The network for 'circulatory system development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

circulatory system development

The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis.

NameDescriptionProbabilityFunc Analog Organism
FosFBJ osteosarcoma oncogene0.832
Junbjun B proto-oncogene0.744
Nr4a3nuclear receptor subfamily 4, group A, member 30.679
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.605
Crisp1cysteine-rich secretory protein 10.554
Actc1actin, alpha, cardiac muscle 10.542
Ccl4chemokine (C-C motif) ligand 40.493
Npr3natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)0.439
Btg2BTG family, member 20.433
Tie1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.429
Acvrl1activin A receptor type II-like 10.412
Id3inhibitor of DNA binding 30.397
Hsd3b6hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 60.379
Gnrhrgonadotropin releasing hormone receptor0.379
Ccl2chemokine (C-C motif) ligand 20.369
Bcl2B-cell CLL/lymphoma 20.366
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.365
Ednrbendothelin receptor type B0.361
Htr2b5-hydroxytryptamine (serotonin) receptor 2B0.358
Mapre1microtubule-associated protein, RP/EB family, member 10.355
Pfn1profilin 10.349
Prrx1paired related homeobox 10.343
Metmet proto-oncogene0.340
F13a1coagulation factor XIII, A1 polypeptide0.327
Myh6myosin, heavy chain 6, cardiac muscle, alpha0.327
Strnstriatin, calmodulin binding protein0.326
Trim47tripartite motif-containing 470.319
Col12a1collagen, type XII, alpha 10.319
Egr1early growth response 10.317
Prkchprotein kinase C, eta0.312
Trib1tribbles homolog 1 (Drosophila)0.307
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.302
Hand2heart and neural crest derivatives expressed 20.299
Sdc3syndecan 30.296
Ceacam10carcinoembryonic antigen-related cell adhesion molecule 100.295
Rararetinoic acid receptor, alpha0.294
Twist2twist homolog 2 (Drosophila)0.292
Dusp1dual specificity phosphatase 10.289
Myl9myosin, light chain 9, regulatory0.288
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.282
Rhoaras homolog gene family, member A0.281
Ngfnerve growth factor (beta polypeptide)0.279
Lama5laminin, alpha 50.273
Egr2early growth response 20.269
Atf3activating transcription factor 30.267
Slit3slit homolog 3 (Drosophila)0.261
Ptgfrprostaglandin F receptor0.257
Sellselectin L0.254
Itgb1integrin, beta 10.249
Tpm4tropomyosin 40.248
Nos3nitric oxide synthase 3, endothelial cell0.246
Apcsamyloid P component, serum0.246
Acta2smooth muscle alpha-actin0.245
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.244
Col10a1collagen, type X, alpha 10.239
Fgfr2fibroblast growth factor receptor 20.239
Atp2a2ATPase, Ca++ transporting, cardiac muscle, slow twitch 20.238
Itgamintegrin, alpha M0.235
Gabrg3gamma-aminobutyric acid (GABA) A receptor, gamma 30.235
Fgfr1Fibroblast growth factor receptor 10.233
Chrna1cholinergic receptor, nicotinic, alpha 1 (muscle)0.229
Nexnnexilin (F actin binding protein)0.227
Jak1Janus kinase 10.225
Dchs1dachsous 1 (Drosophila)0.225
Ifi204interferon activated gene 2040.224
Rhojras homolog gene family, member J0.222
Notch3Notch homolog 3 (Drosophila)0.222
Dab2disabled homolog 2 (Drosophila)0.221
Sod3superoxide dismutase 3, extracellular0.221
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.213
Ppp2r2aprotein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform0.212
Tgfbr2transforming growth factor, beta receptor II0.211
Sec14l3SEC14-like 3 (S. cerevisiae)0.208
Sparcsecreted protein, acidic, cysteine-rich (osteonectin)0.208
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.206
Kdrkinase insert domain receptor0.203
Agtr1aangiotensin II receptor, type 1a0.201
Fstl1follistatin-like 10.197
Adora2aadenosine A2a receptor0.196
Cmklr1chemokine-like receptor 10.195
Lpllipoprotein lipase0.194
Ccr3chemokine (C-C motif) receptor 30.190
Aebp1AE binding protein 10.190
Slc8a1solute carrier family 8 (sodium/calcium exchanger), member 10.189
Col8a1collagen, type VIII, alpha 10.188
F2rl1coagulation factor II (thrombin) receptor-like 10.185
Ccl3chemokine (C-C motif) ligand 30.185
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.180
Pdk4pyruvate dehydrogenase kinase, isozyme 40.176
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.176
Ccr5chemokine (C-C motif) receptor 50.174
Pipprolactin induced protein0.173
Cpxm2carboxypeptidase X (M14 family), member 20.172
Plscr1phospholipid scramblase 10.172
Cd200r1CD200 receptor 10.172
Tnftumor necrosis factor (TNF superfamily, member 2)0.171
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
MadMothers against dpp0.993
EgfrEpidermal growth factor receptor0.985
eyaeyes absent0.974
nkdnaked cuticle0.940
Rho1CG8416 gene product from transcript CG8416-RB0.933
Ras85DRas oncogene at 85D0.928
emcextra macrochaetae0.926
Rac1CG2248 gene product from transcript CG2248-RA0.926
slp1sloppy paired 10.925
LanB2Laminin B20.916
G-oalpha47AG protein oalpha 47A0.906
bab2CG9102 gene product from transcript CG9102-RA0.891
cicubitus interruptus0.890
rheaCG6831 gene product from transcript CG6831-RA0.861
MhcMyosin heavy chain0.856
shotshort stop0.842
stumpsCG31317 gene product from transcript CG31317-RC0.789
S6kRPS6-p70-protein kinase0.749
E2f2E2F transcription factor 20.719
zfh1Zn finger homeodomain 10.705
LanALaminin A0.680
MrtfMyocardin-related transcription factor0.651
eveeven skipped0.633
Sema-1aCG18405 gene product from transcript CG18405-RD0.633
stmAstambha A0.613
wupAwings up A0.613
stcksteamer duck0.600
mewmultiple edematous wings0.594
Vap-33-1CG5014 gene product from transcript CG5014-RB0.584
AtpalphaNa pump alpha subunit0.564
Tsc1CG6147 gene product from transcript CG6147-RA0.558
gcmglial cells missing0.519
Cdc42CG12530 gene product from transcript CG12530-RA0.518
dallydivision abnormally delayed0.516
C15CG7937 gene product from transcript CG7937-RA0.480
Galpha49BG protein alpha49B0.448
Pka-C1cAMP-dependent protein kinase 10.423
sosine oculis0.406
abd-Aabdominal A0.399
pdm2POU domain protein 20.399
eIF-4EEukaryotic initiation factor 4E0.398
rapretina aberrant in pattern0.397
Zasp52Z band alternatively spliced PDZ-motif protein 520.384
snssticks and stones0.381
Akt1CG4006 gene product from transcript CG4006-RA0.380
NFATNFAT homolog0.379
Fmr1CG6203 gene product from transcript CG6203-RC0.362
O-fut1O-fucosyltransferase 10.358
lblladybird late0.355
LanB1CG7123 gene product from transcript CG7123-RA0.355
DadDaughters against dpp0.352
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
EGFRepidermal growth factor receptor1.000
CAV1caveolin 1, caveolae protein, 22kDa1.000
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)1.000
CREBBPCREB binding protein1.000
FN1fibronectin 11.000
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.999
EP300E1A binding protein p3000.999
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.999
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.998
NOTCH1notch 10.997
SMAD2SMAD family member 20.997
FGFR1fibroblast growth factor receptor 10.997
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.996
SMAD3SMAD family member 30.996
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.995
FLNAfilamin A, alpha0.993
PLCG1phospholipase C, gamma 10.992
ACTBactin, beta0.992
JAG1jagged 10.992
PTPN1protein tyrosine phosphatase, non-receptor type 10.991
NR4A1nuclear receptor subfamily 4, group A, member 10.990
TRIM63tripartite motif containing 630.984
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.984
YAP1Yes-associated protein 10.984
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.982
FHL2four and a half LIM domains 20.982
JUNjun proto-oncogene0.980
ESR1estrogen receptor 10.979
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.978
METmet proto-oncogene (hepatocyte growth factor receptor)0.978
SMAD1SMAD family member 10.977
VEGFAvascular endothelial growth factor A0.975
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.974
ANXA1annexin A10.972
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.969
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.967
VCAM1vascular cell adhesion molecule 10.965
MYOD1myogenic differentiation 10.965
FBN1fibrillin 10.963
PAX3paired box 30.963
QKIquaking homolog, KH domain RNA binding (mouse)0.960
NOTCH3notch 30.959
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.958
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.953
TAL1T-cell acute lymphocytic leukemia 10.951
FGF1fibroblast growth factor 1 (acidic)0.949
PKD2polycystic kidney disease 2 (autosomal dominant)0.948
CTGFconnective tissue growth factor0.947
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.947
THBS1thrombospondin 10.942
FGFR2fibroblast growth factor receptor 20.940
CYR61cysteine-rich, angiogenic inducer, 610.935
STK3serine/threonine kinase 30.933
NRP1neuropilin 10.924
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.917
DDX3XDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked0.915
LATlinker for activation of T cells0.915
SP1Sp1 transcription factor0.915
TIMP3TIMP metallopeptidase inhibitor 30.912
GSK3Bglycogen synthase kinase 3 beta0.910
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.907
ARandrogen receptor0.903
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.900
CAV2caveolin 20.891
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.887
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.881
TGFB1transforming growth factor, beta 10.881
LTBP2latent transforming growth factor beta binding protein 20.880
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.880
COL3A1collagen, type III, alpha 10.876
TEKTEK tyrosine kinase, endothelial0.873
COL6A1collagen, type VI, alpha 10.871
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.866
EPAS1endothelial PAS domain protein 10.865
GRB2growth factor receptor-bound protein 20.865
SPARCsecreted protein, acidic, cysteine-rich (osteonectin)0.864
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.863
RUNX1runt-related transcription factor 10.860
SHC1SHC (Src homology 2 domain containing) transforming protein 10.858
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.852
COL4A1collagen, type IV, alpha 10.851
NCK1NCK adaptor protein 10.847
MDM2Mdm2 p53 binding protein homolog (mouse)0.846
MEF2Cmyocyte enhancer factor 2C0.845
TNNC1troponin C type 1 (slow)0.845
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.843
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.842
PECAM1platelet/endothelial cell adhesion molecule0.835
SIRT1sirtuin 10.834
COL2A1collagen, type II, alpha 10.833
H2AFXH2A histone family, member X0.833
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.832
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.831
LMNAlamin A/C0.830
HOXB5homeobox B50.829
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.826
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.820
BCAR1breast cancer anti-estrogen resistance 10.819
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism