956
Nr1i2nuclear receptor subfamily 1, group I, member 20.920
Pck1phosphoenolpyruvate carboxykinase 1, cytosolic0.898
Cyp3a25cytochrome P450, family 3, subfamily a, polypeptide 250.881
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.868
Sult1d1sulfotransferase family 1D, member 10.854
Tgfb1transforming growth factor, beta 10.841
Cyp2b10cytochrome P450, family 2, subfamily b, polypeptide 100.840
Hpd4-hydroxyphenylpyruvic acid dioxygenase0.838
Cyp2a12cytochrome P450, family 2, subfamily a, polypeptide 120.827
Cyp2c50cytochrome P450, family 2, subfamily c, polypeptide 500.826
Cyp4a14cytochrome P450, family 4, subfamily a, polypeptide 140.812
Esr1estrogen receptor 1 (alpha)0.811
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.809
G6pcglucose-6-phosphatase, catalytic0.717
Nr5a2nuclear receptor subfamily 5, group A, member 20.703
Ugt2b1UDP glucuronosyltransferase 2 family, polypeptide B10.701
Cyp2b9cytochrome P450, family 2, subfamily b, polypeptide 90.669
Cyp7a1cytochrome P450, family 7, subfamily a, polypeptide 10.651
Rdh7retinol dehydrogenase 70.622
CrpC-reactive protein, pentraxin-related0.593
Cyp2c54cytochrome P450, family 2, subfamily c, polypeptide 540.585
Sult1b1sulfotransferase family 1B, member 10.567
Lepleptin0.558
Abcc2ATP-binding cassette, sub-family C (CFTR/MRP), member 20.521
Nr1i3nuclear receptor subfamily 1, group I, member 30.512
Ugt2b34UDP glucuronosyltransferase 2 family, polypeptide B340.477
Insrinsulin receptor0.472
Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.467
Cyp3a13cytochrome P450, family 3, subfamily a, polypeptide 130.454
Hrghistidine-rich glycoprotein0.437
Azgp1alpha-2-glycoprotein 1, zinc0.437
Ces2acarboxylesterase 2A0.417
Cyp2d10cytochrome P450, family 2, subfamily d, polypeptide 100.407
Slc2a2solute carrier family 2 (facilitated glucose transporter), member 20.397
Leprleptin receptor0.396
Cyp8b1cytochrome P450, family 8, subfamily b, polypeptide 10.389
Baatbile acid-Coenzyme A: amino acid N-acyltransferase0.386
Il1ainterleukin 1 alpha0.382
Timd2T-cell immunoglobulin and mucin domain containing 20.368
Hsd3b2hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 20.360
Hsd3b3hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 30.358
Tdo2tryptophan 2,3-dioxygenase0.354
Pigrpolymeric immunoglobulin receptor0.353
Slc27a5solute carrier family 27 (fatty acid transporter), member 50.341
Cyp1a2cytochrome P450, family 1, subfamily a, polypeptide 20.341
Upp2uridine phosphorylase 20.341
Slc22a1solute carrier family 22 (organic cation transporter), member 10.337
Aldobaldolase B, fructose-bisphosphate0.335
Bchebutyrylcholinesterase0.332
Hgdhomogentisate 1, 2-dioxygenase0.331
Aadacarylacetamide deacetylase (esterase)0.318
Ces1gcarboxylesterase 1G0.317
Ugt2a3UDP glucuronosyltransferase 2 family, polypeptide A30.295
Vdrvitamin D receptor0.295
Cyp4b1cytochrome P450, family 4, subfamily b, polypeptide 10.286
Cyp2d26cytochrome P450, family 2, subfamily d, polypeptide 260.284
Akr1d1aldo-keto reductase family 1, member D10.281
F13bcoagulation factor XIII, beta subunit0.280
Gsta2glutathione S-transferase, alpha 2 (Yc2)0.270
Mbl2mannose-binding lectin (protein C) 20.267
F9coagulation factor IX0.267
Cfhr1complement factor H-related 10.264
Apohapolipoprotein H0.263
Cyp2e1cytochrome P450, family 2, subfamily e, polypeptide 10.262
Serpina6serine (or cysteine) peptidase inhibitor, clade A, member 60.262
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.261
Slco1b2solute carrier organic anion transporter family, member 1b20.260
Cyp4a31cytochrome P450, family 4, subfamily a, polypeptide 310.258
Akr1c6aldo-keto reductase family 1, member C60.258
Mup5major urinary protein 50.257
Cyp2c39cytochrome P450, family 2, subfamily c, polypeptide 390.238
Adh7alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide0.228
Cyp2c68cytochrome P450, family 2, subfamily c, polypeptide 680.221
Cml2camello-like 20.216
Ces1ccarboxylesterase 1C0.214
Apoc3apolipoprotein C-III0.213
Gata6GATA binding protein 60.213
Fabp1fatty acid binding protein 1, liver0.207
Cyp2d9cytochrome P450, family 2, subfamily d, polypeptide 90.203
Prlrprolactin receptor0.199
Rdh16retinol dehydrogenase 160.193
F12coagulation factor XII (Hageman factor)0.193
Csf1colony stimulating factor 1 (macrophage)0.187
Sult2a2sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 20.185
Plin1perilipin 10.184
Cyp2c69cytochrome P450, family 2, subfamily c, polypeptide 690.183
Gcgroup specific component0.180
Cav1caveolin 1, caveolae protein0.177
Serpina1cserine (or cysteine) peptidase inhibitor, clade A, member 1C0.174
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.172
Uoxurate oxidase0.171
Keg1kidney expressed gene 10.170
Acot12acyl-CoA thioesterase 120.167
Pik3c2gphosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide0.166
Mocs1molybdenum cofactor synthesis 10.166
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism