The network for 'negative regulation of gene expression epigenetic' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of gene expression epigenetic

Any epigenetic process that stops, prevents or reduces the rate of gene expression.

NameDescriptionProbabilityFunc Analog Organism
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
his-64Protein HIS-640.978
his-1Protein HIS-10.977
his-5Protein HIS-50.961
his-16Protein HIS-160.847
his-62Protein HIS-620.832
his-68Protein HIS-680.698
his-45Protein HIS-450.697
his-46Protein HIS-460.615
mcm-2Protein MCM-20.587
his-47Protein HIS-470.582
his-61Protein HIS-610.479
his-50Protein HIS-500.476
his-42Protein HIS-420.473
his-31Protein HIS-310.450
CELE_F19F10.9Protein F19F10.90.436
hsr-9Protein HSR-90.407
CELE_R02D3.3Protein R02D3.30.361
his-30Protein HIS-300.359
his-3Protein HIS-30.359
his-14Protein HIS-140.318
his-48Protein HIS-480.317
his-9Protein HIS-90.309
aspm-1Protein ASPM-10.296
his-29Protein HIS-290.247
B0001.3Protein B0001.30.235
mcm-7Protein MCM-70.231
dcr-1Protein DCR-10.219
rfp-1Protein RFP-10.211
capg-2Protein CAPG-20.204
his-38Protein HIS-380.201
wdr-5.1Protein WDR-5.10.195
mcm-4Protein MCM-40.195
aars-2Protein AARS-20.190
mel-28Protein MEL-280.168
wrm-1Protein WRM-10.167
rbx-1Protein RBX-10.161
eftu-2Protein EFTU-20.156
lin-53Protein LIN-530.140
his-43Protein HIS-430.131
lin-5Protein LIN-50.127
cdt-2Protein CDT-20.123
his-63Protein HIS-630.123
C07A9.2Protein C07A9.20.121
his-44Protein HIS-440.121
his-65Protein HIS-650.119
his-51Protein HIS-510.119
spt-5Protein SPT-50.115
lin-13Protein LIN-130.113
hda-2Protein HDA-20.111
his-26Protein HIS-260.111
D2096.7Protein D2096.70.111
prpf-4Protein PRPF-40.110
K05C4.7Protein K05C4.70.107
his-33Protein HIS-330.105
ain-2Protein AIN-20.104
mcm-3Protein MCM-30.098
ZK328.4Protein ZK328.40.098
prg-2Protein PRG-20.096
ifb-2Protein IFB-20.096
mig-5Protein MIG-50.096
C27F2.8Protein C27F2.80.095
his-2Protein HIS-20.095
Y87G2A.1Protein Y87G2A.10.094
brd-1Protein BRD-10.093
swsn-7Protein SWSN-70.090
rnr-1Protein RNR-10.089
spdl-1Protein SPDL-10.087
npp-3Protein NPP-30.086
kle-2Protein KLE-20.086
his-55Protein HIS-550.085
npp-21Protein NPP-210.083
his-52Protein HIS-520.083
rpa-2Protein RPA-20.082
cdc-6Protein CDC-60.079
npp-19Protein NPP-190.078
D1081.8Protein D1081.80.078
CELE_Y46G5A.8Protein Y46G5A.80.076
his-15Protein HIS-150.075
B0511.12Protein B0511.120.074
max-2Protein MAX-20.073
C52B9.8Protein C52B9.80.070
trr-1Protein TRR-10.070
his-58Protein HIS-580.070
rom-1Protein ROM-10.070
his-11Protein HIS-110.069
top-2Protein TOP-20.067
aps-2Protein APS-20.067
dpy-26Protein DPY-260.067
F33H2.5Protein F33H2.50.066
mix-1Protein MIX-10.066
ucr-2.3Protein UCR-2.30.066
prp-8Protein PRP-80.066
R05H5.3Protein R05H5.30.066
smo-1Protein SMO-10.065
rnp-5Protein RNP-50.065
pgp-6Protein PGP-60.064
vrk-1Protein VRK-10.064
klp-18Protein KLP-180.064
his-25Protein HIS-250.063
F11E6.7Protein F11E6.70.063
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CTCFCG8591 gene product from transcript CG8591-RA1.000
His2AvHistone H2A variant0.996
XNPCG4548 gene product from transcript CG4548-RA0.992
Snr1Snf5-related 10.990
Su(var)3-7Suppressor of variegation 3-70.978
Sir2CG5216 gene product from transcript CG5216-RA0.977
Su(var)205Suppressor of variegation 2050.966
ScmSex comb on midleg0.961
gppgrappa0.960
PcPolycomb0.959
Rpd3CG7471 gene product from transcript CG7471-RA0.956
Su(var)2-HP2CG12864 gene product from transcript CG12864-RB0.951
E(var)3-9Enhancer of variegation 3-90.936
D1D1 chromosomal protein0.926
BEAF-32Boundary element-associated factor of 32kD0.912
crmcramped0.885
piwiCG6122 gene product from transcript CG6122-RA0.873
escextra sexcombs0.839
eggeggless0.838
waplwings apart-like0.826
Pp1-87BProtein phosphatase 1 at 87B0.811
ash1absent, small, or homeotic discs 10.783
PliPellino0.757
e(y)3enhancer of yellow 30.753
pr-set7CG3307 gene product from transcript CG3307-RC0.733
HmgDHigh mobility group protein D0.730
Jarid2CG3654 gene product from transcript CG3654-RD0.692
NNotch0.690
HiraCG12153 gene product from transcript CG12153-RA0.678
barrbarren0.659
Chd1Chromodomain-helicase-DNA-binding protein 10.630
MBD-likeCG8208 gene product from transcript CG8208-RA0.580
SuURSuppressor of Under-Replication0.566
MRG15CG6363 gene product from transcript CG6363-RA0.554
Fmr1CG6203 gene product from transcript CG6203-RC0.545
CG32711CG32711 gene product from transcript CG32711-RA0.522
p53CG33336 gene product from transcript CG33336-RB0.491
JIL-1CG6297 gene product from transcript CG6297-RA0.484
cgcombgap0.461
msl-2male-specific lethal 20.450
lidlittle imaginal discs0.446
Mi-2CG8103 gene product from transcript CG8103-RA0.407
B52CG10851 gene product from transcript CG10851-RB0.398
polybromoCG11375 gene product from transcript CG11375-RA0.395
lwrlesswright0.381
Dp1Dodeca-satellite-binding protein 10.380
Hel25EHelicase at 25E0.378
ParpPoly-(ADP-ribose) polymerase0.378
sxcsuper sex combs0.361
trxtrithorax0.348
HP4Heterochromatin protein 40.341
nejnejire0.323
SMC1CG6057 gene product from transcript CG6057-RA0.300
E(z)Enhancer of zeste0.298
CG5899CG5899 gene product from transcript CG5899-RA0.295
eastenhanced adult sensory threshold0.292
CG12256CG12256 gene product from transcript CG12256-RA0.286
CG1240CG1240 gene product from transcript CG1240-RA0.273
Su(var)3-3Suppressor of variegation 3-30.264
smt3CG4494 gene product from transcript CG4494-RA0.257
RgaRegena0.239
vasvasa0.237
ChroChromator0.233
lokloki0.230
Caf1Chromatin assembly factor 1 subunit0.227
kiskismet0.220
CG13022CG13022 gene product from transcript CG13022-RB0.218
G9aCG2995 gene product from transcript CG2995-RA0.214
Fas2Fasciclin 20.209
sinahsina homologue0.206
CG8165CG8165 gene product from transcript CG8165-RA0.197
CDC45LCG3658 gene product from transcript CG3658-RA0.196
pzgputzig0.193
CG42500CG42500 gene product from transcript CG42500-RA0.192
SMC2CG10212 gene product from transcript CG10212-RA0.190
aspabnormal spindle0.187
Mcm7Minichromosome maintenance 70.185
Hrb27CHeterogeneous nuclear ribonucleoprotein at 27C0.183
Nf-YCNuclear factor Y-box C0.182
CG10630CG10630 gene product from transcript CG10630-RA0.174
CG3815CG3815 gene product from transcript CG3815-RA0.172
CG14204CG14204 gene product from transcript CG14204-RA0.169
mus209mutagen-sensitive 2090.169
Mcm6Minichromosome maintenance 60.168
Saf-BScaffold attachment factor B0.167
pashapartner of drosha0.165
IswiImitation SWI0.154
BRWD3CG31132 gene product from transcript CG31132-RA0.152
Vap-33-1CG5014 gene product from transcript CG5014-RB0.152
PclPolycomblike0.145
spn-Espindle E0.145
nebnebbish0.144
Pp1alpha-96AProtein phosphatase 1alpha at 96A0.142
glugluon0.140
DNApol-epsilonDNA polymerase epsilon0.137
Mcm2Minichromosome maintenance 20.137
CG2926CG2926 gene product from transcript CG2926-RA0.133
DrefDNA replication-related element factor0.131
rinrasputin0.127
RavusCG15889 gene product from transcript CG15889-RA0.123
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HDAC1histone deacetylase 10.999
DNMT1DNA (cytosine-5-)-methyltransferase 10.952
HDAC2histone deacetylase 20.943
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.933
CBX5chromobox homolog 50.905
UHRF1ubiquitin-like with PHD and ring finger domains 10.835
ACTL6Aactin-like 6A0.700
RBBP4retinoblastoma binding protein 40.519
SUV39H1suppressor of variegation 3-9 homolog 1 (Drosophila)0.496
RB1retinoblastoma 10.459
PCNAproliferating cell nuclear antigen0.419
CHD4chromodomain helicase DNA binding protein 40.371
YY1YY1 transcription factor0.368
SIN3ASIN3 homolog A, transcription regulator (yeast)0.328
MCM6minichromosome maintenance complex component 60.310
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.306
HIST1H3Bhistone cluster 1, H3b0.263
MCM7minichromosome maintenance complex component 70.251
HCFC1host cell factor C1 (VP16-accessory protein)0.169
SUMO1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)0.167
CHAF1Achromatin assembly factor 1, subunit A (p150)0.161
SMARCE1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 10.156
NBNnibrin0.149
DAXXdeath-domain associated protein0.146
PARP1poly (ADP-ribose) polymerase 10.139
TMPOthymopoietin0.136
EEDembryonic ectoderm development0.131
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.130
BMI1BMI1 polycomb ring finger oncogene0.128
THOC4THO complex 40.124
MED15mediator complex subunit 150.120
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 20.109
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.109
UBE2Bubiquitin-conjugating enzyme E2B (RAD6 homolog)0.107
HIST1H2AIhistone cluster 1, H2ai0.104
BCORBCL6 corepressor0.102
WDR5WD repeat domain 50.100
MDM2Mdm2 p53 binding protein homolog (mouse)0.099
MRFAP1Morf4 family associated protein 10.094
HDAC3histone deacetylase 30.093
KAT5K(lysine) acetyltransferase 50.093
BRCA1breast cancer 1, early onset0.090
MCM2minichromosome maintenance complex component 20.089
ESR1estrogen receptor 10.089
HIST1H2AMhistone cluster 1, H2am0.089
CBX8chromobox homolog 80.086
SUMO2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)0.081
HIST1H3Dhistone cluster 1, H3d0.078
RING1ring finger protein 10.078
TP53tumor protein p530.074
SUZ12suppressor of zeste 12 homolog (Drosophila)0.074
CHD8chromodomain helicase DNA binding protein 80.074
CDC6cell division cycle 6 homolog (S. cerevisiae)0.073
PBRM1polybromo 10.071
HIST1H4Dhistone cluster 1, H4d0.070
HIST1H2BGhistone cluster 1, H2bg0.069
ORC3origin recognition complex, subunit 30.068
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.067
KDM1Alysine (K)-specific demethylase 1A0.066
CBX3chromobox homolog 30.065
RUVBL1RuvB-like 1 (E. coli)0.064
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.060
DICER1dicer 1, ribonuclease type III0.058
RBBP7retinoblastoma binding protein 70.055
HIST1H3Ahistone cluster 1, H3a0.055
HIST1H2ABhistone cluster 1, H2ab0.054
SP1Sp1 transcription factor0.052
CBX1chromobox homolog 10.051
NCAPHnon-SMC condensin I complex, subunit H0.050
RNF2ring finger protein 20.048
USP11ubiquitin specific peptidase 110.048
HIST1H2AEhistone cluster 1, H2ae0.046
ARID2AT rich interactive domain 2 (ARID, RFX-like)0.045
POLE2polymerase (DNA directed), epsilon 2 (p59 subunit)0.044
MTA1metastasis associated 10.044
CDC7cell division cycle 7 homolog (S. cerevisiae)0.043
CHAF1Bchromatin assembly factor 1, subunit B (p60)0.042
MCM4minichromosome maintenance complex component 40.042
ARID4BAT rich interactive domain 4B (RBP1-like)0.041
CDC73cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.040
SAP30Sin3A-associated protein, 30kDa0.040
HIST2H3Chistone cluster 2, H3c0.040
MSH6mutS homolog 6 (E. coli)0.039
ADNPactivity-dependent neuroprotector homeobox0.039
ING3inhibitor of growth family, member 30.037
ARID1BAT rich interactive domain 1B (SWI1-like)0.037
TRIM28tripartite motif containing 280.037
MORF4L1mortality factor 4 like 10.036
ASF1BASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.035
MCM5minichromosome maintenance complex component 50.035
LEO1Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.034
TOP2Btopoisomerase (DNA) II beta 180kDa0.033
EP300E1A binding protein p3000.033
TFDP1transcription factor Dp-10.033
HIST1H2AJhistone cluster 1, H2aj0.032
H2AFZH2A histone family, member Z0.032
HIST1H2ALhistone cluster 1, H2al0.032
MCM10minichromosome maintenance complex component 100.032
MBD1methyl-CpG binding domain protein 10.032
MORF4L2mortality factor 4 like 20.031
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Rnf2ring finger protein 20.999
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.996
Pou5f1POU domain, class 5, transcription factor 10.996
Smarcc1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.993
Rbbp4retinoblastoma binding protein 40.970
Hdac1histone deacetylase 10.960
Ezh2enhancer of zeste homolog 2 (Drosophila)0.896
Arid1bAT rich interactive domain 1B (SWI-like)0.886
Mcm2minichromosome maintenance deficient 2 mitotin (S. cerevisiae)0.813
Arid1aAT rich interactive domain 1A (SWI-like)0.801
CtcfCCCTC-binding factor0.789
RybpRING1 and YY1 binding protein0.670
Trp53transformation related protein 530.655
Mcm4minichromosome maintenance deficient 4 homolog (S. cerevisiae)0.565
Mcm3minichromosome maintenance deficient 3 (S. cerevisiae)0.559
H3f3aH3 histone, family 3A0.542
Brca1breast cancer 10.508
Chd4chromodomain helicase DNA binding protein 40.502
Smc1astructural maintenance of chromosomes 1A0.489
Smc3structural maintenace of chromosomes 30.467
Suz12suppressor of zeste 12 homolog (Drosophila)0.434
Hdac2histone deacetylase 20.410
Dnmt1DNA methyltransferase (cytosine-5) 10.376
Wdr5WD repeat domain 50.369
Uhrf1ubiquitin-like, containing PHD and RING finger domains, 10.366
Cbx5chromobox homolog 5 (Drosophila HP1a)0.355
Ighimmunoglobulin heavy chain complex0.348
Ep400E1A binding protein p4000.346
Ep300E1A binding protein p3000.316
Mecp2methyl CpG binding protein 20.310
Mll3myeloid/lymphoid or mixed-lineage leukemia 30.304
Stag1stromal antigen 10.292
Tcf3transcription factor 30.286
Ash2lash2 (absent, small, or homeotic)-like (Drosophila)0.271
NanogNanog homeobox0.269
Sin3atranscriptional regulator, SIN3A (yeast)0.256
Mcm5minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)0.240
Kdm2blysine (K)-specific demethylase 2B0.240
Mcm7minichromosome maintenance deficient 7 (S. cerevisiae)0.234
Mta2metastasis-associated gene family, member 20.229
Cdt1chromatin licensing and DNA replication factor 10.170
Dnmt3bDNA methyltransferase 3B0.158
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.154
Sp1trans-acting transcription factor 10.149
Arid2AT rich interactive domain 2 (ARID, RFX-like)0.136
Timelesstimeless homolog (Drosophila)0.129
Trim28tripartite motif-containing 280.127
Cdk1cyclin-dependent kinase 10.121
Pold1polymerase (DNA directed), delta 1, catalytic subunit0.119
Rcc2regulator of chromosome condensation 20.117
Mta1metastasis associated 10.106
Hellshelicase, lymphoid specific0.106
Hist1h3ghistone cluster 1, H3g0.105
CrebbpCREB binding protein0.105
Ccna2cyclin A20.101
Bmi1Bmi1 polycomb ring finger oncogene0.101
E2f1E2F transcription factor 10.101
Atrxalpha thalassemia/mental retardation syndrome X-linked homolog (human)0.097
Lig1ligase I, DNA, ATP-dependent0.094
Tcfcp2l1transcription factor CP2-like 10.086
MgaMAX gene associated0.082
Cbx8chromobox homolog 8 (Drosophila Pc class)0.073
Dnmt3aDNA methyltransferase 3A0.071
Brd4bromodomain containing 40.070
Smarca2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.069
Brca2breast cancer 20.065
Parp1poly (ADP-ribose) polymerase family, member 10.063
Plk1polo-like kinase 1 (Drosophila)0.062
Lrwd1leucine-rich repeats and WD repeat domain containing 10.062
Phc2polyhomeotic-like 2 (Drosophila)0.061
Matr3matrin 30.061
Csnk1a1casein kinase 1, alpha 10.060
Skp1aS-phase kinase-associated protein 1A0.059
Smarcd1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.059
Trim24tripartite motif-containing 240.057
Safbscaffold attachment factor B0.054
Creb1cAMP responsive element binding protein 10.054
Ccnb2cyclin B20.053
Supt16hsuppressor of Ty 16 homolog (S. cerevisiae)0.052
Ddx6DEAD (Asp-Glu-Ala-Asp) box polypeptide 60.052
Ergavian erythroblastosis virus E-26 (v-ets) oncogene related0.050
Hmgb1high mobility group box 10.050
Tfdp1transcription factor Dp 10.048
Krit1KRIT1, ankyrin repeat containing0.047
H2afzH2A histone family, member Z0.045
Suds3suppressor of defective silencing 3 homolog (S. cerevisiae)0.044
Msh2mutS homolog 2 (E. coli)0.043
Rrm1ribonucleotide reductase M10.043
RestRE1-silencing transcription factor0.042
Sae1SUMO1 activating enzyme subunit 10.042
Pcgf2polycomb group ring finger 20.041
Sp4trans-acting transcription factor 40.041
Ilf3interleukin enhancer binding factor 30.039
Eedembryonic ectoderm development0.039
Jarid2jumonji, AT rich interactive domain 20.037
Scaf11SR-related CTD-associated factor 110.037
Lmnb1lamin B10.037
Pcgf6polycomb group ring finger 60.037
Nucks1nuclear casein kinase and cyclin-dependent kinase substrate 10.037
Cdk2cyclin-dependent kinase 20.036
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
SIR2Sir2p0.993
HHT1Hht1p0.992
RPD3Rpd3p0.990
SIR4Sir4p0.984
HMO1Hmo1p0.980
SET1Set1p0.977
SIN3Sin3p0.957
RAP1Rap1p0.956
RLF2Rlf2p0.947
SAS2Sas2p0.947
ORC2Orc2p0.944
HAT1Hat1p0.907
SPT10Spt10p0.876
ORC5Orc5p0.866
HHF1Hhf1p0.849
SNT1Snt1p0.843
CTI6Cti6p0.841
UME1Ume1p0.826
ORC6Orc6p0.816
MCM3Mcm3p0.798
DEF1Def1p0.796
RXT2Rxt2p0.788
UBP8Ubp8p0.787
SDS3Sds3p0.775
YTA7Yta7p0.764
RSC2Rsc2p0.753
ORC1Orc1p0.745
NUP133Nup133p0.736
RTF1Rtf1p0.712
HDA1Hda1p0.707
CTF18Ctf18p0.682
ASF1Asf1p0.678
SDC1Sdc1p0.670
RTT106Rtt106p0.652
HFI1Hfi1p0.644
ISW2Isw2p0.622
RCO1Rco1p0.611
ORC3Orc3p0.611
STB3Stb3p0.607
SIR3Sir3p0.604
SET3Set3p0.600
RPN4Rpn4p0.600
BDF1Bdf1p0.580
SPT21Spt21p0.569
NET1Net1p0.557
PAP2Pap2p0.529
DPB2Dpb2p0.515
HHO1Hho1p0.512
CYC8Cyc8p0.493
IFH1Ifh1p0.488
MSI1Msi1p0.487
RIF1Rif1p0.487
MCM5Mcm5p0.469
SRM1Srm1p0.458
HTB2Htb2p0.442
HAT2Hat2p0.441
STE4Ste4p0.424
ITC1Itc1p0.422
FKH2Fkh2p0.418
ACE2Ace2p0.412
SWD3Swd3p0.402
SPP1Spp1p0.399
ZDS1Zds1p0.397
HHT2Hht2p0.388
STH1Sth1p0.380
ARP4Arp4p0.373
RRM3Rrm3p0.373
CPR1Cpr1p0.362
MMS22Mms22p0.356
RSC4Rsc4p0.356
GSP1Gsp1p0.350
RSC8Rsc8p0.350
CDC45Cdc45p0.340
YLR455Whypothetical protein0.334
NUP82Nup82p0.333
RFM1Rfm1p0.327
NUP1Nup1p0.321
RAD17Rad17p0.321
FOB1Fob1p0.317
HIR2Hir2p0.317
YNG1Yng1p0.308
CDC6Cdc6p0.303
DLS1Dls1p0.295
NUP188Nup188p0.295
NUP170Nup170p0.293
MIG3Mig3p0.291
SAP30Sap30p0.290
LYS5Lys5p0.286
NUP85Nup85p0.284
NRG1Nrg1p0.282
CTK1Ctk1p0.276
BRE2Bre2p0.275
TAF14Taf14p0.266
SET2Set2p0.264
RSC58Rsc58p0.262
SRC1Src1p0.258
BRE1Bre1p0.258
RNR2Rnr2p0.257
PEX22Pex22p0.256
PUF4Puf4p0.253