The network for 'regulation of peptide hormone secretion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of peptide hormone secretion

Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.

NameDescriptionProbabilityFunc Analog Organism
Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.301
Phkg1phosphorylase kinase, gamma 10.293
Neurod2neurogenic differentiation 20.292
Vamp1vesicle-associated membrane protein 10.285
Sftpdsurfactant protein D0.285
Apoa4apolipoprotein A-IV0.266
Dnase1deoxyribonuclease I0.263
Crhbpcorticotropin releasing hormone binding protein0.243
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.243
Rxrgretinoid X receptor gamma0.222
G6pcglucose-6-phosphatase, catalytic subunit0.190
Gastgastrin0.169
Kcnq3potassium voltage-gated channel, KQT-like subfamily, member 30.161
Ins2insulin 20.159
Abcc8ATP-binding cassette, subfamily C (CFTR/MRP), member 80.158
Iappislet amyloid polypeptide0.150
Syt4synaptotagmin IV0.143
Glp1rglucagon-like peptide 1 receptor0.143
RT1-BaRT1 class II, locus Ba0.137
Grk4G protein-coupled receptor kinase 40.132
Adra2cadrenergic, alpha-2C-, receptor0.126
Prlhrprolactin releasing hormone receptor0.123
Tshbthyroid stimulating hormone, beta0.116
Ush1cUsher syndrome 1C homolog (human)0.116
SeboxSEBOX homeobox0.116
Gabrb3gamma-aminobutyric acid (GABA) A receptor, beta 30.112
Necab2N-terminal EF-hand calcium binding protein 20.111
Nr1d2nuclear receptor subfamily 1, group D, member 20.110
Acsl4acyl-CoA synthetase long-chain family member 40.109
Sox17SRY (sex determining region Y)-box 170.108
Esr2estrogen receptor 2 (ER beta)0.106
Scn10asodium channel, voltage-gated, type X, alpha subunit0.102
Lim2lens intrinsic membrane protein 20.101
LOC100362331rCG59612-like0.101
Ecel1endothelin converting enzyme-like 10.099
GperG protein-coupled estrogen receptor 10.098
Syt9synaptotagmin IX0.098
Capza1capping protein (actin filament) muscle Z-line, alpha 10.097
Fbp1fructose-1,6-bisphosphatase 10.096
Camk2gcalcium/calmodulin-dependent protein kinase II gamma0.094
Tmod2tropomodulin 20.094
Aqp2aquaporin 2 (collecting duct)0.094
Ucnurocortin0.093
Fam57bfamily with sequence similarity 57, member B0.093
Rab3bRAB3B, member RAS oncogene family0.092
Sstr2somatostatin receptor 20.092
Naaladl1N-acetylated alpha-linked acidic dipeptidase-like 10.092
Vom1r90vomeronasal 1 receptor 900.090
Syn1synapsin I0.090
Notch4Notch homolog 4 (Drosophila)0.089
Pyypeptide YY (mapped)0.089
Cgaglycoprotein hormones, alpha polypeptide0.089
Egr3early growth response 30.087
Htr5b5-hydroxytryptamine (serotonin) receptor 5B0.086
Mapk10mitogen activated protein kinase 100.085
Syt8synaptotagmin VIII0.082
Acot12acyl-CoA thioesterase 120.082
Slc5a2solute carrier family 5 (sodium/glucose cotransporter), member 20.082
Smad3SMAD family member 30.081
Casp3caspase 30.081
Slco2a1solute carrier organic anion transporter family, member 2a10.080
Pnocprepronociceptin0.077
Slc8a3solute carrier family 8 (sodium/calcium exchanger), member 30.077
Gh1growth hormone 10.077
Sytl4synaptotagmin-like 40.076
Trhr2thyrotropin releasing hormone receptor 20.076
Pparaperoxisome proliferator activated receptor alpha0.076
Grinaglutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)0.075
Pecam1platelet/endothelial cell adhesion molecule 10.075
Fam108b1family with sequence similarity 108, member B10.075
Reg3gregenerating islet-derived 3 gamma0.074
Adam1aa disintegrin and metallopeptidase domain 1a0.074
Cxcr5chemokine (C-X-C motif) receptor 50.073
Socs3suppressor of cytokine signaling 30.073
Gpha2glycoprotein hormone alpha 20.072
Nrsn1neurensin 10.071
Vipvasoactive intestinal peptide0.071
LOC290595hypothetical gene supported by AF1520020.070
Nfascneurofascin0.070
DbpD site of albumin promoter (albumin D-box) binding protein0.070
Foxa1forkhead box A10.070
Chrna7cholinergic receptor, nicotinic, alpha 70.069
Unc13cunc-13 homolog C (C. elegans)0.069
Kcnj13potassium inwardly-rectifying channel, subfamily J, member 130.068
Ucp3uncoupling protein 3 (mitochondrial, proton carrier)0.068
Grm7glutamate receptor, metabotropic 70.067
Grm1glutamate receptor, metabotropic 10.067
Pde3aphosphodiesterase 3A, cGMP inhibited0.067
Cdh22cadherin 220.067
Acrv1acrosomal vesicle protein 10.067
Zfyve20zinc finger, FYVE domain containing 200.067
Grm5glutamate receptor, metabotropic 50.067
Mtmr7myotubularin related protein 70.066
Thtyrosine hydroxylase0.066
Lifrleukemia inhibitory factor receptor alpha0.066
Sctsecretin0.065
Scnn1bsodium channel, nonvoltage-gated 1, beta0.065
Il12binterleukin 12B0.065
Mpp2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)0.064
Slc28a1solute carrier family 28 (sodium-coupled nucleoside transporter), member 10.064
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
daf-1Protein DAF-10.015
lit-1Protein LIT-10.013
daf-11Protein DAF-110.013
smp-1Protein SMP-10.013
unc-32Protein UNC-320.012
daf-4Protein DAF-40.012
unc-43Protein UNC-430.012
rsd-3Protein RSD-30.012
eat-6Protein EAT-60.012
hif-1Protein HIF-10.012
eat-4Protein EAT-40.011
vab-3Protein VAB-30.011
K03E6.7Protein K03E6.70.011
F13H6.1Protein F13H6.10.011
fox-1Protein FOX-10.011
qui-1Protein QUI-10.011
egl-5Protein EGL-50.011
kin-29Protein KIN-290.010
cdc-42Protein CDC-420.010
egl-36Protein EGL-360.010
ZK54.1Protein ZK54.10.010
lin-7Protein LIN-70.010
T27A3.1Protein T27A3.10.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
timtimeless0.340
Plc21CPhospholipase C at 21C0.232
ActbetaActivin-beta0.099
ShawShaker cognate w0.070
unc-13CG2999 gene product from transcript CG2999-RA0.067
shnschnurri0.066
DatDopamine N acetyltransferase0.048
discodisconnected0.044
Eip63F-1Ecdysone-induced protein 63F 10.039
dncdunce0.039
ClkClock0.031
uspultraspiracle0.025
mavmaverick0.023
CadNCadherin-N0.023
TequilaCG4821 gene product from transcript CG4821-RE0.022
CrebB-17ACyclic-AMP response element binding protein B at 17A0.020
Atg9Autophagy-specific gene 90.018
CanA1Calcineurin A10.018
RicRas which interacts with Calmodulin0.017
CaMKIICalcium/calmodulin-dependent protein kinase II0.017
Pka-C1cAMP-dependent protein kinase 10.017
drprdraper0.016
NPFR1neuropeptide F receptor0.015
witwishful thinking0.014
Gyc76CGuanylyl cyclase at 76C0.014
unc-104CG8566 gene product from transcript CG8566-RB0.013
myoglianinCG1838 gene product from transcript CG1838-RD0.013
kibrakibra ortholog0.013
HDAC6CG6170 gene product from transcript CG6170-RA0.013
SNF4AgammaSNF4/AMP-activated protein kinase gamma subunit0.012
Irk3Inwardly rectifying potassium channel 30.012
Pp2B-14DProtein phosphatase 2B at 14D0.012
Rab3Rab-protein 30.011
rtGEFrho-type guanine exchange factor0.011
norpAno receptor potential A0.010
crycryptochrome0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.875
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.837
PTPN1protein tyrosine phosphatase, non-receptor type 10.808
INSRinsulin receptor0.804
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.777
FGAfibrinogen alpha chain0.742
KCNE1potassium voltage-gated channel, Isk-related family, member 10.613
CCR5chemokine (C-C motif) receptor 50.554
FGBfibrinogen beta chain0.523
CCNYcyclin Y0.492
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.488
GABBR2gamma-aminobutyric acid (GABA) B receptor, 20.477
IGF1Rinsulin-like growth factor 1 receptor0.453
CCL4chemokine (C-C motif) ligand 40.452
PPARAperoxisome proliferator-activated receptor alpha0.439
IL1R1interleukin 1 receptor, type I0.437
IL1Binterleukin 1, beta0.380
HLA-DRB5major histocompatibility complex, class II, DR beta 50.379
LIN7Blin-7 homolog B (C. elegans)0.303
GABBR1gamma-aminobutyric acid (GABA) B receptor, 10.303
CHD8chromodomain helicase DNA binding protein 80.284
HCKhemopoietic cell kinase0.268
CRHR1corticotropin releasing hormone receptor 10.259
MPDZmultiple PDZ domain protein0.253
PSEN2presenilin 2 (Alzheimer disease 4)0.247
TEKTEK tyrosine kinase, endothelial0.238
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.232
NOSTRINnitric oxide synthase trafficker0.230
ZFYVE9zinc finger, FYVE domain containing 90.228
EGFRepidermal growth factor receptor0.218
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.213
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.201
IRS1insulin receptor substrate 10.194
CRPC-reactive protein, pentraxin-related0.183
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.172
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.172
SYKspleen tyrosine kinase0.168
CLASP1cytoplasmic linker associated protein 10.163
CXCL9chemokine (C-X-C motif) ligand 90.163
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.162
CCL2chemokine (C-C motif) ligand 20.157
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.144
SNAP25synaptosomal-associated protein, 25kDa0.144
HLA-DMBmajor histocompatibility complex, class II, DM beta0.143
CCL8chemokine (C-C motif) ligand 80.140
MEOX1mesenchyme homeobox 10.139
ARNTLaryl hydrocarbon receptor nuclear translocator-like0.137
DLG4discs, large homolog 4 (Drosophila)0.133
FGGfibrinogen gamma chain0.132
ONECUT1one cut homeobox 10.132
HLA-DRB4major histocompatibility complex, class II, DR beta 40.126
ADORA2Aadenosine A2a receptor0.124
NSFN-ethylmaleimide-sensitive factor0.122
HNF1BHNF1 homeobox B0.121
GRB2growth factor receptor-bound protein 20.118
SNAP23synaptosomal-associated protein, 23kDa0.117
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.115
BLNKB-cell linker0.115
CLOCKclock homolog (mouse)0.113
IL1RNinterleukin 1 receptor antagonist0.112
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.110
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.102
HOXD12homeobox D120.101
ENGendoglin0.099
IRF2interferon regulatory factor 20.099
GRB7growth factor receptor-bound protein 70.097
INCENPinner centromere protein antigens 135/155kDa0.094
HNF4Ahepatocyte nuclear factor 4, alpha0.091
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.090
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.087
MDM2Mdm2 p53 binding protein homolog (mouse)0.085
CCR1chemokine (C-C motif) receptor 10.085
NKX2-1NK2 homeobox 10.084
ABCC8ATP-binding cassette, sub-family C (CFTR/MRP), member 80.084
KCNJ5potassium inwardly-rectifying channel, subfamily J, member 50.082
CDX2caudal type homeobox 20.080
PPP3R1protein phosphatase 3, regulatory subunit B, alpha0.080
IBTKinhibitor of Bruton agammaglobulinemia tyrosine kinase0.080
CCL5chemokine (C-C motif) ligand 50.079
SH3BP4SH3-domain binding protein 40.078
VAC14Vac14 homolog (S. cerevisiae)0.078
UBASH3Bubiquitin associated and SH3 domain containing B0.077
VAMP3vesicle-associated membrane protein 3 (cellubrevin)0.077
CHD7chromodomain helicase DNA binding protein 70.076
GRB10growth factor receptor-bound protein 100.074
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.072
PTGER3prostaglandin E receptor 3 (subtype EP3)0.072
GJD2gap junction protein, delta 2, 36kDa0.071
RASA1RAS p21 protein activator (GTPase activating protein) 10.068
IL8interleukin 80.066
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.066
SH2B1SH2B adaptor protein 10.064
ITKIL2-inducible T-cell kinase0.062
GAD2glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)0.061
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.059
RGS20regulator of G-protein signaling 200.057
AURKBaurora kinase B0.057
BMPR1Bbone morphogenetic protein receptor, type IB0.056
BMP4bone morphogenetic protein 40.055
HDAC2histone deacetylase 20.055
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Gata4GATA binding protein 40.993
Nos3nitric oxide synthase 3, endothelial cell0.967
Pax8paired box gene 80.929
Klklotho0.892
Rxraretinoid X receptor alpha0.890
Arntlaryl hydrocarbon receptor nuclear translocator-like0.874
Clockcircadian locomotor output cycles kaput0.846
Fgf8fibroblast growth factor 80.842
Pdx1pancreatic and duodenal homeobox 10.840
Ephb2Eph receptor B20.801
Ppargperoxisome proliferator activated receptor gamma0.776
Pax2paired box gene 20.772
Tgfb2transforming growth factor, beta 20.709
Efnb2ephrin B20.703
Eya1eyes absent 1 homolog (Drosophila)0.698
Lepleptin0.692
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.684
Prop1paired like homeodomain factor 10.678
Insrinsulin receptor0.661
Bglapbone gamma carboxyglutamate protein0.643
Prox1prospero-related homeobox 10.618
Ctnnb1catenin (cadherin associated protein), beta 10.613
Fgfr2fibroblast growth factor receptor 20.609
Bmp4bone morphogenetic protein 40.609
Epha4Eph receptor A40.601
Sox9SRY-box containing gene 90.555
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.554
Tbx3T-box 30.552
Jag1jagged 10.540
Gli3GLI-Kruppel family member GLI30.515
Cry2cryptochrome 2 (photolyase-like)0.497
Gata6GATA binding protein 60.492
Ghrgrowth hormone receptor0.491
Adrb1adrenergic receptor, beta 10.487
Chd7chromodomain helicase DNA binding protein 70.480
Ltalymphotoxin A0.477
Nkx2-1NK2 homeobox 10.470
Arrb1arrestin, beta 10.443
Fstfollistatin0.441
Sox2SRY-box containing gene 20.434
Smad6MAD homolog 6 (Drosophila)0.412
Adra2aadrenergic receptor, alpha 2a0.410
Gata5GATA binding protein 50.409
Otporthopedia homolog (Drosophila)0.402
Foxg1forkhead box G10.400
Per2period homolog 2 (Drosophila)0.399
Cd160CD160 antigen0.371
Npas1neuronal PAS domain protein 10.358
Nrxn1neurexin I0.340
Nrxn3neurexin III0.340
Lhx3LIM homeobox protein 30.339
Fshrfollicle stimulating hormone receptor0.332
Hand2heart and neural crest derivatives expressed transcript 20.329
Akp3alkaline phosphatase 3, intestine, not Mn requiring0.324
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.320
Foxc1forkhead box C10.317
Fgf3fibroblast growth factor 30.316
Pitx2paired-like homeodomain transcription factor 20.311
Ptenphosphatase and tensin homolog0.308
Pnpla2patatin-like phospholipase domain containing 20.308
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.303
Cyp19a1cytochrome P450, family 19, subfamily a, polypeptide 10.295
Hey2hairy/enhancer-of-split related with YRPW motif 20.294
Pou3f3POU domain, class 3, transcription factor 30.292
Adra2badrenergic receptor, alpha 2b0.291
Pbx1pre B-cell leukemia transcription factor 10.288
Nr5a1nuclear receptor subfamily 5, group A, member 10.287
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.286
Cckbrcholecystokinin B receptor0.285
Hnf4ahepatic nuclear factor 4, alpha0.283
Neurog3neurogenin 30.269
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.268
Nf1neurofibromatosis 10.264
Ern2endoplasmic reticulum (ER) to nucleus signalling 20.262
Sfrp2secreted frizzled-related protein 20.258
Ntf3neurotrophin 30.257
Adra2cadrenergic receptor, alpha 2c0.256
Nkx6-1NK6 homeobox 10.252
Pim1proviral integration site 10.249
Atp2b2ATPase, Ca++ transporting, plasma membrane 20.247
Klf3Kruppel-like factor 3 (basic)0.246
Cideccell death-inducing DFFA-like effector c0.244
Rs1retinoschisis (X-linked, juvenile) 1 (human)0.234
Sstr3somatostatin receptor 30.232
Hes1hairy and enhancer of split 1 (Drosophila)0.232
Hpd4-hydroxyphenylpyruvic acid dioxygenase0.231
Thrbthyroid hormone receptor beta0.227
Cdkn1bcyclin-dependent kinase inhibitor 1B0.226
Sim1single-minded homolog 1 (Drosophila)0.226
Prkacaprotein kinase, cAMP dependent, catalytic, alpha0.224
Insm1insulinoma-associated 10.222
Lmx1bLIM homeobox transcription factor 1 beta0.220
Hif1ahypoxia inducible factor 1, alpha subunit0.214
Sox4SRY-box containing gene 40.212
Sall3sal-like 3 (Drosophila)0.208
Inhbbinhibin beta-B0.207
U46068cDNA sequence U460680.206
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.203
Chrm1cholinergic receptor, muscarinic 1, CNS0.203
Efnb1ephrin B10.201
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism