The network for 'cardiac muscle cell apoptotic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cardiac muscle cell apoptotic process

A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.

NameDescriptionProbabilityFunc Analog Organism
Cct5chaperonin containing Tcp1, subunit 5 (epsilon)0.017
Rps3ribosomal protein S30.013
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
TBX5T-box 50.680
INSRinsulin receptor0.319
MDM2Mdm2 p53 binding protein homolog (mouse)0.271
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.216
IRS1insulin receptor substrate 10.173
EGFRepidermal growth factor receptor0.119
EPORerythropoietin receptor0.111
SRFserum response factor (c-fos serum response element-binding transcription factor)0.095
GRB10growth factor receptor-bound protein 100.079
SIRT3sirtuin 30.078
PTPRZ1protein tyrosine phosphatase, receptor-type, Z polypeptide 10.061
PTPN1protein tyrosine phosphatase, non-receptor type 10.056
IGF1Rinsulin-like growth factor 1 receptor0.054
BLOC1S2biogenesis of lysosomal organelles complex-1, subunit 20.051
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.048
IRS2insulin receptor substrate 20.045
PAX8paired box 80.043
NTRK1neurotrophic tyrosine kinase, receptor, type 10.039
GRIA4glutamate receptor, ionotrophic, AMPA 40.035
GHRgrowth hormone receptor0.035
SH2B1SH2B adaptor protein 10.035
CAMK2Bcalcium/calmodulin-dependent protein kinase II beta0.035
PARVAparvin, alpha0.033
CARD11caspase recruitment domain family, member 110.032
DLG4discs, large homolog 4 (Drosophila)0.030
ARHGEF12Rho guanine nucleotide exchange factor (GEF) 120.028
PARVBparvin, beta0.027
GATA4GATA binding protein 40.026
STAT5Bsignal transducer and activator of transcription 5B0.025
NTRK3neurotrophic tyrosine kinase, receptor, type 30.022
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.021
LATlinker for activation of T cells0.021
MTORmechanistic target of rapamycin (serine/threonine kinase)0.020
C1orf93chromosome 1 open reading frame 930.020
CSF2RBcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.018
ZNF746zinc finger protein 7460.017
GRB14growth factor receptor-bound protein 140.017
HTThuntingtin0.017
BCAR1breast cancer anti-estrogen resistance 10.017
GAB2GRB2-associated binding protein 20.017
CDK5R1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.016
AKT1v-akt murine thymoma viral oncogene homolog 10.016
CSKc-src tyrosine kinase0.015
GOLT1Bgolgi transport 1B0.015
STAT5Asignal transducer and activator of transcription 5A0.015
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.015
LIMS1LIM and senescent cell antigen-like domains 10.013
SMURF1SMAD specific E3 ubiquitin protein ligase 10.013
BCRbreakpoint cluster region0.013
PLEKHB2pleckstrin homology domain containing, family B (evectins) member 20.013
RSU1Ras suppressor protein 10.013
METmet proto-oncogene (hepatocyte growth factor receptor)0.013
ATP6V1DATPase, H+ transporting, lysosomal 34kDa, V1 subunit D0.013
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.012
SMARCB1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 10.012
DUSP23dual specificity phosphatase 230.012
TMEM33transmembrane protein 330.012
GORABgolgin, RAB6-interacting0.012
ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 10.012
CYFIP1cytoplasmic FMR1 interacting protein 10.012
SOCS1suppressor of cytokine signaling 10.012
C15orf29chromosome 15 open reading frame 290.011
HIPK2homeodomain interacting protein kinase 20.011
UBE2L3ubiquitin-conjugating enzyme E2L 30.011
ATP6V1B2ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B20.011
NEUROG3neurogenin 30.011
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.011
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.011
TRPV6transient receptor potential cation channel, subfamily V, member 60.011
GYG1glycogenin 10.011
ZNF133zinc finger protein 1330.011
SLC4A1solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)0.011
BAG3BCL2-associated athanogene 30.010
PRKCAprotein kinase C, alpha0.010
ARPC5actin related protein 2/3 complex, subunit 5, 16kDa0.010
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.010
DPH3DPH3, KTI11 homolog (S. cerevisiae)0.010
PEA15phosphoprotein enriched in astrocytes 150.010
JAK3Janus kinase 30.010
CALCAcalcitonin-related polypeptide alpha0.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Hand2heart and neural crest derivatives expressed transcript 20.992
Otx2orthodenticle homolog 2 (Drosophila)0.715
Neurod1neurogenic differentiation 10.708
Emx1empty spiracles homolog 1 (Drosophila)0.606
Ascl1achaete-scute complex homolog 1 (Drosophila)0.597
Hand1heart and neural crest derivatives expressed transcript 10.538
Gata4GATA binding protein 40.407
Isl1ISL1 transcription factor, LIM/homeodomain0.395
MecomMDS1 and EVI1 complex locus0.296
Trp53transformation related protein 530.240
Fliiflightless I homolog (Drosophila)0.240
Neurog2neurogenin 20.222
Pdx1pancreatic and duodenal homeobox 10.206
Insm1insulinoma-associated 10.205
Kiss1KiSS-1 metastasis-suppressor0.173
Ptf1apancreas specific transcription factor, 1a0.160
Lhcgrluteinizing hormone/choriogonadotropin receptor0.151
Gata1GATA binding protein 10.146
Sfrp1secreted frizzled-related protein 10.144
Rararetinoic acid receptor, alpha0.125
Sfrp2secreted frizzled-related protein 20.102
Nkx6-1NK6 homeobox 10.100
Pax6paired box gene 60.096
Foxc2forkhead box C20.082
Neurod4neurogenic differentiation 40.080
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.078
Lhx3LIM homeobox protein 30.074
Ntf3neurotrophin 30.073
Sox2SRY-box containing gene 20.070
Grin2bglutamate receptor, ionotropic, NMDA2B (epsilon 2)0.070
Cbfa2t3core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)0.069
Ptenphosphatase and tensin homolog0.061
Itgb1integrin beta 1 (fibronectin receptor beta)0.059
Hes5hairy and enhancer of split 5 (Drosophila)0.059
Hoxd13homeobox D130.057
Tcf15transcription factor 150.054
Arxaristaless related homeobox0.053
Ptpn11protein tyrosine phosphatase, non-receptor type 110.052
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.052
Neurog1neurogenin 10.052
Six6sine oculis-related homeobox 6 homolog (Drosophila)0.048
Madcam1mucosal vascular addressin cell adhesion molecule 10.048
Cdx2caudal type homeobox 20.047
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.047
Mdm4transformed mouse 3T3 cell double minute 40.045
Hes2hairy and enhancer of split 2 (Drosophila)0.045
Shhsonic hedgehog0.045
Mdm2transformed mouse 3T3 cell double minute 20.043
Nkx3-2NK3 homeobox 20.042
Cdkn1bcyclin-dependent kinase inhibitor 1B0.041
Gdnfglial cell line derived neurotrophic factor0.040
Lhx5LIM homeobox protein 50.039
Eporerythropoietin receptor0.039
Rtn4rreticulon 4 receptor0.038
Bdnfbrain derived neurotrophic factor0.038
Hspa8heat shock protein 80.036
Fgf15fibroblast growth factor 150.036
Dnm1dynamin 10.036
Grm1glutamate receptor, metabotropic 10.035
Mtap2microtubule-associated protein 20.035
Phox2bpaired-like homeobox 2b0.034
Sfrp5secreted frizzled-related sequence protein 50.032
Neurog3neurogenin 30.032
Nkx2-9NK2 transcription factor related, locus 9 (Drosophila)0.031
Ascl2achaete-scute complex homolog 2 (Drosophila)0.030
Runx1t1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.030
Otporthopedia homolog (Drosophila)0.030
Rprmreprimo, TP53 dependent G2 arrest mediator candidate0.029
Btbd17BTB (POZ) domain containing 170.029
Ntrk3neurotrophic tyrosine kinase, receptor, type 30.029
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.029
Actn2actinin alpha 20.028
Sox9SRY-box containing gene 90.027
Dlx2distal-less homeobox 20.027
Alx3aristaless-like homeobox 30.027
Glis3GLIS family zinc finger 30.026
Pax9paired box gene 90.026
Rb1retinoblastoma 10.026
Fgf17fibroblast growth factor 170.026
Hba-xhemoglobin X, alpha-like embryonic chain in Hba complex0.024
Tcf3transcription factor 30.023
Mesp1mesoderm posterior 10.023
Atoh7atonal homolog 7 (Drosophila)0.023
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.022
Foxd4forkhead box D40.022
Hey2hairy/enhancer-of-split related with YRPW motif 20.022
Plecplectin0.021
Utf1undifferentiated embryonic cell transcription factor 10.020
Myh10myosin, heavy polypeptide 10, non-muscle0.020
BC057022cDNA sequence BC0570220.019
Sipa1signal-induced proliferation associated gene 10.019
Prphperipherin0.019
Tbrachyury0.018
Mapk8mitogen-activated protein kinase 80.018
Pou4f3POU domain, class 4, transcription factor 30.018
MdfiMyoD family inhibitor0.018
Foxe1forkhead box E10.018
Tln1talin 10.018
Dctn1dynactin 10.018
Rhbdl3rhomboid, veinlet-like 3 (Drosophila)0.018
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism