The network for 'organ formation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

organ formation

The process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ.

NameDescriptionProbabilityFunc Analog Organism
Robo1roundabout homolog 1 (Drosophila)0.230
Unc5bunc-5 homolog B (C. elegans)0.199
F13a1coagulation factor XIII, A1 polypeptide0.194
Itpr2inositol 1,4,5-triphosphate receptor, type 20.168
Olfml2bolfactomedin-like 2B0.141
Ucn2urocortin 20.134
Kcnq3potassium voltage-gated channel, KQT-like subfamily, member 30.115
Slc5a1solute carrier family 5 (sodium/glucose cotransporter), member 10.113
Bcl2B-cell CLL/lymphoma 20.110
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.102
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.099
Axin1axin 10.087
SnrkSNF related kinase0.086
Arntaryl hydrocarbon receptor nuclear translocator0.084
Ccl22chemokine (C-C motif) ligand 220.082
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.081
Igfbp5insulin-like growth factor binding protein 50.080
Kcnj5potassium inwardly-rectifying channel, subfamily J, member 50.077
Arnt2aryl hydrocarbon receptor nuclear translocator 20.077
Bmp6bone morphogenetic protein 60.074
GperG protein-coupled estrogen receptor 10.069
Hist1h1dhistone cluster 1, H1d0.068
Mpp2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)0.067
Ugt2a1UDP glucuronosyltransferase 2 family, polypeptide A10.066
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.066
Glg1golgi apparatus protein 10.064
Flt1FMS-related tyrosine kinase 10.063
Gjb4gap junction protein, beta 40.063
Sox13SRY (sex determining region Y)-box 130.062
Syt9synaptotagmin IX0.061
Otx1orthodenticle homeobox 10.061
Tgfb2transforming growth factor, beta 20.061
Smad7SMAD family member 70.059
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.058
Fgf5fibroblast growth factor 50.058
Metmet proto-oncogene0.058
Prrx1paired related homeobox 10.057
Apba1amyloid beta (A4) precursor protein-binding, family A, member 10.056
Nr2f2nuclear receptor subfamily 2, group F, member 20.055
Accn5amiloride-sensitive cation channel 5, intestinal0.055
Irs1insulin receptor substrate 10.055
Efnb1ephrin B10.054
Nfibnuclear factor I/B0.054
Socs3suppressor of cytokine signaling 30.054
Sdc3syndecan 30.053
Rararetinoic acid receptor, alpha0.053
Creb1cAMP responsive element binding protein 10.052
Myh9myosin, heavy chain 9, non-muscle0.052
Sox17SRY (sex determining region Y)-box 170.051
Ccdc102acoiled-coil domain containing 102A0.051
Il3interleukin 30.051
RY2G5potential ligand-binding protein0.051
Xylt1xylosyltransferase 10.051
Abcb4ATP-binding cassette, subfamily B (MDR/TAP), member 40.050
Nfe2l2nuclear factor, erythroid derived 2, like 20.050
Scn8asodium channel, voltage gated, type VIII, alpha subunit0.050
Prph2peripherin 20.049
Fgfr2fibroblast growth factor receptor 20.049
Foxc2forkhead box C20.049
Gdf11growth differentiation factor 110.048
Fzd2frizzled homolog 2 (Drosophila)0.048
Tas2r119taste receptor, type 2, member 1190.048
Cd4Cd4 molecule0.048
Notch2Notch homolog 2 (Drosophila)0.048
Six3SIX homeobox 30.048
Bmp3bone morphogenetic protein 30.048
Fgf11fibroblast growth factor 110.047
Hoxb7homeo box B70.047
Cxxc4CXXC finger 40.047
Foxs1forkhead box S10.047
Hoxc4homeo box C40.046
Man1a2mannosidase, alpha, class 1A, member 20.046
Itga6integrin, alpha 60.045
Crybb3crystallin, beta B30.045
Ednraendothelin receptor type A0.045
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.045
Syt7synaptotagmin VII0.045
Grin2aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.044
Dccdeleted in colorectal carcinoma0.044
Pou2f3POU class 2 homeobox 30.044
RGD1309821similar to KIAA1161 protein0.044
Foxd4forkhead box D40.044
Tgfbr3transforming growth factor, beta receptor III0.043
Lims1LIM and senescent cell antigen-like domains 10.043
Clstn3calsyntenin 30.043
Enpepglutamyl aminopeptidase0.043
Cpxm2carboxypeptidase X (M14 family), member 20.043
Cngb1cyclic nucleotide gated channel beta 10.043
Cxcr3chemokine (C-X-C motif) receptor 30.042
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.042
Pax8paired box 80.041
Megf6multiple EGF-like-domains 60.041
Glra1glycine receptor, alpha 10.040
P2rx6purinergic receptor P2X, ligand-gated ion channel, 60.040
Foxd1forkhead box D10.040
Tpc1808tropic 18080.040
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
shhasonic hedgehog a0.950
tbx1T-box 10.882
bmp4bone morphogenetic protein 40.880
ndr2nodal-related 20.812
bmp2bbone morphogenetic protein 2b0.784
fgf8afibroblast growth factor 8 a0.717
pax2apaired box gene 2a0.703
tbx16T-box gene 160.685
dlx5adistal-less homeobox gene 5a0.673
flhfloating head0.635
slit3slit (Drosophila) homolog 30.572
pcdh8protocadherin 80.495
etv2ets variant gene 20.491
gli1GLI-Kruppel family member 10.473
foxi1forkhead box I10.460
tbx5aT-box 5a0.441
notch3notch homolog 30.368
gata4GATA-binding protein 40.336
kdrlkinase insert domain receptor like0.329
wnt5bwingless-type MMTV integration site family, member 5b0.329
fgf24fibroblast growth factor 240.325
bmp2abone morphogenetic protein 2a0.325
foxg1aforkhead box G1a0.320
dlx3bdistal-less homeobox gene 3b0.319
hnf1baHNF1 homeobox Ba0.307
six3bsine oculis homeobox homolog 3b0.300
wlswntless homolog (Drosophila)0.284
dlx1adistal-less homeobox gene 1a0.276
atoh1batonal homolog 1b0.274
wt1awilms tumor 1a0.263
lhx1aLIM homeobox 1a0.223
hmgcrb3-hydroxy-3-methylglutaryl-Coenzyme A reductase b0.200
ptch2patched 20.199
emx3empty spiracles homeobox 30.193
tal1T-cell acute lymphocytic leukemia 10.186
jag2jagged 20.173
foxp2forkhead box P20.167
wnt3wingless-type MMTV integration site family, member 30.166
evx1even-skipped homeobox 10.166
her15.1hairy and enhancer of split-related 15.10.163
wnt8bwingless-type MMTV integration site family, member 8b0.162
nkx2.7NK2 transcription factor related 70.158
hey1hairy/enhancer-of-split related with YRPW motif 10.155
sox9aSRY-box containing gene 9a0.153
nkx2.5NK2 transcription factor related 50.144
cdh2cadherin 2, neuronal0.139
hey2hairy/enhancer-of-split related with YRPW motif 20.138
tbx24T-box 240.138
her1hairy-related 10.137
wnt11wingless-type MMTV integration site family, member 110.135
gata5GATA-binding protein 50.134
lfnglunatic fringe homolog0.133
igfbp3insulin-like growth factor binding protein 30.131
dlx2adistal-less homeobox gene 2a0.127
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.127
fgfrl1bfibroblast growth factor receptor-like 1b0.126
six3asine oculis homeobox homolog 3a0.125
crabp2acellular retinoic acid binding protein 2, a0.123
her5hairy-related 50.123
robo1roundabout homolog 10.123
her7hairy and enhancer of split related-70.122
fn1fibronectin 10.121
alcambactivated leukocyte cell adhesion molecule b0.119
tbx20T-box 200.115
etv5bets variant 5b0.114
ventventral expressed homeobox0.108
fstafollistatin a0.108
otpborthopedia homolog b0.107
runx2brunt-related transcription factor 2b0.105
tll1tolloid-like 10.102
rx3retinal homeobox gene 30.102
jag1bjagged 1b0.100
rfx2regulatory factor X, 2 (influences HLA class II expression)0.098
col15a1bcollagen, type XV, alpha 1b0.097
fgf3fibroblast growth factor 30.097
col2a1acollagen type II, alpha-1a0.095
tbx2bT-box 2b0.094
osr2odd-skipped related 2 (Drosophila)0.091
wnt4awingless-type MMTV integration site family, member 4a0.091
ascl1aachaete-scute complex-like 1a (Drosophila)0.090
six4bsine oculis homeobox homolog 4b0.090
atoh1aatonal homolog 1a0.088
hoxa9ahomeo box A9a0.087
mibmind bomb0.085
mespamesoderm posterior a0.084
dmrt2adoublesex and mab-3 related transcription factor 2a0.081
fgf4fibroblast growth factor 40.080
arxaristaless related homeobox0.079
sox17SRY-box containing gene 170.078
pax6bpaired box gene 6b0.077
her12hairy-related 120.076
hoxc6ahomeo box C6a0.074
gata6GATA-binding protein 60.074
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
cicubitus interruptus0.998
E(spl)Enhancer of split0.996
HLHmdeltaE(spl) region transcript mdelta0.993
TomTwin of m40.979
HLHm5E(spl) region transcript m50.974
HLHm7E(spl) region transcript m70.963
HLHmbetaE(spl) region transcript mbeta0.908
malphaE(spl) region transcript malpha0.888
HLHmgammaE(spl) region transcript mgamma0.887
eyaeyes absent0.758
snssticks and stones0.743
abd-Aabdominal A0.729
LanB1CG7123 gene product from transcript CG7123-RA0.693
aopanterior open0.614
bab2CG9102 gene product from transcript CG9102-RA0.611
HLH54FCG5005 gene product from transcript CG5005-RA0.585
stumpsCG31317 gene product from transcript CG31317-RC0.548
m4E(spl) region transcript m40.512
LanB2Laminin B20.436
emcextra macrochaetae0.404
wbwing blister0.401
CG14869CG14869 gene product from transcript CG14869-RB0.378
LanALaminin A0.358
m2E(spl) region transcript m20.323
MadMothers against dpp0.286
numbCG3779 gene product from transcript CG3779-RB0.285
Lim1CG11354 gene product from transcript CG11354-RA0.278
nkdnaked cuticle0.239
amosabsent MD neurons and olfactory sensilla0.230
Traf4TNF-receptor-associated factor 40.224
bowlbrother of odd with entrails limited0.217
NotumCG13076 gene product from transcript CG13076-RB0.215
argosCG4531 gene product from transcript CG4531-RA0.210
fz2frizzled 20.205
Mef2Myocyte enhancer factor 20.201
HLHm3E(spl) region transcript m30.195
TolloCG6890 gene product from transcript CG6890-RA0.160
gcmglial cells missing0.152
Abd-BAbdominal B0.147
DadDaughters against dpp0.146
EgfrEpidermal growth factor receptor0.143
C15CG7937 gene product from transcript CG7937-RA0.141
Su(H)Suppressor of Hairless0.133
Akt1CG4006 gene product from transcript CG4006-RA0.127
hipkhomeodomain interacting protein kinase0.122
jebjelly belly0.118
zfh2Zn finger homeodomain 20.109
BobABrother of Bearded A0.109
PoxnPox neuro0.107
bab1bric a brac 10.091
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
FGFR2fibroblast growth factor receptor 21.000
NOTCH1notch 11.000
JAG1jagged 11.000
FGFR1fibroblast growth factor receptor 11.000
FGF1fibroblast growth factor 1 (acidic)0.999
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.999
CSNK1Ecasein kinase 1, epsilon0.998
DVL3dishevelled, dsh homolog 3 (Drosophila)0.997
FHL2four and a half LIM domains 20.992
SOX10SRY (sex determining region Y)-box 100.992
FOXD3forkhead box D30.985
FGF10fibroblast growth factor 100.984
DVL1dishevelled, dsh homolog 1 (Drosophila)0.979
SUFUsuppressor of fused homolog (Drosophila)0.965
SP1Sp1 transcription factor0.960
NKX2-1NK2 homeobox 10.957
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.952
TBX5T-box 50.904
FGF8fibroblast growth factor 8 (androgen-induced)0.900
GATA4GATA binding protein 40.896
HOXD13homeobox D130.877
EP300E1A binding protein p3000.874
MEOX2mesenchyme homeobox 20.853
POU3F2POU class 3 homeobox 20.844
AMMECR1Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 10.844
WT1Wilms tumor 10.841
NCOA2nuclear receptor coactivator 20.834
HDAC4histone deacetylase 40.819
FGF2fibroblast growth factor 2 (basic)0.806
JAG2jagged 20.784
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.780
TP73tumor protein p730.778
MAML1mastermind-like 1 (Drosophila)0.776
TGFB3transforming growth factor, beta 30.774
ITGB4integrin, beta 40.774
NTRK2neurotrophic tyrosine kinase, receptor, type 20.745
PAX2paired box 20.740
PLCG1phospholipase C, gamma 10.732
LHX3LIM homeobox 30.720
NOTCH3notch 30.715
SIX6SIX homeobox 60.714
SOX2SRY (sex determining region Y)-box 20.700
SMAD1SMAD family member 10.696
FGFR3fibroblast growth factor receptor 30.695
ZNF512Bzinc finger protein 512B0.691
FGF3fibroblast growth factor 30.685
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.677
LBX1ladybird homeobox 10.669
CABLES1Cdk5 and Abl enzyme substrate 10.668
MYOD1myogenic differentiation 10.629
LMX1ALIM homeobox transcription factor 1, alpha0.620
RAXretina and anterior neural fold homeobox0.608
OTPorthopedia homeobox0.607
TFAP2Atranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha)0.602
FOXE1forkhead box E1 (thyroid transcription factor 2)0.578
NR4A1nuclear receptor subfamily 4, group A, member 10.577
HOXD9homeobox D90.562
DLL1delta-like 1 (Drosophila)0.555
STK36serine/threonine kinase 360.555
LHX1LIM homeobox 10.553
LRP6low density lipoprotein receptor-related protein 60.544
FSTL1follistatin-like 10.540
CDK11Bcyclin-dependent kinase 11B0.520
TGFB1transforming growth factor, beta 10.516
FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1)0.505
LHX5LIM homeobox 50.503
BMP7bone morphogenetic protein 70.501
NEDD4neural precursor cell expressed, developmentally down-regulated 40.493
FOXA2forkhead box A20.487
HOXA10homeobox A100.485
CTBP1C-terminal binding protein 10.482
VAX2ventral anterior homeobox 20.479
FGF7fibroblast growth factor 70.473
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.464
FGF4fibroblast growth factor 40.462
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.456
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.451
PHOX2Apaired-like homeobox 2a0.444
HOXB5homeobox B50.440
SIX2SIX homeobox 20.440
NEUROG3neurogenin 30.440
NCOR2nuclear receptor corepressor 20.438
RAB11FIP1RAB11 family interacting protein 1 (class I)0.435
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.433
CTNNBIP1catenin, beta interacting protein 10.424
ALX3ALX homeobox 30.421
ATXN1Lataxin 1-like0.419
TGIF1TGFB-induced factor homeobox 10.416
CPEcarboxypeptidase E0.408
TLX2T-cell leukemia homeobox 20.406
ZIC1Zic family member 1 (odd-paired homolog, Drosophila)0.405
SIM2single-minded homolog 2 (Drosophila)0.405
SOX1SRY (sex determining region Y)-box 10.403
ALX4ALX homeobox 40.398
HIC1hypermethylated in cancer 10.393
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.386
FOXB1forkhead box B10.386
SOX11SRY (sex determining region Y)-box 110.382
NOVA2neuro-oncological ventral antigen 20.379
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism