The network for 'skeletal muscle myosin thick filament assembly' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

skeletal muscle myosin thick filament assembly

The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in skeletal muscle.

NameDescriptionProbabilityFunc Analog Organism
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
emb-9Protein EMB-90.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
mef2cbmyocyte enhancer factor 2cb0.999
smyhc1slow myosin heavy chain 10.996
myogmyogenin0.991
tnnc1btroponin C type 1b (slow)0.896
smyd1bSET and MYND domain containing 1b0.886
smyd1aSET and MYND domain containing 1a0.822
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.817
tnni1altroponin I, skeletal, slow like0.787
unc45bunc-45 homolog B (C. elegans)0.716
myhz2myosin, heavy polypeptide 2, fast muscle specific0.577
actn3aactinin alpha 3a0.575
smyhc2slow myosin heavy chain 20.553
myhz1.1myosin, heavy polypeptide 1.1, skeletal muscle0.550
myhz1.2myosin, heavy polypeptide 1.2, skeletal muscle0.503
vgll2bvestigial like 2b0.371
tnni1btroponin I, skeletal, slow b0.290
LOC100149148novel protein similar to myosin heavy chain 4 (myhc4)0.267
myhc4myosin heavy chain 40.227
mef2camyocyte enhancer factor 2ca0.201
xirp1xin actin-binding repeat containing 10.177
ryr1bryanodine receptor 1b (skeletal)0.173
fhlafour and a half LIM domains a0.161
pdlim7PDZ and LIM domain 70.147
hsp90a.1heat shock protein 90-alpha 10.145
myod1myogenic differentiation 10.132
smyd2bSET and MYND domain containing 2b0.083
stac3SH3 and cysteine rich domain 30.075
mstnamyostatin a0.067
defbl3defensin, beta-like 30.057
popdc2popeye domain containing 20.052
lamb2laminin, beta 2 (laminin S)0.051
rnf41ring finger protein 410.049
ckmacreatine kinase, muscle a0.045
actn3bactinin alpha 3b0.038
smyhc3slow myosin heavy chain 30.037
myl1myosin, light chain 1, alkali; skeletal, fast0.036
dmrt2bdoublesex and mab-3 related transcription factor 2b0.034
ttnatitin a0.032
flncbfilamin C, gamma b (actin binding protein 280)0.031
tnnt1troponin T1, skeletal, slow0.031
apobec2aapolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2a0.030
hspb8heat shock protein, alpha-crystallin-related, b80.026
fabp3fatty acid binding protein 3, muscle and heart0.023
mylz2myosin, light polypeptide 2, skeletal muscle0.021
actn2actinin, alpha 20.021
rbfox1lRNA binding protein, fox-1 homolog (C. elegans) 1-like0.021
mef2dmyocyte enhancer factor 2d0.021
meox2amesenchyme homeobox 2a0.014
dynlt3dynein, light chain, Tctex-type 30.014
meox1mesenchyme homeobox 10.014
ppp3r1aprotein phosphatase 3 (formerly 2B), regulatory s1ubunit B, alpha isoform, a0.013
acta1bactin, alpha 1b, skeletal muscle0.012
nr4a2bnuclear receptor subfamily 4, group A, member 2b0.012
tpm2tropomyosin 2 (beta)0.011
mbnl2muscleblind-like 2 (Drosophila)0.011
sema3aasemaphorin 3aa0.011
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Tm2Tropomyosin 20.530
slssallimus0.241
wupAwings up A0.191
Act88FActin 88F0.130
upupheld0.120
Actnalpha actinin0.115
Mlc2Myosin light chain 20.109
Zasp52Z band alternatively spliced PDZ-motif protein 520.057
Zasp66Z band alternatively spliced PDZ-motif protein 660.055
flwflapwing0.044
GpdhGlycerol 3 phosphate dehydrogenase0.034
PrmParamyosin0.024
Cf2Chorion factor 20.021
tmodtropomodulin0.018
Gpo-1Glycerophosphate oxidase-10.016
chicchickadee0.015
salssarcomere length short0.012
CanB2Calcineurin B20.011
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HSP90AB1heat shock protein 90kDa alpha (cytosolic), class B member 10.607
TRIM63tripartite motif containing 630.500
TTNtitin0.359
HSPH1heat shock 105kDa/110kDa protein 10.258
DNAJA1DnaJ (Hsp40) homolog, subfamily A, member 10.226
NEBnebulin0.164
ARHGAP1Rho GTPase activating protein 10.107
ANK1ankyrin 1, erythrocytic0.081
CAPN3calpain 3, (p94)0.034
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.029
ACTN2actinin, alpha 20.029
MYOZ1myozenin 10.025
OBSL1obscurin-like 10.021
TCAPtitin-cap (telethonin)0.017
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.014
ROCK1Rho-associated, coiled-coil containing protein kinase 10.013
RHOCras homolog gene family, member C0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Myl3myosin, light polypeptide 30.665
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.639
Tnnc2troponin C2, fast0.456
Hdac4histone deacetylase 40.409
Tnni2troponin I, skeletal, fast 20.310
Tnnt3troponin T3, skeletal, fast0.288
Mef2cmyocyte enhancer factor 2C0.207
Ldb3LIM domain binding 30.155
Hdac5histone deacetylase 50.142
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.140
Hrchistidine rich calcium binding protein0.128
Ckmt2creatine kinase, mitochondrial 20.126
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.121
Actn2actinin alpha 20.111
Pgam2phosphoglycerate mutase 20.103
Map3k5mitogen-activated protein kinase kinase kinase 50.102
Cox6a2cytochrome c oxidase, subunit VI a, polypeptide 20.096
Mef2dmyocyte enhancer factor 2D0.088
Hspa8heat shock protein 80.085
Cox8bcytochrome c oxidase, subunit VIIIb0.083
Ckmcreatine kinase, muscle0.080
Myom1myomesin 10.079
Ttntitin0.076
Myh8myosin, heavy polypeptide 8, skeletal muscle, perinatal0.075
Chrna1cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)0.074
Myom2myomesin 20.069
Casq2calsequestrin 20.068
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.067
Itgb1bp2integrin beta 1 binding protein 20.065
Nrapnebulin-related anchoring protein0.064
Tnnc1troponin C, cardiac/slow skeletal0.062
Trdntriadin0.053
Myh2myosin, heavy polypeptide 2, skeletal muscle, adult0.052
Prkceprotein kinase C, epsilon0.052
Myh7myosin, heavy polypeptide 7, cardiac muscle, beta0.052
Wdr1WD repeat domain 10.048
Fbxo32F-box protein 320.047
Actn3actinin alpha 30.046
Csrp3cysteine and glycine-rich protein 30.045
Ryr1ryanodine receptor 1, skeletal muscle0.045
Chordc1cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 10.044
Xirp1xin actin-binding repeat containing 10.042
Atp2a1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.040
Trim54tripartite motif-containing 540.039
Rac1RAS-related C3 botulinum substrate 10.038
Myh3myosin, heavy polypeptide 3, skeletal muscle, embryonic0.038
Actc1actin, alpha, cardiac muscle 10.036
Cav3caveolin 30.036
Myl1myosin, light polypeptide 10.034
Hsph1heat shock 105kDa/110kDa protein 10.034
Cacng1calcium channel, voltage-dependent, gamma subunit 10.031
Sgcgsarcoglycan, gamma (dystrophin-associated glycoprotein)0.030
Vimvimentin0.030
Cryabcrystallin, alpha B0.030
Ppp3cbprotein phosphatase 3, catalytic subunit, beta isoform0.029
Lmod2leiomodin 2 (cardiac)0.027
Art1ADP-ribosyltransferase 10.026
Fabp3fatty acid binding protein 3, muscle and heart0.026
Srpk3serine/arginine-rich protein specific kinase 30.025
Apobec2apolipoprotein B mRNA editing enzyme, catalytic polypeptide 20.025
Acta1actin, alpha 1, skeletal muscle0.024
Pygmmuscle glycogen phosphorylase0.024
Mef2amyocyte enhancer factor 2A0.023
Myoz2myozenin 20.023
Cdkn1bcyclin-dependent kinase inhibitor 1B0.021
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.020
Txlnbtaxilin beta0.017
Tnnt1troponin T1, skeletal, slow0.017
Hspb1heat shock protein 10.017
Iqcb1IQ calmodulin-binding motif containing 10.017
Tnnt2troponin T2, cardiac0.017
Pdlim3PDZ and LIM domain 30.017
Rab11fip5RAB11 family interacting protein 5 (class I)0.016
Mrvi1MRV integration site 10.016
Clip1CAP-GLY domain containing linker protein 10.016
Myf6myogenic factor 60.015
Runx1t1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.015
Hdac9histone deacetylase 90.015
Cacna2d1calcium channel, voltage-dependent, alpha2/delta subunit 10.015
Myotmyotilin0.014
Kbtbd5kelch repeat and BTB (POZ) domain containing 50.014
Lmod3leiomodin 3 (fetal)0.014
Sgcasarcoglycan, alpha (dystrophin-associated glycoprotein)0.014
Zeb2zinc finger E-box binding homeobox 20.014
Tpm4tropomyosin 40.013
Mylpfmyosin light chain, phosphorylatable, fast skeletal muscle0.013
Popdc3popeye domain containing 30.013
Casq1calsequestrin 10.013
Tmem182transmembrane protein 1820.013
Sh2d1aSH2 domain protein 1A0.013
Nav1neuron navigator 10.012
Hfe2hemochromatosis type 2 (juvenile) (human homolog)0.012
Hspb2heat shock protein 20.012
Trim63tripartite motif-containing 630.012
Flncfilamin C, gamma0.012
Synpo2lsynaptopodin 2-like0.012
Gucy1b3guanylate cyclase 1, soluble, beta 30.012
Hspb7heat shock protein family, member 7 (cardiovascular)0.012
Capn3calpain 30.012
Prkg1protein kinase, cGMP-dependent, type I0.012
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism