The network for 'muscle cell apoptotic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

muscle cell apoptotic process

A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle.

NameDescriptionProbabilityFunc Analog Organism
Stip1stress-induced phosphoprotein 10.307
LOC100362824caveolin 2-like0.184
Hspa8heat shock protein 80.174
Hmgcs13-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)0.173
Cav1caveolin 1, caveolae protein0.117
Hsph1heat shock 105/110 protein 10.109
Akt1v-akt murine thymoma viral oncogene homolog 10.109
Fgfr2fibroblast growth factor receptor 20.089
Cav2caveolin 20.067
Fgf16fibroblast growth factor 160.065
Cd4Cd4 molecule0.065
Jak2Janus kinase 20.061
Edn1endothelin 10.059
Cmtm2aCKLF-like MARVEL transmembrane domain containing 2A0.050
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.044
Gata6GATA binding protein 60.041
Sdc3syndecan 30.035
Nek9NIMA (never in mitosis gene a)- related kinase 90.035
Strnstriatin, calmodulin binding protein0.033
Slc22a9solute carrier family 22 (organic anion transporter), member 90.032
Foxe3forkhead box E30.031
Soat1sterol O-acyltransferase 10.030
Cd38CD38 molecule0.029
Smad1SMAD family member 10.029
Adrb1adrenergic, beta-1-, receptor0.029
Socs5suppressor of cytokine signaling 50.028
Celcarboxyl ester lipase0.027
Ubtfupstream binding transcription factor, RNA polymerase I0.027
Jak1Janus kinase 10.026
Hk1hexokinase 10.026
Vom2r27vomeronasal 2 receptor, 270.025
LOC100361389hypothetical protein LOC1003613890.025
Csnk1g2casein kinase 1, gamma 20.024
Eef2eukaryotic translation elongation factor 20.024
Npr3natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)0.024
Fdpsfarnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)0.024
Rararetinoic acid receptor, alpha0.024
St13suppression of tumorigenicity 130.023
Emp1epithelial membrane protein 10.023
Glg1golgi apparatus protein 10.023
Bmycbrain expressed myelocytomatosis oncogene0.023
Pde5aphosphodiesterase 5A, cGMP-specific0.021
Tgfbr1transforming growth factor, beta receptor 10.021
Wdr26WD repeat domain 260.021
RGD1309537similar to Myosin regulatory light chain 2-A, smooth muscle isoform (Myosin RLC-A)0.020
Nedd4neural precursor cell expressed, developmentally down-regulated 40.019
Tgfbr3transforming growth factor, beta receptor III0.019
Chrm1cholinergic receptor, muscarinic 10.019
Kcnq1potassium voltage-gated channel, KQT-like subfamily, member 10.019
Dnajb1DnaJ (Hsp40) homolog, subfamily B, member 10.019
Usf1upstream transcription factor 10.018
Bmp6bone morphogenetic protein 60.018
Cdk4cyclin-dependent kinase 40.018
Gnb3guanine nucleotide binding protein (G protein), beta polypeptide 30.018
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.018
Pitx3paired-like homeodomain 30.018
Nmuneuromedin U0.018
Crybb3crystallin, beta B30.017
Gpr182G protein-coupled receptor 1820.017
Kcnj16potassium inwardly-rectifying channel, subfamily J, member 160.017
Hist1h2afhistone cluster 1, H2af0.017
Actg1actin, gamma 10.017
Nos3nitric oxide synthase 3, endothelial cell0.017
Pcdhgc3protocadherin gamma subfamily C, 30.017
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.017
Pdia2protein disulfide isomerase family A, member 20.016
Irs1insulin receptor substrate 10.016
Ascl1achaete-scute complex homolog 1 (Drosophila)0.016
Rnf138ring finger protein 1380.016
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.016
Timp2TIMP metallopeptidase inhibitor 20.016
Tmem8ctransmembrane protein 8C0.016
Sfpqsplicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)0.015
Eif4beukaryotic translation initiation factor 4B0.015
Ncf1neutrophil cytosolic factor 10.015
Itpr2inositol 1,4,5-triphosphate receptor, type 20.015
Mpripmyosin phosphatase Rho interacting protein0.015
Calycalcyon neuron-specific vesicular protein0.015
Mat1amethionine adenosyltransferase I, alpha0.015
Plekho1pleckstrin homology domain containing, family O member 10.015
Hand2heart and neural crest derivatives expressed 20.015
Gja6gap junction protein, alpha 60.015
Igfbp3insulin-like growth factor binding protein 30.015
Sellselectin L0.015
MrgprfMAS-related GPR, member F0.015
Arhgap23Rho GTPase activating protein 230.015
Gltscr2glioma tumor suppressor candidate region gene 20.014
Nmur2neuromedin U receptor 20.014
Gna15guanine nucleotide binding protein, alpha 150.014
Sqlesqualene epoxidase0.014
Pfn1profilin 10.014
Notch2Notch homolog 2 (Drosophila)0.014
Tmem171transmembrane protein 1710.014
Mdm2Mdm2 p53 binding protein homolog (mouse)0.014
Ets1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.014
Fgf11fibroblast growth factor 110.014
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
EGFRepidermal growth factor receptor0.369
TBX5T-box 50.326
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.230
DLG4discs, large homolog 4 (Drosophila)0.216
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.205
ARRB1arrestin, beta 10.203
SHC1SHC (Src homology 2 domain containing) transforming protein 10.107
IRS1insulin receptor substrate 10.105
PTPN1protein tyrosine phosphatase, non-receptor type 10.103
HSPB8heat shock 22kDa protein 80.063
GRB2growth factor receptor-bound protein 20.048
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.044
IL23Ainterleukin 23, alpha subunit p190.035
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.033
CTDP1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 10.030
LRRK2leucine-rich repeat kinase 20.030
TNRC6Atrinucleotide repeat containing 6A0.025
EPORerythropoietin receptor0.025
ITGB1BP3integrin beta 1 binding protein 30.024
PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activator0.023
GSK3Bglycogen synthase kinase 3 beta0.023
HSPB1heat shock 27kDa protein 10.022
IGF1Rinsulin-like growth factor 1 receptor0.022
AKT1v-akt murine thymoma viral oncogene homolog 10.020
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.020
SOCS3suppressor of cytokine signaling 30.020
KAT2BK(lysine) acetyltransferase 2B0.019
BCAR1breast cancer anti-estrogen resistance 10.018
APPamyloid beta (A4) precursor protein0.018
CSKc-src tyrosine kinase0.018
JAK2Janus kinase 20.018
CAV1caveolin 1, caveolae protein, 22kDa0.016
CRYABcrystallin, alpha B0.016
SRFserum response factor (c-fos serum response element-binding transcription factor)0.015
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.015
FUNDC2FUN14 domain containing 20.014
PAX8paired box 80.013
IGF2Rinsulin-like growth factor 2 receptor0.013
ANKS1Bankyrin repeat and sterile alpha motif domain containing 1B0.012
MAPTmicrotubule-associated protein tau0.012
FYNFYN oncogene related to SRC, FGR, YES0.012
NTRK1neurotrophic tyrosine kinase, receptor, type 10.011
INSRinsulin receptor0.011
DKK1dickkopf homolog 1 (Xenopus laevis)0.011
SMAD7SMAD family member 70.011
PTPRZ1protein tyrosine phosphatase, receptor-type, Z polypeptide 10.010
GRB10growth factor receptor-bound protein 100.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Hand2heart and neural crest derivatives expressed transcript 20.827
Ptenphosphatase and tensin homolog0.796
Neurod1neurogenic differentiation 10.782
Ascl1achaete-scute complex homolog 1 (Drosophila)0.763
Ptpn11protein tyrosine phosphatase, non-receptor type 110.642
Isl1ISL1 transcription factor, LIM/homeodomain0.641
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.634
Emx1empty spiracles homolog 1 (Drosophila)0.581
Mdm2transformed mouse 3T3 cell double minute 20.558
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.554
Ptf1apancreas specific transcription factor, 1a0.473
Shhsonic hedgehog0.405
Ddx60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.386
Hey2hairy/enhancer-of-split related with YRPW motif 20.314
Hand1heart and neural crest derivatives expressed transcript 10.297
Trp53transformation related protein 530.274
Grin2bglutamate receptor, ionotropic, NMDA2B (epsilon 2)0.272
Nos3nitric oxide synthase 3, endothelial cell0.269
Hspa8heat shock protein 80.267
Pdx1pancreatic and duodenal homeobox 10.253
Sfrp2secreted frizzled-related protein 20.230
Tbx3T-box 30.184
Tgfb1transforming growth factor, beta 10.169
Bdkrb2bradykinin receptor, beta 20.154
Loxlysyl oxidase0.139
Sfrp1secreted frizzled-related protein 10.126
Tgfbr2transforming growth factor, beta receptor II0.124
Fliiflightless I homolog (Drosophila)0.119
Lhcgrluteinizing hormone/choriogonadotropin receptor0.118
Gata4GATA binding protein 40.112
Agtr1aangiotensin II receptor, type 1a0.111
Tcf15transcription factor 150.109
Pthlhparathyroid hormone-like peptide0.108
MecomMDS1 and EVI1 complex locus0.106
Ep300E1A binding protein p3000.103
Fgf8fibroblast growth factor 80.102
Actn2actinin alpha 20.098
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.094
Ren1renin 1 structural0.092
Mdm4transformed mouse 3T3 cell double minute 40.088
Neurod4neurogenic differentiation 40.086
Hes5hairy and enhancer of split 5 (Drosophila)0.081
Grb10growth factor receptor bound protein 100.080
Cdx2caudal type homeobox 20.078
Nhlh1nescient helix loop helix 10.077
Tbx5T-box 50.075
Pcdh12protocadherin 120.072
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.070
Ntf3neurotrophin 30.070
Nkx6-1NK6 homeobox 10.069
Meox1mesenchyme homeobox 10.068
Alx3aristaless-like homeobox 30.065
Fgf17fibroblast growth factor 170.065
Apcadenomatosis polyposis coli0.063
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.062
Foxc2forkhead box C20.060
Rb1retinoblastoma 10.060
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.060
Cdkn1bcyclin-dependent kinase inhibitor 1B0.059
Oasl22'-5' oligoadenylate synthetase-like 20.059
Gata1GATA binding protein 10.058
Mesp1mesoderm posterior 10.056
Itgb1integrin beta 1 (fibronectin receptor beta)0.055
Hoxd13homeobox D130.055
Hey1hairy/enhancer-of-split related with YRPW motif 10.054
Six6sine oculis-related homeobox 6 homolog (Drosophila)0.054
Mtap2microtubule-associated protein 20.054
Fgf15fibroblast growth factor 150.050
Pitx3paired-like homeodomain transcription factor 30.049
Foxa2forkhead box A20.048
Fbn1fibrillin 10.045
Lhx5LIM homeobox protein 50.044
Myh10myosin, heavy polypeptide 10, non-muscle0.043
En1engrailed 10.043
Gp9glycoprotein 9 (platelet)0.043
Pax6paired box gene 60.042
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.042
Prph2peripherin 20.041
Glis3GLIS family zinc finger 30.039
Cdh23cadherin 23 (otocadherin)0.039
Otporthopedia homolog (Drosophila)0.039
Nkx3-2NK3 homeobox 20.038
Socs1suppressor of cytokine signaling 10.038
Hba-xhemoglobin X, alpha-like embryonic chain in Hba complex0.038
Sfrp5secreted frizzled-related sequence protein 50.037
Onecut1one cut domain, family member 10.036
Col1a1collagen, type I, alpha 10.036
Irf7interferon regulatory factor 70.035
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.035
Igf2rinsulin-like growth factor 2 receptor0.035
Gsk3bglycogen synthase kinase 3 beta0.035
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.035
Wnt6wingless-related MMTV integration site 60.034
Foxe1forkhead box E10.033
Hspa1bheat shock protein 1B0.033
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.032
Vegfavascular endothelial growth factor A0.032
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism