The network for 'somatic diversification of immune receptors' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

somatic diversification of immune receptors

The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences.

NameDescriptionProbabilityFunc Analog Organism
Hspa8heat shock protein 80.066
Cycscytochrome c, somatic0.049
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.041
Ppidpeptidylprolyl isomerase D (cyclophilin D)0.034
Cd37CD37 molecule0.034
Hspa5heat shock protein 50.033
Hsph1heat shock 105/110 protein 10.030
Casp1caspase 10.027
Dnaja1DnaJ (Hsp40) homolog, subfamily A, member 10.021
Bin2bridging integrator 20.021
Cxcr4chemokine (C-X-C motif) receptor 40.021
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.020
Arl5cADP-ribosylation factor-like 5C0.019
Ndufab1NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 10.016
Hckhemopoietic cell kinase0.016
Ptafrplatelet-activating factor receptor0.015
Plcg2phospholipase C, gamma 20.014
LOC681996similar to AHA1, activator of heat shock 90kDa protein ATPase homolog 10.014
Map4k4mitogen-activated protein kinase kinase kinase kinase 40.014
Lcp2lymphocyte cytosolic protein 20.014
Hspe1heat shock protein 1 (chaperonin 10)0.014
Myh9myosin, heavy chain 9, non-muscle0.014
Smad7SMAD family member 70.014
Chordc1cysteine and histidine-rich domain (CHORD)-containing 10.013
Fmnl1formin-like 10.013
Apbb1ipamyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein0.013
Cdc42bpbCDC42 binding protein kinase beta (DMPK-like)0.013
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.012
Pik3cdphosphoinositide-3-kinase, catalytic, delta polypeptide0.012
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.012
RT1-BaRT1 class II, locus Ba0.012
Il2rginterleukin 2 receptor, gamma0.012
Rassf5Ras association (RalGDS/AF-6) domain family member 50.012
Cd2Cd2 molecule0.012
Acap1ArfGAP with coiled-coil, ankyrin repeat and PH domains 10.012
RGD1305222similar to RIKEN cDNA 1810029B160.012
Myo1emyosin IE0.011
Sykspleen tyrosine kinase0.011
Ndufa5NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 50.011
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.011
Il1binterleukin 1 beta0.011
Clec9aC-type lectin domain family 9, member a0.011
Psd4pleckstrin and Sec7 domain containing 40.011
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.011
Dnm2dynamin 20.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
IL4Rinterleukin 4 receptor0.581
RAD50RAD50 homolog (S. cerevisiae)0.560
MSH6mutS homolog 6 (E. coli)0.389
MDC1mediator of DNA-damage checkpoint 10.315
MLH1mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)0.245
APLFaprataxin and PNKP like factor0.215
XRCC5X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)0.208
PRKDCprotein kinase, DNA-activated, catalytic polypeptide0.100
H2AFXH2A histone family, member X0.098
TAL1T-cell acute lymphocytic leukemia 10.088
TP53BP1tumor protein p53 binding protein 10.083
BRCA1breast cancer 1, early onset0.073
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.068
MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.065
GRAP2GRB2-related adaptor protein 20.056
LIG4ligase IV, DNA, ATP-dependent0.053
MSH2mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)0.053
MSH3mutS homolog 3 (E. coli)0.043
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.042
TNFRSF13Btumor necrosis factor receptor superfamily, member 13B0.037
PMS2PMS2 postmeiotic segregation increased 2 (S. cerevisiae)0.034
RUNX1runt-related transcription factor 10.034
XRCC4X-ray repair complementing defective repair in Chinese hamster cells 40.032
SMC1Astructural maintenance of chromosomes 1A0.031
PCNAproliferating cell nuclear antigen0.031
BRIP1BRCA1 interacting protein C-terminal helicase 10.027
HMGB2high mobility group box 20.026
THOC5THO complex 50.025
ZNF830zinc finger protein 8300.024
FANCD2Fanconi anemia, complementation group D20.023
PARP1poly (ADP-ribose) polymerase 10.021
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.021
PTPN6protein tyrosine phosphatase, non-receptor type 60.021
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.021
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.020
PMS1PMS1 postmeiotic segregation increased 1 (S. cerevisiae)0.020
HMGB1high mobility group box 10.019
CSNK1A1casein kinase 1, alpha 10.018
PTMAprothymosin, alpha0.018
CD22CD22 molecule0.016
FERMT2fermitin family member 20.014
ID3inhibitor of DNA binding 3, dominant negative helix-loop-helix protein0.014
RAD21RAD21 homolog (S. pombe)0.014
SEMA4Dsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D0.013
IKIK cytokine, down-regulator of HLA II0.013
TCF12transcription factor 120.012
PCDH9protocadherin 90.012
RPA1replication protein A1, 70kDa0.012
INPP5Dinositol polyphosphate-5-phosphatase, 145kDa0.011
TCF4transcription factor 40.011
POLR2Apolymerase (RNA) II (DNA directed) polypeptide A, 220kDa0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tnftumor necrosis factor1.000
Ighimmunoglobulin heavy chain complex0.998
Il10interleukin 100.998
Ifnginterferon gamma0.996
Ikzf1IKAROS family zinc finger 10.996
Atmataxia telangiectasia mutated homolog (human)0.996
Rag2recombination activating gene 20.989
Il4interleukin 40.986
Foxp3forkhead box P30.983
FynFyn proto-oncogene0.980
Prf1perforin 1 (pore forming protein)0.955
Rag1recombination activating gene 10.950
Cd19CD19 antigen0.942
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.901
Il6interleukin 60.897
Stat5bsignal transducer and activator of transcription 5B0.885
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.879
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.862
TcraT-cell receptor alpha chain0.843
Lef1lymphoid enhancer binding factor 10.833
Tbx3T-box 30.812
Cd40CD40 antigen0.803
Stat3signal transducer and activator of transcription 30.800
Socs1suppressor of cytokine signaling 10.784
Cd28CD28 antigen0.691
Pou5f1POU domain, class 5, transcription factor 10.685
Card11caspase recruitment domain family, member 110.655
Stat5asignal transducer and activator of transcription 5A0.640
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.631
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.589
Cd247CD247 antigen0.572
Il2interleukin 20.550
Latlinker for activation of T cells0.523
Nos2nitric oxide synthase 2, inducible0.498
Zeb1zinc finger E-box binding homeobox 10.483
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.480
Tlr4toll-like receptor 40.475
Tcf3transcription factor 30.453
Ltalymphotoxin A0.446
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.442
BtkBruton agammaglobulinemia tyrosine kinase0.429
Brca1breast cancer 10.426
Lcklymphocyte protein tyrosine kinase0.405
Brca2breast cancer 20.386
Il2rginterleukin 2 receptor, gamma chain0.379
Irf9interferon regulatory factor 90.358
Tcf7transcription factor 7, T-cell specific0.341
Chd7chromodomain helicase DNA binding protein 70.334
Map3k14mitogen-activated protein kinase kinase kinase 140.333
Il21rinterleukin 21 receptor0.319
Ltblymphotoxin B0.317
Trp53transformation related protein 530.314
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.314
Hcn4hyperpolarization-activated, cyclic nucleotide-gated K+ 40.314
Pitx1paired-like homeodomain transcription factor 10.297
Inpp5dinositol polyphosphate-5-phosphatase D0.290
Tbx21T-box 210.275
Il1r1interleukin 1 receptor, type I0.274
Wt1Wilms tumor 1 homolog0.273
Mmp9matrix metallopeptidase 90.261
Ptenphosphatase and tensin homolog0.238
Nlrp3NLR family, pyrin domain containing 30.211
Tal1T-cell acute lymphocytic leukemia 10.209
FasFas (TNF receptor superfamily member 6)0.197
Nbnnibrin0.194
Gli2GLI-Kruppel family member GLI20.193
Il4rainterleukin 4 receptor, alpha0.193
Il22interleukin 220.185
Cd40lgCD40 ligand0.181
Gdf3growth differentiation factor 30.179
ItkIL2-inducible T-cell kinase0.175
Sh2d1aSH2 domain protein 1A0.175
Ccl2chemokine (C-C motif) ligand 20.172
Rc3h1RING CCCH (C3H) domains 10.167
Ccr7chemokine (C-C motif) receptor 70.167
Myd88myeloid differentiation primary response gene 880.166
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.145
Lag3lymphocyte-activation gene 30.144
Lifleukemia inhibitory factor0.143
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.138
Pdcd1programmed cell death 10.135
Ptgs2prostaglandin-endoperoxide synthase 20.135
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.133
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.132
Bcl6B-cell leukemia/lymphoma 60.132
Cbfa2t3core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)0.132
FaslFas ligand (TNF superfamily, member 6)0.132
Timelesstimeless homolog (Drosophila)0.125
Stat2signal transducer and activator of transcription 20.123
Trp63transformation related protein 630.122
Lyz2lysozyme 20.120
Pgrmc1progesterone receptor membrane component 10.118
Orc1origin recognition complex, subunit 10.117
Smad3MAD homolog 3 (Drosophila)0.114
Runx2runt related transcription factor 20.113
Htthuntingtin0.111
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.110
TcrbT-cell receptor beta chain0.109
Ppap2bphosphatidic acid phosphatase type 2B0.108
Cd44CD44 antigen0.108
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism