The network for 'negative regulation of secretion by cell' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of secretion by cell

Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell.

NameDescriptionProbabilityFunc Analog Organism
Trhr2thyrotropin releasing hormone receptor 20.161
Kcnq3potassium voltage-gated channel, KQT-like subfamily, member 30.156
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.121
Rgs9regulator of G-protein signaling 90.115
Grm5glutamate receptor, metabotropic 50.113
Cyp2c11cytochrome P450, subfamily 2, polypeptide 110.110
Lgals3lectin, galactoside-binding, soluble, 30.102
Prkcgprotein kinase C, gamma0.099
Ins2insulin 20.096
Gucy2dguanylate cyclase 2d0.094
Kcnk9potassium channel, subfamily K, member 90.091
Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.088
Itgb1integrin, beta 10.078
Clstn3calsyntenin 30.075
Rab11aRAB11a, member RAS oncogene family0.075
Cx3cr1chemokine (C-X3-C motif) receptor 10.075
Pspparotid secretory protein0.074
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.072
Gata4GATA binding protein 40.070
Flt1FMS-related tyrosine kinase 10.070
Hpcal4hippocalcin-like 40.069
Crhbpcorticotropin releasing hormone binding protein0.068
Neurod2neurogenic differentiation 20.065
Prlhrprolactin releasing hormone receptor0.065
Ccbp2chemokine binding protein 20.065
Dlg4discs, large homolog 4 (Drosophila)0.063
Olr1078olfactory receptor 10780.062
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.062
Olr226olfactory receptor 2260.061
Cacng4calcium channel, voltage-dependent, gamma subunit 40.061
S100a6S100 calcium binding protein A60.061
Olr414olfactory receptor 4140.061
S100a10S100 calcium binding protein A100.061
Adcy5adenylate cyclase 50.059
Unc5aunc-5 homolog A (C. elegans)0.058
Slc18a3solute carrier family 18 (vesicular acetylcholine), member 30.057
Egr3early growth response 30.057
Ctsjcathepsin J0.057
B3gat1beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)0.057
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.057
Scn10asodium channel, voltage-gated, type X, alpha subunit0.056
Notch4Notch homolog 4 (Drosophila)0.056
Glp1rglucagon-like peptide 1 receptor0.055
P2rx5purinergic receptor P2X, ligand-gated ion channel, 50.055
Drd1adopamine receptor D1A0.055
Hand1heart and neural crest derivatives expressed 10.055
Prl3a1Prolactin family 3, subfamily a, member 10.054
Scn4asodium channel, voltage-gated, type IV, alpha subunit0.053
Olr1641olfactory receptor 16410.053
Hcn1hyperpolarization-activated cyclic nucleotide-gated potassium channel 10.052
Cmklr1chemokine-like receptor 10.051
Adcyap1r1adenylate cyclase activating polypeptide 1 receptor 10.050
Syn1synapsin I0.050
Barhl2BarH-like homeobox 20.050
Reg3gregenerating islet-derived 3 gamma0.049
Anxa2annexin A20.049
Slc8a2solute carrier family 8 (sodium/calcium exchanger), member 20.049
Celsr3cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)0.048
Adora1adenosine A1 receptor0.048
Serpinb6aserine (or cysteine) peptidase inhibitor, clade B, member 6a0.048
Impg2interphotoreceptor matrix proteoglycan 20.048
Ghsrgrowth hormone secretagogue receptor0.048
Cnga4cyclic nucleotide gated channel alpha 40.047
Prph2peripherin 20.046
Trpm1transient receptor potential cation channel, subfamily M, member 10.046
Afap1actin filament associated protein 10.046
Ccl2chemokine (C-C motif) ligand 20.046
Ccr5chemokine (C-C motif) receptor 50.046
Adora2aadenosine A2a receptor0.045
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.045
Htr75-hydroxytryptamine (serotonin) receptor 70.044
Trpm8transient receptor potential cation channel, subfamily M, member 80.044
Sox17SRY (sex determining region Y)-box 170.044
Lim2lens intrinsic membrane protein 20.044
Htr65-hydroxytryptamine (serotonin) receptor 60.044
Olr1496olfactory receptor 14960.043
Hrh3histamine receptor H30.043
Anxa5annexin A50.043
Map6microtubule-associated protein 60.043
Ptger2prostaglandin E receptor 2 (subtype EP2)0.043
Cacng5calcium channel, voltage-dependent, gamma subunit 50.042
Nrg2neuregulin 20.042
Mmp3matrix metallopeptidase 30.042
Mapk10mitogen activated protein kinase 100.042
Pde1aphosphodiesterase 1A, calmodulin-dependent0.041
Clockclock homolog (mouse)0.041
Smgbneonatal submandibular gland protein B0.041
Tpbpatrophoblast specific protein alpha0.041
Gfi1growth factor independent 1 transcription repressor0.041
Necab2N-terminal EF-hand calcium binding protein 20.041
Ankrd11ankyrin repeat domain 110.041
Magmyelin-associated glycoprotein0.041
Slc7a3solute carrier family 7 (cationic amino acid transporter, y+ system), member 30.041
Acmsdaminocarboxymuconate semialdehyde decarboxylase0.041
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
anxa1bannexin A1b0.350
kdrlkinase insert domain receptor like0.287
cyp19a1acytochrome P450, family 19, subfamily A, polypeptide 1a0.178
hcrthypocretin (orexin) neuropeptide precursor0.174
ptgs2aprostaglandin-endoperoxide synthase 2a0.167
fabp11afatty acid binding protein 11a0.166
tnfatumor necrosis factor a (TNF superfamily, member 2)0.165
nf1aneurofibromin 1a0.159
mef2amyocyte enhancer factor 2a0.157
jag1bjagged 1b0.143
nlgn1neuroligin 10.127
sepw1selenoprotein W, 10.124
mnx1motor neuron and pancreas homeobox 10.122
anxa2aannexin A2a0.117
uts1urotensin 10.115
LOC100332193growth hormone secretagogue receptor type 1-like0.110
dao.2D-amino-acid oxidase 20.097
dab1adisabled homolog 1a (Drosophila)0.095
foxa3forkhead box A30.093
id1inhibitor of DNA binding 10.091
nf1bneurofibromin 1b0.089
nr1d2bnuclear receptor subfamily 1, group D, member 2b0.088
il8interleukin 80.084
pcp4aPurkinje cell protein 4a0.082
cyp19a1bcytochrome P450, family 19, subfamily A, polypeptide 1b0.081
etv2ets variant gene 20.079
mapk7mitogen-activated protein kinase 70.076
cldn2claudin 20.072
mchr1bmelanin-concentrating hormone receptor 1b0.068
hcrtr2hypocretin (orexin) receptor 20.066
syne1aspectrin repeat containing, nuclear envelope 1a0.065
gsdfgonadal somatic cell derived factor0.064
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.064
cry-dashcryptochrome DASH0.063
ptger2aprostaglandin E receptor 2a (subtype EP2)0.060
ascl1aachaete-scute complex-like 1a (Drosophila)0.060
tspan7btetraspanin 7b0.057
gad1bglutamate decarboxylase 1b0.057
foxo3bforkhead box O3b0.057
hsf2heat shock factor 20.056
ghrlghrelin/obestatin preprohormone0.056
anxa1cannexin A1c0.055
cyp1b1cytochrome P450, family 1, subfamily B, polypeptide 10.053
duoxdual oxidase0.053
robo1roundabout homolog 10.053
cnr1cannabinoid receptor 10.053
pdx1pancreatic and duodenal homeobox 10.052
gfra1agdnf family receptor alpha 1a0.052
mc3rmelanocortin 3 receptor0.050
LOC100003330melanocortin-2 receptor accessory protein 2-like0.050
tshbthyroid stimulating hormone, beta subunit0.049
bsk146brain specific kinase 1460.049
anxa1aannexin A1a0.048
dedd1death effector domain-containing 10.048
drd2adopamine receptor D2a0.048
drd2bdopamine receptor D2b0.047
nlgn3aneuroligin 3a0.047
adora2badenosine A2b receptor0.047
gpiaglucose phosphate isomerase a0.047
slc17a7solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 70.046
inhbabinhibin, beta Ab0.045
igf3insulin-like growth factor 30.044
znf395bzinc finger protein 395b0.044
col7a1lcollagen type VII alpha 1-like0.044
nlgn4bneuroligin 4b0.043
bmp15bone morphogenetic protein 150.043
hspb6heat shock protein, alpha-crystallin-related, b60.042
csf3rcolony stimulating factor 3 receptor (granulocyte)0.042
sulf2lsulfatase 2, like0.041
cry1bcryptochrome 1b0.041
mbnl1muscleblind-like (Drosophila)0.040
mc5rbmelanocortin 5b receptor0.040
ghsragrowth hormone secretagogue receptor a0.040
ghrhrlgrowth hormone releasing hormone receptor, like0.039
LOC100537723hypothetical protein LOC1005377230.039
tuba8l3tubulin, alpha 8 like 30.039
hspb9heat shock protein, alpha-crystallin-related, 90.039
prdm5PR domain containing 50.038
abcc5ATP-binding cassette, sub-family C (CFTR/MRP), member 50.038
aldobaldolase b, fructose-bisphosphate0.038
LOC793458peptide Y-like0.038
kcnq3potassium voltage-gated channel, KQT-like subfamily, member 30.038
adra2badrenergic, alpha-2B-, receptor0.038
nlgn3bneuroligin 3b0.037
drd2ldopamine receptor D2 like0.037
nkx2.3NK2 transcription factor related 30.037
klf2bKruppel-like factor 2b0.037
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Drep-2DNA fragmentation factor-related protein 20.020
Octbeta2RCG33976 gene product from transcript CG33976-RA0.018
cv-2crossveinless 20.017
Plc21CPhospholipase C at 21C0.016
witwishful thinking0.015
DatDopamine N acetyltransferase0.014
TbhTyramine beta hydroxylase0.013
CG14840CG14840 gene product from transcript CG14840-RA0.012
Irk3Inwardly rectifying potassium channel 30.011
Pi3K68DPhosphotidylinositol 3 kinase 68D0.011
IppInositol polyphosphate 1-phosphatase0.011
ShawShaker cognate w0.011
CG42629CG42629 gene product from transcript CG42629-RB0.011
CG32635CG32635 gene product from transcript CG32635-RA0.011
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SNAP23synaptosomal-associated protein, 23kDa0.958
TRAF2TNF receptor-associated factor 20.838
ANXA1annexin A10.805
INSRinsulin receptor0.799
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.790
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.784
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.757
PTPN1protein tyrosine phosphatase, non-receptor type 10.689
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.615
MPDZmultiple PDZ domain protein0.612
SMN1survival of motor neuron 1, telomeric0.612
LILRA1leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 10.588
ADORA2Aadenosine A2a receptor0.567
PILRApaired immunoglobin-like type 2 receptor alpha0.564
PTPN6protein tyrosine phosphatase, non-receptor type 60.524
GABBR1gamma-aminobutyric acid (GABA) B receptor, 10.492
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.487
GABBR2gamma-aminobutyric acid (GABA) B receptor, 20.487
KCNE1potassium voltage-gated channel, Isk-related family, member 10.485
GRB10growth factor receptor-bound protein 100.460
MED15mediator complex subunit 150.443
JAG1jagged 10.425
SIGLEC7sialic acid binding Ig-like lectin 70.424
LIN7Blin-7 homolog B (C. elegans)0.409
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.392
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.364
UBE2V1ubiquitin-conjugating enzyme E2 variant 10.347
FOXD3forkhead box D30.342
PTAFRplatelet-activating factor receptor0.337
CAV1caveolin 1, caveolae protein, 22kDa0.330
IGF1Rinsulin-like growth factor 1 receptor0.319
RIPK2receptor-interacting serine-threonine kinase 20.319
IL22RA1interleukin 22 receptor, alpha 10.307
VAC14Vac14 homolog (S. cerevisiae)0.285
IL1Binterleukin 1, beta0.285
S100A10S100 calcium binding protein A100.263
IL1R1interleukin 1 receptor, type I0.258
KCNJ5potassium inwardly-rectifying channel, subfamily J, member 50.255
AXLAXL receptor tyrosine kinase0.253
UBE2D1ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)0.222
CHRNA4cholinergic receptor, nicotinic, alpha 40.219
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.215
DRD2dopamine receptor D20.212
ANXA7annexin A70.206
BIRC3baculoviral IAP repeat containing 30.200
LILRA2leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 20.199
IL22RA2interleukin 22 receptor, alpha 20.189
SSTR3somatostatin receptor 30.187
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.185
IRS2insulin receptor substrate 20.185
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.183
APOA1apolipoprotein A-I0.183
IL10RAinterleukin 10 receptor, alpha0.177
SLC11A1solute carrier family 11 (proton-coupled divalent metal ion transporters), member 10.172
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.168
STX4syntaxin 40.167
STX7syntaxin 70.163
STX6syntaxin 60.155
ZNF263zinc finger protein 2630.154
TRAF1TNF receptor-associated factor 10.148
GOLGA2golgin A20.137
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.137
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.135
WWP2WW domain containing E3 ubiquitin protein ligase 20.135
CHMP1Achromatin modifying protein 1A0.132
EDF1endothelial differentiation-related factor 10.122
TRIM39tripartite motif containing 390.121
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.110
APOC1apolipoprotein C-I0.110
TFF1trefoil factor 10.110
RASGRF1Ras protein-specific guanine nucleotide-releasing factor 10.109
TRIM5tripartite motif containing 50.105
AOAHacyloxyacyl hydrolase (neutrophil)0.103
SCP2sterol carrier protein 20.102
TREM1triggering receptor expressed on myeloid cells 10.102
IRS1insulin receptor substrate 10.101
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.101
CACNA1Hcalcium channel, voltage-dependent, T type, alpha 1H subunit0.099
PECAM1platelet/endothelial cell adhesion molecule0.099
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.098
HK3hexokinase 3 (white cell)0.096
TRIM43tripartite motif containing 430.096
MAPTmicrotubule-associated protein tau0.096
IL6Rinterleukin 6 receptor0.092
CCR1chemokine (C-C motif) receptor 10.091
TEKTEK tyrosine kinase, endothelial0.088
SOX2SRY (sex determining region Y)-box 20.087
XIAPX-linked inhibitor of apoptosis0.087
CD33CD33 molecule0.086
IL1RNinterleukin 1 receptor antagonist0.086
IL10interleukin 100.085
FPR2formyl peptide receptor 20.085
TNFRSF10Ctumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain0.084
SSTR2somatostatin receptor 20.083
TYMPthymidine phosphorylase0.082
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.082
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.972
Ppargperoxisome proliferator activated receptor gamma0.838
Esr1estrogen receptor 1 (alpha)0.804
Ptgs2prostaglandin-endoperoxide synthase 20.775
Socs1suppressor of cytokine signaling 10.735
Nos2nitric oxide synthase 2, inducible0.633
Pnpla2patatin-like phospholipase domain containing 20.563
Drd2dopamine receptor D20.501
Pdcd1programmed cell death 10.473
Insrinsulin receptor0.472
Nfatc2nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 20.442
Nos1nitric oxide synthase 1, neuronal0.441
Il1r1interleukin 1 receptor, type I0.419
Arntlaryl hydrocarbon receptor nuclear translocator-like0.394
Nr3c1nuclear receptor subfamily 3, group C, member 10.390
Clockcircadian locomotor output cycles kaput0.371
Pax8paired box gene 80.367
Leprleptin receptor0.357
Tgfbr2transforming growth factor, beta receptor II0.348
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.311
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.305
Cd80CD80 antigen0.303
Tnftumor necrosis factor0.299
Per2period homolog 2 (Drosophila)0.285
Pim1proviral integration site 10.275
Esr2estrogen receptor 2 (beta)0.272
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.262
Ccl2chemokine (C-C motif) ligand 20.252
MefvMediterranean fever0.238
Inhbainhibin beta-A0.236
Tlr4toll-like receptor 40.235
Htr45 hydroxytryptamine (serotonin) receptor 40.223
Cxcr2chemokine (C-X-C motif) receptor 20.201
Ptpn11protein tyrosine phosphatase, non-receptor type 110.190
Bmpr1abone morphogenetic protein receptor, type 1A0.173
Ern2endoplasmic reticulum (ER) to nucleus signalling 20.169
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.161
Arandrogen receptor0.161
Ccl4chemokine (C-C motif) ligand 40.156
Nos3nitric oxide synthase 3, endothelial cell0.154
Bglapbone gamma carboxyglutamate protein0.151
Gata6GATA binding protein 60.146
Sstr3somatostatin receptor 30.146
Mc5rmelanocortin 5 receptor0.144
Cd44CD44 antigen0.139
S1pr2sphingosine-1-phosphate receptor 20.137
Adrb3adrenergic receptor, beta 30.136
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.135
Batfbasic leucine zipper transcription factor, ATF-like0.126
Cyp19a1cytochrome P450, family 19, subfamily a, polypeptide 10.120
Atp4bATPase, H+/K+ exchanging, beta polypeptide0.119
Tgfbr1transforming growth factor, beta receptor I0.117
Oprd1opioid receptor, delta 10.116
Ccl3chemokine (C-C motif) ligand 30.116
Mup10major urinary protein 100.116
Nf1neurofibromatosis 10.115
Fut1fucosyltransferase 10.111
Adora2aadenosine A2a receptor0.111
Bmp4bone morphogenetic protein 40.110
Ageradvanced glycosylation end product-specific receptor0.108
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.106
Grm1glutamate receptor, metabotropic 10.106
Ucp3uncoupling protein 3 (mitochondrial, proton carrier)0.104
Grin2aglutamate receptor, ionotropic, NMDA2A (epsilon 1)0.104
Kcnj3potassium inwardly-rectifying channel, subfamily J, member 30.100
Oprm1opioid receptor, mu 10.100
Lag3lymphocyte-activation gene 30.099
Ctla4cytotoxic T-lymphocyte-associated protein 40.097
Apoeapolipoprotein E0.097
Npy1rneuropeptide Y receptor Y10.095
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.095
Apcadenomatosis polyposis coli0.095
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.095
Il1rl1interleukin 1 receptor-like 10.093
Fshrfollicle stimulating hormone receptor0.093
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.092
Mup9major urinary protein 90.092
Nkx2-3NK2 transcription factor related, locus 3 (Drosophila)0.092
Npy2rneuropeptide Y receptor Y20.091
CblCasitas B-lineage lymphoma0.090
Atoh7atonal homolog 7 (Drosophila)0.090
Egfrepidermal growth factor receptor0.089
Cx3cr1chemokine (C-X3-C) receptor 10.088
Gpr3G-protein coupled receptor 30.087
Gpr33G protein-coupled receptor 330.086
Csf2colony stimulating factor 2 (granulocyte-macrophage)0.086
Syt6synaptotagmin VI0.085
Il12binterleukin 12b0.085
S100a5S100 calcium binding protein A50.085
Pitx3paired-like homeodomain transcription factor 30.085
Trpc4transient receptor potential cation channel, subfamily C, member 40.084
Wnt7awingless-related MMTV integration site 7A0.084
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.083
Bdkrb1bradykinin receptor, beta 10.083
Prlrprolactin receptor0.081
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism