The network for 'positive regulation of adenylate cyclase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of adenylate cyclase activity

Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity.

NameDescriptionProbabilityFunc Analog Organism
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.229
S100a10S100 calcium binding protein A100.198
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.179
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.162
Fgf14fibroblast growth factor 140.147
Chrna7cholinergic receptor, nicotinic, alpha 70.098
Adora1adenosine A1 receptor0.093
Calm1calmodulin 10.083
Cyp21a1cytochrome P450, family 21, subfamily a, polypeptide 10.080
Gpr6G protein-coupled receptor 60.079
Csf1colony stimulating factor 1 (macrophage)0.072
Gabrg1gamma-aminobutyric acid (GABA) A receptor, gamma 10.067
Slc18a3solute carrier family 18 (vesicular acetylcholine), member 30.064
Adora2aadenosine A2a receptor0.061
Kalrnkalirin, RhoGEF kinase0.059
Kcnh7potassium voltage-gated channel, subfamily H (eag-related), member 70.059
Lgals3lectin, galactoside-binding, soluble, 30.056
Atp2b1ATPase, Ca++ transporting, plasma membrane 10.055
Ifitm3interferon induced transmembrane protein 30.051
Drd2dopamine receptor D20.051
Odf4outer dense fiber of sperm tails 40.047
Avparginine vasopressin0.044
Camk4calcium/calmodulin-dependent protein kinase IV0.043
Hpcal4hippocalcin-like 40.042
Prl2a1Prolactin family 2, subfamily a, member 10.042
Mcpt1mast cell protease 10.040
Gng7guanine nucleotide binding protein (G protein), gamma 70.040
Pde1bphosphodiesterase 1B, calmodulin-dependent0.040
Syt7synaptotagmin VII0.039
Gpr176G protein-coupled receptor 1760.039
Gad2glutamate decarboxylase 20.038
Hrh2histamine receptor H 20.038
KitlgKIT ligand0.037
Taf6TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor0.037
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.035
Folh1folate hydrolase 10.034
Anxa5annexin A50.034
Gabra3gamma-aminobutyric acid (GABA) A receptor, alpha 30.033
Calm2calmodulin 20.033
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.033
Insrinsulin receptor0.033
Ptp4a2protein tyrosine phosphatase 4a20.032
Rgs9regulator of G-protein signaling 90.031
Sfrp4secreted frizzled-related protein 40.031
Cx3cr1chemokine (C-X3-C motif) receptor 10.031
Pfkfb26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 20.031
Prrx1paired related homeobox 10.030
Kcnq3potassium voltage-gated channel, KQT-like subfamily, member 30.029
Gabra4gamma-aminobutyric acid (GABA) A receptor, alpha 40.029
Grm1glutamate receptor, metabotropic 10.028
Slc1a2solute carrier family 1 (glial high affinity glutamate transporter), member 20.028
N5DNA binding protein N50.028
Pgam1phosphoglycerate mutase 1 (brain)0.028
Cckarcholecystokinin A receptor0.027
Cav1caveolin 1, caveolae protein0.027
Anxa2annexin A20.026
Kcnc2potassium voltage gated channel, Shaw-related subfamily, member 20.026
RGD1564327similar to integrin alpha 80.025
Mchr1melanin-concentrating hormone receptor 10.025
Lims1LIM and senescent cell antigen-like domains 10.025
Olr416olfactory receptor 4160.025
Dlx5distal-less homeobox 50.024
Actr2ARP2 actin-related protein 2 homolog (yeast)0.024
Igf2insulin-like growth factor 20.024
Ptger3prostaglandin E receptor 3 (subtype EP3)0.024
Itpr2inositol 1,4,5-triphosphate receptor, type 20.024
Adam10ADAM metallopeptidase domain 100.023
Cntn3contactin 3 (plasmacytoma associated)0.023
S100a4S100 calcium-binding protein A40.023
Uhmk1U2AF homology motif (UHM) kinase 10.023
Sepw1selenoprotein W, 10.023
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.023
Sub1SUB1 homolog (S. cerevisiae)0.023
Soat1sterol O-acyltransferase 10.022
Grik3glutamate receptor, ionotropic, kainate 30.022
Unc5aunc-5 homolog A (C. elegans)0.022
Znf483zinc finger protein 4830.022
Crhbpcorticotropin releasing hormone binding protein0.022
Neu2sialidase 2 (cytosolic sialidase)0.022
Tpsb2tryptase beta 20.022
Aqp2aquaporin 2 (collecting duct)0.022
Myo1bmyosin Ib0.022
Fgf7fibroblast growth factor 70.022
Dynll1dynein light chain LC8-type 10.021
Adam3aADAM metallopeptidase domain 3A (cyritestin 1)0.021
Dock8dedicator of cytokinesis 80.021
Map3k3mitogen activated protein kinase kinase kinase 30.021
Gabrr1gamma-aminobutyric acid (GABA) receptor, rho 10.021
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.020
Agtr1aangiotensin II receptor, type 1a0.020
Pcsk1proprotein convertase subtilisin/kexin type 10.020
Emp1epithelial membrane protein 10.020
Syt8synaptotagmin VIII0.020
Slc14a2solute carrier family 14 (urea transporter), member 20.020
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CG13253CG13253 gene product from transcript CG13253-RB0.626
TbhTyramine beta hydroxylase0.544
oa2octopamine receptor 20.297
Atf-2Activating transcription factor-20.095
PIP5K59BCG3682 gene product from transcript CG3682-RE0.067
jebjelly belly0.065
CG34400CG34400 gene product from transcript CG34400-RD0.061
Octbeta2RCG33976 gene product from transcript CG33976-RA0.055
CG42629CG42629 gene product from transcript CG42629-RB0.032
dnr1defense repressor 10.030
CG18437CG18437 gene product from transcript CG18437-RB0.029
tauCG31057 gene product from transcript CG31057-RA0.028
CG34353CG34353 gene product from transcript CG34353-RA0.028
Fer248 related 20.027
dcodiscs overgrown0.026
pHClCG33989 gene product from transcript CG33989-RD0.024
Nmdar1NMDA receptor 10.022
CCKLR-17D1CCK-like receptor at 17D10.021
fd85Eforkhead domain 85E0.019
eagether a go-go0.018
CG11317CG11317 gene product from transcript CG11317-RA0.017
RanBPMRan-binding protein M0.017
CG3857CG3857 gene product from transcript CG3857-RA0.016
5-HT1ASerotonin receptor 1A0.016
Ast-CAllatostatin C0.016
Sox100BCG15552 gene product from transcript CG15552-RA0.016
CrebB-17ACyclic-AMP response element binding protein B at 17A0.016
Tdc2Tyrosine decarboxylase 20.015
Task6CG9637 gene product from transcript CG9637-RC0.014
CG4857CG4857 gene product from transcript CG4857-RD0.013
CG32635CG32635 gene product from transcript CG32635-RA0.012
RicRas which interacts with Calmodulin0.012
nordCG30418 gene product from transcript CG30418-RA0.012
DhDiuretic hormone0.011
CG9997CG9997 gene product from transcript CG9997-RA0.011
CG34354CG34354 gene product from transcript CG34354-RA0.011
CG7191CG7191 gene product from transcript CG7191-RA0.010
CG15088CG15088 gene product from transcript CG15088-RC0.010
2mitCG42573 gene product from transcript CG42573-RA0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CALM1calmodulin 1 (phosphorylase kinase, delta)1.000
DRD2dopamine receptor D20.996
RASSF5Ras association (RalGDS/AF-6) domain family member 50.988
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.960
RALAv-ral simian leukemia viral oncogene homolog A (ras related)0.958
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.867
RALBv-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)0.823
RALBP1ralA binding protein 10.795
MPDZmultiple PDZ domain protein0.685
CACNA1Ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.629
CRHcorticotropin releasing hormone0.623
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.437
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.344
ADORA2Aadenosine A2a receptor0.290
AKAP10A kinase (PRKA) anchor protein 100.285
CP110CP110 protein0.264
MEOX2mesenchyme homeobox 20.200
ATP2B2ATPase, Ca++ transporting, plasma membrane 20.198
RALGDSral guanine nucleotide dissociation stimulator0.192
MAP2K1mitogen-activated protein kinase kinase 10.177
CALCAcalcitonin-related polypeptide alpha0.176
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.168
NECAB2N-terminal EF-hand calcium binding protein 20.152
ARRDC3arrestin domain containing 30.143
AKT1v-akt murine thymoma viral oncogene homolog 10.138
RIN1Ras and Rab interactor 10.110
NAMPTnicotinamide phosphoribosyltransferase0.110
RASSF1Ras association (RalGDS/AF-6) domain family member 10.101
ADORA1adenosine A1 receptor0.098
KCNH1potassium voltage-gated channel, subfamily H (eag-related), member 10.095
SSTR3somatostatin receptor 30.091
SMAD2SMAD family member 20.087
PLEKHA1pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 10.076
BAG1BCL2-associated athanogene0.076
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.074
PRKACBprotein kinase, cAMP-dependent, catalytic, beta0.062
TSHRthyroid stimulating hormone receptor0.061
ABL2v-abl Abelson murine leukemia viral oncogene homolog 20.055
PEBP4phosphatidylethanolamine-binding protein 40.052
PEBP1phosphatidylethanolamine binding protein 10.052
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.051
GABARAPL1GABA(A) receptor-associated protein like 10.045
GABRG2gamma-aminobutyric acid (GABA) A receptor, gamma 20.044
GPR6G protein-coupled receptor 60.043
RHEBRas homolog enriched in brain0.041
KRASv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.041
FKBP8FK506 binding protein 8, 38kDa0.040
GHRHRgrowth hormone releasing hormone receptor0.037
RAP1ARAP1A, member of RAS oncogene family0.036
GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O0.035
EMP3epithelial membrane protein 30.033
NELL2NEL-like 2 (chicken)0.030
PTGER3prostaglandin E receptor 3 (subtype EP3)0.029
PTENphosphatase and tensin homolog0.028
ACTR2ARP2 actin-related protein 2 homolog (yeast)0.028
ADRB3adrenergic, beta-3-, receptor0.027
CALCRcalcitonin receptor0.027
PAWRPRKC, apoptosis, WT1, regulator0.026
ODF1outer dense fiber of sperm tails 10.025
RASGRF1Ras protein-specific guanine nucleotide-releasing factor 10.025
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.024
HTR45-hydroxytryptamine (serotonin) receptor 40.023
HTR1A5-hydroxytryptamine (serotonin) receptor 1A0.022
GUCA2Bguanylate cyclase activator 2B (uroguanylin)0.022
OPRM1opioid receptor, mu 10.022
PLEKHF2pleckstrin homology domain containing, family F (with FYVE domain) member 20.021
SLC6A7solute carrier family 6 (neurotransmitter transporter, L-proline), member 70.021
PAX3paired box 30.021
SCTRsecretin receptor0.021
UBE2Mubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)0.020
TBC1D10ATBC1 domain family, member 10A0.020
PRKAR2Aprotein kinase, cAMP-dependent, regulatory, type II, alpha0.019
GAD2glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)0.019
CEND1cell cycle exit and neuronal differentiation 10.018
GABBR2gamma-aminobutyric acid (GABA) B receptor, 20.018
PDE4DIPphosphodiesterase 4D interacting protein0.018
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.018
PPP3R1protein phosphatase 3, regulatory subunit B, alpha0.018
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.017
TBR1T-box, brain, 10.017
DRD1dopamine receptor D10.017
RAMP2receptor (G protein-coupled) activity modifying protein 20.017
DLGAP2discs, large (Drosophila) homolog-associated protein 20.017
ADRA1Aadrenergic, alpha-1A-, receptor0.017
ACRV1acrosomal vesicle protein 10.017
RAMP3receptor (G protein-coupled) activity modifying protein 30.017
IGSF21immunoglobin superfamily, member 210.016
SLC30A3solute carrier family 30 (zinc transporter), member 30.016
FGF4fibroblast growth factor 40.016
SVOPSV2 related protein homolog (rat)0.016
BZW1basic leucine zipper and W2 domains 10.016
HTR75-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)0.015
FEZF2FEZ family zinc finger 20.015
SLC13A2solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 20.015
KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)0.015
HCRThypocretin (orexin) neuropeptide precursor0.015
RETret proto-oncogene0.015
PAMpeptidylglycine alpha-amidating monooxygenase0.015
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Leprleptin receptor0.627
Drd2dopamine receptor D20.569
Esr1estrogen receptor 1 (alpha)0.563
Ghrgrowth hormone receptor0.487
Arandrogen receptor0.403
Kcna2potassium voltage-gated channel, shaker-related subfamily, member 20.120
Pnpla2patatin-like phospholipase domain containing 20.111
Gnrh1gonadotropin releasing hormone 10.091
Pgrprogesterone receptor0.091
Lhbluteinizing hormone beta0.089
Pax8paired box gene 80.088
Sstr4somatostatin receptor 40.073
Mc5rmelanocortin 5 receptor0.070
Cckbrcholecystokinin B receptor0.066
Actr3ARP3 actin-related protein 3 homolog (yeast)0.049
Cyp19a1cytochrome P450, family 19, subfamily a, polypeptide 10.045
BrafBraf transforming gene0.043
Ptenphosphatase and tensin homolog0.041
Nr5a1nuclear receptor subfamily 5, group A, member 10.040
Gabra2gamma-aminobutyric acid (GABA) A receptor, subunit alpha 20.039
Chrm1cholinergic receptor, muscarinic 1, CNS0.037
Duox2dual oxidase 20.036
Shc3src homology 2 domain-containing transforming protein C30.036
CblCasitas B-lineage lymphoma0.036
Ctnnb1catenin (cadherin associated protein), beta 10.035
Nfatc2nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 20.033
Ppargperoxisome proliferator activated receptor gamma0.031
Thrbthyroid hormone receptor beta0.031
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.030
Vdrvitamin D receptor0.029
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.028
Prlrprolactin receptor0.028
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.028
Cgaglycoprotein hormones, alpha subunit0.028
Trp53transformation related protein 530.027
Neurog3neurogenin 30.027
Kcna4potassium voltage-gated channel, shaker-related subfamily, member 40.027
Fgf10fibroblast growth factor 100.025
Adora2aadenosine A2a receptor0.025
Npy2rneuropeptide Y receptor Y20.024
Krt86keratin 860.024
Adrb1adrenergic receptor, beta 10.023
Fgf4fibroblast growth factor 40.023
Lhcgrluteinizing hormone/choriogonadotropin receptor0.023
Rac1RAS-related C3 botulinum substrate 10.023
Oprk1opioid receptor, kappa 10.022
Mobkl1bMOB1, Mps One Binder kinase activator-like 1B (yeast)0.022
Amhr2anti-Mullerian hormone type 2 receptor0.021
Kiss1KiSS-1 metastasis-suppressor0.021
Npy6rneuropeptide Y receptor Y60.021
Slc12a1solute carrier family 12, member 10.020
Gsx1GS homeobox 10.020
Btn1a1butyrophilin, subfamily 1, member A10.020
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.019
Esr2estrogen receptor 2 (beta)0.019
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.018
Tacr2tachykinin receptor 20.018
Bglapbone gamma carboxyglutamate protein0.017
Npy5rneuropeptide Y receptor Y50.017
Grid1glutamate receptor, ionotropic, delta 10.017
Ppyr1pancreatic polypeptide receptor 10.017
Tgfb1transforming growth factor, beta 10.017
Syn2synapsin II0.016
Hif1ahypoxia inducible factor 1, alpha subunit0.016
Tpm4tropomyosin 40.016
Prkccprotein kinase C, gamma0.015
Kcnd1potassium voltage-gated channel, Shal-related family, member 10.015
Slc2a5solute carrier family 2 (facilitated glucose transporter), member 50.015
Cdkn2acyclin-dependent kinase inhibitor 2A0.015
Mdm2transformed mouse 3T3 cell double minute 20.015
Gpr27G protein-coupled receptor 270.014
S100a5S100 calcium binding protein A50.014
Htr75-hydroxytryptamine (serotonin) receptor 70.014
Ccnd1cyclin D10.014
Apcadenomatosis polyposis coli0.014
Gabrg3gamma-aminobutyric acid (GABA) A receptor, subunit gamma 30.014
Atp4aATPase, H+/K+ exchanging, gastric, alpha polypeptide0.013
Lmx1bLIM homeobox transcription factor 1 beta0.013
Sstr1somatostatin receptor 10.013
Tacr1tachykinin receptor 10.013
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.013
Trpc5transient receptor potential cation channel, subfamily C, member 50.013
Zp2zona pellucida glycoprotein 20.013
Slc16a8solute carrier family 16 (monocarboxylic acid transporters), member 80.013
Lhx6LIM homeobox protein 60.013
Ptafrplatelet-activating factor receptor0.012
Rod1ROD1 regulator of differentiation 1 (S. pombe)0.012
Gnrhrgonadotropin releasing hormone receptor0.012
Gfra2glial cell line derived neurotrophic factor family receptor alpha 20.012
Crhr1corticotropin releasing hormone receptor 10.012
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.012
Adrb2adrenergic receptor, beta 20.012
Foxf2forkhead box F20.012
Rap2cRAP2C, member of RAS oncogene family0.012
Khdc1bKH domain containing 1B0.012
Tac2tachykinin 20.012
Sntb1syntrophin, basic 10.012
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism